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    Kreb's Cycle, also known as the citric acid cycle or tricarboxylic acid cycle, is a series of chemical reactions in aerobic conditions that produces energy through the oxidation of acetyl-CoA derived from pyruvate. The cycle converts oxaloacetate and acetyl-CoA into citrate, and involves a series of oxidation-reduction reactions that generate NADH, FADH2, and GTP, which are used to produce ATP through oxidative phosphorylation. The cycle is a key step in aerobic respiration to produce energy through the oxidation of pyruvate.

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    Kreb's Cycle, also known as the citric acid cycle or tricarboxylic acid cycle, is a series of chemical reactions in aerobic conditions that produces energy through the oxidation of acetyl-CoA derived from pyruvate. The cycle converts oxaloacetate and acetyl-CoA into citrate, and involves a series of oxidation-reduction reactions that generate NADH, FADH2, and GTP, which are used to produce ATP through oxidative phosphorylation. The cycle is a key step in aerobic respiration to produce energy through the oxidation of pyruvate.

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    Kreb Cycle

    Uploaded by

    Navine Nav
    Kreb's Cycle, also known as the citric acid cycle or tricarboxylic acid cycle, is a series of chemical reactions in aerobic conditions that produces energy through the oxidation of acetyl-CoA derived from pyruvate. The cycle converts oxaloacetate and acetyl-CoA into citrate, and involves a series of oxidation-reduction reactions that generate NADH, FADH2, and GTP, which are used to produce ATP through oxidative phosphorylation. The cycle is a key step in aerobic respiration to produce energy through the oxidation of pyruvate.

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    Kreb's Cycle

    1. Kreb's Cycle was first worked out by Sir Hans Krebs in 1937.
    2. It is also called the Tricarboxylic Acid Cycle or Citric Cycle.
    3. Kreb's Cycle also take place in aerobic conditions.
    4. Pyruvate will give out CO2, converting NAD+ to NADH and react with Coenzyme A to form
    Acetyl Coenzyme A.
    5. Acetyl Coenzyme A react with Oxaloacetate to form Citrate, catalysed by citrate synthetase
    enzyme.
    6. Citrate rearrange itself to become isocitrate, catalysed by Aconitase enzyme.
    7. Oxidative decarboxylation of isocitric acid produces alpha-ketoglutaric acid. CO2 is released,
    NAD+ isconverted into NADH.
    8. Oxidative decarboxylation of alpha-ketoglutaric acid will produce succinic acid. CO2 and NADH
    formedGTP is produced before hydrolysed into GDP, producing energy which is used for
    phosphorylation of ADP to ATP.
    9. Succinate oxidised to fumarate. FADH2 is formed from FAD.
    10. Fumarate is hydrated to malate.
    11. Malate is oxidised to produce oxaloacetate again. NAD+ is converted to NADH.
    12. The whole cycle began again.

    Importance of Kreb's Cycle


    1. Forms 6C compound (citrate) that can be oxidised to produce CO2, reduced coenzyme and
    energy.
    2. Produces NADH and FADH2.
    3. Forms GTP.
    4. Synthesise substances such as amino acids, glycerol, chlorophyll and fatty acids.

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