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  • TDD LD50

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    Barlafuss Rebelhot
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    The document provides dosage information and lethal dose 50 (LD50) values for four cephalosporin antibiotics: cefuroxime sodium, cefoxitin sodium, cefotaxime sodium, and cefriaxone sodium. For each, the typical daily dosage for adults is given from sources like the Merck Manual. LD50 values from studies in mice and dogs are also listed, indicating the dosage at which 50% of subjects are expected to die, ranging from 240 mg/kg to over 4970 mg/kg depending on the antibiotic and administration route.

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    TDD-LD50

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    The document provides dosage information and lethal dose 50 (LD50) values for four cephalosporin antibiotics: cefuroxime sodium, cefoxitin sodium, cefotaxime sodium, and cefriaxone sodium. For each, the typical daily dosage for adults is given from sources like the Merck Manual. LD50 values from studies in mice and dogs are also listed, indicating the dosage at which 50% of subjects are expected to die, ranging from 240 mg/kg to over 4970 mg/kg depending on the antibiotic and administration route.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    5 views1 page

    TDD LD50

    Uploaded by

    Barlafuss Rebelhot
    The document provides dosage information and lethal dose 50 (LD50) values for four cephalosporin antibiotics: cefuroxime sodium, cefoxitin sodium, cefotaxime sodium, and cefriaxone sodium. For each, the typical daily dosage for adults is given from sources like the Merck Manual. LD50 values from studies in mice and dogs are also listed, indicating the dosage at which 50% of subjects are expected to die, ranging from 240 mg/kg to over 4970 mg/kg depending on the antibiotic and administration route.

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    CEFUROXIME SODIUM

    TDD (adults not children) - I.M., I.V.: 750 mg to 1.5 g every 6-8 hours or 100-150 mg/kg/day in divided
    doses every 6-8 hours (maximum: 6 g/day). FROM 2.25 g/day TO 6 g/day (Source: Merck Manual)

    LD50:

    > 1500mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349,
    dog LD50 intravenous  
    (1500mg/kg) 1982.

    CEFOXITIN SODIUM

    TDD (adults not children) - I.M., I.V.: 750 mg to 1.5 g every 6-8 hours or 100-150 mg/kg/day in divided
    doses every 6-8 hours (maximum: 6 g/day). FROM 2.25 g/day TO 6 g/day (Source: Merck Manual)

    LD50:

    BEHAVIORAL: ALTERED SLEEP TIME


    (INCLUDING CHANGE IN RIGHTING
    REFLEX)
    4970mg/kg Chemotherapy Vol.
    mouse LD50 intravenous BEHAVIORAL: CONVULSIONS OR EFFECT
    (4970mg/kg) 26(Suppl1), Pg. 150, 1978
    ON SEIZURE THRESHOLD

    LUNGS, THORAX, OR RESPIRATION:


    RESPIRATORY DEPRESSION

    CEFOTAXIME SODIUM

    TDD (Adults not children) - I.M., I.V.: 1-2 g every 4-12 hours. FROM 6g/day to 12g/day (Source: Merck
    Manual)

    LD50:

    > 716mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349,
    dog LD50 intramuscular  
    (716mg/kg) 1982.

    CEFTRIAXONE SODIUM

    TDD (Adults not children) - I.M., I.V.: I.M., I.V.: 1-2 g every 12-24 hours. FROM 2g/day to 4g/day
    (Source: Merck Manual)

    LD50: 240 mg/kg (Sagent Pharmaceuticals MSDS, Bedford Pharmaceuticals MSDS)

    1889 mg/kg (Pfizer MSDS)

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