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Differences between Skeletal,

Cardiac and Smooth Muscle.


By Khalid Shakeel Babar

Roll No 7

Gomal Medical College


Location
Appearance
Motor End Plate
• Cardiac Muscle • Skeletal Muscle
• Smooth Muscle

• Axon that innervate • Axon that innervate


• Axon that innervate
cardiac muscle do not skeletal muscle
smooth muscle do not
form end plate, terminal form end plate, will
form end plate, terminal
axons have multiple have pre synaptic
axons have multiple
varicosities of and post synaptic
varicosities of autonomic
nerve fibers diffuse on autonomic nerve fibers areas and receptors
top sheet of muscle- diffuse on top sheet of on post synaptic
Diffuse Junction. muscle-Diffuse membrane.
Junction.
• Varicosities contain • The transmitter
norepinephrine and • Varicosities contain released is
acetylcholine. norepinephrine and acetylcholine
acetylcholine.
Fibers
• Smooth Muscle • Cardiac Muscle • Skeletal Muscle
• Actin filaments are more • Actin filaments are • Actin filaments are
than Myosin filaments equal in number to equal in number to
and are attached to dense Myosin filaments. Myosin filaments.
bodies. • Cylindrical and
• Myosin filaments have long.
• Lattice-work,
side polar cross bridges so • Myosin filaments
combine and
that bridges on one side have cross bridges
recombine, form
hinges in one direction and pull in one
syncytium and
and the other in opposite direction.
intercalated disc.
direction. • This allows skeletal
• This allows smooth muscle to contract
muscle to contract almost almost 30 % of
80 % of their length. their length.
SR and Source of Ca
• Smooth Muscle • Cardiac Muscle • Skeletal Muscle

• SR is moderately • SR is extensively • SR is extensively


developed. SR lie near developed. developed.
the cell membrane. • It has T-tubule • It has T-tubule
Small invagination of system.
cell membrane, called system, bigger in
Caveoli represent size/diameter. • AP of T-tunule
transverse tubule system • AP of T-tunule causes release of Ca
of Smooth Muscle. causes release of Ca which excite actin
• AP transmitted to which excite actin myosin coupling.
Caveoli excite Ca myosin coupling. • Source of Ca is SR
release from SR. • Source of Ca is SR T-tubule.
• Source of Ca is mainly T-tubule system, IC
ECF.
source, EC source.
Excitation and Contraction
• Smooth Muscle • Cardiac Muscle • Skeletal Muscle

• Excitation by nervous • Excitation • Excitation


signals, hormonal exclusively by exclusively by
stimulation, stretch of nervous signals. nervous signals.
muscle.

• Contraction is • Contraction is
• Contraction is voluntary. Contain
involuntary and having involuntary. Contain
troponin complex. troponin complex.
Calmodulin in place of
troponin.
• ATPase activity is • ATPase activity is
• ATPase activity is little. average. much.
• Pacemaker is present. • Pacemaker is • Pacemaker is not
Slow present. Fast present
Action Potential
• Cardiac Muscle • Skeletal Muscle
• Smooth Muscle

• RMP -85 to -90mV • RMP -90mV


• RMP -50 to -60 mV

• AP Plateau type • Spike Potential


• Two Types
• 1-Spike Potential
• Duration 0.2-0.3sec. • Duration 1-2 msec
• 2-AP with Plateaus

• Duration- variable
The End

Thank You

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