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  • Transmitter Properties

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    Naveed Pasha
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    This document summarizes the major neurotransmitter systems in the brain, including monoamines, acetylcholine, serotonin, catecholamines, amino acids, and neuropeptides. For each neurotransmitter, it lists the receptors, second messenger systems affected, ion channels impacted, and key brain regions involved. In total, the table provides a high-level overview of the major neurotransmitters in the brain, their receptors, downstream effects, and places of action in condensed form.

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    This document summarizes the major neurotransmitter systems in the brain, including monoamines, acetylcholine, serotonin, catecholamines, amino acids, and neuropeptides. For each neurotransmitter, it lists the receptors, second messenger systems affected, ion channels impacted, and key brain regions involved. In total, the table provides a high-level overview of the major neurotransmitters in the brain, their receptors, downstream effects, and places of action in condensed form.

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    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    8 views1 page

    Transmitter Properties

    Uploaded by

    Naveed Pasha
    This document summarizes the major neurotransmitter systems in the brain, including monoamines, acetylcholine, serotonin, catecholamines, amino acids, and neuropeptides. For each neurotransmitter, it lists the receptors, second messenger systems affected, ion channels impacted, and key brain regions involved. In total, the table provides a high-level overview of the major neurotransmitters in the brain, their receptors, downstream effects, and places of action in condensed form.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 1

    Second

    Transmitter Receptor Net Channel Effects Places in Brain


    Messenger
    Monoamines
    Nicotinic (α is ↑Na+, K+ Neuromuscular junction,
    Acetylcholine the candidate autonomic ganglia, post ganglionic
    (each nicotinic for M. gravis) parasympathetic fibers; in brain
    receptor is M1, M3, M5 ↑IP3, DAG ↑Ca2+ basal forebrain complex and
    made of five pontomesencephalic cholinergic
    subunits from a M2, M4 ↓cAMP ↑ K+ complex
    menu of 16 (α,
    β, γ, δ, ε)
    Serotonin 5-HT3 ↑Na+ Brain Stem (midline Raphe nucleus)
    projecting to hypothalamus,
    neocortex, limbic system,
    cerebellum, spinal cord
    Catecholamines
    Dopamine D1, D5 ↑cAMP Nigrostriatal system, mesocortical
    D2 ↓cAMP ↑K+, ↓Ca2+ system projecting to nucleus
    D3, D4 ↓cAMP accumbens and limbic areas
    Norepinephrine α1 ↑IP3, DAG ↓K+ Locus ceruleus + other medullary
    α2 ↓cAMP ↑K+,↓Ca2+ and pontine nuclei  spinal cord,
    β1 ↑cAMP cerebellum and paraventricular,
    β2 ↑cAMP supraoptic, periventricular nuclei of
    β3 ↑cAMP thalamus, hypothalamus, basal
    telencephalon, entire neocortex
    Amino Acids
    Glutamate Metabotopic (many, don’t care)
    Ionotropic:
    AMPA, Kainate ↑Na+, K+

    NMDA ↑Na+, K+, Ca2+


    GABA GABAA ↑Cl-
    GABAB ↑IP3, DAG ↑K+,↓Ca2+
    Glycine Glycine ↑Cl-
    Neuropeptides
    Substance P NK-1 receptor ↑IP3, DAG - Pain pathways in peripheral tissue
    and spinal cord
    Enkephalins ↓cAMP ↓K+ (µ), closing of All are involved in the pain pathway
    µ, κ, δ Ca2+ channels (κ, δ) modulation, stimulation causes
    Endorphins µ ↓cAMP ↓K+ analgesia, especially found in the
    raphe nucleus of RF

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