DRUG

MECHANISM OF ACTION

CONTRAINDICATION

ADVERSE EFFECT

ACTIONS

NURSING CONSIDERATIONS Assessment History: Allergy tobenazepril or other ACE inhibitors, impaired renal function, CHF, salt or volume depletion, lactation, pregnancy Physical: Skin color, lesions, turgor; T; P, BP, peripheral perfusion; mucous membranes, bowel sounds, liver evaluation; urinalysis, LFTs, renal function tests, CBC and differential Interventions WARNING: Alert surgeon:Note use of benazepril onpatient's chart; theangiotensin II formationsubsequ ent tocompensatory reninrelease during surgery willbe blocked; hypotensionmay

Generic name: Benazeprilhydrochloride Brand Name: Lotensin Pregnancy Category C (first trimester)Pregnancy Category D(second and third trimesters)

Benazepril and its metabolite benazeprilat inhibit ACE that catalyzes the conversion of angiotensin I to angiotensin II, thus leading to reduce daldosterone secretion by the adrenal cortex and decreased vasopressor activity.

Hypersensitivity. History of bilateral renal artery stenosis, angioedema; pregnancy

Headache, dizziness, fatigue ; cough; somnolence, nausea; hypotension, transient elevations in BUN and serum creatinine; palpitations; constipation ,gastritis; melena,rash, pruritus; musculoskeletal pain; paraesthesia, anxiety; UTI; hyperkalaemia; leucopeniaand flushing. PotentiallyFatal: Angioedema(rare)

Treatment of hypertension alone or in combination with thiazide-type diuretics

Classification: Antihypertensive ACE inhibitor DOSAGE: Oral Hypertension Adult: Initially, 10 mg oncedaily. Maintenance: 20-40mg daily as a single or in 2divided doses. Max dose: 80mg/day. Child: 6 yr: 0.2 mg/kg/day.Max dose: 40 mg/day. Renal impairment: Avoidusage in children with CrCl<30 ml/min.

be reversed withvolume expansion. Monitor patient for possibledrop in BP secondary toreduction in fluid volume(excessive perspiration anddehydration, vomiting,diarrhea) becauseexcessiv e hypotension mayoccur.