MAGALONA, JANNEL S. Pharma 1Y2-1 ENDOCRINE SYSTEM ORGAN ACTION HYPOSECRETION 1.PITUITARY GLAND A.

Anterior pituitary gland It is a major Dwarfism participant in control of several complex physiologic processes, including growth and metabolism. Stimulates the thyroid gland to release thyroid hormone. Stimulates adrenal glands to produce hormones. isa trophicpeptide hor mone responsible for the release of folliclestimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary stimulates mammary gland growth and milk production 1.PITUITARY GLAND Myxedema crentenism Addisonss disease Kallmann syndrome, HYPERSECRETION

Growth hormone (GH)

anterior pituitary

Gigantism Acromegaly

Thyrotropin (TSH) Corticotropin (ACTH) Gonadotropins

thyroid adrenal glands ovaries and testes

Thyrotoxicosis Crushings disease

Hyperglycemia

Prolactin (PRL)

ovaries

Inability to produce milk after pregnancy.

Amenorrhea Galactorrhea.

Antidiurtic hormones (ADH) Oxytocin

Thyroxine (T4) Triiodothyronine (T3) Calcitonin

Parathyroid hormone (PTH)

Glucocorticoids

B. Posterior pituitary gland kidneys Regulates water Diabetes insipidus balance mammary Induces milk Low blood pressure glands and movement and uterine uterine inertia uterus contractions during child birth 2.THYROID GLAND thyroid Stimulates metabolic lethargy, weight gain rate for growth, cell metabolism thyroid cell metabolism, blood Myxedema levels Hashimotos disease thyroid Inhibits breakdown of hypercalcemia bone and causes decreases in blood calcium concentrations 3. PARATHYROID GLAND Skeletal Bone resorption Tenany system/bones Decreased urinary hypocalcemia ,kidneys excretion of calcium ,small gastrointestinal intestine absorption of calcium (vitamin D) Hypercalcemia Increased 4. ADRENAL GLAND liver cells Increases blood Addison disease glucose level by (muscle weakness stimulating liver cells, fatigue, weight loss) reduce inflammation.

abnormal water retention Impotence

hyperthyroidism Grave's disease hypocalcemia

Polyuria Polydipsia hypercalcemia

Crushing syndrome (moon face, red stretch marks, thin skin)

Mineralocorticoids Epinephrine/ Norepinephrine Gland

Kidney cells sympathetic nerve, heart, blood vessels, airways(brac hial tubes), and liver cells

retention of ions Intensifies and prolongs the sympathetic response during stress.

Decrease in water in blood low blood pressure. no problems

Conns syndrome Increased BP, increased HR, increased Cardiac force, increased Breathing rate, DECREASE in metabolism in digestive system, anxiety, sweating, exhaustion Premature male sexual development

Testosterone

Testes

5. GONADS A. Male Gonads Maturation of male reproductive organs 5. GONADS B. Female Gonads Promotes development and maintenance of female sexual characteristics Promotes conditions needed for pregnancy 6. PANCREATIC ISLET Stimulates glycogenolysis causing increase in blood glucose concentration Promotes glucose entry into cells causing

Lack of sexual development gynecomastia lack of female sexual development, infertility and osteoporosis Sterility Uncertain

Estrogen

Ovaries

premature sexual development in females and infertility

Progesterone Glucagon

Ovaries

pancreatic islets

Uncertain

Insulin

pancreatic islets

diabetes mellitus

severe insulin shock or hypoglycemia

Thymosin

Bone marrow

decrease in blood glucose concentration 7. THYMUS Promotes development of immune system cells

immune system

Maturation of T lymphocytes involved in immune response