Pathophysiology of BREAST CANCER

Predisposing Precipitating
factor factor
Gender M<F Cell death = Cell Life style
Genetic/Heredit Sexual practice
Virus
Response with Environmental
carcinogen Chemical
Physical
Damage/Change in
genetic material
[DNA]

Hyperplas

Recurrent
Absorb injury
Surrounding
Nutrients metaplasia

Cell Prolonged
injury

Hypothala Mutation
mus
Loss of P53
Lipolys
is Loss of
apoptysis
Fat
loss Dysplasia

Weakne anaplasia
ss Decreased T- BREAST
CELL
Weight Lump
loss Neoplasia
Tail of Spence
Anorex
ia Orange peel
1cm growth dumpling
Wasting
syndrome Angio genesis Nipple
growth factor inversion
Cachex
ia

Hypoxia Anoxia Inflammation kinis

Lactic Cell
acid Death Pyrogen Recurrent

Pain