appendix1C

chapter

Therapeutic Serum Drug

Concentrations for Selected Drugs
Listed below are generally accepted therapeutic serum drug listed for selected drugs. SI units have not been established
concentrations, in conventional and SI units, for several for some drugs.
commonly used drugs. In addition, toxic concentrations are

Drug Conventional Units SI Units

Acetaminophen 0.20.6 mg/dL 1340 mol/L

Toxic >5 mg/dL >300 mol/L
Amikacin (peak) 1632 mcg/mL 2030 mg/L
(trough) 8 mcg/mL
Amitriptyline 110250 ng/mL 375900 nmol/L
Carbamazepine 412 mcg/mL 1750 mol/L
Desipramine 125300 ng/mL 470825 nmol/L
Digoxin 0.52.2 ng/mL 12.6 nmol/L
Disopyramide 28 mcg/mL 618 mol/L
Ethosuximide 40110 mcg/mL 280780 mol/L
Gentamicin (peak) 48 mcg/mL 510 mg/L
(trough) 2 mcg/mL
Imipramine 200350 ng/mL 530950 nmol/L
Lidocaine 1.56 mcg/mL 621 mol/L
Lithium 0.51.5 mEq/L 0.51.5 mmol/L
Maprotiline 50200 ng/mL 180270 nmol/L
Netilmicin (peak) 610 mcg/mL 510 mg/L
(trough) 2 mcg/mL
Nortriptyline 50150 ng/mL 190570 nmol/L
Phenobarbital 1550 mcg/mL 65170 mol/L
Phenytoin 1020 mcg/mL 4080 mol/L
Primidone 512 mcg/mL 2545 mol/L
Procainamide 48 mcg/mL 1740 mol/L
Propranolol 50200 ng/mL 190770 nmol/L
Protriptyline 100300 ng/mL 3801140 nmol/L
Quinidine 26 mcg/mL 4.69.2 mol/L
Salicylate 100200 mg/L 7241448 mol/L
Toxic >200 mg/L >1450 mol/L
Theophylline 1020 mcg/mL 55110 mol/L
Tobramycin (peak) 48 mcg/mL 510 mg/L
(trough) 2 mcg/mL
Valproic acid 50100 mcg/mL 350700 mol/L
Vancomycin (peak) 3040 mg/mL (peak) 2040 mg/L
(trough) 510 mg/mL (trough) 510 mg/L

mcg, microgram; ng, nanogram; mol, micromole.

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