ASPIRIN

Aspirin, or acetylsalicylic acid (ASA), is a common drug that is generally used as a pain reliever for minor aches and pains, to
reduce fever, and also as an anti-inflammatory drug.
Aspirin has also become increasingly popular as a drug to prevent clot-forming; it is used long-term in low doses to prevent heart
attacks and strokes in high-risk patients.
Nowadays, aspirin is often given to patients immediately after a heart attack to prevent recurrence or cardiac tissue death.

Fast facts on aspirin

Here are some key points about aspirin. More detail and supporting information is in the main article.
Aspirin is one of the most widely used medications in the world
Aspirin is a derivative of salicylate, which can be found in such plants as willow trees and myrtle
Aspirin was the first non-steroidal anti-inflammatory drug to be discovered
Apollo Moon astronauts had Aspirin included in their self-medication kits
Aspirin interacts with a number of other drugs, including warfarin and methotrexate

What is aspirin?
A bottle of aspirin.
Aspirin is commonly used to relieve pain, inflammation, and fever and prevent clot formation.
Aspirin is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are medications with the following effects
Analgesic - pain relief without anesthesia or loss of consciousness
Antipyretic - reduces a fever
Anti-inflammatory - in higher doses
Non-steroidal simply means they are not steroids, which often have similar effects.
As analgesics, NSAIDs are generally non-narcotic (do not cause insensibility or stupor). Aspirin was the first NSAID to be
discovered.
Aspirin in its present form has been around for over 100 years and is still one of the most widely used medications in the world. It
is estimated that approximately 35,000 metric tons of aspirin is consumed annually. Aspirin is a trademark owned by German
pharmaceutical company - Bayer; the generic term for aspirin is acetylsalicylic acid (ASA).
Therapeutic uses of aspirin
Aspirin is one of the most commonly used drugs for the treatment of mild to moderate pain, as well as migraines and fever. For
the treatment of moderate to severe pain, it is frequently used along with other opioid analgesic and NSAIDs.

Below are some of the therapeutic uses of aspirin:

Mild to moderate pain
Moderate to severe pain combined with other medications
Rheumatic fever (in higher doses)
Rheumatic arthritis (in higher doses)
Many other inflammatory joint conditions (in higher doses)
To inhibit platelet aggregations (blood clot formations) to reduce risk of transient ischemic attacks and unstable angina (in lower
doses)
For the prevention of stroke (in lower doses)
For the prevention of myocardial infarction in patients with cardiovascular disease
In the treatment of pericarditis
In the treatment of coronary artery disease
In the treatment of myocardial infarction

Aspirin and children

Acetaminophen (paracetamol, Tylenol) and ibuprofen are generally used for children; not aspirin. Aspirin and salicylate NSAID
usage in children raise the risk of developing Reye's Syndrome. In some countries, such as the United Kingdom, aspirin is only
occasionally used in children under specialist supervision for Kawasaki disease and to prevent blood clot formation after heart
surgery.

Low-dose aspirin
Low-dose aspirin (75 milligrams per day) is used as an antiplatelet medication - to prevent the formation of clots in the blood.
Low-dose aspirin may be given to patients who had:
A coronary artery bypass graft operation
A heart attack
A stroke
Atrial fibrillation
Acute coronary syndrome
The following people may also be given low-dose aspirin if the doctor believes they are at risk of heart attack or stroke:
Patients with high blood cholesterol levels
Patients with hypertension (high blood pressure)
Patients with diabetes
Some smokers

The following patients may also be advised to take low-dose aspirin:

Those with damage to the retina (retinopathy)
Some patients who have had diabetes for over 10 years
Some patients who are taking antihypertensive medications
In all these cases, low-dose aspirin will be taken daily for the rest of the patient's life.

Precautions for aspirin use

Aspirin is not recommended for the following patients:
People who have a peptic ulcer
Patients with hemophilia or any other bleeding disorder
People with a known allergy to aspirin
People who are allergic to any NSAIDs, such as ibuprofen
Children under 16 years of age (unless under specialist medical supervision)

The following people should be cautious about taking aspirin, and should only do so if the doctor agrees:
Patients with asthma
Patients with uncontrolled hypertension
People who have had a previous peptic ulcer
Patients with liver problems
Patients with kidney problems
Anyone planning to have a surgical operation should tell their doctor if they are taking regular aspirin. In many cases, patients will
be asked to stop taking the aspirin for 7 days before the operation.
Pregnant or breast-feeding patients may take low-dose aspirin, but only under their doctor's supervision. High-dose aspirin is not
recommended.
Drug interactions with aspirin
A bottle of ibuprofen.
If taken alongside anti-inflammatory painkillers such as ibuprofen and diclofenac, aspirin can increase the risk of stomach
bleeding.
Sometimes, one medication can undermine the efficacy of another medication - this is called a drug interaction. Below is a list of
the most common drugs that aspirin interacts with (there are more):
Anti-inflammatory painkillers - such as diclofenac, ibuprofen, indomethacin, and naproxen increase the risk of stomach bleeding if
taken in combination with aspirin.
Methotrexate - used in the treatment of cancer and some autoimmune diseases. Aspirin can make it harder for the body to
eliminate methotrexate, resulting in high and potentially dangerous levels of methotrexate in the body.
SSRI (selective serotonin reuptake inhibitors) antidepressants - drugs, such as citalopram, fluoxetine, paroxetine, venlafaxine,
and sertraline, taken with aspirin can increase the risk of bleeding.
Warfarin - this is an anticoagulant drug (a blood thinner); it stops the blood from clotting. Aspirin taken with warfarin can reduce
the drug's anticoagulant effects, increasing the risk of bleeding. In some situations, however, a doctor may prescribe aspirin
together with warfarin.
Aspirin side effects
The most common side effects of aspirin are:
Irritation of the stomach or gut
Indigestion
Nausea
The following side effects are possible, but less common:
Asthma symptoms may worsen
Vomiting
Inflammation of the stomach
Stomach bleeding
Bruising
An extremely rare side effect of low-dose aspirin is hemorrhagic stroke.