TUGAS EBM

“PICO”

NAMA : MARLENI

NPM : 1102010156

KELOMPOK : B-1

FAKULTAS KEDOKTERAN

UNIVERSITAS YARSI

2010
KASUS

Seorang wanita berusia 22 tahun menderita sakit kepala sebelah (migrain). Sebagai obat
pereda nyeri kepalanya dokter meresepkan aspirin, namun, pasien tersebut mengatakan
bahwa sebelumnya dia telah mengkonsumsi ibuprofen.

PERTANYAAN

Apakah penggunaan ibuprofen pada penderita sakit kepala sebelah (migrain) lebih efektif
meredakan sakit kepala dibanding dengan penggunaan aspirin?

PICO

Population : Penderita sakit kepala sebelah (migrain)

Intervention : Ibuprofen

Comparison : Aspirin

Objection : Cepat reda/sembuh sakit kepala

KATA KUNCI

Migraine AND ibuprofen AND aspirin

PEMILIHAN SITUS

http://www.yarsi.ac.id/web.ebscohost.com/ehost/resultsadvanced

HASIL PENCARIAN 9

1. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute

migraine: results from a multicenter, double-blind, randomized, parallel-group, single-
dose, placebo-controlled study.Full Text Available (eng; includes abstract) By
Goldstein J, Silberstein SD, Saper JR, Ryan RE Jr, Lipton RB, Headache [Headache],
ISSN: 0017-8748, 2006 Mar; Vol. 46 (3), pp. 444-53; PMID: 16618262

Subjects: Acetaminophen administration & dosage; Analgesics, Non-Narcotic

administration & dosage; Anti-Inflammatory Agents, Non-Steroidal administration & dosage;
Aspirin administration & dosage; Caffeine administration & dosage; Central Nervous System
Stimulants administration & dosage; Ibuprofen therapeutic use; Migraine Disorders drug
therapy; Adult: 19-44 years; All Adult: 19+ years; Female; Male

2. OTC analgesics in headache treatment: open-label phase vs randomized double-blind

phase of a large clinical trial.Full Text Available (eng; includes abstract) By
Pfaffenrath V, Diener HC, Pageler L, Peil H, Aicher B, Headache [Headache], ISSN:
1526-4610, 2009 May; Vol. 49 (5), pp. 638-45; PMID: 19472437

Subjects: Acetaminophen administration & dosage; Aspirin administration & dosage;

Caffeine administration & dosage; Headache Disorders drug therapy; Nonprescription Drugs
administration & dosage; Adolescent: 13-18 years; Adult: 19-44 years; Aged: 65+ years;
Middle Aged: 45-64 years; All Child: 0-18 years; All Adult: 19+ years; Female; Male

3. Intracranial hypotension following motor vehicle accident: an overlooked cause of

post-traumatic head and neck pain?Full Text Available (eng; includes abstract) By
Huntoon MA, Watson JC, Pain Practice: The Official Journal Of World Institute Of
Pain [Pain Pract], ISSN: 1533-2500, 2007 Mar; Vol. 7 (1), pp. 47-52; PMID:
17305680

Subjects: Accidents, Traffic; Aspirin therapeutic use; Headache drug therapy; Intracranial
Hypotension etiology; Intracranial Hypotension therapy; Middle Aged: 45-64 years; All
Adult: 19+ years; Female

4. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and

ibuprofen in the treatment of migraine attacks.Full Text Available (eng; includes
abstract) By Diener HC, Bussone G, de Liano H, Eikermann A, Englert R, Floeter T,
Gallai V, Göbel H, Hartung E, Jimenez MD, Lange R, Manzoni GC, Mueller-Schwefe
G, Nappi G, Pinessi L, Prat J, Puca FM, Titus F, Voelker M, EMSASI Study Group,
Cephalalgia: An International Journal Of Headache [Cephalalgia], ISSN: 0333-1024,
2004 Nov; Vol. 24 (11), pp. 947-54; PMID: 15482357

Subjects: Aspirin therapeutic use; Ibuprofen therapeutic use; Migraine Disorders drug
therapy; Sumatriptan therapeutic use; Adult: 19-44 years; Middle Aged: 45-64 years; All
Adult: 19+ years; Female; Male

5. Over-the-counter analgesics and risk of ovarian cancer.Full Text Available (eng;

includes abstract) By Cramer DW, Harlow BL, Titus-Ernstoff L, Bohlke K, Welch
WR, Greenberg ER, Lancet [Lancet], ISSN: 0140-6736, 1998 Jan 10; Vol. 351 (9096),
pp. 104-7; PMID: 9439495

Subjects: Analgesics, Non-Narcotic adverse effects; Anti-Inflammatory Agents, Non-

Steroidal adverse effects; Nonprescription Drugs adverse effects; Ovarian Neoplasms
chemically induced; Adult: 19-44 years; Aged: 65+ years; Middle Aged: 45-64 years; All
Adult: 19+ years; Female

6. Community pharmacy treatment of minor ailments in refugees.Full Text Available

(eng; includes abstract) By Parmentier H, Golding S, Ashworth M, Rowlands G,
Journal Of Clinical Pharmacy And Therapeutics [J Clin Pharm Ther], ISSN: 0269-
4727, 2004 Oct; Vol. 29 (5), pp. 465-9; PMID: 15482391

Subjects: Community Pharmacy Services; Delivery of Health Care organization &

administration; Nonprescription Drugs therapeutic use; Refugees

7. Efficacy of diclofenac sodium softgel 100 mg with or without caffeine 100 mg in

migraine without aura: a randomized, double-blind, crossover study.Full Text
Available (eng; includes abstract) By Peroutka SJ, Lyon JA, Swarbrick J, Lipton RB,
 Kolodner K, Goldstein J, Headache [Headache], ISSN: 0017-8748, 2004 Feb; Vol. 44
(2), pp. 136-41; PMID: 14756851

Subjects: Anti-Inflammatory Agents, Non-Steroidal administration & dosage; Caffeine

administration & dosage; Diclofenac administration & dosage; Migraine without Aura drug
therapy; Adolescent: 13-18 years; Adult: 19-44 years; Middle Aged: 45-64 years; All Child:
0-18 years; All Adult: 19+ years; Female; Male

8. Elevated hepatic transaminases associated with telithromycin therapy: a case report

and literature review.Full Text Available (eng; includes abstract) By Bolesta S,
Roslund BP, American Journal Of Health-System Pharmacy: AJHP: Official Journal
Of The American Society Of Health-System Pharmacists [Am J Health Syst Pharm],
ISSN: 1535-2900, 2008 Jan 1; Vol. 65 (1), pp. 37-41; PMID: 18159037

Subjects: Alanine Transaminase blood; Anti-Bacterial Agents adverse effects; Aspartate

Aminotransferases blood; Drug-Induced Liver Injury etiology; Ketolides adverse effects;
Respiratory Tract Infections drug therapy; Adult: 19-44 years; All Adult: 19+ years; Male

9. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis

and rheumatoid arthritis.Full Text Available (eng; includes abstract) By Hedner T,
Samulesson O, Währborg P, Wadenvik H, Ung KA, Ekbom A, Drugs [Drugs], ISSN:
0012-6667, 2004; Vol. 64 (20), pp. 2315-43; discussion 2344-5; PMID: 15456329

Subjects: Anti-Inflammatory Agents, Non-Steroidal metabolism; Anti-Inflammatory

Agents, Non-Steroidal pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal
therapeutic use; Arthritis, Rheumatoid drug therapy; Butanones metabolism; Butanones
pharmacokinetics; Butanones therapeutic use; Cyclooxygenase Inhibitors adverse effects;
Cyclooxygenase Inhibitors therapeutic use; Osteoarthritis drug therapy; Stomach Diseases
chemically induced; Adolescent: 13-18 years; Adult: 19-44 years; Aged: 65+ years; Child: 6-
12 years; Child, Preschool: 2-5 years; Middle Aged: 45-64 years; All Child: 0-18 years; All
Adult: 19+ years

ARTIKEL YANG DIPILIH

Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine:
results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-
controlled study