DOC/LP/00/28.02.

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LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 1 of 7
Branch: BIOTECHNOLOGY Semester : IV

OBJECTIVE:

At the end of this course, the students would have learnt about classical thermodynamics.
This subject will facilitate the students by providing basic concepts for courses like
bioprocess principles, heat transfer, etc.

SCOPE:

Applied thermodynamics for biotechnologists enlists thermodynamic properties of fluids

for both ideal and non-ideal solutions and understanding phase equilibria and chemical
reaction equilibria. This course will also help the student to take up course in Bioprocess
principles and an advanced elective course like Molecular modeling and Drug design. At
the industry level, students will gain knowledge about thermodynamic analysis of
processes.
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LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 2 of 7
Unit : I Branch: BIOTECHNOLOGY Semester :
IV
Unit syllabus: THERMODYNAMIC LAW AND PROPERTIES OF FLUIDS 9 hrs
First Law of Thermodynamics, a generalized balance equation and conserved quantities,
Volumetric properties of fluids exhibiting non ideal behavior; residual properties;
estimation of thermodynamic properties using equations of state; calculations involving
actual property exchanges; Maxwell’s relations and applications.

Session
No Topics to be covered Time Ref/Page Numbers Teaching
(min) Aids
1 Introduction to Thermodynamics, Classification of 50 TB 1 (1-15) LCD/BB
Thermodynamic properties. &
TB 2 (188-189)
2 Volumetric properties of pure fluids-PVT behavior, Virial 50 TB 1 (52-59) LCD/BB
equation and its application, various correlations, Simple
problems.
3 Residual properties-Gibbs energy, Thermodynamic 50 TB 1 (190-202) LCD/BB
diagrams.

4 Equations of state-Maxwells equation, Clapeyron equation, 50 TB 2 (193-197) LCD/BB

Entropy heat capacity equations.

5 Effect of temperature, pressure and volume on U, H and S, 50 TB 2 (202-209) LCD/BB

CP-CV relationship, Problems.

6 Joule-Thomson Coefficient, Gibbs-Helmholtz Equation. 50 TB 2 (214-216) LCD/BB

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7 Problems involving actual property exchanges. 50 TB 2 (248-252) LCD/BB
8 Maxwell’s relations and applications, Additional problems 50 TB 1 (182-190) LCD/BB
in Unit 1
9 Review of unit 1 and giving assignment for students from 50 - BB
Unit 1 problems.

LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 3 of 7
Unit: II Branch: BIOTECHNOLOGY Semester : IV

Unit syllabus: SOLUTION THERMODYNAMICS 9 hrs

Partial molar properties; concepts of chemical potential and fugacity; ideal and non-ideal
solutions; concepts and applications of excess properties of mixtures; activity coefficient;
composition models; Gibbs Duhem equation.

Session Topics to be covered

No Time Ref Teaching
(min) Aids
1 Partial molar properties-physical meaning of partial molar 50 TB1 (315-316) LCD/BB
properties, determination of partial molar properties. TB2 (254-264)
TB3 (333 – 342)
2 Chemical potential, Effect of temperature and pressure on 50 TB1 (317-319) LCD/BB
Chemical potential. TB2 (265-268)
TB3 (343-346)
3 Fugacity and Fugacity coefficient for pure species and 50 TB1 (332-346) LCD/BB
species in solution, Generalized correlations for Fugacity TB 2 (269-274)
coefficient, Problems involving Fugacity and Fugacity TB3 (353 – 359)
coefficient.
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4 Ideal and non-ideal solutions, Raoult’s law, Henry’s law, 50 TB1 (347-348) LCD/BB
Problems. TB2 (274-275)
TB3 (360 – 365)
5 Concepts and applications of excess properties of mixtures 50 TB1 (349-351) LCD/BB
TB2 (298-299)
TB3 (366 – 370)
6 Activity, Activity coefficient, Effect of temperature and 50 TB2 (278-282) LCD/BB
pressure on Activity coefficient, Problems. TB3 (347 – 349)
7 Gibbs Duhem Equation and problems related to it. 50 TB2 (283-287) LCD/BB
TB3 (349-352)
8 Additional problems in unit 2 50 TB 1 (360-365) BB
TB 2(303-308)

9 Tutorial –I 50 - BB

LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 4 of 7
Unit: III Branch: BIOTECHNOLOGY Semester : IV

Unit syllabus: PHASE EQUILIBRIA 9 hrs

Criteria for phase equilibria; v-l-e calculations for binary and multi component systems;
liquid-liquid equilibria and solid-solid equilibria.

Session
No Topics to be covered Time Ref Teaching
(min) Aids
1 Criteria of Phase equilibria-Constant U and V, Constant T 50 TB2 (310-312) LCD/BB
and V, Constant P and T. TB3 (383 – 386)
2 Criterion of stability, Vapor-liquid equilibria, Phase 50 TB1 (501-507) LCD/BB
diagram for binary solutions, Problems. TB 2 (312-314,
326-330)
TB3 ( 387- 390)
3 Vapor-liquid equilibria for multicomponent system, 50 TB1 (516-525) LCD/BB
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Problems. TB 2 (362-366)
TB3 (391 – 395)
4 Binary liquid-liquid equilibria, Diagrams, Problems. 50 TB 2 (381, LCD/BB
384-386)
TB3 (449 – 453)
5 Multicomponent liquid-liquid equilibria, Diagrams, 50 TB 2 (382-386) LCD/BB
Problems

6 Solid- Solid equilibria 50 TB1 (526-535) LCD/BB

TB3 (454-455)
7 Additional problems in unit 3 50 TB1 (555-558) LCD/BB
TB2 (386-397)

8 Review of unit 3 and giving assignment for students from 50 - BB

Unit 3 problems.

9 Tutorial - II 50 - BB

LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 5 of 7
Unit : IV Branch: BIOTECHNOLOGY Semester :
IV

Unit syllabus: CHEMICAL REACTION EQUILIBRIA 9 hrs

Equilibrium criteria for homogeneous chemical reactions; evaluation of equilibrium
constant; effect of temperature and pressure on equilibrium constant; calculation of
equilibrium conversion and yields for single and multiple reactions.

Session
No Topics to be covered Time Ref Teaching Aids
(min)
1 Equilibrium criteria for homogeneous chemical reactions 50 TB1 (564-567) LCD/BB
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and its applications, Standard Gibbs energy. TB2 (399-403)
TB3 (470 – 474)
2 Equilibrium constant, effect of temperature and pressure 50 TB1 (565-567) LCD/BB
on equilibrium constant, Problems. TB 2 (404-420)
TB3 (475-476)
3 Evaluation of equilibrium constant, Problems. 50 TB1 (571-573) LCD/BB
TB3 (475-476)
4 Calculation of equilibrium conversion and yields for 50 TB1 (577-589) LCD/BB
single reaction and related problems.
5 Calculation of equilibrium conversion and yields for 50 TB1 (594-603) LCD/BB
multiple reaction and related problems.
6 Other factors affecting equilibrium conversion like inert 50 TB2 (422-428) LCD/BB
materials, excess of reactants, products etc., TB3 (493- 496)
7 Additional problems in Unit 4 50 TB 1 (604-611) LCD/BB

8 Additional problems in Unit 4 50 TB 2 (441-450) BB

9 Tutorial III 50 - BB

LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 6 of 7
Unit : V Branch: BIOTECHNOLOGY Semester : IV

Unit syllabus: THERMODYNAMIC DESCRIPTION OF MICROBIAL GROWTH

AND PRODUCT FORMATION 9 hrs
Thermodynamics of microbial growth stoichiometry thermodynamics of maintenance,
Calculation of the Operational Stoichiometry of a growth process at different growth
rates, including Heat using the Herbert-Pirt relation for Electron donor, thermodynamics
and stoichiometry of product formation.
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Session
No Topics to be covered Time Ref Teaching Aids
(min)
1 Thermodynamics of microbial growth 50 Internet notes LCD/BB

2 Stoichiometry thermodynamics of maintenance 50 Internet notes LCD/BB

3 Non-growth components and models for microbial 50 Internet notes LCD/BB

maintenance
4 Herbert Model & Pirt Model 50 Internet notes LCD/BB

5 Compromise Model 50 Internet notes LCD/BB

6 Relationship between three models 50 Internet notes LCD/BB

7 Overall maintenance coefficient and Multi-Parameter 50 Internet notes LCD/BB

Sensitivity analysis

8 Implications of microbial ecology modeling 50 Internet notes LCD/BB

9 Tutorial IV 50 - BB

LESSON PLAN LP- BT6402

LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS Date: 30-12-14
FOR BIOTECHNOLOGISTS Page 7 of 7
Branch: BIOTECHNOLOGY Semester : IV

COURSE DELIVERY PLAN:

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Week 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Units
I II III IV V

TEXT BOOK (TB):

1. Smith J.M., Van Ness H.C., Abbot M.M. Chemical Engineering Thermodynamics.
6th Edition. McGraw-Hill, 2001.
2. Narayanan K.V. A Text Book of Chemical Engineering Thermodynamics. Prentice
Hall India, 2001.
3. Gopinath Halder. Introduction to Chemical Engineering Thermodynamics, PHI,
2009.

REFERENCE BOOK (RB):

1. Sandler S.I. Chemical and Engineering Thermodynamics. John Wiley,
1989.
2. Christiana D.Smolke, The Metabolic pathway engineering handbook
fundamentals, CRC Press Taylor & Francis Group, 2010.
3. Urs von Stockar, Thomas Maskow, Jingsong Liu, Ian W.Marison, Rodrigo
Patino, Thermodynamics of microbial growth and metabolism: an analysis of the
current situation (2006) Journal of Biotechnology, 121, 517-533.

Prepared by Approved by
Signature

Name P. K. Praveen Kumar Dr. Sulochana Somasundaram

Designation Assistant Professor Professor and HOD

Department of Biotechnology Department of Biotechnology

Date 30-12-2014 30-12-2014