DRUG STUDY

Name Mechanism of Action Indication/Contraindication Side Effects Nursing Responsibility

Generic Name: Second-generation Indication: Body as a Whole:  Determine history of

CEFUROXIME cephalosporin that inhibits cell- Thrombophlebitis (IV site); hypersensitivity
wall synthesis, promoting Pharyngitis, tonsillitis, pain,burning, cellulitis( IM reactions to
Brand Name: osmotic instability; usually infections of the urinary and site);superinfections,positive cephalosphorins,
ZOLTAX bactericidal. lower respiratory tracts, and Coombs'test. penicillins and history
skin and skin-structure of allergies
Classification: infections caused by GI: particularly to drugs
ANTIBIOTIC Streptococcus pneumoniae Diarrhea, before therapy is
and S. pyogenes, nausea, antibiotic-associated initiated.
Frequency: Haemophillus influenzae, colitis.
BID Staphylococcus aureus,  Report onselt of loose
Escherichia coli. Skin: stools
Dosage: Rash, pruritus, urticaria.
1 tab 500 mg  Absorption of
Contraindicated: Urogenital: cefuroxime is
Route: Increased serum cretonne enhanced by food.
PO * Contraindicated in patients and BUN, decreased creatinine
hypersensitive to drug. clearance  Notify prescriber
* Use cautiously in patients about rashes or
hypersensitive to penicillin superinfections
because of possibility of cross-
sensitivity with other beta-
lactam antibiotics.
* Use with caution in breast-
feeding women and in
patients with history of colitis
or renal sufficiency.