Glycine 7 +

7 NH 3
NH 3+ H2C 5
H2C 5
5 5 O C4 N 5,N10-
P O CH 2 P O CH 2 P O CH 2 O C4 NH Methenyl-
9 O– P O H2C H
ATP AMP Glutamine Glutamate + H 4 folate H 4 folate
H H NH 3 N
O 1 O H 2O
2
PPi O 3 O 4 H2C5 7 8 CH
4 1
H H Mg 2+ H H H H Mg 2+ H H C4 9 O
H OH H 3 2 O P O P PRPP Glutamyl H H H H Formyltransferase NH
Amidotransferase ATP ADP + Pi O
PRPP
OH OH Synthase OH OH OH OH OH OH R-5- P
α-D-Ribose 5-phosphate Phosphoribosyl 5-Phospho-β-D-ribosylamine Glycinamide
(I) pyrophosphate (PRPP) (II) (III) ribosyl-5-phosphate Formylglycinamide
(IV) ribosyl-5-phosphate
(V)

– OOC
Gln
+ ATP
HC NH3 VI Synthetase 5 2
Mg +
Aspartate Glu
CH2
– OOC

COO – O O ATP, Mg 2 +
– OOC
H 2O CO2 H2O Ring closure N
CH C N C N N H
HC N1 6 C 8 –O 6 5 7 HC 6 H2C5 7 8 CH
5
H 4
CH CH CH
HC 4
H 2C 3 C 3 C 3 C4 9 O
H2 N N IX Synthetase H2 N N VII Carboxylase H2N N VII Synthetase NH
– OOC HN
– OOC
R-5- P R-5- P R-5- P R-5- P
Fumarate
Aminoimidazole succinyl Aminoimidazole Aminoimidazole Formylglycinamidine
9 carboxamide ribosyl-5-phosphate carboxylate ribosyl-5-phosphate ribosyl-5-phosphate ribosyl-5-phosphate
(IX) (VIII) (VII) (VI)

Adenylosuccinase

O N 10 -Formyl- O O
H 4 folate H 4 folate H 2O
C N C N C N
H2 N C 10 H2N C 11 HN C
CH CH CH
C O C C Ring closure HC C
H2N N Formyltransferase H N N N N
H IMP Cyclohydrolase
R-5- P R-5- P R-5- P

Aminoimidazole carboxamide Formimidoimidazole carboxamide Inosine monophosphate (IMP)

ribosyl-5-phosphate ribosyl-5-phosphate (XII)
(X) (XI)

FIGURE 332 Purine biosynthesis from ribose 5-phosphate and ATP. See the text for explanations. ( P , PO32− or PO2−.)

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