Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.

2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
acyclovir 1- Withdraw exact dose Maintain
KCL- Y
500 mg/10 mL adequate
Doses less than SP n/a 2- Further dilute with NS to 5 mg/mL 60 minutes D5W-Y
(50 mg/mL) hydration
250 mg final concentration of NS-Y
during course
5 mg/mL
acyclovir Maintain
KCL- Y
500 mg/10 mL Withdraw exact dose and inject in adequate
Doses 250 mg or LVP n/a n/a 60 minutes D5W-Y
(50 mg/mL) 100 mL NS hydration
greater NS-Y
during course
mL/hr
Blood bank
LVP Dosing: product,
albumin 5% n/a n/a No dilution 50 mg/mL 5-10 mL/kg as
SP expires in 4
single bolus over 30 hours
min to 1 hour
mL/hr Blood bank
Dosing: product,
LVP
albumin 25% 12.5 gm/50 mL n/a No dilution 250 mg/mL 1-2 g/kg/24hrs expires in 4
SP
for replacement - hours
give over 4 hours
2 step DILUTION
Must be
1- Add 12 mL SW to make
Amphotericin B filtered with
4 mg/mL KCL-N
(liposomal) greater than 1
(Ambisome®) SP 50 mg SW 2- Withdraw exact dose and 1 mg/mL 120 minutes NS-N micron filter
further dilute with D5W to D5W-Y
Doses less than 50 mg Compatible
final concentration
with D5W only
1 mg/mL
Must be
Amphotericin B 2 step DILUTION
filtered with
(liposomal) 1- Add 12 mL SW to make KCL-N greater than 1
(Ambisome®) LVP 50 mg SW 4 mg/mL n/a 120 minutes NS-N micron filter
Doses 51 mg-100 mg 2- Withdraw exact dose and D5W-Y
Compatible
inject in 100 mL D5W
with D5W only

1
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION Must be
Amphotericin B 1- Add 12 mL SW to make filtered with
(liposomal) 4 mg/mL KCL-N greater than 1
(Ambisome®) LVP 50 mg SW n/a 120 minutes NS-N micron filter
2- Withdraw exact dose and D5W-Y
Doses 101-250 mg inject in 250 mL D5W Compatible
with D5W only
KCL- Y
Add 5 mL SW and withdraw exact
ampicillin SP 500 mg SW 100 mg/mL 15 minutes D5W-N
dose
NS-Y
2 step DILUTION
1- Add 5 mL SW to make
azithromycin 100 mg/mL KCL-Y
(Zithromax®) SP 500 mg SW 2- Withdraw exact dose and 2 mg/mL 60 minutes D5W-Y
Doses less than 100 mg further dilute with NS to a NS-Y
final concentration of
2 mg/mL
2 step DILUTION
azithromycin 1- Add 5 mL to make KCL-Y
(Zithromax®) LVP 500 mg SW 100 mg/mL n/a 60 minutes D5W-Y
Doses 101-200 mg 2- Withdraw exact dose and NS-Y
inject in 100 mL NS
2 step DILUTION
azithromycin
1- Add 5 mL SW to make KCL-Y
(Zithromax®)
LVP 500 mg SW 100 mg/mL n/a 60 minutes D5W-Y
Doses 201 mg or NS-Y
2- Withdraw exact dose and
greater
inject in 250 mL NS
½ rate for 1st 15 min
(max 50 mL/hr) Use Blood
then full rate for filter
blood LVP n/a n/a n/a n/a remainder of time n/a
(max rate 150 Expires in 4
mL/hr, max 4 hour hours!
infusion)

2
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
½ rate for 1st 15 min
(max 50 mL/hr) Use Blood
then full rate for filter
platelets LVP n/a n/a n/a n/a remainder of time n/a
(max rate 150 Expires in 4
mL/hr, max 4 hour hours!
infusion)
Withdraw exact dose 10 minutes Prepare in 3
Caffeine Citrate doses 60 mg/3 mL
SP n/a QS with D5W to 1 mL for final n/a (30 minutes for mL syringe
less than 20 mg (20 mg/mL)
volume of 1 mL loading dose) Special access
Prepare in at
10 minutes
Caffeine Citrate doses 60 mg/3 mL Withdraw exact dose least 3 mL
SP n/a n/a (30 minutes for
20 mg or greater (20 mg/mL) syringe size
loading dose)
Special access
Calcium Gluconate SP 1000 mg/10 mL n/a Withdraw exact dose and qs to n/a 30 minutes KCL-Y
Doses less than 500 mg (100 mg/mL) 25 mL with NS D5W-N
NS-Y
Calcium Gluconate SP 1000 mg/10 mL n/a Withdraw exact dose and qs to n/a 30 minutes KCL-Y
Doses 500mg-1000 mg (100 mg/mL) 50 mL with NS D5W-N
NS-Y
Calcium Gluconate LVP 1000 mg/10 mL n/a Withdraw exact dose and inject in n/a 60 minutes KCL-Y
Doses 1001 mg or (100 mg/mL) 100 mL NS D5W-N
greater NS-Y
**note strength of vial**
2 step DILUTION
1- For 50 mg vial - Add 10.5 mL
of NS to make 5.2 mg/mL
50 mg OR KCL-Y
caspofungin Note: dosing in
SP Or NS For 70 mg vial -Add 10.5 mL 0.5 mg/mL 60 minutes D5W-N
Doses less than 25 mg of NS to make 7.2 mg/mL BSA*
70 mg NS-Y
2- Withdraw exact dose and
further dilute with NS to
final concentration of
0.5 mg/mL

3
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
**note strength of vial**
2 step DILUTION
1- For 50 mg vial - Add 10.5 mL
caspofungin 50 mg of NS to make 5.2 mg/mL KCL-Y
OR Note: dosing in
Doses 26 – 50 mg LVP Or NS n/a 60 minutes D5W-N
For 70 mg vial -Add 10.5 mL BSA*
70 mg NS-Y
of NS to make 7.2 mg/mL
2- Withdraw exact dose and
inject in 100 mL NS
**note strength of vial**
2 step DILUTION
3- For 50 mg vial - Add 10.5 mL
caspofungin 50 mg of NS to make 5.2 mg/mL KCL-Y
OR Note: dosing in
Doses 51 – 70 mg LVP Or NS n/a 60 minutes D5W-N
For 70 mg vial -Add 10.5 mL BSA*
70 mg NS-Y
of NS to make 7.2 mg/mL
4- Withdraw exact dose and
inject in 250 mL NS
KCL-Y
ceFAZolin Add 10 mL NS and withdraw exact
SP 1000 mg NS 100 mg/mL 30 minutes D5W-Y
(Ancef®) dose
NS-Y
2 step DILUTION
1- Add 10 mL NS
ceFAZolin minibag KCL-Y
(Ancef®) 2- Withdraw exact dose and Syringe doses
LVP n/a NS n/a 30 minutes D5W-Y
inject in 50 mL NS preferred
Doses 1000 -2000 mg NS-Y
*Note: docked doses from pharmacy
come in 100 mL NS bag*
KCL-Y
Add 20 mL NS and withdraw exact
cefepime SP 2000 mg NS 100 mg/mL 30 minutes D5W-Y
dose
NS-Y
KCL-Y
cefTRIAXone Add 10 mL NS and withdraw exact
SP 1000 mg NS 100 mg/mL 30 minutes D5W-Y
(Rocephin ®) dose
NS-Y

4
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
1- Add 10 mL NS
cefTRIAXone minibag KCL-Y
(Rocephin ®) 2- Withdraw exact dose and Syringe doses
LVP n/a NS n/a 30 minutes D5W-Y
inject in 50 mL NS preferred
Doses 1000 -2000 mg NS-Y
*Note: docked doses from pharmacy
come in 100 mL NS bag*
KCL-Y
cefTAZidime Add 10 mL SW and withdraw exact
SP 1000 mg SW 100 mg/mL 30 minutes D5W-Y
(Fortaz®) dose
NS-Y
KCL-Y
cefotaxime Add 10 mL SW and withdraw exact
SP 1000 mg SW 100 mg/mL 30 minutes D5W-Y
(Claforan®) dose
NS-Y
KCL-Y
cefuroxime Add 7.5 mL SW and withdraw exact
SP 750 mg SW 100 mg/mL 30 minutes D5W-Y
(Zinacef®) dose
NS-Y
KCL-Y
cefOXitin Add 10 mL SW and withdraw exact
SP 1000 mg SW 100 mg/mL 30 minutes D5W-Y
(Mefoxin®) dose
NS-Y
ciprofloxacin 400 mg/200 mL KCL-Y
(Cipro®) Already diluted. Withdraw and Protect from
SP premixed bag n/a 2 mg/mL 60 minutes D5W-Y
(2 mg/mL)
Infuse exact dose light
Doses less than 100 mg NS-Y
ciprofloxacin
(Cipro®) 400 mg/200 mL Already diluted. Withdraw exact KCL-Y
Protect from
LVP premixed bag n/a dose and inject into empty Viaflex 2 mg/mL 60 minutes D5W-Y
Doses 100 mg or (2 mg/mL)
light
bag. NS-Y
greater
2 step DILUTION
clindamycin 1- Withdraw exact dose KCL-Y
(Dalacin C®) 300 mg/2 mL D5W-Y
SP n/a 2- Further dilute with NS to 10 mg/mL 30 minutes
(150 mg/mL) NS-Y
Doses less than 500 mg final concentration of
10 mg/mL
clindamycin
(Dalacin C®) KCL-Y
300 mg/2 mL Withdraw exact dose and inject in
LVP n/a n/a 30 minutes D5W-Y
Doses 500 mg or (150 mg/mL) 50 mL NS bag
NS-Y
greater

5
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
1- Add 10 mL SW to make
100 mg/mL concentration KCL-N
cloxacillin D5W-Y
SP 1000 mg SW 2- Withdraw exact dose and 20 mg/mL 30 minutes
Doses less than 1000 mg NS-Y
further dilute with NS to
final concentration of
20 mg/mL
2 step DILUTION
cloxacillin 1- Add 10 mL of SW to make KCL-N
100 mg/mL D5W-Y
Doses 1000 mg or LVP 1000 mg SW n/a 30 minutes
NS-Y
greater 2- Withdraw exact dose and
inject in 100 mL NS
2 step DILUTION
1- Withdraw exact dose KCL-Y
20 mg/5 mL
dexamethasone SP n/a 2- Further dilute with NS to a 1 mg/mL 15 minutes D5W-Y
(4 mg/mL)
final concentration of NS-Y
1 mg/mL
KCL-N
diazePAM 10 mg/2 mL IVP over 2-5
n/a n/a Withdraw and inject exact dose 5 mg/mL D5W-N
(Valium®) (5 mg/mL) minutes
NS-N
KCL-Y
dimenhyDRINATE 50 mg/1 mL Withdraw exact dose and qs to
SP n/a n/a 15 minutes D5W-Y
(Gravol®) (50 mg/mL) 10 mL with NS
NS-Y
KCL-Y
diphenhydrAMINE 50 mg/1 mL Withdraw exact dose and qs to
SP n/a n/a 15 minutes D5W-Y
(Benadryl®) (50 mg/mL) 5 mL with NS
NS-Y
KCL-Y
diphenhydrAMINE Withdraw exact dose and inject in
LVP 50 mg/mL n/a n/a 15 minutes D5W-Y
(Benadryl®) 50 mL NS bag
NS-Y
1. Withdraw 20 mL (250 mg)
CONTINUOUS
DOBUTamine PEDS DOBUTamine
continuous infusion LVP 250 mg/20 mL 2. Remove 20 mL overfill from 250 mg/250 mL Dosing range: Central line
n/a n/a
(12.5 mg/mL) 250 mL NS and discard (1 mg/mL) 1-20 mcg/kg/min preferred*
(ICU only) 3. Inject 20 mL (250 mg)
DOBUTamine in 250 mL NS

6
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
CONTINUOUS
DOPamine PEDS 400 mg/250 mL INFUSION
continuous infusion LVP 400 mg/250 mL Central line
premixed bag n/a infuse premixed bag Dosing range: n/a
(1.6 mg/mL) preferred*
(ICU only) (1.6 mg/mL) 1-20 mcg/kg/min

Syringe:
1. Withdraw 1 mL (1 mg) CONTINUOUS
EPINEPHrine PEDS 0.01 mg/mL
LVP 1 mg/1 mL epinephrine INFUSION
continuous infusion n/a n/a Central line
(1 mg/mL) 2. Inject 1 mL (1 mg) in Bag:
Dosing range: preferred*
(ICU only) 100 mL NS bag 1 mg/100 mL
0.02-1 mcg/kg/min
(0.01 mg/ml)
2 step DILUTION
1- Add 10 mL NS to make
100 mg/mL KCL-Y
ertapenem Incompatible
SP 1000 mg NS 2- Withdraw exact dose and 20 mg/mL 30 minutes D5W-N
(Invanz®) with D5W
further dilute with NS to NS-Y
final concentration of
20 mg/mL
Supplies needed:
10 x fentaNYL 50 mcg/mL (2 mL) vials
1x 100 mL NS bag CONTINUOUS
fentaNYL Steps: 1000 mcg/ 100 mL INFUSION
continuous infusion LVP 100 mcg/2 mL 1- Withdraw 20 mL (1000 mcg)
n/a of fentaNYL 50 mcg/mL Dosing range: n/a
(50 mcg/mL
(ICU only) 2- Withdraw 20 mL from 100 mL (10 mcg/mL) 0.5-5 mcg/kg/HOUR
NS bag and discard
3- Inject 20 mL (1000 mcg) of
fentaNYL 50 mcg/mL in NS Bag
fluconazole 200 mg/ 100 mL KCL-Y
(Diflucan®) SP premixed bag n/a Withdraw and infuse exact dose 2 mg/mL 120 minutes NS-Y
Doses less than 100 mg (2 mg/mL) D5W-Y
fluconazole
(Diflucan®) 200 mg/ 100 mL Already diluted. Withdraw exact KCL-Y
LVP premixed bag n/a dose and inject into empty Viaflex 2 mg/mL 120 minutes NS-Y
Doses 100 mg or (2 mg/mL) bag. D5W-Y
greater
KCL-Y
furosemide 40 mg/4 mL IVP over 2-5
n/a n/a Exact dose – No dilution 10 mg/mL D5W-Y
(Lasix®) (10 mg/mL) minutes
NS-Y

7
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
**Cytotoxic**
must be
ganciclovir Infuse over 60 prepared in
KCL-Y
(Cytovene®) Prepared by pharmacy minutes chemo hood,
SP 500 mg SW 5 mg/mL D5W-Y
(Hazardous) Flush pre/post with contact 4WES
NS-Y
NS for chemo bin
for disposal of
drug
2 step DILUTION
gentamicin KCL-Y
20 mg/2 mL 1- Withdraw exact dose
(Garamycin®) SP n/a 5 mg/mL 60 minutes D5W-Y
(10 mg/mL) 2- Further dilute with NS to
Doses less than 250 mg NS-Y
5 mg/mL
gentamicin
(Garamycin®) KCL-Y
20 mg/2 mL Withdraw exact dose and inject in
LVP n/a n/a 60 minutes D5W-Y
Doses 250 mg or (10 mg/mL) 100 mL NS
NS-Y
greater
KCL-Y
granisetron 1 mg/1 mL Withdraw exact dose and
SP n/s n/a 15 minutes D5W-Y
(Kytril®) (1 mg/mL) QS to 20 mL NS
NS-Y
100 mg/2 mL KCL-Y
Dilute per instructions on vial
hydrocortisone n/a Act-O-Vial n/a n/a IVP over 2 minutes D5W-Y
Withdraw exact dose
(50 mg/mL) NS-Y
KCL-Y
2 mg/1 mL Withdraw exact dose, qs to 10 mL
HYDROmorphone SP n/a n/a 15 minutes D5W-Y
(2 mg/mL) with NS
NS-Y
300 units/3 mL On floor-use insulin prep kit CONTINUOUS
instructions INFUSION KCL-Y
insulin PEDS (100 units/mL) High Alert-
LVP n/a For Pharmacy: Withdraw 0.1 units/mL Dosing range: D5W-Y
continuous infusion Insulin GE Double Check
25 units (0.25 mL) Regular Insulin 0.05-0.1 NS-Y
TORONTO Insert 25 units in 250 mL NS units/kg/HOUR
IV Fluids LVP n/a n/a mL/HR
IV Fluids - KCL LVP n/a n/a mL/HR
KCL-Y
ketorolac 30 mg/1 mL Withdraw exact dose, qs to 10 mL
SP n/a n/a 15 minutes D5W-Y
(Toradol®) (30 mg/mL) with NS
NS-Y

8
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
levetiracetam KCL-N
500 mg/5 mL 1- Withdraw exact dose
(Keppra®) SP NS 10 mg/mL 15 minutes D5W-Y Special access
(100 mg/mL) 2- Further dilute with NS to
Doses less than 500 mg NS-Y
10 mg/mL
levetiracetam KCL-N
500 mg/5 mL Withdraw exact dose and inject in
(Keppra®) LVP n/a n/a 15 minutes D5W-Y Special access
(100 mg/mL) 100 mL NS bag
Doses 501 mg-1000 mg NS-Y
levetiracetam KCL-N
500 mg/5 mL Withdraw exact dose and inject in
(Keppra®) LVP n/a n/a 15 minutes D5W-Y Special access
(100 mg/mL) 250 mL NS bag
Doses 1001 mg-1500 mg NS-Y
linezolid 600 mg/300 mL KCL-Y
(Zyvoxam®) Already diluted withdraw and infuse
SP premixed bag n/a 2 mg/mL 60 minutes D5W-Y
(2 mg/mL)
exact dose
Doses less than 100 mg NS-Y
linezolid
(Zyvoxam®) 600 mg/300 mL Already diluted. Withdraw exact KCL-Y
LVP premixed bag n/a dose and inject into empty Viaflex 2 mg/mL 60 minutes D5W-Y
Doses 100 mg or (2 mg/mL) bag. NS-Y
greater
KCL-Y
Infuse as ordered from stock bag
lipids LVP n/a n/a n/a mL/hr D5W-Y
over 24 hours
NS-Y
KCL-Y
LORazepam 2mg/1 mL IVP over 2-5
n/a n/a Withdraw exact dose 2 mg/mL D5W-Y
(Ativan®) (2 mg/mL) minutes
NS-Y
2 Step DILUTION
Asthma:
1- Withdraw exact dose
20 minutes KCL-Y
2000 mg/10 mL 2- Further dilute with equal
magnesium sulfate SP n/a 100 mg/mL Electrolyte D5W-Y
(200 mg/mL) parts NS for a final
replacement: NS-Y
concentration of
60 minutes
100 mg/mL
2 Step DILUTION Asthma: KCL-Y
2000 mg/10 mL 1- Withdraw exact dose
magnesium sulfate LVP n/a n/a 20 minutes D5W-Y
(200 mg/mL)
2- Inject in 50 mL NS NS-Y

9
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
1- Reconstitute with 10 mL
meropenem SW to make 50 mg/mL KCL-Y
(Merrem®) SP 500 mg SW 2- Withdraw exact dose and 20 mg/mL 30 minutes D5W-Y
Doses less than 1000 mg further dilute to final NS-Y
concentration of 20 mg/mL
with NS
2 step DILUTION
meropenem
1- Reconstitute with 10 mL KCL-Y
(Merrem®)
LVP 500 mg SW SW to make 50 mg/mL n/a 30 minutes D5W-Y
Doses 1000 mg or NS-Y
2- Withdraw exact dose and
greater
inject in 100 mL NS
methylPREDNISolone
(Solumedrol®) Note KCL-N
Dilute per instructions on vial IVP over 3-15 Asthma/
SP concentration n/a n/a D5W-Y
Doses less than Withdraw exact dose minutes reaction doses
of vial NS-Y
250 mg
methylPREDNISolone Note Dilute per instructions on vial KCL-N
(Solumedrol®) LVP Immune-
concentration n/a Withdraw exact dose n/a 30 minutes D5W-Y
SP Related Dosing
Doses 251 mg-500 mg of vial QS to 50 mL (minibag or syringe)-NS NS-Y
methylPREDNISolone Note Dilute per instructions on vial KCL-N
(Solumedrol®) Immune-
LVP concentration n/a Withdraw exact dose n/a 60 minutes D5W-Y
Related Dosing
Doses 501mg -1000 mg of vial Inject dose in 100 mL NS Bag NS-Y
2 step DILUTION
1- Withdraw exact dose KCL-Y
metoclopramide 10 mg/2mL
SP n/a 1 mg/mL 30 minutes D5W-Y
(Maxeran®) (5 mg/mL) 2- Further dilute to 1 mg/mL NS-Y
with NS
KCL-Y
metoclopramide 10 mg/2mL Withdraw exact dose and inject in
LVP NS n/a 30 minutes D5W-Y
(Maxeran®) (5 mg/mL) 50 mL NS
NS-Y
500 mg/100 mL
metroNIDAZOLE KCL-Y
premixed bag Already diluted Protect from
(Flagyl®) SP n/a 5 mg/mL 30 minutes D5W-Y
(5 mg/mL) Withdraw/Infuse exact dose light
Doses less than 250 mg NS-Y
metroNIDAZOLE 500 mg/100 mL
(Flagyl®) Already diluted. Withdraw exact KCL-Y
premixed bag Protect from
LVP n/a dose and inject into empty Viaflex 5 mg/mL 30 minutes D5W-Y
Doses 250 mg or (5 mg/mL) light
bag. NS-Y
greater
10
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
CONTINUOUS
midazolam PEDS 1 mg/1 mL KCL-Y
LVP INFUSION
continuous infusion premixed bag n/a * Use premixed bags from pharmacy* 1 mg/mL D5W-Y
(1 mg/mL) Dosing range: NS-Y
(ICU Only)
0.5-5 mcg/kg/min
5 mg/1 mL
(5 mg/mL) 5 mg/mL KCL-Y
NO dilution -Withdraw exact dose. IVP ONLY over 2-5
midazolam Bolus Dose n/a OR n/a OR D5W-Y
2 mg/2 mL
*Note concentration of vial minutes
1 mg/mL NS-Y
(1 mg/mL)
1- Withdraw 20 mL (20 mg) CONTINUOUS
milrinone INFUSION
milrinone PEDS
continuous infusion 10 mg/10 mL 2- Withdraw 20 mL overfill from 20 mg/100 mL Dosing range:
LVP N/A 100 mL NS bag and discard
(1 mg/mL) (0.2 mg/mL) 0.25-0.75
(ICU Only) 3- Inject 20 mL (20 mg) milrinone mcg/kg/min
into 100 mL NS

1- Withdraw 2 mL (20 mg) of CONTINUOUS

morphine PEDS INFUSION KCL-Y
10 mg/1 mL 10 mg/mL morphine
continuous infusion LVP n/a 0.2 mg/mL D5W-Y
(10 mg/mL) 2- Inject 2 mL (20 mg) morphine Dosing range: NS-Y
in 100 mL NS 10-40 mcg/kg/HOUR
If pain crisis
Withdraw exact dose (if giving IVP) 2 mg/mL IVP slow over 2-5 KCL-Y
2 mg/1 mL give IVP
morphine bolus SP NS Otherwise, withdraw exact dose and (if straight minutes D5W-Y
(2 mg/mL) If chronic use,
qs to 10 mL with NS drug) 10 minutes (IVPB) NS-Y
give IVPB
Withdraw exact dose in an empty viaflex
400 mg/250 mL KCL-Y
SP bag 1.6 mg/mL
Moxifloxacin premixed bag n/a 60 minutes D5W-Y
LVP *(For doses less than 50 mL (80 mg), (premixed)
(1.6 mg/mL) NS-Y
prepare in syringe)*
KCL-Y
naloxone 0.4 mg/mL No Dilution 0.4 mg/mL
n/a n/a IVP over 30 seconds D5W-Y
(Narcan®) **Note concentration of vial**
NS-Y
CONTINUOUS
NORepinephrine PEDS 4 mg/4 mL 1- Withdraw 4 mg (4 mL)
4 mg/250 mL INFUSION
continuous infusion LVP (1 mg/mL) n/a norepinephrine n/a
(0.016 mg/mL) Dosing range:
(ICU ONLY) 2- Inject in 250 mL NS
0.02-1 mcg/kg/min

11
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
1- Withdraw exact dose KCL-Y
ondansetron 4 mg/2 mL
SP n/a 2- Dilute with equal parts for 1 mg/mL 15 minutes D5W-Y
(Zofran®) (2 mg/mL)
final concentration of NS-Y
1 mg/mL with NS
KCL-Y
ondansetron 4 mg/2 mL Withdraw exact dose and inject in
LVP n/a n/a 15 minutes D5W-Y
(Zofran®) (2 mg/mL) 50 mL NS bag
NS-Y
2 step DILUTION
1- Dilute vial with 10ml NS to
pantoprazole make 4 mg/mL KCL-Y
(Pantoloc®) D5W-Y
SP 40 mg NS 2- Withdraw exact dose and 0.8 mg/mL 15 minutes
NS-Y
further dilute with NS to
final concentration of
0.8 mg/mL
pantoprazole
(Pantoloc®) CONTINUOUS
1- Add 10 mL NS to 40 mg vial INFUSION
continuous infusion KCL-Y
2- Withdraw entire contents of 40 mg/100 mL
for GI Bleed LVP 40 mg NS Dosing: D5W-Y
vial (40 mg) and inject in 0.4 mg/mL
0.1 mg/kg/hr NS-Y
40 kg or less 100 mL NS
(max 4 mg/hr)
(ICU only)
1- Add 10 mL NS each to 2 X 40
pantoprazole
mg vials
(Pantoloc®) 2- Withdraw entire contents of CONTINUOUS KCL-Y
continuous infusion 2 vials (80 mg) 80 mg/100 mL INFUSION D5W-Y
for GI Bleed LVP 40 mg NS 3- Withdraw 20 mL overfill from 0.8 mg/mL Dosing: NS-Y
40.1 kg or more NS and discard 4-8 mg/hr
4- Inject 80 mg (20 mL) in
(ICU only) 100 mL NS
2 step DILUTION
1- Dilute vial with 8.2 mL NS
penicillin G to make 500,000 units/mL KCL-Y
50,000
Doses less than SP 5 million NS 2- Withdraw exact dose and 30 minutes D5W-Y
units/mL
2.5 million units further dilute with NS to NS-Y
final concentration of
50,000 units/mL

12
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
penicillin G 1- Dilute vial with 8.2 mL NS KCL-Y
Doses 2.5 million units LVP 5 million NS to make 500,000 units/mL N/A 30 minutes D5W-Y
or greater 2- Withdraw exact dose and NS-Y
place in 100 mL NS bag
2 step DILUTION
120 mg/1 mL 1- Withdraw exact dose
(120 mg/mL) (*note concentration of
PHENobarbital KCL-Y
Or vial)* 15 minutes
SP n/a 10 mg/mL D5W-Y
Doses less than 500 mg 30 mg/1 mL (Max 1 mg/kg/min)
2- Further dilute with NS to NS-Y
(30 mg/mL)
final concentration of
10 mg/mL
120 mg/1 mL
(120 mg/mL)
PHENobarbital Withdraw exact dose and place in 30 minutes, KCL-Y
Or
LVP n/a 100 mL NS n/a (no faster than 1 D5W-Y
Doses 501-1000 mg 30 mg/1 mL
**Note concentration of vial* mg/kg/min) NS-Y
(30 mg/mL)

KCL-Y NS-ONLY
phenytoin (Dilantin®) 100 mg/2 mL Withdraw exact dose and
SP n/a n/a 30 minutes D5W-N 0.22 micron
Doses less than 100 mg (50 mg/mL) qs to 20 mL with NS
NS-Y filter
KCL-Y NS-ONLY
phenytoin (Dilantin®) 100 mg/2 mL Withdraw exact dose and
SP n/a n/a 30 minutes D5W-N 0.22 micron
Doses 101-500 mg (50 mg/mL) qs to 50 mL with NS
NS-Y filter
phenytoin (Dilantin®) KCL-Y NS-ONLY
100 mg/2 mL Withdraw exact dose and
Dose 501 mg or LVP n/a n/a 60 minutes D5W-N 0.22 micron
(50 mg/mL) Inject into 100 mL NS
greater NS-Y filter
Add 10 mL SW for final Note: Dosing
172 mg/mL KCL-Y
piperacillin/tazobactam concentration of 172 mg/mL based on
SP 2.25 gm SW PIPERACILLIN 30 minutes D5W-Y
(Tazocin®) (piperacillin component) piperacillin
CONTENT NS-Y
Withdraw exact dose needed content
Add 15 mL SW for final KCL-Y Note: Dosing
172 mg/mL
piperacillin/tazobactam concentration of 172 mg/mL D5W-Y based on
SP 3.375 gm SW PIPERACILLIN 30 minutes
(Tazocin®) (piperacillin component) NS-Y piperacillin
CONTENT
Withdraw exact dose needed content

13
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
Add 20 mL SW for final KCL-Y Note: Dosing
172 mg/mL
piperacillin/tazobactam concentration of 172 mg/mL D5W-Y based on
SP 4.5 gm SW PIPERACILLIN 30 minutes
(Tazocin®) (piperacillin component) NS-Y piperacillin
CONTENT
Withdraw exact dose needed content
piperacillin/tazobactam KCL-Y Note: Dosing
2.25 gm
(Tazocin®) D5W-Y based on
LVP 3.375 gm n/a All in 100 mL NS minibag plus n/a 30 minutes
“docked” doses from NS-Y piperacillin
4.5 gm
pharmacy content
potassium CHLORIDE
Intermittent (KCL)
*Peripheral line* Doses in 100 mL NS NS-Y
LVP n/a n/a n/a 120 minutes
Doses less than Prepared by pharmacy D5W-Y
10 mmoL

potassium CHLORIDE
Intermittent (KCL)
Doses in 250 mL NS NS-Y
*Peripheral line* LVP n/a n/a n/a 120 minutes
Prepared by pharmacy D5W-Y
Doses 11-20 mmoL

potassium CHLORIDE
Intermittent (KCL)
*Central line* Doses in 100 mL NS NS-Y
LVP n/a n/a n/a 120 minutes
Doses less than Prepared by pharmacy D5W-Y
20 mmoL

potassium
PHOSPHATE 0.22 micron
Intermittent (KPhos) *Note Doses in 50 mL NS filter
concentration NS-Y
*Peripheral line* LVP n/a Prepared by pharmacy n/a 4 hours Dosing based
of mEq or D5W-Y
Doses less than on PHOSPHATE
MMOL on vial
2.5 mmol component

14
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
potassium
PHOSPHATE 0.22 micron
*Note Doses in 100 mL NS NS-Y filter
Intermittent (KPhos) concentration
LVP n/a Prepared by pharmacy n/a 4 hours Dosing based
*Peripheral Line* of mEq or D5W-Y
Doses 2.6 - 5 mmoL MMOL on vial on PHOSPHATE
KCL-Y component

potassium
PHOSPHATE 0.22 micron
*Note Doses in 250 mL NS NS-Y filter
Intermittent (KPhos) concentration
LVP n/a Prepared by pharmacy n/a 4 hours Dosing based
*Peripheral line* of mEq or D5W-Y
Doses 5.1 - 12.5 mmoL MMOL on vial on PHOSPHATE
KCL-Y component

potassium
PHOSPHATE 0.22 micron
Intermittent (KPhos) *Note Doses in 50 mL NS NS-Y filter
concentration Prepared by pharmacy
*Central line* LVP n/a n/a 4 hours Dosing based
of mEq or D5W-Y
Doses less than on PHOSPHATE
MMOL on vial
6 mmoL KCL-Y component

potassium
PHOSPHATE 0.22 micron
*Note Doses in 100 mL NS NS-Y filter
Intermittent (Kphos) concentration
LVP n/a Prepared by pharmacy n/a 4 hours Dosing based
*Central line* of mEq or D5W-Y
Doses 6.1 - 12 mmoL MMOL on vial on PHOSPHATE
KCL-Y component

potassium
PHOSPHATE 0.22 micron
*Note Doses in 250 mL NS NS-Y filter
Intermittent (KPhos) concentration
LVP n/a Prepared by pharmacy n/a 4 hours Dosing based
*Central line* of mEq or D5W-Y
Doses 12.1 - 30 mmoL MMOL on vial on PHOSPHATE
KCL-Y component

2 step DILUTION
1- Withdraw exact dose KCL-Y
raNITIdine 50 mg/2 mL
SP n/a 1 mg/mL 15 minutes D5W-Y
(Zantac®) (25 mg/mL) 2- Further dilute with NS to NS-Y
1 mg/mL

15
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
sodium
PHOSPHATE
Intermittent (NaPhos) *Note Doses in 50 mL NS NS-Y Dosing based
concentration
*Peripheral line* LVP n/a Prepared by pharmacy n/a 4 hours D5W-Y on PHOSPHATE
of mEq or
Doses less than KCL-Y component
MMOL on vial
2.5 mmoL

sodium
PHOSPHATE *Note Doses in 100 mL NS
Intermittent (NaPhos) NS-Y Dosing based
concentration Prepared by pharmacy
LVP n/a n/a 4 hours D5W-Y on PHOSPHATE
*Peripheral Line* of mEq or
KCL-Y component
Doses 2.6 - 5 mmoL MMOL on vial

sodium
PHOSPHATE *Note Doses in 250 mL NS
Intermittent (NaPhos) NS-Y Dosing based
concentration Prepared by pharmacy
LVP n/a n/a 4 hours D5W-Y on PHOSPHATE
*Peripheral line* of mEq or
KCL-Y component
Doses 5.1 - 12.5 mmoL MMOL on vial

sodium
PHOSPHATE
Intermittent (NaPhos) *Note Doses in 50 mL NS NS-Y Dosing based
concentration Prepared by pharmacy
*Central line* LVP n/a n/a 4 hours D5W-Y on PHOSPHATE
of mEq or
Doses less than KCL-Y component
MMOL on vial
6 mmoL

sodium
PHOSPHATE *Note Doses in 100 mL NS
Intermittent (Naphos) NS-Y Dosing based
concentration Prepared by pharmacy
LVP n/a n/a 4 hours D5W-Y on PHOSPHATE
*Central line* of mEq or
KCL-Y component
Doses 6.1 - 12 mmoL MMOL on vial

16
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
sodium
PHOSPHATE *Note Doses in 250 mL NS
Intermittent (NaPhos) NS-Y Dosing based
concentration Prepared by pharmacy
LVP n/a n/a 4 hours D5W-Y on PHOSPHATE
*Central line* of mEq or
KCL-Y component
Doses 12.1 - 30 mmoL MMOL on vial

Sulfamethoxazole 400 mg SMX & Calculate dose based on TMP

(SMX) & 80 mg TMP component D5W-Y Protect from
Trimethoprim (TMP) per 5 mL Divide by 16 mg to get amount of KCL-N light
SP n/a 1:5 ratio 60 minutes
(Septra®,Bactrim®) mL’s needed NS-(better in 6 hour stability
Doses less than 136 (80 mg SMX & Use ratio of 1mL TMP to 5 mL D5W 0.45 vs 0.9) ONLY
16 TMP mg/mL)
mg to achieve final volume of solution
Sulfamethoxazole 400 mg SMX & Calculate dose based on TMP
(SMX) & 80 mg TMP component D5W-Y Protect from
Trimethoprim (TMP) per 5 mL Divide by 16 mg to get amount of KCL-N light
LVP n/a 1:5 ratio 60 minutes
(Septra®,Bactrim®) mL’s needed NS-(better in 6 hour stability
(Septra®,Bactrim®) (80 mg SMX & Inject desired TMP dose in 0.45 vs 0.9) ONLY
16 TMP mg/mL)
Doses 137 -320 mg 100 mL D5W
Sulfamethoxazole 400 mg SMX & Calculate dose based on TMP
(SMX) & 80 mg TMP component D5W-Y Protect from
Trimethoprim (TMP) per 5 mL Divide by 16 mg to get amount of KCL-N light
LVP n/a 1:5 ratio 60 minutes
(Septra®,Bactrim®) mL’s needed NS-(better in 6 hour stability
(Septra®,Bactrim®) (80 mg SMX & Inject desired TMP dose in 0.45 vs 0.9) ONLY
16 TMP mg/mL)
Doses 321 -800 mg 250 mL D5W
2 step DILUTION
1- Withdraw exact dose KCL-Y
tobramycin 80 mg/2mL
SP n/a 5 mg/mL 60 minutes D5W-Y
Doses less than 250 mg (40 mg/mL) 2- Further dilute with NS to NS-Y
5 mg/mL
tobramycin KCL-Y
80 mg/2mL Withdraw exact dose and place in
Doses 250 mg or LVP n/a n/a 60 minutes D5W-Y
(40 mg/mL) 100 mL NS
greater NS-Y
2 step DILUTION
1- Add 10 mL SW to make
vancomycin 60 minutes KCL-Y
50 mg/mL
(Vancocin®) SP 500 mg SW 5 mg/mL (longer in redmans D5W-Y
2- Withdraw exact dose and reaction) NS-Y
Doses less than 250 mg
further dilute to 5 mg/mL
with NS

17
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex
 Windsor Regional Hospital [PEDIATRIC STANDARD CONCENTRATION/DILUTION MEDICATION CHART] updated 4.30.2019

Drug Pump Vial Reconstitution Instructions for Dilution Final Administration Compatibility Other
Type (Concentration) Solution Concentration
2 step DILUTION
vancomycin 1- Add 10 mL SW to make 60 minutes KCL-Y
(Vancocin®) LVP 500 mg SW 50 mg/mL n/a (longer in redmans D5W-Y
Doses 251 mg-500 mg 2- Withdraw exact dose and reaction) NS-Y
inject into 100 mL NS
2 step DILUTION
vancomycin 1- Add 10 mL SW to make 90 minutes KCL-Y
(Vancocin®) LVP 500 mg SW 50 mg/mL n/a (longer in redmans D5W-Y
Doses 501 mg-1250 mg 2- Withdraw exact dose and reaction) NS-Y
inject into 250 mL NS
2 step DILUTION
1- Add 10 mL SW to make 90 minutes (longer KCL-Y
vancomycin
LVP 500 mg SW 50 mg/mL n/a in redmans D5W-Y
Doses 1251 mg-1500 mg
2- Withdraw exact dose and reaction) NS-Y
inject into 500 mL NS

18
NS=normal saline IVP=IV push, IVPB=IV piggyback D5W=dextrose 5% in water SW=sterile water KCL=potassium chloride Y=yes N=no, qs=quantity sufficient, LVP=large volume pump-Baxter Sigma®, SP=syringe pump-BBraun®
References for stability/compatibility LexiComp and Micromedex