Drug Name Dosage Form

Theophylline Capsule (Extended Release)

Theophylline (100 mg and 200 mg) Tablet (Extended Release)
Theophylline (300 mg and 450 mg) Tablet (Extended Release)
Theophylline (600 mg and 400 mg) Tablet (Extended Release)
USP Apparatus Speed (RPMs)

II (Paddle) 50
II (Paddle) 50
I (Basket) 100
Medium
Refer to USP
SGF without Enzyme, pH 1.2 during 1st hour. Phosphate Buffer at pH 7.5 from end of hour 1 through the duration of testing
SGF without Enzyme, pH 1.2 during 1st hour. Phosphate Buffer at pH 7.5 from end of hour 1 through the duration of testing
SGF without enzyme, pH 1.2 during 1st hour. SIF without enzyme from end of hour 1 through the duration of the testing
Volume (mL) Recommended Sampling Times (minutes) Date Updated
900 10/06/2008
900 1, 4, 8, 12 hours 10/06/2008
900 1, 4, 8, 12 hours 10/06/2008
900 1, 2, 4, 8, 12 and 24 hours 10/06/2008