6 Computational and Mathematical Methods in Medicine

plung (cmH2 O)

plung (cmH2 O)
20 20
10 10
0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 0 1 2 3 4 5 6 7 8 9 10 11 12
Time (s) Time (s)

Rr (cmH2 O/L/s)
Rr (cmH2 O/L/s)

4 4
0 0
−4 −4
0 1 2 3 4 5 6 7 8 9 10 11 12 0 1 2 3 4 5 6 7 8 9 10 11 12
Time (s) Time (s)

ploss (cmH2 O)
ploss (cmH2 O)

2 2
1 1
0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 0 1 2 3 4 5 6 7 8 9 10 11 12
Time (s) Time (s)

EPAP = 4 Ti = 1.0
EPAP = 6 Ti = 1.2
EPAP = 8 Ti = 1.4

Figure 7: Influence of the EPAP on the air pressure dynamic. Figure 9: Influence of the 𝑇𝑖 on the air pressure dynamic.
plung (cmH2 O)

24
plung (cmH2 O)

12
0 20
0 1 2 3 4 5 6 7 8 9 10 11 12 10
0
Time (s) 0 1 2 3 4 5 6 7 8 9 10 11 12
Time (s)
Rr (cmH2 O/L/s)

4
Rr (cmH2 O/L/s)

0
−4 4
0
0 1 2 3 4 5 6 7 8 9 10 11 12
−4
Time (s) 0 1 2 3 4 5 6 7 8 9 10 11 12
Time (s)
ploss (cmH2 O)

2
ploss (cmH2 O)

1
2
0
0 1 2 3 4 5 6 7 8 9 10 11 12 1
Time (s) 0
0 1 2 3 4 5 6 7 8 9 10 11 12
BPM = 20 Time (s)
BPM = 25
BPM = 30 Tr = 0.2
Tr = 0.3
Figure 8: Influence of the BPM on the air pressure dynamic. Tr = 0.4

Figure 10: Influence of 𝑇𝑟 on the air pressure dynamic.

4.2. Influence of the Respiratory Compliance (𝐶). The respira-
tory compliance (𝐶) of the lung simulator is set to 5 mL/cm
H2 O, 10 mL/cm H2 O, and 15 mL/cm H2 O, and the simulation
results are illustrated in Figure 11. The relationship between
the peak pressure of lung simulator and the respiratory
compliance (𝐶) is studied, with the results shown in Figure 12.
From Figures 11 and 12, the following can be seen.
Firstly, with the decline in the respiratory compliance (𝐶),
the rise and fall velocity of air pressure in the lung simulator
ascend significantly, but the respiratory resistance (𝑅𝑟 ) and
pressure loss of the system descend distinctively.
Furthermore, when the respiratory compliance (𝐶) is
smaller than 10, the air pressure in the lung simulator can
reach IPAP. However, when the 𝐶 is bigger than 10, the peak
pressure of the lung simulator is inversely proportional to the
respiratory compliance (𝐶).
Finally, the amplitude of the respiratory resistance (𝑅𝑟 )
and the pressure loss of the system go down with a drop in
the respiratory compliance (𝐶).