FORMULATION AND EVALUATION OF NANOPARTICLES OF

SODIUM CROMOGLYCATE FOR THE TREATMENT OF ASTHMA

M.Pharm Dissertation Protocol Submitted to

Rajiv Gandhi University of Health Sciences, Karnataka

Bangalore– 560 041

By

Mr. SHAH HARDIKKUMAR GOPALDAS B.Pharm

Under the Guidance of

Ms. JAYANTHI

Asst. Professor

Department of Pharmaceutics,
Acharya & B.M. Reddy College of Pharmacy,
Soldevanahalli, Chikkabanavara (Post)
Hesaraghatta Main Road, Bangalore – 560 090.
2011-2013

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 RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
KARNATAKA, BANGALORE.
ANNEXURE - II
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

2
6.0 BRIEF RESUME OF THE INTENDED WORK:
1. Name of the Candidate Mr. SHAH HARDIKKUMAR GOPALDAS
and Address S/o GOPALDAS N SHAH.
6.1 NEED FOR THE STUDY: C-77, Saikrupa Society, Near Anandnagar ,
Water Tank
In the last few decades, nanotechnology Road, Karelibaug,
has emerged as one of the very promising fields
9 Signature of the candidate: Vadodara-390018,
of biomedical research. NanotechnologyGujarat.
for diagnosis, treatment and monitoring of diseases is a
fast developing area of biomedical research. Drug delivery is one of the areas where this
The topic selected for dissertation is satisfactory.
10technology
Remarks ofhasthemade remarkable progress. In 1959 American Physical Society talk entitled
Guide:
2. Name of the Institution ACHARYA & B.M.equipments
Adequate REDDY COLLEGE OF are available to
and chemicals
‘There's Plenty of Room at the Bottom' PHARMACY,
by physicist Richard Feynman is considered as the first
carry out project work.
Soldevanahalli,was
hint of nanotechnology. The term ‘Nanotechnology' Hesaraghatta
coined by Main Road,
K. Eric Drexler in 1980s.
Chikkabanavara Post.
11AACR
Namewebsite
and Designation of: this term was actually coined in 1974 by Norio Taniguchi1.
mentions that Bangalore-560090
Nanotechnology can be defined as the technology at the scale of one-billionth of a metre.
3. It is Course of Study
the design, and Subject synthesis
characterization, M.Pharm
and application of materials, structures, devices and
(Pharmaceutics)
systems by controlling shape and size at nanometre scale. Materials exhibit
Ms. unique properties at
JAYANTHI
11.1
nanoscale. Institutional
The changes Guide: are due to increase in surface area and dominance of
in properties
Asst. Professor
quantum effects which is associated with very small sizes and large surface area to volume ratio2.
4. Date of Admission 18-12-2011
Nanoparticles are particulate dispersions having particle size of 10-1000nm. In
Signature:
11.2
nanoparticles drug may be dissolved, entrapped, encapsulated or attached to a nanoparticle
matrix. Some of the challenges of most drug delivery systems include poor bioavailability, in
11.3 Co-Guide:
5. vivo
TITLE OF THEless
instability, PROJECT:-
solubility, less intestinal absorption, inability for sustained and targeted
delivery to site of action, lower therapeutic effectiveness, side effects, and plasma fluctuations of
Signature:
11.4 which either fall below the minimum effective concentrations or exceed the safe
drugs
therapeutic concentrations. AND
FORMULATION However, nanotechnology
EVALUATION in drug delivery is anOF
OF NANOPARTICLES approach
SODIUM designed
Dr. SHIVANAND KALYANAPPA
CROMOGLYCATE
to overcome these challenges due FORto theTHE TREATMENT
development OF ASTHMA
M.Pharm,
and fabrication Ph.D
of nanostructures at
Professor and H.O.D
submicron scale and nanoscale which are mainly polymeric and have Dept.multiple advantages. They
of Pharmaceutics
11.5 Head of the Department:
increase oral bioavailability of drugs due to their Acharya & B.M.
specialized Reddy
uptake College ofsuch
mechanisms Pharmacy,
as
Bangalore-560 090.
absorptive endocytosis and are able to remain in the blood circulation for a longer time, releasing
the incorporated drug in a sustained and continuous manner leading to less plasma fluctuations
thereby minimizing side-effects caused by drugs. Due to the size of nanostructures, they are able
Signature
to 11.6
penetrate into tissues and are taken up by cells, allowing efficient delivery of drugs to sites of
action. The uptake of nanostructures
Remarks of the Principalwas found to be 15-250 times greater than that of
12 12.1
microparticles in the 1-10μm range2.
Bronchial asthma is characterized by hyperresponsiveness of tracheobronchial smooth
muscles to variety of stimuli, resulting in narrowing of air tube, often accompanied by increased
Dr. Divakar Goli M.Pharm, Ph.D
Signature
secretion,
12.2 mucosal edema and mucus plugging. Some symptoms are dyspnoea, wheezing cough
Principal
Acharya
and may be limitation of activity3. The prevalence of asthma has&increased
B.M. Reddy College of
significantly Pharmacy,
since the
Bangalore.

1970s. As of 2010, 300 million people were affected worldwide. In 2009 asthma caused 3
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250,000 deaths globally . Effective treatment for asthma exist, but morbidity and mortality have
continued to climb. In many patients, asthma symptoms arise during night which is called as