ADVANCED TEHNOLOGY IN PHARMACEUTICAL SCIENCE

Polymeric Nanoparticles: Smart Materials for drug delivery

Name- Pawar Atul Santosh Guided By- Dr . Sanjeevani Deshkar

INTRODUCTION 2. Solvent evaporation: Sr. No. Polymer Drug Diseases Reference

Research in nanotechnology for drug delivery systems has made great
impact in pharmaceutical science (Grottkau et al., 2013). Nanomedicine Characterization
.
has emerged as active research areas of nanotechnology which has
application in diagnosis, prevention and treatment of diseases (Lobatto et 1. PLGA Monensin Malaria Surolia et. Sr. No. Parameter Technique
al., 2011, Richemann et al., 2009). Over the past few decades, polymeric al., 2012
nanoparticles has became choice of researchers for targeted drug
delivery and a lot of studies have been performed on polymeric 1. Particle Size Dynamic light Scattering, X-Ray,
2. PLGA Lycopene Human Gharib et.
nanoparticle system for poorly soluble drugs, genes, antibodies and leukemia al., 2014 TEM, SEM, and AFM
peptide drugs (Kiriyama et al., 2013). Biodegradable polymeric
nanoparticles have been used most frequently as drug delivery vehicles 3. Poly(lactic acid) Lomustine Lung cancer Mehrotra 2. Surface Charge Zeta potential measurement and
because of its easy bioavailability, controlled release, better (PLA) and Pandit, Laser droplet anemometry
encapsulation and less toxic properties (Kumari et al., 2010). Natural 2012
Schematic representation of the emulsification evaporation 3. Crystallinity DSC and X-Ray Diffraction
polymers include chitosan, gelatin, sodium alginate and albumin.
technique (Pinto Reis et al., 2006)
Synthetic polymers are PLGA, PLA, PGA. There are various methods of
preparation of polymeric nanoparticles of different sizes such as ionic 4. Salting out
gelation method, precipitation method, solvent evaporation method etc. Sr. Polymer Drug Diseases Reference
No
1. Chitosan and Curcumin Cancer Malesu et.al.,
Characteristics
METHODS OF PREPARATION sodium alginate 2011
1. Ionic gelation: 1. Drug Loading
Calvo and co-workers developed a method for preparing hydrophilic 2. PLGA Curcumin Cancer Tsai et
al.,2011
2. Surface Modification
chitosan nanoparticles by ionic gelation ( Calvo et al., 1997).
3. Tumor Targetting

3. PLGA Quercetin Anti oxidant Kumari et al.,

Route of administration
2010
1. Intravenous administration
2. Subcutaneous or intramuscular injection
3. Ophthalmic application
3. Nanoprecipitation: Schematic representation of salting out method for
preparation of polymer nanoparticles (Nagavarma et al.,
2012)
Schematic representation of preparation of polymeric REFERENCES
nanoparticles by ionic gelation method (Nagavarma et al., 2012) Sr. No. Polymer Drug Diseases Reference
Grottkau BE, Cai X. Wang J, Yang X, Lin Y. Polymeric nanoparticles for a
drug delivery system. Curr. Drug Metab. 2013 Oct, 14(8):840-846.
Sr.NO Polymer Drug Disease Reference
Nagavarma BVN, Yadav HKS, Ayaz A, Vasudha LS, Shivakumar HG.
1. Chitosan Temoxifen Breast cancer Patel et al., 1. Gelatin Colchicine Breast Chandrethi Different techniques for preparation of polymeric nanoparticles - A Review.
citrate 2011 cancer ya et al.,
2013 Astan. J. Pharmaceut. Clin. Res. 2012 Jun;5(3):16-23.
2. Chitosan Rizatriptan Migraine Jadhav and
benzoate Bhalerao, 2. PLGA Clonazepam Nah et al.,
2013 1998
3. Chitosan Curcumin Human Phuc Le et
Embryonic al., 2013 3. PCL and Triiodothyroa Thyroid dos Santos
Schematic diagram of preparation of polymeric nanoparticles by PMMA cetic acid (Triac) et al., 2012
Kidney
nanoprecipitation method (Nagavarma et al., 2012)

Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research Pimpri, Pune 411018
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