Cop Ans, CNS and PNS MCQ

Exams  Print
Exam Test - 1 (02/Sept/2019) #813
1. Which is the shortest acting mydriatic
(A) Atropine
(B) Tropicamide
(C) Cyclopentolate
(D) Homatropine
Selected answer: (Not selected..)
The correct answer is: (B)
2. Catecholamine includes except
(A) Ephedrine
(B) Epinephrine
(C) Isoprenaline
(D) Norepinephrine
Selected answer: (A)
Correct!
3. Epinephrine is used in the treatment of all of the following disorders except
(A) Bronchospasm
(B) Anaphylactic shock
(C) Cardiac arrhythmia
(D) Open angle glaucoma
Selected answer: (C)
Correct!
4. Which of the following drugs causes bronchodilation without signi cant

cardiac
(A) Isoprenaline
(B) Terbutaline
(C) Xylometazoline
(D) Methoxamine
Selected answer: (B)
The correct answer is: (D)
5. Hyperglycemia induced by epinephrine is due to
(A) Gluconeogenesis
(B) Inhibition of insulin secretion
(C) Stimulation of glycogenolysis
(D) All of the above
6. Which of the following sympathomimetic is a beta-2 selective agonist?
(A) Terbutaline
(B) Xylometazoline
(C) Isoproterenol
(D) Dobutamine
Selected answer: (D)
The correct answer is: (A)
7. Which of the following agents is an alpha-2 selective agonist with ability to

promote constriction of the nasal mucosa?
(A) Xylometazoline
(B) Phenylephrine
(C) Methoxamine
(D) Epinephrine
Correct!
8. Norepinephrine action at synaptic cleft is terminated by……….
(A) Metabolism by Glutamic acid decarboxylase

(B) Metabolism by MAO
(C) Reuptake
(D) Metabolism by acetylcholinesterase
The correct answer is: (C)
9. The following is a selective alpha-2 adrenoceptor……….
(A) Prazocin
(B) Phentolamine
(C) Yohimbine
(D) Clonidine
Correct!
10. First drug to be used in anaphylactic shock is
(A) Subcutaneous adrenaline

(B) I.V. corticosteroid
(C) Theophylline
(D) Antihistaminic
Correct!
11. Indicate the beta adrenoreceptor antagonist, which has partial beta-agonist
activity
(A) Propranolol
(B) Metoprolol
(C) Pindolol
(D) Betaxolol
12. Indicate the alpha-1 selective antagonist
(A) Phentolamine
(B) Dihydroergotamine
(C) Prazocin
(D) Labetalol
Correct!
13. What is true of sildena l
(A) It enhance sexual enjoyment in normal men

(B) It delays ejaculation
(C) It improve penile tumescence in men with erectile dysfunction
(D) It blocks cavernosal alpha-2 adrenoreceptor
14. Propanolol induced adverse e ects include all of the following, except
(A) Bronchoconstriction
(B) Supersenstivity of beta adrenergic receptors
(C) Hyperglycemia
(D) Sedation, sleep disturbance, depression and sexual dysfunction
15. Which of the following anti-glaucoma medication is unsafe in infants
(A) Timolol
(B) Brimonidine
(C) Latanoprost
(D) Dorzolamide
16. Select the drug which is administered orally for erectile dysfunction in men
(A) Yohimbine
(B) Papaverine
(C) Alprostadil
(D) Sildena l
17. Subtype selective alpha-1 antagonist such as tamsulosin, terazosin, alfusosin

are e cacious in
(A) Hyperthyroidism
(B) Cardiac arrhythmias
(C) Benign prostatic hyperplasia
(D) Asthma
18. Bimtoprost is used in ………
(A) Glaucoma
(B) Barrett esophagus
(C) Hypertrichosis of eyelid
(D) NSAIDS ulcer
19. Most commonly postural hypotension is seen with ……..
(A) Prazocin
(B) ACE inhibitor
(C) Atenolol
(D) Both a & b
20. Beta blocker with peripheral vasodilator action is …….
(A) Carvedilol
(B) Propranolol
(C) Atenolol
(D) Acebutalol
Correct!
21. Which of the following has the shortest plasma half life……..
(A) Propranolol
(B) Esmolol
(C) Sotalol
(D) Atenolol
22. Beta blocking agents have all of the following e ects except
(A) Increases plasma concentration of HDL and decreases of VLDL
(B) Bronchoconstriction
(C) Decrease of aqueous humor production
(D) Membrane stabilizing e ect
Correct!
23. Which of the following is not given in a patient with pheochromocytoma
(A) Atenolol
(B) Prazosin
(C) Nitroprusside
(D) Metyrosine
24. The enzyme pseudocholinesterase acts on
(A) Decamethonium
(B) Tubocurarine
(C) Gallamine
(D) Suxamethonium
25. The following antagonizes the visceral side e ects of neostigmine used in
reversal of d-TC blockade
(A) Atropine
(B) Nicotine
(C) Pilocarpine
(D) Pyridostigmine
26. Idiosyncrasy is
(A) Genetically determined abnormal reaction

(B) Immunologically mediated reaction.
(C) Appearance of characteristic toxic e ect of a drug in an individual at therapeutic doses.
(D) Unwanted but often unavoidable pharmacodynamic e ects at therapeutic dose.
27. Prodrug is
(A) Levodopa
(B) Amitriptyline
(C) Primidone
(D) Digitoxin
Correct!
28. Therapeutic index is
(A) ED50/LD50
(B) LD50/ED50
(C) ED50-LD50
(D) ED50XLD50
29. ED50 is used for determining
(A) Potency
(B) E cacy
(C) Safety
(D) Toxicity
30. High plasma protein binding
(A) Increases volume of distribution of drug

(B) Facilitates glomerular ltration of drug
(C) Minimizes drug interactions
(D) Generally makes the drug long acting
31. On I.V. drug administration, elimination of drug depends upon
(A) Lipid solubility

(B) Volume of distribution
(C) Clearance, drug concentration
Correct!
32. Loading dose of drug primarily depends upon
(A) Volume of distribution

(B) Clearance
(C) Rate of administration
(D) Half life
Correct!
33. Which of the following drug in an inhibitor of cytochrome P450 enzymes?
(A) Ketocanazole
(B) Rifampicine
(C) Phenytoin
(D) Isoniazid
34. Drug NOT metabolized in liver………….
(A) Penicillin G
(B) Phenytoin
(C) Erythromycin
(D) Cimetidine
Correct!
35. Cytochrome P450 is inhibited by………
(A) Phenobarbitone
(B) Cimetidine
(C) Phenytoin
(D) CCl4
36. Clearance……….
(A) Refers to elimination of a drug by an organ or whole body

(B) Cannot be greater than blood ow to an organ
(C) Determines the steady state of drug concentration
37. Time for peak plasma concentration (Tmax) indicates….
(A) The rate of elimination

(B) The rate of absorption
(C) The onset of e ect
(D) The intensity of e ect
Correct!
38. An agonist is a substance that
(A) Interacts with the receptor without inducing any e ect.

(B) Interacts with the receptor and initiate changes in cell function, producing various e ects
(C) Increases the concentration of another substance to produce e ect
(D) Interacts with plasma proteins and doesn’t produce any e ect
Correct!
39. Which of the following drug produces therapeutic window phenomenon?
(A) Captopril
(B) Furosemide
(C) Diazepam
(D) Imipramine
40. Tachyphylaxis is………….
(A) A drug interaction between two similar types of drugs

(B) Very rapidly developing tolerance
(C) A decrease in responsiveness to a drug, taking days or week to develop
(D) None of the above
Correct!
41. Types of antagonism are…….
(A) Summarized
(B) Potentiated
(C) Additive
(D) Competitive
Correct!
42. A teratogenic action is ………….
(A) Toxic action on liver

(B) Negative action on fetus causing fetal malformation
(C) Toxic action on blood system
(D) Toxic action on kidneys
Correct!
43. Target proteins which a drugs molecule binds are……
(A) Receptors
(B) Ion channels
(C) Carriers
44. Alpha-1 receptor actions are mediated through…….
(A) cAMP
(B) cGMP
(C) Calcium ion
(D) ADP
45. If an agonist can produce maximal e ect and has high e cacy it’s called………
(A) Partial agonist

(B) Antagonist
(C) Agonist-Antagonist
(D) Full agonist
Correct!
46. Irreversible interaction of an antagonist with a receptor is due to……….
(A) Ionic bond

(B) Hydrogen bond
(C) Covalent bond
Correct!
47. All of the following sub-serve as intracellular second messenger in receptor

mediated signal transduction except
(A) cAMP
(B) Inositol triphosphate
(C) Diacylgycerol
(D) G protein
Correct!
48. A receptor which itself has enzymatic property is….
(A) Insulin receptor

(B) Progesterone receptor
(C) Thyroxine receptor
(D) Glucagon receptor
Correct!
49. The receptor transduction mechanism with the fastest time course of
response e ectuation is
(A) Adenylylcyclase: cAMP pathway

(B) Phospholipase C-IP3/DAG pathway
(C) Intrinsic ion channel operation
(D) Protein synthesis
50. Therapeutic drug monitoring is required in all except….
(A) Phenytoin
(B) Metformin
(C) Tacrolimus
(D) Cyclosporin
Information for the solved exam
Started in: September 2, 2019, 1:58 pm
Finished in: September 2, 2019, 2:11 pm
Assesment: Very good 4.50!
Points: 66
Right: 21
Wrong: 18
Not Answered: 11

Cop Ans, CNS and PNS MCQ

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Cop Ans, CNS and PNS MCQ

Uploaded by

Copyright:

Available Formats

Exams  Print

Exam Test - 1 (02/Sept/2019) #813

1. Which is the shortest acting mydriatic

2. Catecholamine includes except

3. Epinephrine is used in the treatment of all of the following disorders except

4. Which of the following drugs causes bronchodilation without signi cant

5. Hyperglycemia induced by epinephrine is due to

6. Which of the following sympathomimetic is a beta-2 selective agonist?

7. Which of the following agents is an alpha-2 selective agonist with ability to

8. Norepinephrine action at synaptic cleft is terminated by……….

(A) Metabolism by Glutamic acid decarboxylase

10. First drug to be used in anaphylactic shock is

(A) Subcutaneous adrenaline

12. Indicate the alpha-1 selective antagonist

13. What is true of sildena l

(A) It enhance sexual enjoyment in normal men

15. Which of the following anti-glaucoma medication is unsafe in infants

17. Subtype selective alpha-1 antagonist such as tamsulosin, terazosin, alfusosin

18. Bimtoprost is used in ………

19. Most commonly postural hypotension is seen with ……..

20. Beta blocker with peripheral vasodilator action is …….

23. Which of the following is not given in a patient with pheochromocytoma

24. The enzyme pseudocholinesterase acts on

(A) Genetically determined abnormal reaction

28. Therapeutic index is

29. ED50 is used for determining

30. High plasma protein binding

(A) Increases volume of distribution of drug

(A) Lipid solubility

32. Loading dose of drug primarily depends upon

(A) Volume of distribution

33. Which of the following drug in an inhibitor of cytochrome P450 enzymes?

34. Drug NOT metabolized in liver………….

35. Cytochrome P450 is inhibited by………

(A) Refers to elimination of a drug by an organ or whole body

37. Time for peak plasma concentration (Tmax) indicates….

(A) The rate of elimination

38. An agonist is a substance that

(A) Interacts with the receptor without inducing any e ect.

39. Which of the following drug produces therapeutic window phenomenon?

(A) A drug interaction between two similar types of drugs

41. Types of antagonism are…….

42. A teratogenic action is ………….

(A) Toxic action on liver

43. Target proteins which a drugs molecule binds are……

44. Alpha-1 receptor actions are mediated through…….

(A) Partial agonist

46. Irreversible interaction of an antagonist with a receptor is due to……….

(A) Ionic bond

47. All of the following sub-serve as intracellular second messenger in receptor

48. A receptor which itself has enzymatic property is….

(A) Insulin receptor

(A) Adenylylcyclase: cAMP pathway

50. Therapeutic drug monitoring is required in all except….

Information for the solved exam

Started in: September 2, 2019, 1:58 pm

Finished in: September 2, 2019, 2:11 pm

Assesment: Very good 4.50!

You might also like