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The typical technical data above serve to generally characterize the excipient.

These values are not meant as specifications and they do


not have binding character. The product specification is available separately from the website www.merckmillipore.com

We provide information and advice to our customers on application technologies and regulatory matters to the best of our knowledge
and ability, but without obligation or liability. Existing laws and regulations are to be observed in all cases by our customers. This also
applies in respect to any rights of third parties. Our information and advice do not relieve our customers of their own responsibility for
checking the suitability of our products for the envisaged purpose.

Our tools –
your inspiration
Chemicals for
Pharmaceutical Formulation
Merck Millipore is a division of

For more information and documentation


please contact:
Phone: +49 6151-72 0
Email: pcs.salessupportEU@merckgroup.com

Merck Millipore
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt, Germany

www.merckmillipore.com
Merck Millipore and the M logo are trademarks of Merck KGaA, Darmstadt, Germany.
w303114 07/13

Parteck and EMPROVE are registered trademarks of Merck KGaA, Darmstadt, Germany.
PS-SBU-11-04579 05/2013
© 2013 Merck KGaA, Darmstadt, Germany. All rights reserved.
The typical technical data above serve to generally characterize the excipient. These values are not meant as specifications and they do
not have binding character. The product specification is available separately from the website www.merckmillipore.com

We provide information and advice to our customers on application technologies and regulatory matters to the best of our knowledge
and ability, but without obligation or liability. Existing laws and regulations are to be observed in all cases by our customers. This also
applies in respect to any rights of third parties. Our information and advice do not relieve our customers of their own responsibility for
checking the suitability of our products for the envisaged purpose.

Our tools –
your inspiration
Chemicals for
Pharmaceutical Formulation
Merck Millipore is a division of

For more information and documentation


please contact:
Phone: +49 6151-72 0
Email: pcs.salessupportEU@merckgroup.com

Merck Millipore
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt, Germany

www.merckmillipore.com
Merck Millipore and the M logo are trademarks of Merck KGaA, Darmstadt, Germany.
w303114 07/13

Parteck and EMPROVE are registered trademarks of Merck KGaA, Darmstadt, Germany.
PS-SBU-11-04579 05/2013
© 2013 Merck KGaA, Darmstadt, Germany. All rights reserved.
Catalog No. Article

API Product List


You’re in the fast lane to di-Potassium hydrogen phosphate anhydrous, low in sodium,

market your product


106752 Benzyl nicotinate, suitable for use as active 109828
suitable for use as active pharmaceutical ingredient
pharma­ceutical ingredient EMPROVE® api DAB EMPROVE® api Ph Eur, BP, USP

That’s why EMPROVE® keeps 100164 Boric acid cryst., suitable for use as active pharmaceutical
ingredient EMPROVE® api Ph Eur, BP, NF
105040 Potassium iodide, suitable for use as active pharmaceutical
ingredient EMPROVE® api Ph Eur, BP, JP, USP

the paperwork out of your way 102422 Calcium carbonate precipitated (≤ 0.002 % Fe), suitable
for use as active pharmaceutical ingredient
106236 Sodium acetate anhydrous, suitable for use as active
EMPROVE® api Ph Eur, BP, USP pharmaceutical ingredient EMPROVE® api USP, FCC, E 262

102465 Calcium chloride dihydrate, suitable for use as active 106235 Sodium acetate trihydrate, suitable for use
as active pharmaceutical ingredient
pharmaceutical ingredient EMPROVE® api Ph Eur, BP, JP, USP EMPROVE® api Ph Eur, BP, JP, USP, FCC, E 262

Preparing the documentation for your products can With Merck Millipore and EMPROVE® you’re on 500112 Cocarboxylase chloride (thiamine diphosphoric acid ester 106444 Sodium chloride, suitable for use as active pharmaceutical
chloride), suitable for use as active pharmaceutical
be time-consuming and costly, but it is necessary the safe side – now and in the future. Our experts ingredient EMPROVE® api ingredient EMPROVE® api Ph Eur, BP, JP, USP
due to increasing regulatory requirements. So what are actively involved in various international
500111 Cocarboxylase tetrahydrate (thiamine diphosphoric acid 106441 Sodium fluoride, suitable for use as active pharmaceutical
if somebody already did this work for you, providing committees occupied with developing regulations ester tetrahydrate), suitable for use as active
pharma­ceutical ingredient EMPROVE® api ingredient EMPROVE® api Ph Eur, BP, USP
top quality at the same time? With the EMPROVE® for pharmaceutical raw materials. Thus, we can
concept, we have set a worldwide benchmark for quickly recognize regulatory trends, helping you to 102367 Magnesium chloride hexahydrate cryst., suitable for use as 500667 Thiamine phosphoric acid ester chloride dihydrate, suitable
the documentation of pharma­ceutical raw materials. react promptly. active pharmaceutical ingredient
EMPROVE® api Ph Eur, BP, USP for use as active pharmaceutical ingredient EMPROVE® api
We already offer about 300 EMPROVE® products –
and the list is getting longer. What EMPROVE® means for you: 105303 D(-)-Mannitol low in endotoxins, suitable for use as active 108432 Urea cryst., suitable for use as active pharmaceutical
pharmaceutical ingredient EMPROVE® api Ph Eur, BP, USP, JP ingredient EMPROVE® api Ph Eur, BP, USP
All EMPROVE® raw materials are accompanied • Top-quality raw materials
106143 Meglumine low in endotoxins, suitable for use as active 108815 Zinc chloride, suitable for use as active pharmaceutical
by comprehensive dossiers in the internationally • Comprehensive documentation pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP ingredient EMPROVE® api Ph Eur, BP, USP
accepted CTD format. The usage categories are: • Faster time to market
EMPROVE® exp for excipients, EMPROVE® bio for • Lower costs 100320 Potassium chloride, suitable for use as active pharmaceutical
biopharmaceutical production, and EMPROVE® api • Safer products ingredient EMPROVE® api Ph Eur, USP, FCC, E 262
for active pharmaceutical ingredients. For APIs
we provide access to ASMF, DMF, or CEP. Our web page www.merckmillipore.com is the
central platform for our customers in the pharma­
EMPROVE® 4 Depending on your application, the corresponding ceutical industry. Here you can find information
EMPROVE® dossiers offer information on the on products and services, you can download the
Pharmaceutical Raw Materials by Merck Millipore 5 manufacturing process, test methods used, or EMPROVE® Basic Dossiers, and get information
stability data. That way, you can avoid potential about our other dossiers – simply, quickly, and
Formulations 6 sources of error and gain certainty in the approval conveniently, 24/7.
process, ensuring the safety of your products.
Formulations for Solid Dosage Forms 6
Since EMPROVE® dossiers are ready-to-use, you
Formulations for Semi-solid Dosage Forms 7 are also able to accelerate internal qualification
pro­cesses and bring your products to market faster.
Formulations for Liquid Dosage Forms 7 You don’t have to develop test methods or evaluate
stability data. All details on the raw materials used
Active Pharmaceutical Ingredients (API) 8 are already professionally prepared – reducing your
workload and speeding up your processes.
Drug Delivery Compounds (DDC) 10

Products for Solid Dosage Forms 12

Products for Semi-solid Dosage Forms 19

Products for Liquid Dosage Forms 24

Products for Active Pharmaceutical Ingredients (API) 33

4 For more information, visit www.merckmillipore.com For more information, visit www.merckmillipore.com 33
Catalog No. Article

API Product List


You’re in the fast lane to di-Potassium hydrogen phosphate anhydrous, low in sodium,

market your product


106752 Benzyl nicotinate, suitable for use as active 109828
suitable for use as active pharmaceutical ingredient
pharma­ceutical ingredient EMPROVE® api DAB EMPROVE® api Ph Eur, BP, USP

That’s why EMPROVE® keeps 100164 Boric acid cryst., suitable for use as active pharmaceutical
ingredient EMPROVE® api Ph Eur, BP, NF
105040 Potassium iodide, suitable for use as active pharmaceutical
ingredient EMPROVE® api Ph Eur, BP, JP, USP

the paperwork out of your way 102422 Calcium carbonate precipitated (≤ 0.002 % Fe), suitable
for use as active pharmaceutical ingredient
106236 Sodium acetate anhydrous, suitable for use as active
EMPROVE® api Ph Eur, BP, USP pharmaceutical ingredient EMPROVE® api USP, FCC, E 262

102465 Calcium chloride dihydrate, suitable for use as active 106235 Sodium acetate trihydrate, suitable for use
as active pharmaceutical ingredient
pharmaceutical ingredient EMPROVE® api Ph Eur, BP, JP, USP EMPROVE® api Ph Eur, BP, JP, USP, FCC, E 262

Preparing the documentation for your products can With Merck Millipore and EMPROVE® you’re on 500112 Cocarboxylase chloride (thiamine diphosphoric acid ester 106444 Sodium chloride, suitable for use as active pharmaceutical
chloride), suitable for use as active pharmaceutical
be time-consuming and costly, but it is necessary the safe side – now and in the future. Our experts ingredient EMPROVE® api ingredient EMPROVE® api Ph Eur, BP, JP, USP
due to increasing regulatory requirements. So what are actively involved in various international
500111 Cocarboxylase tetrahydrate (thiamine diphosphoric acid 106441 Sodium fluoride, suitable for use as active pharmaceutical
if somebody already did this work for you, providing committees occupied with developing regulations ester tetrahydrate), suitable for use as active
pharma­ceutical ingredient EMPROVE® api ingredient EMPROVE® api Ph Eur, BP, USP
top quality at the same time? With the EMPROVE® for pharmaceutical raw materials. Thus, we can
concept, we have set a worldwide benchmark for quickly recognize regulatory trends, helping you to 102367 Magnesium chloride hexahydrate cryst., suitable for use as 500667 Thiamine phosphoric acid ester chloride dihydrate, suitable
the documentation of pharma­ceutical raw materials. react promptly. active pharmaceutical ingredient
EMPROVE® api Ph Eur, BP, USP for use as active pharmaceutical ingredient EMPROVE® api
We already offer about 300 EMPROVE® products –
and the list is getting longer. What EMPROVE® means for you: 105303 D(-)-Mannitol low in endotoxins, suitable for use as active 108432 Urea cryst., suitable for use as active pharmaceutical
pharmaceutical ingredient EMPROVE® api Ph Eur, BP, USP, JP ingredient EMPROVE® api Ph Eur, BP, USP
All EMPROVE® raw materials are accompanied • Top-quality raw materials
106143 Meglumine low in endotoxins, suitable for use as active 108815 Zinc chloride, suitable for use as active pharmaceutical
by comprehensive dossiers in the internationally • Comprehensive documentation pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP ingredient EMPROVE® api Ph Eur, BP, USP
accepted CTD format. The usage categories are: • Faster time to market
EMPROVE® exp for excipients, EMPROVE® bio for • Lower costs 100320 Potassium chloride, suitable for use as active pharmaceutical
biopharmaceutical production, and EMPROVE® api • Safer products ingredient EMPROVE® api Ph Eur, USP, FCC, E 262
for active pharmaceutical ingredients. For APIs
we provide access to ASMF, DMF, or CEP. Our web page www.merckmillipore.com is the
central platform for our customers in the pharma­
EMPROVE® 4 Depending on your application, the corresponding ceutical industry. Here you can find information
EMPROVE® dossiers offer information on the on products and services, you can download the
Pharmaceutical Raw Materials by Merck Millipore 5 manufacturing process, test methods used, or EMPROVE® Basic Dossiers, and get information
stability data. That way, you can avoid potential about our other dossiers – simply, quickly, and
Formulations 6 sources of error and gain certainty in the approval conveniently, 24/7.
process, ensuring the safety of your products.
Formulations for Solid Dosage Forms 6
Since EMPROVE® dossiers are ready-to-use, you
Formulations for Semi-solid Dosage Forms 7 are also able to accelerate internal qualification
pro­cesses and bring your products to market faster.
Formulations for Liquid Dosage Forms 7 You don’t have to develop test methods or evaluate
stability data. All details on the raw materials used
Active Pharmaceutical Ingredients (API) 8 are already professionally prepared – reducing your
workload and speeding up your processes.
Drug Delivery Compounds (DDC) 10

Products for Solid Dosage Forms 12

Products for Semi-solid Dosage Forms 19

Products for Liquid Dosage Forms 24

Products for Active Pharmaceutical Ingredients (API) 33

4 For more information, visit www.merckmillipore.com For more information, visit www.merckmillipore.com 33
The pharmaceutical market is
getting more complex
Which is why we
make things easier for you

In pharmaceutics, the regulatory world is changing. It’s changing fast. And it’s
not always easy to keep track of the latest requirements. The market, too, is
changing. With rising pressure caused by generics and biosimilars and with less
time to market. Quality factors matter. Even more. When extremes in high
and low dosages are needed and bioavai­lability of active ingredients becomes
a big issue.

Our answer to these challenges is twofold:

• We offer you a comprehensive portfolio of over 400 raw materials meeting


highest quality and safety standards.

• We give you the support you need with our regulatory expertise, market
knowledge, and substantial service.

Both these factors combine to create what we call the full spectrum of quality.
This is our strategy to confront the demands of today, whether you want to
manu­f acture a new pharmaceutical product, optimize an approved one, or
develop new dosage forms.

With our broad range of products we cover raw materials for solid, semi-solid,
and liquid dosage forms as well as active pharmaceutical ingredients (APIs)
and drug delivery compounds (DDCs). Our products are subject to strict quality
control procedures and are produced considering appropriate and applicable
cGMP for excipients, respectively cGMP for API.

Another important issue in the pharmaceutical industry today: There are fewer
new biological or chemical entities. So formulations are becoming the focus
of innovation. Manufacturers look here for possible product line extensions.
To help you stand out from the competition, Merck Millipore offers a number
of innovative excipients with unique functionalities, accelerating the release
of APIs or controlling the release even more accurately.

As an integral part of this, we offer you application support in every step


of deve­lopment, scale-up, and production – from process optimization to
regulatory affairs – with docu­mentation and individual solutions. With
our new Research & Development Center for Formulation in Darmstadt we
can improve our capabilities even further. Using a wide range of technical
equipment we work on new excipients and solutions for formulation development
challenges side by side with our customers.

We’re taking your perspective in a difficult market. That’s our approach to


making things easier for you – not more complex.

For more information, visit www.merckmillipore.com 5


When the road to innovation narrows –
keep open-minded
We have the formulation you need
for the success of your product

Our extensive portfolio of raw materials for


solid, semi-solid, and liquid dosage forms makes
Merck Millipore an ideal partner for the pharma-
ceutical industry. Especially in a market where the
number of NBEs/NCEs is decreasing and the pres-
sure for innovative products is increasing.

It’s one more reason why we work together with


you closely to assist you effectively in develop-
ment and production. And why we respond to your
specific needs – by supplying extended specifica-
tion parameters, individual particle sizes or colors.

Solid
dosage forms
Developing solid dosage forms with controlled
release functionalities is one of today’s key
challenges in the pharmaceutical industry. It
requires innovative approaches and suitable
formulations. Our comprehensive portfolio
for solid dosage forms includes additives,
lubricants, binding agents, fillers,
sweeteners, and many other application-
oriented items for your products. For
details on our product portfolio for
solid dosage forms, please see page 12.

In addition, you can benefit from our


experience and our expertise with production-
dependent requirements when developing new
products or when optimizing proven ones.

6 For more information, visit www.merckmillipore.com


Semi-solid
dosage forms
Our portfolio for semi-solid dosage forms enables
you to work flexibly in development and production.
It covers gelling agents, antioxidants, moisture
enhancers, and products for targeted acidification.
Solubility and stability can be achieved via sur-
factants or gum arabic for example. Our reper-
tory of preservatives takes into account all
required pH ranges. For details on our product
portfolio for semi-solid dosage forms, please see
page 19.

Liquid
dosage forms
With the combination of cutting-edge products,
customer-oriented solutions, and competent
contacts, Merck Millipore is your excellent partner
for liquid applications. Our product offer for liquid
applications comprises a wide range of substances
with different functionalities, and we provide
support for solving even difficult formulation
challenges.

Our portfolio covers solvents, preservatives, stabi-


lizers, and products needed for pH adjustments
as well as solutions for enteral nutrition
and renal care, meeting all your special
demands in these fields. For details
on our product portfolio for
liquid dosage forms, please
see page 25.

For more information, visit www.merckmillipore.com 7


Two additional qualities of Merck Millipore products –
experience and service
Raising your efficiency with our
active pharmaceutical ingredients

Quality, regulatory compliance, and reliable supply


are the most important factors when formulating
active pharmaceutical ingredients. Merck Millipore
supports you with high-quality products and
ex­ceptional service, from development to registration
and supply – facilitating research and production
for you.

With EMPROVE® api, custom synthesis of APIs,


and high-purity folates, our portfolio includes
innovative and proven substances as well as
tailor-made solutions to meet your needs.

8 For more information, visit www.merckmillipore.com


EMPROVE® api
EMPROVE® api completes our EMPROVE® concept in compliance with regulatory
requirements for active pharmaceutical ingredients. The whole API process
follows cGMP guidelines and is subject to strict quality and control measures.

What’s more: our support in regulatory affairs. We provide our EMPROVE® api
with exactly the documentation you need, such as Certificates of Suitability
according to the European Pharmacopoeia (CEP) or Letters of Access to Drug
Master Files (DMF) or Active Substance Master Files (ASMF) – each in the
internationally accepted CTD format and tailored to your individual needs.

In short: with EMPROVE® api you can achieve optimal product safety, lower
your costs of drug registration, and speed up time to market.

APIs and Custom Synthesis


For several decades, we have been known as a well-established and reliable
API manufacturer. Our offer comprises APIs for the animal and human health
market. In some therapy fields, for example certain APIs for imaging products
and anthelmintics, Merck Millipore plays a leading role in the market. For
other specific targets we operate on an exclusive basis.

In addition to our own product range, we also offer a broad portfolio of


custom synthesis services. This way, we can provide you with customized
high-performance products that are specifically designed to meet your require-
ments as well as current pharmaceutical and regulatory standards.

Folates for Pharma and Nutrition


Merck Millipore assists you with over 50 years of experience in the production
of folates. Our portfolio includes a wide range of high-purity folates for
pharmaceutical production and nutrition.

With our patented Metafolin®, for example, we have succeeded in manufac-


turing L-methylfolate in a stable form, and making it commercially available.
Its advantages: Metafolin® is the naturally-occurring predominant form of
folate, and – unlike folic acid – it is directly bioavailable.

With Merck Millipore you can count on a global production network that
operates according to cGMP standards. And you can rely on our extensive
services along your entire process chain.

For more information, visit www.merckmillipore.com 9


Your products are already doing a great job
Our drug delivery compounds
help them to work even better

Every API is unique and requires tailor-made


delivery technology to improve its performance.
We offer a wide portfolio of drug delivery
compounds (DDCs) covering customized PEGs,
lipids, PEG-lipids, linkers, spacers, and activators.
Our expertise in analytical services facilitates
your method development and validation.
In addition, we offer regulatory services
and keep you informed of the latest
requirements.

10 For more information, visit www.merckmillipore.com


Activated PEGs
Activated PEGs by Merck Millipore enable your drug molecules to unfold their
full potential. They are available as linear, multi-arm, homo-, or heterofunctionalized
PEGs – produced strictly according to cGMP guidelines. Therefore, we can
provide you with consistent quality for your entire process chain from R & D to
manufacturing.

Lipids
Liposomes assembled from our range of specialty lipids can increase the bio-
availability of your APIs and protect them from quick degradation in parenteral
applications. Due to our scalable synthesis and innovative purification process
we can offer crystalline lipids from gram to ton scale – simplifying your life in
lipid formulation.

PEG-lipids
PEG-lipids mask the surface of liposomal drug containers and modify their
circulation time in the body. If you want to improve the delivery timing of your
API, PEGylated lipids by Merck Millipore help you get the results you need –
with consistent quality and reproducible results.

Linkers and Activators


Modification of lipids or biomolecules with PEG requires polymer activation
with reactive functional groups such as amines and thiols. With our high-
purity linkers and activators you can achieve better control and higher efficiency
during linking reactions.

Merck Millipore is your reliable source for DDCs with consistent quality
throughout your product’s lifetime.

Please contact your local representative for more information on drug delivery
compounds and the custom synthesis services Merck Millipore offers. Further
details can be found at www.merckmillipore.com

For more information, visit www.merckmillipore.com 11


Catalog No. Article

Solid Dosage Form


pH Adjustment Ingredients - Solid

480745 Acetic acid 30 % extra pure Ph Helv 101700 L-Alanine, suitable for use as excipient
EMPROVE® exp Ph Eur, USP

101071 Aluminium hydroxide acetate hydrate (basic aluminium 101131 Ammonium hydrogen carbonate, suitable for use as excipient
acetate) pure EMPROVE® exp Ph Eur, BP, E 503

101136 Ammonium carbonate, suitable for use as excipient 101206 di-Ammonium hydrogen phosphate, suitable for use as
EMPROVE® exp Ph Franç, NF, E 503 excipient EMPROVE® exp NF

101142 Ammonium chloride, suitable for use as excipient 500090 L(+)-Ascorbyl palmitate (6-palmitoyl-L-ascorbic acid),
suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, NF, FCC, E 304

101155 di-Ammonium hydrogen citrate, suitable for use as excipient 101750 Barium sulfate, suitable for use as excipient
EMPROVE® exp EMPROVE® exp Ph Eur, BP, USP

102052 Calcium acetate hydrate extra pure DAC, FCC 100130 Benzoic acid powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, E 210

100247 Citric acid anhydrous fine-granular, suitable for use as 102584 Caffeine, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC EMPROVE® exp Ph Eur, BP, USP

100241 Citric acid anhydrous powder, suitable for use as excipient 112120 Calcium carbonate precipitated (≤ 0.0001 % Al), suitable for
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC use as excipient EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 170

100242 Citric acid monohydrate cryst., suitable for use as excipient 102064 Calcium carbonate precipitated (≤ 0.002 % Fe),
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC EMPROVE® Ph Eur, BP, USP, JP, FCC

100243 Citric acid monohydrate powder, suitable for use as excipient 102074 Calcium carbonate precipitated, special grade (≤ 0.002 % Fe),
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC suitable for use as excipient EMPROVE® exp Ph Eur, BP, USP

105862 Magnesium oxide light extra pure Ph Eur, BP, E 530 102069 Calcium carbonate precipitated, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, E 170, FCC

817058 Maleic acid Ph Eur, NF 102148 Calcium D-saccharate, suitable for use as excipient
EMPROVE® exp USP

100383 DL-Malic acid, suitable for use as excipient 102160 Calcium sulfate dihydrate precipitated, suitable for use as
EMPROVE® exp Ph Eur, NF, FCC, E 296 excipient EMPROVE® exp Ph Eur, BP, E 516

106143 Meglumine low in endotoxins, suitable for use as active 104112 Calcium glycerophosphate hydrate, suitable for use as
pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP excipient EMPROVE® exp Ph Eur, FCC

104871 Potassium dihydrogen phosphate cryst., suitable for use as 102555 Charcoal activated Ph Eur
excipient EMPROVE® exp Ph Eur, BP, NF, E 340

106281 Sodium acetate anhydrous extra pure USP, FCC, E 262 500117 Choline chloride, suitable for use as excipient
EMPROVE® exp DAB 10, FCC

106265 Sodium acetate trihydrate extra pure 500115 Choline hydrogen tartrate, suitable for use as excipient
Ph Eur, BP, JP, USP, FCC, E 262 EMPROVE® exp DAB 10, FCC

100803 L(+)-Tartaric acid powder, suitable for use as excipient 102792 Copper(II) sulfate anhydrous, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF, E 334 EMPROVE® exp Ph Eur, BP

102787 Copper(II) sulfate pentahydrate cryst., suitable for use as


excipient EMPROVE® exp Ph Eur, BP, USP

102788 Copper(II) sulfate pentahydrate powder, suitable for use as


excipient EMPROVE® exp Ph Eur, BP, USP

12 For more information, visit www.merckmillipore.com


Catalog No. Article

Solid Dosage Form


114737 ForMaxx Calcium carbonate 70 (calcium carbonate-sorbitol) 105882 Magnesium sulfate heptahydrate, suitable for use as
excipient EMPROVE® exp Ph Eur, BP, USP, JP

104731 myo-Inositol, suitable for use as excipient 105885 Magnesium sulfate hydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, FCC EMPROVE® exp DAC

103815 Iron extra pure reduced particle size about 10 µm 105999 Manganese(II) sulfate monohydrate spray-dried, suitable for
use as excipient EMPROVE® exp Ph Eur, USP, FCC

103962 Iron(II) fumarate extra pure (ca. 33 % Fe) Ph Eur, BP, USP, FCC 500299 Nicotinamide Ph Eur, BP, USP, FCC

103868 Iron(II) gluconate dihydrate Ph Eur, BP, USP, E 579 500005 Nicotinic acid extra pure Ph Eur, BP, USP

103963 Iron(II) sulfate heptahydrate cryst., suitable for use as 107130 Pancreatin (from porcine pancreas) 350 FIP-U/g Protease,
6000 FIP-U/g Lipase, 7500 FIP-U/g Amylase, suitable for use
excipient EMPROVE® exp Ph Eur, BP, USP, FCC as excipient EMPROVE® exp USP

103967 Iron(II) sulfate hydrate (about 87 % FeSO4) extra pure 107133 Pancreatin 1400 FIP-U/g Protease, 24000 FIP-U/g Lipase,
30000 FIP-U/g Amylase, suitable for use as excipient
Ph Eur, BP, USP EMPROVE® exp Ph Eur, 4 x USP

817066 Iron(II) sulfate hydrate (about 87 % FeSO4) extra pure 107149 Papain 30000 USP-U/mg stabilized with sodium disulfite,
Ph Eur, BP, USP suitable for use as excipient EMPROVE® exp

103862 Iron(III) citrate hydrate (about 19 % Fe) 107147 Papain 6000 USP-U/mg stabilized with sodium disulfite,
suitable for use as excipient EMPROVE® exp

103814 Iron(III)-chloride-hexahydrate, suitable for use as excipient 102440 Parteck® Mg DC (Magnesium hydroxide carbonate) heavy,
suitable for use as excipient
EMPROVE® exp Ph Eur, JP EMPROVE® exp Ph Eur, BP, USP, E 504

108117 Kieselguhr purified and calcined, suitable for use as excipient 100909 Petroleum benzine boiling range 40-60 °C, suitable for use
EMPROVE® exp NF as excipient EMPROVE® exp DAB

105671 Lithium carbonate extra pure Ph Eur, BP, USP 817001 Polyethylene glycol 200, suitable for use as excipient
EMPROVE® exp DAB 8

105683 tri-Lithium citrate tetrahydrate, suitable for use as excipient 817002 Polyethylene glycol 300, suitable for use as excipient
EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur

105832 Magnesium chloride hexahydrate cryst. 817003 Polyethylene glycol 400, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JPC, FCC, E 511 EMPROVE® exp Ph Eur, JP

105904 Magnesium citrate extra pure 817004 Polyethylene glycol 600, suitable for use as excipient
EMPROVE® exp Ph Eur

102314 Magnesium gluconate USP 817009 Polyethylene glycol 1000, suitable for use as excipient
EMPROVE® exp Ph Eur

105872 Magnesium hydrogen phosphate trihydrate, suitable for use 817005 Polyethylene glycol 1500 (scales), suitable for use as
as excipient EMPROVE® exp DAB excipient EMPROVE® exp Ph Eur

105870 Magnesium hydroxide extra pure Ph Eur, BP, USP 817020 Polyethylene glycol 2000, suitable for use as excipient
EMPROVE® exp DAB

105867 Magnesium oxide heavy, suitable for use as excipient 817019 Polyethylene glycol 3000, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur

105862 Magnesium oxide light extra pure Ph Eur, BP, E 530 817006 Polyethylene glycol 4000 (powder), suitable for use as
excipient EMPROVE® exp Ph Eur

104643 Magnesium phosphinate hexahydrate (Magnesium 817063 Polyethylene glycol 4000 (scales), suitable for use as
hypophosphite hexahydrate) extra pure excipient EMPROVE® exp Ph Eur

For more information, visit www.merckmillipore.com 13


Catalog No. Article

Solid Dosage Form


817007 Polyethylene glycol 6000, suitable for use as excipient 106602 Sodium salicylate powder, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, USP

817018 Polyethylene glycol 20000, suitable for use as excipient 106645 Sodium sulfate anhydrous extra pure fine powder
EMPROVE® exp Ph Eur Ph Eur, BP, USP

104924 Potassium carbonate, suitable for use as excipient 106643 Sodium sulfate anhydrous, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, E 501 EMPROVE® exp Ph Eur, BP, USP, E 514

104937 Potassium chloride, suitable for use as excipient 106642 Sodium sulfate decahydrate cryst., suitable for use as
EMPROVE® exp Ph Eur, BP, E 508 excipient EMPROVE® exp Ph Eur, BP, USP

104935 tri-Potassium chloride, suitable for use as excipient 106514 Sodium thiosulfate pentahydrate cryst., suitable for use as
EMPROVE® exp Ph Eur, BP, USP, FCC, E 508 excipient EMPROVE® exp Ph Eur, BP, USP

104956 tri-Potassium citrate monohydrate, suitable for use as 100773 Tannic acid powder, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, USP, FCC, E 332 EMPROVE® exp Ph Eur, JP, USP

104871 Potassium dihydrogen phosphate cryst., suitable for use as 500923 Thiamine chloride hydrochloride (Vitamin B1-hydrochloride)
excipient EMPROVE® exp Ph Eur, BP, NF, E 340 Ph Eur, BP, USP, FCC

104852 Potassium hydrogen carbonate, suitable for use as excipient 500849 Vitamin A water-miscible 1 ml = 200,000 I.U. for oral use,
EMPROVE® exp Ph Eur, BP, USP, FCC, E 501 suitable for use as excipient EMPROVE® exp BP, Ph Eur

105150 Potassium sulfate cryst., suitable for use as excipient 524950 Vitamin B12 (cyanocobalamin) Ph Eur, BP, USP
EMPROVE® exp Ph Eur, BP, JP

105151 Potassium sulfate powder, suitable for use as excipient 500601 Vitamin B12-lactose trituration 0.1  %
EMPROVE® exp Ph Eur, BP, JP, E 515

500257 Riboflavin Ph Eur, BP, JP, USP, E 101 (i) 500619 Vitamin B12-mannitol trituration 0.1  %

500259 Riboflavine 5'-phosphate monosodium salt dihydrate 500936 Vitamin D3 (cholecalciferol) cryst. (1 g = 40 Mio. I.U.),
Ph Eur, BP, JP, USP, E 101a suitable for use as excipient EMPROVE® exp Ph Eur, BP, USP

100635 Salicylic acid fine powder, suitable for use as excipient 501551 Vitamin D3 dry powder 1 g = 100,000 I.U. colecalciferol,
EMPROVE® exp Ph Eur, BP, USP stabilized with DL-α-tocopherol Ph Eur, BP

100631 Salicylic acid, suitable for use as excipient 500878 Vitamin E dry powder sprayed (50 g all-rac-α-tocopheryl
acetate in 100 g substance), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP

106398 Sodium carbonate anhydrous, suitable for use as excipient 500858 Vitamin E dry powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF EMPROVE® exp Ph Eur, BP, USP

106384 Sodium carbonate decahydrate, suitable for use as excipient 500859 Vitamin E dry powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, E 500 EMPROVE® exp Ph Eur, BP, USP

106386 Sodium carbonate monohydrate, suitable for use as excipient 500854 Vitamin E ready-to-press granules (33 g all-rac-α-tocopheryl
acetate in 100 g substance), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, E 500 EMPROVE® exp Ph Eur, BP

106323 Sodium hydrogen carbonate, suitable for use as excipient 500862 Vitamin E water-miscible 1 ml = 500 mg DL-α-tocopherol
acetate for oral use, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, FCC, E 500 EMPROVE® exp USP

106520 Sodium iodide, suitable for use as excipient 501890 Vitamin K1 (phytomenadione), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP EMPROVE® exp Ph Eur, BP, USP, FCC

104646 Sodium phosphinate monohydrate (sodium hypophosphite 108800 Zinc acetate dihydrate extra pure Ph Eur, USP
monohydrate), suitable for use as excipient EMPROVE® exp DAC

106600 Sodium salicylate cryst., suitable for use as excipient 817079 Zinc gluconate USP
EMPROVE® exp Ph Eur, BP, USP

14 For more information, visit www.merckmillipore.com


Catalog No. Article

Solid Dosage Form


108846 Zinc oxide, suitable for use as excipient 104061 D(+)-Galactose, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP

108881 Zinc sulfate heptahydrate, suitable for use as excipient 104072 Gelatin (sheets), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, FCC EMPROVE® exp Ph Eur, BP, NF

108882 Zinc sulfate heptahydrate, suitable for use as excipient 104078 Gelatin powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, FCC EMPROVE® exp Ph Eur, BP, NF

108346 D(+)-Glucose monohydrate, suitable for use as excipient


Surfactants and Stabilizers EMPROVE® exp Ph Eur, BP, USP

106143 Meglumine low in endotoxins, suitable for use as active 108117 Kieselguhr purified and calcined, suitable for use as excipient
pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP EMPROVE® exp NF

137065 Poloxamer 188, suitable for biopharmaceutical production 107656 Lactose monohydrate (milk sugar) powder, suitable for use as
Ph Eur, NF excipient EMPROVE® exp Ph Eur, BP, NF, JP

817072 Tween® 20 (Polysorbate), suitable for use as excipient 108195 Lactose monohydrate (milk sugar) special grade for tabletting,
EMPROVE® exp Ph Eur, JPE, NF suitable for use as excipient EMPROVE® exp Ph Eur, BP, NF, JP

817076 Tween® 60 (Polysorbate), suitable for use as excipient 105829 Magnesium hydroxide carbonate heavy extra pure
EMPROVE® exp Ph Eur, JPE, NF Ph Eur, BP, USP, E 504

817061 Tween® 80 (Polysorbate), suitable for use as excipient 105828 Magnesium hydroxide carbonate light extra pure
EMPROVE® exp Ph Eur, JP, NF Ph Eur, BP

105911 Maltose monohydrate, suitable for use as excipient


Binders and Fillers EMPROVE® exp

101615 Agar extra pure, fine powder Ph Eur, BP 105988 D(−)-Mannitol fine powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 421

105006 Bole white powder low bacterial content, for internal use, 105980 D(−)-Mannitol, suitable for use as excipient
suitable for use as excipient EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 421

112120 Calcium carbonate precipitated (≤ 0.0001  % Al), suitable for 112635 Parteck® Delta M (Mannitol), suitable for use as excipient
use as excipient EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 170 EMPROVE® exp Ph Eur, BP, USP, JP, E 421

102064 Calcium carbonate precipitated (≤ 0.002 % Fe) 100494 Parteck® M 100 (Mannitol), suitable for use as excipient
EMPROVE® Ph Eur, BP, USP, JP, FCC EMPROVE® exp Ph Eur, BP, JP, USP, E 421

102074 Calcium carbonate precipitated, special grade (≤ 0.002 % Fe), 100419 Parteck® M 200 (Mannitol), suitable for use as excipient
suitable for use as excipient EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, JP, USP, E 421

102069 Calcium carbonate precipitated, suitable for use as excipient 100493 Parteck® M 300 (Mannitol), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, E 170, FCC EMPROVE® exp Ph Eur, BP, JP, USP, E 421

102304 Calcium hydrogen phosphate anhydrous extra fine powder, 102440 Parteck® Mg DC (Magnesium hydroxide carbonate) heavy,
suitable for use as excipient suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, FCC, E 341 EMPROVE® exp Ph Eur, BP, USP, E 504

102144 Calcium hydrogen phosphate anhydrous extra fine powder, 100490 Parteck® ODT, suitable for use as excipient EMPROVE® exp
suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, FCC, E 341

102146 Calcium hydrogen phosphate dihydrate extra fine powder, 103583 Parteck® SI 150 (Sorbitol), suitable for use as excipient
suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, FCC, E 341 EMPROVE® exp Ph Eur, BP, JP, NF, JSFA, E 420

102143 Calcium phosphate dried, suitable for use as excipient 115079 Parteck® SI 200 (Sorbitol), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, E 341 EMPROVE® exp Ph Eur, BP, JP, NF, E 420

114737 ForMaxx Calcium carbonate 70 (calcium carbonate-sorbitol) 103140 Parteck® SI 400 (Sorbitol), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JSFA, NF, E 420

For more information, visit www.merckmillipore.com 15


Catalog No. Article

Solid Dosage Form


103557 Parteck® SI 450 (Sorbitol), suitable for use as excipient
EMPROVE® exp NF, FCC, JSFA Coatings and Supporting Material

141350 Polyvinyl alcohol 4-88, suitable for use as excipient 105006 Bole white powder low bacterial content, for internal use,
EMPROVE® exp Ph Eur, USP, JPE suitable for use as excipient EMPROVE® exp Ph Eur, BP

141354 Polyvinyl alcohol 5-88, suitable for use as excipient 100989 Cetyl alcohol, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, BP, NF, JP

141351 Polyvinyl alcohol 8-88, suitable for use as excipient 102492 Chlorophyllin water-soluble (Na-Cu-Chlorophyllin)
EMPROVE® exp Ph Eur, USP, JPE (C.I. 75815) minimum 98 % E 141 (ii)

141355 Polyvinyl alcohol 18-88, suitable for use as excipient 817067 Dibutyl sebacate NF
EMPROVE® exp Ph Eur, USP, JPE

141352 Polyvinyl alcohol 26-88, suitable for use as excipient 104091 Glycerol 85 %, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, BP

141356 Polyvinyl alcohol 28-99, suitable for use as excipient 104093 Glycerol anhydrous, suitable for use as excipient
EMPROVE® exp JPE EMPROVE® exp Ph Eur, BP, JP, USP, E 422

141353 Polyvinyl alcohol 40-88, suitable for use as excipient 104228 Gum arabic spray-dried, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, BP

141360 Polyvinyl alcohol 4-88, powder, suitable for use as excipient 108070 PARTECK® LUB Talc, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur, BP, JP, USP

141364 Polyvinyl alcohol 5-88, powder EMPROVE® exp Ph Eur, USP 141350 Polyvinyl alcohol 4-88, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE

141361 Polyvinyl alcohol 8-88, powder EMPROVE® exp Ph Eur, USP 141354 Polyvinyl alcohol 5-88, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE

141365 Polyvinyl alcohol 18-88, powder EMPROVE® exp Ph Eur, USP 141351 Polyvinyl alcohol 8-88, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE

141362 Polyvinyl alcohol 26-88, powder EMPROVE® exp Ph Eur, USP 141355 Polyvinyl alcohol 18-88, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE

141363 Polyvinyl alcohol 40-88, powder EMPROVE® exp Ph Eur, USP 141352 Polyvinyl alcohol 26-88, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE

101253 Starch soluble extra pure 141356 Polyvinyl alcohol 28-99, suitable for use as excipient
EMPROVE® exp JPE

107653 Sucrose, suitable for use as excipient 141353 Polyvinyl alcohol 40-88, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF EMPROVE® exp Ph Eur, USP, JPE

108196 Tabletting aid D 141360 Polyvinyl alcohol 4-88, powder, suitable for use as excipient
EMPROVE® exp Ph Eur, USP

108197 Tabletting aid K cellulose powder Ph Eur, BP, JP, NF, E 460 ii 141364 Polyvinyl alcohol 5-88, powder EMPROVE® exp Ph Eur, USP

100805 Titanium(IV) oxide, suitable for use as excipient 141361 Polyvinyl alcohol 8-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur, BP, USP, JP, E 171

108692 D(+) Xylose Ph Eur, BP 141365 Polyvinyl alcohol 18-88, powder EMPROVE® exp Ph Eur, USP

16 For more information, visit www.merckmillipore.com


Catalog No. Article

Solid Dosage Form


141362 Polyvinyl alcohol 26-88, powder EMPROVE® exp Ph Eur, USP 106070 Methyl salicylate synthetic, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF

141363 Polyvinyl alcohol 40-88, powder EMPROVE® exp Ph Eur, USP 817022 Saccharin, suitable for use as excipient
EMPROVE® exp Ph Eur, NF

100805 Titanium(IV) oxide, suitable for use as excipient 817042 Saccharin sodium dihydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP, E 171 EMPROVE® Ph Eur, USP

103000 Triacetin, suitable for use as excipient 817044 Sodium cyclamate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP

817059 Triethyl citrate Ph Eur, JPE, NF 106445 Sodium L-glutamate monohydrate, suitable for use as
excipient EMPROVE® exp FCC, NF, E 621

108808 Zinc hydroxide carbonate pure (zinc carbonate basic) 100895 Sucralose granular, suitable for use as excipient
EMPROVE® exp Ph Eur, NF

108846 Zinc oxide, suitable for use as excipient 100894 Sucralose powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, NF

107653 Sucrose, suitable for use as excipient


Disintegrants EMPROVE® exp Ph Eur, BP, JP, NF

101253 Starch soluble extra pure 100803 L(+)-Tartaric acid powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF, E 334

108510 Vanillin, suitable for use as excipient


Taste Modifiers EMPROVE® exp Ph Eur, BP, NF

101141 Ammonium chloride pure


Lubricants and Glidants

101142 Ammonium chloride, suitable for use as excipient 100664 Parteck® LUB CST (Calcium stearate vegetable grade), suitable
EMPROVE® exp Ph Eur, BP, USP for use as excipient EMPROVE® exp Ph Eur, BP, JP, NF, FCC

100247 Citric acid anhydrous fine-granular, suitable for use as 100663 Parteck® LUB MST (Magnesium stearate vegetable grade),
excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC suitable for use as excipient EMPROVE® exp Ph Eur, BP, JP, NF, FCC

100241 Citric acid anhydrous powder, suitable for use as excipient 100661 Parteck® LUB STA 50 (Stearic acid 50 vegetable grade),
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC suitable for use as excipient EMPROVE® exp Ph Eur, BP, JP, NF

100242 Citric acid monohydrate cryst., suitable for use as excipient 108070 PARTECK® LUB Talc, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC EMPROVE® exp Ph Eur, BP, JP, USP

100243 Citric acid monohydrate powder, suitable for use as excipient 817009 Polyethylene glycol 1000, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC EMPROVE® exp Ph Eur

105321 D(-)-Fructose, suitable for use as excipient 817005 Polyethylene glycol 1500 (scales), suitable for use as
EMPROVE® exp Ph Eur, BP, USP, FCC excipient EMPROVE® exp Ph Eur

108346 D(+)-Glucose monohydrate, suitable for use as excipient 817006 Polyethylene glycol 4000 (powder), suitable for use as
EMPROVE® exp Ph Eur, BP, USP excipient EMPROVE® exp Ph Eur

101791 L-Glutamic acid, suitable for use as excipient 817063 Polyethylene glycol 4000 (scales), suitable for use as
EMPROVE® exp Ph Eur excipient EMPROVE® exp Ph Eur

105911 Maltose monohydrate, suitable for use as excipient 817007 Polyethylene glycol 6000, suitable for use as excipient
EMPROVE® exp EMPROVE® exp Ph Eur

105995 Menthol cryst., suitable for use as excipient 113126 Silicon dioxide colloidal, highly dispersed, suitable for use as
EMPROVE® exp Ph Eur, BP, JP, USP excipient EMPROVE® exp Ph Eur, NF, JP, E 551

For more information, visit www.merckmillipore.com 17


Catalog No. Article

Solid Dosage Form


Candurin® - Gold Colors
Candurin® - Mineral Pearl Effect Colors

120610 Candurin® Gold Lustre


Candurin® – Silver Colors

120600 Candurin® Silver Fine  120608 Candurin® Gold Sheen 

120602 Candurin® Silver Lustre  120623 Candurin® Gold Sparkle 

120601 Candurin® Silver Sheen  120609 Candurin® Light Gold 

120603 Candurin® Silver Sparkle  Candurin® - Iron Oxide Colors

Candurin® - Interference Colors 120617 Candurin® Brown Amber 

120606 Candurin® Blue Shimmer  120615 Candurin® Orange Amber 

120604 Candurin® Gold Shimmer  120613 Candurin® Red Amber 

120607 Candurin® Green Shimmer  120619 Candurin® Red Lustre 

120605 Candurin® Red Shimmer  120622 Candurin® Red Sparkle

18 For more information, visit www.merckmillipore.com


Catalog No. Article

Semi-solid Dosage Form


100563 ortho-Phosphoric acid 85 %, suitable for use as excipient
Acidulents and pH Adjustment EMPROVE® exp Ph Eur, BP, JPE, NF, E 338

100056 Acetic acid (glacial) 100 %, suitable for use as excipient 100564 ortho-Phosphoric acid 89 % extra pure Ph Eur, BP
EMPROVE® exp Ph Eur, BP, JP, USP, E 260

480745 Acetic acid 30 % extra pure Ph Helv 104871 Potassium dihydrogen phosphate cryst., suitable for use as
excipient EMPROVE® exp Ph Eur, BP, NF, E 340

100058 Acetic acid 96 %, suitable for use as excipient 105101 di-Potassium hydrogen phosphate anhydrous, suitable for
EMPROVE® exp use as excipient EMPROVE® exp Ph Eur, BP, E 340

100090 Adipic acid, suitable for use as excipient 105032 Potassium hydroxide pellets, suitable for use as excipient
EMPROVE® exp Ph Eur, NF, FCC, E 355 EMPROVE® exp Ph Eur, BP, JP, NF, FCC, E 525

480905 Ammonia solution 10 %, suitable for biopharmaceutical 480864 Potassium hydroxide solution 46-48 %
production EMPROVE® bio

105408 Ammonia solution 19 % 105102 tri-Potassium phosphate trihydrate extra pure

105422 Ammonia solution 25 %, suitable for use as excipient 105150 Potassium sulfate cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, BP, JP

101124 Ammonium dihydrogen phosphate cryst. extra pure 105151 Potassium sulfate powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, E 515

101216 Ammonium sulfate extra pure 106281 Sodium acetate anhydrous extra pure USP, FCC, E 262

102119 Calcium hydroxide precipitated (≤ 0.0005 % Al), suitable for 106265 Sodium acetate trihydrate extra pure
use as excipient EMPROVE® exp USP, FCC, E 526 Ph Eur, BP, JP, USP, FCC, E 262

102110 Calcium hydroxide, suitable for use as excipient 106431 tri-Sodium citrate 5,5-hydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP, FCC EMPROVE® exp FU VIII, E 331

102102 Calcium lactate pentahydrate, suitable for use as excipient 111037 tri-Sodium citrate anhydrous, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, E 327 EMPROVE® exp USP, FCC, E 331

104091 Glycerol 85 %, suitable for use as excipient 106432 tri-Sodium citrate dihydrate cryst., suitable for use as
EMPROVE® exp Ph Eur, BP excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 331

104093 Glycerol anhydrous, suitable for use as excipient 106446 tri-Sodium citrate dihydrate powder, suitable for use as
EMPROVE® exp Ph Eur, BP, JP, USP, E 422 excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 331

100312 Hydrochloric acid 25 %, suitable for use as excipient 106447 tri-Sodium citrate dihydrate, suitable for use as excipient
EMPROVE® exp Ph Helv EMPROVE® exp Ph Eur, BP, JP, USP, E 331

100314 Hydrochloric acid fuming 37 %, suitable for use as excipient 106345 Sodium dihydrogen phosphate dihydrate, suitable for use as
EMPROVE® exp Ph Eur, BP, JP, NF excipient EMPROVE® exp Ph Eur, BP, USP, JPE, E 339

100366 (S)-Lactic acid about 90 %, suitable for use as excipient 106349 Sodium dihydrogen phosphate monohydrate, suitable for
EMPROVE® exp Ph Eur, BP, E 270 use as excipient EMPROVE® exp BP, USP

817058 Maleic acid Ph Eur, NF 106585 di-Sodium hydrogen phosphate anhydrous, suitable for use
as excipient EMPROVE® exp Ph Eur, BP, USP, E 339

480787 ortho-Phosphoric acid 0.5 % 106576 di-Sodium hydrogen phosphate dihydrate, suitable for use as
excipient EMPROVE® exp Ph Eur, BP, USP

100250 Phosphoric acid 75 %, suitable for biopharmaceutical 106573 di-Sodium hydrogen phosphate dodecahydrate cryst.,
production suitable for use as excipient EMPROVE® exp Ph Eur, BP, JP, USP

For more information, visit www.merckmillipore.com 19


Catalog No. Article

Semi-solid Dosage Form


106574 di-Sodium hydrogen phosphate heptahydrate, suitable for 104061 D(+)-Galactose, suitable for use as excipient
use as excipient EMPROVE® exp DAC, USP EMPROVE® exp Ph Eur, BP

106482 Sodium hydroxide pellets, suitable for use as excipient 104760 Iodine purified by sublimation, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, FCC, JP, NF, E 524 EMPROVE® exp Ph Eur, BP, USP

106577 tri-Sodium phosphate dodecahydrate, suitable for use as 100366 (S)-Lactic acid about 90 %, suitable for use as excipient
excipient EMPROVE® exp NF, E 339 EMPROVE® exp Ph Eur, BP, E 270

106522 Sodium-(S)-lactate-solution about 50 %, suitable for use as 105995 (−)-Menthol cryst., suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, JP, USP

480704 Sulfuric acid 10 % extra pure 817071 Methyl nicotinate Ph Eur

108372 Triethanolamine (Trolamine), suitable for use as excipient 106070 Methyl salicylate synthetic, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, NF

108369 Triethanolamine solution 50 % in water 107174 Paraffin highly liquid Ph Eur, BP, NF, JP

108386 Tris(hydroxymethyl)aminomethane (Trometamol), suitable 100909 Petroleum benzine boiling range 40-60 °C, suitable for use
for use as excipient EMPROVE® exp Ph Eur, BP, JPC, USP as excipient EMPROVE® exp DAB

501260 Pyridoxol (pyridoxine) vitamin B6 base


Ingredients - Semi-solid

101084 Aluminium chloride hexahydrate, suitable for use as 107590 Resorcinol extra pure Ph Eur, BP, USP
excipient EMPROVE® exp Ph Eur, BP, USP

101071 Aluminium hydroxide acetate hydrate (basic aluminium 500064 Rutin water-soluble in flakes (rutin sulfate sodium salt)
acetate) pure

100102 4-Aminobenzoic acid, suitable for use as excipient 100635 Salicylic acid fine powder, suitable for use as excipient
EMPROVE® exp USP EMPROVE® exp Ph Eur, BP, USP

101142 Ammonium chloride, suitable for use as excipient 100631 Salicylic acid, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, USP

101131 Ammonium hydrogen carbonate, suitable for use as excipient 113126 Silicon dioxide colloidal, highly dispersed, suitable for use as
EMPROVE® exp Ph Eur, BP, E 503 excipient EMPROVE® exp Ph Eur, NF, JP, E 551

101206 di-Ammonium hydrogen phosphate, suitable for use as 101510 Silver nitrate cryst. extra pure Ph Eur, BP, USP
excipient EMPROVE® exp NF

101565 L-Asparagine monohydrate, suitable for use as excipient 817081 Sodium caprylate, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, NF

100160 Boric acid cryst., suitable for use as excipient 106600 Sodium salicylate cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF EMPROVE® exp Ph Eur, BP, USP

100162 Boric acid powder, suitable for use as excipient 106602 Sodium salicylate powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF EMPROVE® exp Ph Eur, BP, USP

102148 Calcium D-saccharate, suitable for use as excipient 106514 Sodium thiosulfate pentahydrate cryst., suitable for use as
EMPROVE® exp USP excipient EMPROVE® exp Ph Eur, BP, USP

100989 Cetyl alcohol, suitable for use as excipient 106513 Sodium thiosulfate pentahydrate pure
EMPROVE® exp Ph Eur, BP, NF, JP

103672 Cholesterol from wool fat extra pure, powdered Ph Eur, BP, 100895 Sucralose granular, suitable for use as excipient
NF, JP EMPROVE® exp Ph Eur, NF

20 For more information, visit www.merckmillipore.com


Catalog No. Article

Semi-solid Dosage Form


100894 Sucralose powder, suitable for use as excipient 817001 Polyethylene glycol 200, suitable for use as excipient
EMPROVE® exp Ph Eur, NF EMPROVE® exp DAB 8

107983 Sulfur for external use Ph Eur, BP 817002 Polyethylene glycol 300, suitable for use as excipient
EMPROVE® exp Ph Eur

100773 Tannic acid powder, suitable for use as excipient 817003 Polyethylene glycol 400, suitable for use as excipient
EMPROVE® exp Ph Eur, JP, USP EMPROVE® exp Ph Eur, JP

108167 Thymol cryst., suitable for use as excipient 817004 Polyethylene glycol 600, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF EMPROVE® exp Ph Eur

100805 Titanium(IV) oxide, suitable for use as excipient 817009 Polyethylene glycol 1000, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP, E 171 EMPROVE® exp Ph Eur

100810 Trichloroacetic acid cryst., suitable for use as excipient 817005 Polyethylene glycol 1500 (scales), suitable for use as
EMPROVE® exp Ph Eur excipient EMPROVE® exp Ph Eur

108484 Urea beads, suitable for use as excipient EMPROVE® exp USP 817020 Polyethylene glycol 2000, suitable for use as excipient
EMPROVE® exp DAB

108486 Urea cryst., suitable for use as excipient 817019 Polyethylene glycol 3000, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP EMPROVE® exp Ph Eur

108510 Vanillin, suitable for use as excipient 817006 Polyethylene glycol 4000 (powder), suitable for use as
EMPROVE® exp Ph Eur, BP, NF excipient EMPROVE® exp Ph Eur

524950 Vitamin B12 (cyanocobalamin) Ph Eur, BP, USP 817063 Polyethylene glycol 4000 (scales), suitable for use as
excipient EMPROVE® exp Ph Eur

501551 Vitamin D3 dry powder 1 g = 100,000 I.U. colecalciferol 817007 Polyethylene glycol 6000, suitable for use as excipient
stabilized with DL-α-tocopherol Ph Eur, BP EMPROVE® exp Ph Eur

111544 Wax white in pastilles, suitable for use as excipient 817018 Polyethylene glycol 20000, suitable for use as excipient
EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur

108846 Zinc oxide, suitable for use as excipient 141350 Polyvinyl alcohol 4-88, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, USP, JPE

141355 Polyvinyl alcohol 5-88, suitable for use as excipient


Thickeners - Semi-solid EMPROVE® exp Ph Eur, USP, JPE

101615 Agar extra pure, fine powder Ph Eur, BP 141354 Polyvinyl alcohol 8-88, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE

105006 Bole white powder low bacterial content, for internal use, 141355 Polyvinyl alcohol 18-88, suitable for use as excipient
suitable for use as excipient EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, USP, JPE

104072 Gelatin (sheets), suitable for use as excipient 141352 Polyvinyl alcohol 26-88, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF EMPROVE® exp Ph Eur, USP, JPE

104078 Gelatin powder, suitable for use as excipient 141356 Polyvinyl alcohol 28-99, powder suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF EMPROVE® exp JPE

104091 Glycerol 85 %, suitable for use as excipient 141353 Polyvinyl alcohol 40-88, suitable for use as excipient
EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, USP, JPE

104093 Glycerol anhydrous, suitable for use as excipient 141360 Polyvinyl alcohol 4-88, powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, E 422 EMPROVE® exp Ph Eur, USP

104228 Gum arabic spray-dried, suitable for use as excipient 141364 Polyvinyl alcohol 5-88, powder, EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur, BP

For more information, visit www.merckmillipore.com 21


Catalog No. Article

Semi-solid Dosage Form


141361 Polyvinyl alcohol 8-88, powder EMPROVE® exp Ph Eur, USP 107427 Propyl 4-hydroxybenzoate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF, FCC

141365 Polyvinyl alcohol 18-88, powder EMPROVE® exp Ph Eur, USP 106290 Sodium benzoate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, FCC, E 211

141362 Polyvinyl alcohol 26-88, powder EMPROVE® exp Ph Eur, USP 106357 Sodium disulfite (sodium metabisulfite), suitable for use as
excipient EMPROVE® exp Ph Eur, BP, JP, NF, E 223

141363 Polyvinyl alcohol 40-88, powder EMPROVE® exp Ph Eur, USP 106652 Sodium sulfite, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, E 221

101253 Starch soluble extra pure 100662 Sorbic acid, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, FCC, E 200

108035 Sulfanilamide extra pure


Preservatives

817046 Benzalkonium chloride (50 % aqueous solution), suitable for 817043 Thimerosal Ph Eur, BP, USP
use as excipient EMPROVE® exp Ph Eur, NF

817032 Benzalkonium chloride, suitable for use as excipient 108421 Titriplex® III (ethylenedinitrilotetraacetic acid disodium
salt dihydrate), suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, JP, USP

100130 Benzoic acid powder, suitable for use as excipient 101005 1,1,1,-Trichloro-2-methyl-2-propanol hemihydrate
EMPROVE® exp Ph Eur, BP, USP, E 210 Ph Eur, BP, JP, NF

101806 Benzyl benzoate Ph Eur, BP, USP


Antioxidants

100160 Boric acid cryst., suitable for use as excipient 500090 L(+)-Ascorbyl palmitate (6-palmitoyl-L-ascorbic acid), suitable
EMPROVE® exp Ph Eur, BP, NF for use as excipient EMPROVE® exp Ph Eur, BP, NF, FCC, E 304

100162 Boric acid powder, suitable for use as excipient 817023 Butylhydroxyanisole Ph Eur, NF, E 320
EMPROVE® exp Ph Eur, BP, NF

100886 Ethyl 4-hydroxybenzoate sodium salt Ph Eur, E 215 817074 Butylhydroxytoluene Ph Eur, JPE, NF, E 321

100887 Ethyl 4-hydroxybenzoate, suitable for use as excipient 108330 Oxynex® L liquid antioxidant for fats and oils, suitable for
EMPROVE® exp Ph Eur, BP, JP, NF, E 214 use as excipient EMPROVE® exp

100944 Ethylenedinitrilotetraacetic acid extra pure Ph Eur, NF 106946 Oxynex® LM antioxidant for fats and oils, suitable for use as
excipient EMPROVE® exp

106756 Methyl 4-hydroxybenzoate sodium salt, suitable for use as 105056 Potassium disulfite, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, NF, E 219 EMPROVE® exp Ph Eur, NF, E 224

106757 Methyl 4-hydroxybenzoate, suitable for use as excipient 107813 Tin(II) chloride dihydrate extra pure Ph Eur, BP
EMPROVE® exp Ph Eur, BP, JP, NF, FCC, E 218

105056 Potassium disulfite, suitable for use as excipient 500976 DL-A-Tocopherol hydrogen succinate food grade USP
EMPROVE® exp Ph Eur, NF, E 224

105119 Potassium sorbate granules, suitable for use as excipient 500949 All-rac-α-Tocopherol, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, FCC, E 202 EMPROVE® exp Ph Eur, BP, USP, E 307

105118 Potassium sorbate powder, suitable for use as excipient 500952 All-rac-α-Tocopheryl acetate (Vitamin E acetate), suitable
EMPROVE® exp Ph Eur, BP, NF, FCC, E 202 for use as excipient EMPROVE® exp Ph Eur, BP, USP, FCC

107428 Propyl 4-hydroxybenzoate sodium salt, suitable for use as


excipient EMPROVE® exp Ph Eur, BP, NF

22 For more information, visit www.merckmillipore.com


Catalog No. Article

Semi-solid Dosage Form


141354 Polyvinyl alcohol 8-88, suitable for use as excipient
Surfactants and Stabilizers EMPROVE® exp Ph Eur, USP, JPE

100989 Cetyl alcohol, suitable for use as excipient 141355 Polyvinyl alcohol 18-88, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, JP EMPROVE® exp Ph Eur, USP, JPE

115419 Cetyl palmitate 15 (cetylesters wax), suitable for use as 141352 Polyvinyl alcohol 26-88, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, NF EMPROVE® exp Ph Eur, USP, JPE

100944 Ethylenedinitrilotetraacetic acid extra pure Ph Eur, NF 141356 Polyvinyl alcohol 28-99, powder, suitable for use as
excipient EMPROVE® exp JPE

104061 D(+)-Galactose, suitable for use as excipient 141353 Polyvinyl alcohol 40-88, suitable for use as excipient
EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, USP, JPE

137065 Poloxamer 188, suitable for biopharmaceutical production 141360 Polyvinyl alcohol 4-88, powder, suitable for use as excipient
Ph Eur, NF EMPROVE® exp Ph Eur, USP

817001 Polyethylene glycol 200, suitable for use as excipient 141364 Polyvinyl alcohol 5-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp DAB 8

817002 Polyethylene glycol 300, suitable for use as excipient 141361 Polyvinyl alcohol 8-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur

817003 Polyethylene glycol 400, suitable for use as excipient 141365 Polyvinyl alcohol 18-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur, JP

817004 Polyethylene glycol 600, suitable for use as excipient 141362 Polyvinyl alcohol 26-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur

817009 Polyethylene glycol 1000, suitable for use as excipient 141363 Polyvinyl alcohol 40-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur

817005 Polyethylene glycol 1500 (scales), suitable for use as 817034 Sodium dodecyl sulfate Ph Eur
excipient EMPROVE® exp Ph Eur

817020 Polyethylene glycol 2000, suitable for use as excipient 108421 Titriplex® III (ethylenedinitrilotetraacetic acid
disodium salt dihydrate), suitable for use as excipient
EMPROVE® exp DAB EMPROVE® exp Ph Eur, BP, JP, USP

817019 Polyethylene glycol 3000, suitable for use as excipient 108369 Triethanolamine solution 50 % in water
EMPROVE® exp Ph Eur

817006 Polyethylene glycol 4000 (powder), suitable for use as 817072 Tween® 20 (Polysorbate), suitable for use as excipient
excipient EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, JPE, NF

817063 Polyethylene glycol 4000 (scales), suitable for use as 817076 Tween® 60 (Polysorbate), suitable for use as excipient
excipient EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, JPE, NF

817007 Polyethylene glycol 6000, suitable for use as excipient 817061 Tween® 80 (Polysorbate), suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, JP, NF

817018 Polyethylene glycol 20000, suitable for use as excipient


EMPROVE® exp Ph Eur

141350 Polyvinyl alcohol 4-88, suitable for use as excipient


EMPROVE® exp Ph Eur, USP, JPE

141355 Polyvinyl alcohol 5-88, suitable for use as excipient


EMPROVE® exp Ph Eur, USP, JPE

For more information, visit www.merckmillipore.com 23


Catalog No. Article

Liquid Dosage Form


817033 Diethyltoluamide USP
Ingredients – Liquid

101700 L-Alanine, suitable for use as excipient 104061 D(+)-Galactose, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur, BP

101084 Aluminium chloride hexahydrate, suitable for use as 108346 D(+)-Glucose monohydrate, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, USP

101042 Aluminium potassium sulfate dodecahydrate, suitable for 100286 L-Glutamine, suitable for use as excipient
use as excipient EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp DAB, USP

101102 Aluminium sulfate-18-hydrate extra pure Ph Eur, BP 100590 Glycine cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP

100102 4-Aminobenzoic acid, suitable for use as excipient 104354 L-Histidine monohydrochloride monohydrate, suitable for
EMPROVE® exp USP use as excipient EMPROVE® exp Ph Eur, BP

100924 Ammonium chloride extra pure Ph Eur, BP, USP 104352 L-Histidine, suitable for use as excipient
EMPROVE® exp Ph Eur, USP

101142 Ammonium chloride, suitable for use as excipient 103963 Iron(II) sulfate heptahydrate cryst., suitable for use as
EMPROVE® exp Ph Eur, BP, USP excipient EMPROVE® exp Ph Eur, BP, USP, FCC

101131 Ammonium hydrogen carbonate, suitable for use as excipient 103814 Iron(III)-chloride-hexahydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, E 503 EMPROVE® exp Ph Eur, JP

101544 L-Arginine monohydrochloride, suitable for use as excipient 105357 L-Isoleucine, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, USP

101587 L-Arginine, suitable for use as excipient 105020 L-Leucine, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur, USP

101565 L-Asparagine monohydrate, suitable for use as excipient 105701 L-Lysine monohydrochloride, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, USP

100129 L-Aspartic acid extra pure Ph Eur, BP, USP 105999 Manganese(II) sulfate monohydrate spray-dried, suitable for
use as excipient EMPROVE® exp Ph Eur, USP, FCC

142000 Calcium chloride dihydrate 500986 DL-Methionine, suitable for use as excipient
EMPROVE® Ph Eur, BP, JP, USP, FCC, E 509 EMPROVE® exp Ph Eur, BP

102092 tri-Calcium dicitrate tetrahydrate, suitable for use as 103583 Parteck® SI 150 (Sorbitol), suitable for use as excipient
excipient EMPROVE® exp DAC, USP, E 333, FCC EMPROVE® exp Ph Eur, BP, JP, NF, JSFA, E 420

102148 Calcium D-saccharate, suitable for use as excipient 115079 Parteck® SI 200 (Sorbitol), suitable for use as excipient
EMPROVE® exp USP EMPROVE® exp Ph Eur, BP, JP, NF, E 420

102425 Chloral hydrate, suitable for use as excipient 103140 Parteck® SI 400 (Sorbitol), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP EMPROVE® exp Ph Eur, BP, JSFA, NF, E 420

102492 Chlorophyllin water-soluble (Na-Cu-Chlorophyllin) 111597 Parteck® SI 400 LEX (Sorbitol), suitable for use as excipient
(C.I.: 75815) minimum 98 % E 141 (ii) EMPROVE® exp Ph Eur, BP, NF, JP

500117 Choline chloride, suitable for use as excipient 103557 Parteck® SI 450 (Sorbitol), suitable for use as excipient
EMPROVE® exp DAB 10, FCC EMPROVE® exp NF, FCC, JSFA

500115 Choline hydrogen tartrate, suitable for use as excipient 107267 L-Phenylalanine, suitable for use as excipient
EMPROVE® exp DAB 10, FCC EMPROVE® exp Ph Eur, USP

102735 L-Cysteine hydrochloride monohydrate, suitable for use as 104956 tri-Potassium citrate monohydrate, suitable for use as
excipient EMPROVE® exp Ph Eur, USP excipient EMPROVE® exp Ph Eur, BP, USP, FCC, E 332

24 For more information, visit www.merckmillipore.com


Catalog No. Article

Liquid Dosage Form


105061 Potassium nitrate extra pure Ph Eur, BP, USP, FCC, E 252 108484 Urea beads, suitable for use as excipient EMPROVE® exp USP

105102 tri-Potassium phosphate trihydrate extra pure 108486 Urea cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP

107430 L-Proline, suitable, for use as excipient 500849 Vitamin A water-miscible 1 ml = 200,000 I.U. for oral use,
EMPROVE® exp Ph Eur, USP suitable for use as excipient EMPROVE® exp BP, Ph Eur

501260 Pyridoxol (pyridoxine) vitamin B6 base 524950 Vitamin B12 (cyanocobalamin) Ph Eur, BP, USP

500064 Rutin water-soluble in flakes (rutin sulfate sodium salt) 500936 Vitamin D3 (cholecalciferol) cryst. (1 g = 40 Mio. I.U.),
suitable for use as excipient EMPROVE® exp Ph Eur, BP, USP

100635 Salicylic acid fine powder, suitable for use as excipient 500878 Vitamin E dry powder sprayed (50 g all-rac-α-tocopheryl
acetate in 100 g substance), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP

100631 Salicylic acid, suitable for use as excipient 500858 Vitamin E dry powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, USP

107647 L-Serine, suitable for use as excipient 500859 Vitamin E dry powder, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur, BP, USP

101536 Silver protein mild (19-23 % Ag) BPC 1968 500854 Vitamin E ready-to-press granules (33 g all-rac-α-tocopheryl
acetate in 100 g substance), suitable for use as excipient
EMPROVE® exp Ph Eur, BP

104164 Sodium glycerophosphate hydrate extra pure 500862 Vitamin E water-miscible 1 ml = 500 mg DL-α-tocopherol
acetate for oral use, suitable for use as excipient
EMPROVE® exp USP

106544 Sodium nitrite extra pure Ph Eur, USP 501890 Vitamin K1 (phytomenadione), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, FCC

106600 Sodium salicylate cryst., suitable for use as excipient 108846 Zinc oxide, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, USP

106602 Sodium salicylate powder, suitable for use as excipient


EMPROVE® exp Ph Eur, BP, USP
Thickeners

106645 Sodium sulfate anhydrous extra pure fine powder 101615 Agar extra pure, fine powder Ph Eur, BP
Ph Eur, BP, USP

106514 Sodium thiosulfate pentahydrate cryst., suitable for use as 104072 Gelatin (sheets), suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, NF

100713 Sulfuric acid 95-98 %, suitable for use as excipient 104078 Gelatin powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, Ph Franç EMPROVE® exp Ph Eur, BP, NF

100773 Tannic acid powder, suitable for use as excipient 104091 Glycerol 85 %, suitable for use as excipient
EMPROVE® exp Ph Eur, JP, USP EMPROVE® exp Ph Eur, BP

500923 Thiamine chloride hydrochloride (Vitamin B1-hydrochloride) 104093 Glycerol anhydrous, suitable for use as excipient
Ph Eur, BP, USP, FCC EMPROVE® exp Ph Eur, BP, JP, USP, E 422

100810 Trichloroacetic acid cryst., suitable for use as excipient 104228 Gum arabic spray-dried, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP

108396 L-Tryptophan, suitable for use as excipient 817001 Polyethylene glycol 200, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp DAB 8

108378 L-Tyrosine, suitable for use as excipient 817002 Polyethylene glycol 300, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur

For more information, visit www.merckmillipore.com 25


Catalog No. Article

Liquid Dosage Form


817003 Polyethylene glycol 400, suitable for use as excipient 141362 Polyvinyl alcohol 26-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur, JP

817004 Polyethylene glycol 600, suitable for use as excipient 141363 Polyvinyl alcohol 40-88, powder EMPROVE® exp Ph Eur, USP
EMPROVE® exp Ph Eur

817009 Polyethylene glycol 1000, suitable for use as excipient 101253 Starch soluble extra pure
EMPROVE® exp Ph Eur

817005 Polyethylene glycol 1500 (scales), suitable for use as


excipient EMPROVE® exp Ph Eur
Preservatives

817020 Polyethylene glycol 2000, suitable for use as excipient 817046 Benzalkonium chloride (50 % aqueous solution), suitable for
EMPROVE® exp DAB use as excipient EMPROVE® exp Ph Eur, NF

817019 Polyethylene glycol 3000, suitable for use as excipient 817032 Benzalkonium chloride, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur

817006 Polyethylene glycol 4000 (powder), suitable for use as 100130 Benzoic acid powder, suitable for use as excipient
excipient EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, USP, E 210

817063 Polyethylene glycol 4000 (scales), suitable for use as 101806 Benzyl benzoate Ph Eur, BP, USP
excipient EMPROVE® exp Ph Eur

817007 Polyethylene glycol 6000, suitable for use as excipient 100160 Boric acid cryst., suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, NF

817018 Polyethylene glycol 20000, suitable for use as excipient 100162 Boric acid powder, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, NF

141350 Polyvinyl alcohol 4-88, suitable for use as excipient 108439 Calcium Titriplex® dihydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, BP, USP

141354 Polyvinyl alcohol 5-88, suitable for use as excipient 100886 Ethyl 4-hydroxybenzoate sodium salt Ph Eur, E 215
EMPROVE® exp Ph Eur, USP, JPE

141351 Polyvinyl alcohol 8-88, suitable for use as excipient 100887 Ethyl 4-hydroxybenzoate, suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, BP, JP, NF, E 214

141355 Polyvinyl alcohol 18-88, suitable for use as excipient 100944 Ethylenedinitrilotetraacetic acid extra pure Ph Eur, NF
EMPROVE® exp Ph Eur, USP, JPE

141352 Polyvinyl alcohol 26-88, suitable for use as excipient 108597 Hydrogen peroxide 30 % stabilized, suitable for use as
EMPROVE® exp Ph Eur, USP, JPE excipient EMPROVE® exp Ph Eur, BP, USP

141356 Polyvinyl alcohol 28-99, suitable for use as excipient 108600 Hydrogen peroxide 35 %, suitable for use as excipient
EMPROVE® exp JPE EMPROVE® exp

141353 Polyvinyl alcohol 40-88, suitable for use as excipient 106756 Methyl 4-hydroxybenzoate sodium salt, suitable for use as
EMPROVE® exp Ph Eur, USP, JPE excipient EMPROVE® exp Ph Eur, BP, NF, E 219

141360 Polyvinyl alcohol 4-88, powder, suitable for use as excipient 106757 Methyl 4-hydroxybenzoate, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur, BP, JP, NF, FCC, E 218

141364 Polyvinyl alcohol 5-88, powder EMPROVE® exp Ph Eur, USP 104005 Paraformaldehyde, suitable for use as excipient
EMPROVE® exp DAC

141361 Polyvinyl alcohol 8-88, powder EMPROVE® exp Ph Eur, USP 100201 Phenol, suitable for use as excipient
EMPROVE® exp Ph Eur, JP, USP

141365 Polyvinyl alcohol 18-88, powder EMPROVE® exp Ph Eur, USP 105056 Potassium disulfite, suitable for use as excipient
EMPROVE® exp Ph Eur, NF, E 224

26 For more information, visit www.merckmillipore.com


Catalog No. Article

Liquid Dosage Form


105119 Potassium sorbate granules, suitable for use as excipient 500949 All-rac-α-Tocopherol, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, FCC, E 202 EMPROVE® exp Ph Eur, BP, USP, E 307

105118 Potassium sorbate powder, suitable for use as excipient 500952 All-rac-α-Tocopheryl acetate (Vitamin E acetate), suitable
EMPROVE® exp Ph Eur, BP, NF, FCC, E 202 for use as excipient EMPROVE® exp Ph Eur, BP, USP, FCC

107428 Propyl 4-hydroxybenzoate sodium salt, suitable for use as


excipient EMPROVE® exp Ph Eur, BP, NF
Surfactants and Stabilizers

107427 Propyl 4-hydroxybenzoate, suitable for use as excipient 108439 Calcium Titriplex® dihydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF, FCC EMPROVE® exp Ph Eur, BP, USP

106290 Sodium benzoate, suitable for use as excipient 100944 Ethylenedinitrilotetraacetic acid extra pure Ph Eur, NF
EMPROVE® exp Ph Eur, BP, NF, FCC, E 211

106357 Sodium disulfite (sodium metabisulfite), suitable for use as 105321 D(-)-Fructose, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, JP, NF, E 223 EMPROVE® exp Ph Eur, BP, USP, FCC

106652 Sodium sulfite, suitable for use as excipient 104061 D(+)-Galactose, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, E 221 EMPROVE® exp Ph Eur, BP

100662 Sorbic acid, suitable for use as excipient 108346 D(+)-Glucose monohydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, FCC, E 200 EMPROVE® exp Ph Eur, BP, USP

108035 Sulfanilamide extra pure 100590 Glycine cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP

817043 Thimerosal Ph Eur, BP, USP 104354 L-Histidine monohydrochloride monohydrate, suitable for
use as excipient EMPROVE® exp Ph Eur, BP

108421 Titriplex® III (ethylenedinitrilotetraacetic acid 104352 L-Histidine, suitable for use as excipient
disodium salt dihydrate), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP EMPROVE® exp Ph Eur, USP

101005 1,1,1,-Trichloro-2-methyl-2-propanol hemihydrate 105988 D(−)-Mannitol fine powder, suitable for use as excipient
Ph Eur, BP, JP, NF EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 421

105303 D(−)-Mannitol low in endotoxins, suitable for use as active


Antioxidants pharmaceutical ingredient EMPROVE® api Ph Eur, BP, USP, JP

500090 L(+)-Ascorbyl palmitate (6-palmitoyl-L-ascorbic acid), 105980 D(−)-Mannitol, suitable for use as excipient
suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, FCC, E 304 EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 421

817023 Butylhydroxyanisole Ph Eur, NF, E 320 106143 Meglumine low in endotoxins, suitable for use as active
pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP

817074 Butylhydroxytoluene Ph Eur, JPE, NF, E 321 111597 Parteck® SI 400 LEX (Sorbitol), suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF, JP

108330 Oxynex® L liquid antioxidant for fats and oils, suitable for 137065 Poloxamer 188, suitable for biopharmaceutical production
use as excipient EMPROVE® exp Ph Eur, NF

106946 Oxynex® LM antioxidant for fats and oils, suitable for use as 817001 Polyethylene glycol 200, suitable for use as excipient
excipient EMPROVE® exp EMPROVE® exp DAB 8

105056 Potassium disulfite, suitable for use as excipient 817002 Polyethylene glycol 300, suitable for use as excipient
EMPROVE® exp Ph Eur, NF, E 224 EMPROVE® exp Ph Eur

107813 Tin(II) chloride dihydrate extra pure Ph Eur, BP 817003 Polyethylene glycol 400, suitable for use as excipient
EMPROVE® exp Ph Eur, JP

500976 DL-A-Tocopherol hydrogen succinate food grade USP 817004 Polyethylene glycol 600, suitable for use as excipient
EMPROVE® exp Ph Eur

For more information, visit www.merckmillipore.com 27


Catalog No. Article

Liquid Dosage Form


817009 Polyethylene glycol 1000, suitable for use as excipient 817034 Sodium dodecyl sulfate Ph Eur
EMPROVE® exp Ph Eur

817005 Polyethylene glycol 1500 (scales), suitable for use as 102975 Sorbitol FP liquid (sorbitol syrup, non-crystallizing), suitable
excipient EMPROVE® exp Ph Eur for use as excipient EMPROVE® exp Ph Eur, BP, NF, E 420

817020 Polyethylene glycol 2000, suitable for use as excipient 102994 Sorbitol liquid (sorbitol syrup, crystallizing), suitable for use
EMPROVE® exp DAB as excipient EMPROVE® exp Ph Eur, BP, USP, E 420

817019 Polyethylene glycol 3000, suitable for use as excipient 100892 Sucrose low in endotoxins, suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, JP, NF

817006 Polyethylene glycol 4000 (powder), suitable for use as 107653 Sucrose, suitable for use as excipient
excipient EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, JP, NF

817063 Polyethylene glycol 4000 (scales), suitable for use as 108421 Titriplex® III (ethylenedinitrilotetraacetic acid
disodium salt dihydrate), suitable for use as excipient
excipient EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, BP, JP, USP

817007 Polyethylene glycol 6000, suitable for use as excipient 108369 Triethanolamine solution 50 % in water
EMPROVE® exp Ph Eur

817018 Polyethylene glycol 20000, suitable for use as excipient 817072 Tween® 20 (Polysorbate), suitable for use as excipient
EMPROVE® exp Ph Eur EMPROVE® exp Ph Eur, JPE, NF

141350 Polyvinyl alcohol 4-88, suitable for use as excipient 817076 Tween® 60 (Polysorbate), suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, JPE, NF

141354 Polyvinyl alcohol 5-88, suitable for use as excipient 817061 Tween® 80 (Polysorbate), suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, JP, NF

141351 Polyvinyl alcohol 8-88, suitable for use as excipient 108692 D(+) Xylose Ph Eur, BP
EMPROVE® exp Ph Eur, USP, JPE

141355 Polyvinyl alcohol 18-88, suitable for use as excipient


EMPROVE® exp Ph Eur, USP, JPE
Taste Modifiers

141352 Polyvinyl alcohol 26-88, suitable for use as excipient 100247 Citric acid anhydrous fine-granular, suitable for use as
EMPROVE® exp Ph Eur, USP, JPE excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC

141356 Polyvinyl alcohol 28-99, suitable for use as excipient 100241 Citric acid anhydrous powder, suitable for use as excipient
EMPROVE® exp JPE EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC

141353 Polyvinyl alcohol 40-88, suitable for use as excipient 100242 Citric acid monohydrate cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, USP, JPE EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC

141360 Polyvinyl alcohol 4-88, powder, suitable for use as excipient 100243 Citric acid monohydrate powder, suitable for use as excipient
EMPROVE® exp Ph Eur, USP EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC

141364 Polyvinyl alcohol 5-88, powder EMPROVE® exp Ph Eur, USP 105321 D(-)-Fructose, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, FCC

141361 Polyvinyl alcohol 8-88, powder EMPROVE® exp Ph Eur, USP 108346 D(+)-Glucose monohydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP

141365 Polyvinyl alcohol 18-88, powder EMPROVE® exp Ph Eur, USP 101791 L-Glutamic acid, suitable for use as excipient
EMPROVE® exp Ph Eur

141362 Polyvinyl alcohol 26-88, powder EMPROVE® exp Ph Eur, USP 105995 (−)-Menthol cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP

141363 Polyvinyl alcohol 40-88, powder EMPROVE® exp Ph Eur, USP 106070 Methyl salicylate synthetic, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF

28 For more information, visit www.merckmillipore.com


Catalog No. Article

Liquid Dosage Form


817022 Saccharin, suitable for use as excipient 107147 Papain 6000 USP-U/mg stabilized with sodium disulfite,
EMPROVE® exp Ph Eur, NF suitable for use as excipient EMPROVE® exp

817042 Saccharin sodium dihydrate, suitable for use as excipient 107197 Pepsin (from porcine gastric mucosa) 0.7 Ph Eur U/mg,
EMPROVE® Ph Eur, USP suitable for use as excipient EMPROVE® exp

817044 Sodium cyclamate, suitable for use as excipient 107190 Pepsin (from porcine gastric mucosa) 2000 FIP-U/g EC
EMPROVE® exp Ph Eur, BP 3.4.23.1, suitable for use as excipient EMPROVE® exp

106445 Sodium L-glutamate monohydrate, suitable for use as 107190 Pepsin (from porcine gastric mucosa) 2000 FIP-U/g EC
excipient EMPROVE® exp FCC, NF, E 621 3.4.23.1, suitable for use as excipient EMPROVE® exp

102975 Sorbitol FP liquid (sorbitol syrup, non-crystallizing), suitable


for use as excipient EMPROVE® exp Ph Eur, BP, NF, E 420
pH Adjustment and Buffers

102994 Sorbitol liquid (sorbitol syrup, crystallizing), suitable for use 100056 Acetic acid (glacial) 100 %, suitable for use as excipient
as excipient EMPROVE® exp Ph Eur, BP, USP, E 420 EMPROVE® exp Ph Eur, BP, JP, USP, E 260

100895 Sucralose granular, suitable for use as excipient 480745 Acetic acid 30 % extra pure Ph Helv
EMPROVE® exp Ph Eur, NF

100894 Sucralose powder, suitable for use as excipient 100058 Acetic acid 96 %, suitable for use as excipient EMPROVE® exp
EMPROVE® exp Ph Eur, NF

107653 Sucrose, suitable for use as excipient 100090 Adipic acid, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF EMPROVE® exp Ph Eur, NF, FCC, E 355

100773 Tannic acid powder, suitable for use as excipient 480905 Ammonia solution 10 %, suitable for biopharmaceutical
EMPROVE® exp Ph Eur, JP, USP production EMPROVE® bio

100803 Tartaric acid powder, suitable for use as excipient 105408 Ammonia Solution 19 %
EMPROVE® exp Ph Eur, BP, JP, NF, E 334

108167 L(+)-Thymol cryst., suitable for use as excipient 105422 Ammonia solution 25 %, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF EMPROVE® exp Ph Eur, BP

108510 Vanillin, suitable for use as excipient 101124 Ammonium dihydrogen phosphate cryst. extra pure
EMPROVE® exp Ph Eur, BP, NF

101216 Ammonium sulfate extra pure


Enzymes

101681 Benzonase® ELISA kit II for the immunological detection of 100160 Boric acid cryst., suitable for use as excipient
Benzonase® EMPROVE® exp Ph Eur, BP, NF

101654 Benzonase® purity grade II (>90 %) for biotechnology 100162 Boric acid powder, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF

101656 Benzonase® purity grade II (>90 %) for biotechnology 102052 Calcium acetate hydrate extra pure DAC, FCC

101675 Benzonase® technical grade 5 Mio. units/vial 102101 Calcium gluconate monohydrate low in endotoxins, suitable
for use as excipient EMPROVE® exp Ph Eur, BP, USP, FCC, E 578

107130 Pancreatin (from porcine pancreas) 350 FIP-U/g Protease, 102094 Calcium gluconate monohydrate, suitable for use as excipient
6000 FIP-U/g Lipase, 7500 FIP-U/g Amylase, suitable for
use as excipient EMPROVE® exp USP EMPROVE® exp Ph Eur, BP, USP, FCC, E 578

107133 Pancreatin 1400 FIP-U/g Protease, 24000 FIP-U/g Lipase, 102119 Calcium hydroxide precipitated (≤ 0.0005 % Al), suitable for
30000 FIP-U/g Amylase, suitable for use as excipient
EMPROVE® exp Ph Eur, 4 x USP use as excipient EMPROVE® exp USP, FCC, E 526

107149 Papain 30000 USP-U/mg stabilized with sodium disulfite, 102110 Calcium hydroxide, suitable for use as excipient
suitable for use as excipient EMPROVE® exp EMPROVE® exp Ph Eur, BP, USP, JP, FCC

For more information, visit www.merckmillipore.com 29


Catalog No. Article

Liquid Dosage Form


102102 Calcium lactate pentahydrate, suitable for use as excipient 100563 ortho-Phosphoric acid 85 %, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, E 327 EMPROVE® exp Ph Eur, BP, JPE, NF, E 338

100247 Citric acid anhydrous fine-granular, suitable for use as 100564 ortho-Phosphoric acid 89 % extra pure Ph Eur, BP
excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC

100241 Citric acid anhydrous powder, suitable for use as excipient 137065 Poloxamer 188, suitable for biopharmaceutical production
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC Ph Eur, NF

100242 Citric acid monohydrate cryst., suitable for use as excipient 104820 Potassium acetate extra pure Ph Eur, BP, E 261
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC

100243 Citric acid monohydrate powder, suitable for use as excipient 104871 di-Potassium dihydrogen phosphate cryst., suitable for use
EMPROVE® exp Ph Eur, BP, JP, USP, E 330, FCC as excipient EMPROVE® exp Ph Eur, BP, NF, E 340

100844 Ethanolamine, suitable for use as excipient 105101 Potassium hydrogen phosphate anhydrous, suitable for use
EMPROVE® exp BP, NF as excipient EMPROVE® exp Ph Eur, BP, E 340

100263 Formic acid 98-100 %, suitable for use as excipient 105032 Potassium hydroxide pellets, suitable for use as excipient
EMPROVE® exp DAC EMPROVE® exp Ph Eur, BP, JP, NF, FCC, E 525

817073 Fumaric acid NF 480864 Potassium hydroxide solution 46-48 %

500190 Glycine cryst., suitable for use as excipient 105102 tri-Potassium phosphate trihydrate extra pure
EMPROVE® exp Ph Eur, BP, JP, USP

100590 Glycine cryst., suitable for use as excipient 105150 Potassium sulfate cryst., suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP EMPROVE® exp Ph Eur, BP, JP

104354 L-Histidine monohydrochloride monohydrate, suitable for 105151 Potassium sulfate powder, suitable for use as excipient
use as excipient EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, BP, JP, E 515

104352 L-Histidine, suitable for use as excipient 106281 Sodium acetate anhydrous extra pure USP, FCC, E 262
EMPROVE® exp Ph Eur, USP

100312 Hydrochloric acid 25 %, suitable for use as excipient 106265 Sodium acetate trihydrate extra pure Ph Eur, BP, JP, USP,
EMPROVE® exp Ph Helv FCC, E 262

100314 Hydrochloric acid fuming 37 %, suitable for use as excipient 106431 tri-Sodium citrate 5,5-hydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF EMPROVE® exp FU VIII, E 331

100366 (S)-Lactic acid about 90 %, suitable for use as excipient 111037 tri-Sodium citrate anhydrous, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, E 270 EMPROVE® exp USP, FCC, E 331

102314 Magnesium gluconate USP 106432 tri-Sodium citrate dihydrate cryst., suitable for use as
excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 331

817058 Maleic acid Ph Eur, NF 106446 tri-Sodium citrate dihydrate powder, suitable for use as
excipient EMPROVE® exp Ph Eur, BP, JP, USP, E 331

100383 DL-Malic acid, suitable for use as excipient 106447 tri-Sodium citrate dihydrate, suitable for use as excipient
EMPROVE® exp Ph Eur, NF, FCC, E 296 EMPROVE® exp Ph Eur, BP, JP, USP, E 331

106143 Meglumine low in endotoxins, suitable for use as active 106345 Sodium dihydrogen phosphate dihydrate, suitable for use as
pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP excipient EMPROVE® exp Ph Eur, BP, USP, JPE, E 339

480787 ortho-Phosphoric acid 0.5 % 106349 Sodium dihydrogen phosphate monohydrate, suitable for
use as excipient EMPROVE® exp BP, USP

100250 Phosphoric acid 75 %, suitable for biopharmaceutical 106585 di-Sodium hydrogen phosphate anhydrous, suitable for use
production as excipient EMPROVE® exp Ph Eur, BP, USP, E 339

30 For more information, visit www.merckmillipore.com


Catalog No. Article

Liquid Dosage Form


106576 di-Sodium hydrogen phosphate dihydrate, suitable for use as 105303 D(-)-Mannitol low in endotoxins, suitable for use as active
excipient EMPROVE® exp Ph Eur, BP, USP pharmaceutical ingredient EMPROVE® api Ph Eur, BP, USP, JP

106573 di-Sodium hydrogen phosphate dodecahydrate cryst., 105980 D(-)-Mannitol, suitable for use as excipient
suitable for use as excipient EMPROVE® exp Ph Eur, BP, JP, USP EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 421

106574 di-Sodium hydrogen phosphate heptahydrate, suitable for 104937 Potassium chloride, suitable for use as excipient
use as excipient EMPROVE® exp DAC, USP EMPROVE® exp Ph Eur, BP, E 508

106482 Sodium hydroxide pellets, suitable for use as excipient 104935 Potassium chloride, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, FCC, JP, NF, E 524 EMPROVE® exp Ph Eur, BP, USP, FCC, E 508

106577 tri-Sodium phosphate dodecahydrate, suitable for use as 116224 Sodium chloride low in endotoxins, suitable for use as
excipient EMPROVE® exp NF, E 339 excipient EMPROVE® exp Ph Eur, BP, JP, USP

106303 di-Sodium tetraborate decahydrate, suitable for use as 106400 Sodium chloride, suitable for use as excipient
excipient EMPROVE® exp Ph Eur, BP, JP, NF EMPROVE® exp Ph Eur, BP, USP

106522 Sodium-(S)-lactate-solution about 50 %, suitable for use as


excipient EMPROVE® exp Ph Eur, BP, USP
Solvents

100681 Succinic acid cryst., suitable for use as excipient 100013 Acetone, suitable for use as excipient
EMPROVE® exp NF, JPE EMPROVE® exp Ph Eur, BP, JPE, NF

480704 Sulfuric acid 10 % extra pure 100987 Benzyl alcohol special grade (benzaldehyde ≤ 0.05 %),
suitable for use as excipient EMPROVE® exp Ph Eur, BP, JP, NF

100802 L(+)-Tartaric acid cryst., suitable for use as excipient 100981 Benzyl alcohol, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, NF, E 334 EMPROVE® exp Ph Eur, BP, JP, NF

100803 L(+)-Tartaric acid powder, suitable for use as excipient 100988 1-Butanol, suitable for use as excipient EMPROVE® exp NF
EMPROVE® exp Ph Eur, BP, JP, NF, E 334

108372 Triethanolamine (Trolamine), suitable for use as excipient 102431 Chloroform, suitable for use as excipient EMPROVE® exp BP
EMPROVE® exp Ph Eur

108369 Triethanolamine solution 50 % in water 106049 Dichloromethane, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF

108386 Tris(hydroxymethyl)aminomethane (Trometamol), suitable 100926 Diethyl ether, suitable for use as excipient
for use as excipient EMPROVE® exp Ph Eur, BP, JPC, USP EMPROVE® exp Ph Eur, BP

100971 Ethanol 96 %, suitable for use as excipient


Tonicity Agents EMPROVE exp Ph Eur, BP

142000 Calcium chloride dihydrate 100967 Ethanol 96 %, suitable for use as excipient
EMPROVE® Ph Eur, BP, JP, USP, FCC, E 509 EMPROVE exp Ph Eur, JP, USP

108346 D(+)-Glucose monohydrate, suitable for use as excipient 100986 Ethanol absolute, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP EMPROVE® exp Ph Eur, BP, JP, USP

104091 Glycerol 85%, suitable for use as excipient 100864 Ethyl acetate, suitable for use as excipient
EMPROVE® exp Ph Eur, BP EMPROVE® exp Ph Eur, BP, NF

104093 Glycerol anhydrous, suitable for use as excipient 104091 Glycerol 85 %, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, JP, USP, E 422 EMPROVE® exp Ph Eur, BP

105832 Magnesium chloride hexahydrate cryst. 104093 Glycerol anhydrous, suitable for use as excipient
EMPROVE® Ph Eur, BP, USP, JPC, FCC, E 511 EMPROVE® exp Ph Eur, BP, JP, USP, E 422

105988 D(-)-Mannitol fine powder, suitable for use as excipient 106008 Methanol, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, USP, JP, FCC, E 421 EMPROVE® exp Ph Eur, BP, NF

For more information, visit www.merckmillipore.com 31


Catalog No. Article

Liquid Dosage Form


100471 Oleic acid vegetable, suitable for use as excipient
EMPROVE® exp Ph Eur, BP, NF

107174 Paraffin highly liquid Ph Eur, BP, NF, JP

104005 Paraformaldehyde, suitable for use as excipient


EMPROVE® exp DAC

100909 Petroleum benzine boiling range 40-60 °C, suitable for use
as excipient EMPROVE® exp DAB

817001 Polyethylene glycol 200, suitable for use as excipient


EMPROVE® exp DAB 8

817002 Polyethylene glycol 300, suitable for use as excipient


EMPROVE® exp Ph Eur

817003 Polyethylene glycol 400, suitable for use as excipient


EMPROVE® exp Ph Eur, JP

817004 Polyethylene glycol 600, suitable for use as excipient


EMPROVE® exp Ph Eur

817009 Polyethylene glycol 1000, suitable for use as excipient


EMPROVE® exp Ph Eur

817005 Polyethylene glycol 1500 (scales), suitable for use as


excipient EMPROVE® exp Ph Eur

817020 Polyethylene glycol 2000, suitable for use as excipient


EMPROVE® exp DAB

817019 Polyethylene glycol 3000, suitable for use as excipient


EMPROVE® exp Ph Eur

817006 Polyethylene glycol 4000 (powder), suitable for use as


excipient EMPROVE® exp Ph Eur

817063 Polyethylene glycol 4000 (scales), suitable for use as


excipient EMPROVE® exp Ph Eur

817007 Polyethylene glycol 6000, suitable for use as excipient


EMPROVE® exp Ph Eur

817018 Polyethylene glycol 20000, suitable for use as excipient


EMPROVE® exp Ph Eur

107478 1,2-Propanediol, suitable for use as excipient


EMPROVE® exp Ph Eur, BP, USP

105008 2-Propanol, suitable for preparative chromatography


EMPROVE® bio Ph Eur, BP, USP

100995 2-Propanol, suitable for use as excipient


EMPROVE® exp Ph Eur, BP, JP, USP

32 For more information, visit www.emdmillipore.com

w303914_me_brosch_application_RZ_v2.indd 32 10.07.13 13:48


Catalog No. Article

API Product List


You’re in the fast lane to di-Potassium hydrogen phosphate anhydrous, low in sodium,

market your product


106752 Benzyl nicotinate, suitable for use as active 109828
suitable for use as active pharmaceutical ingredient
pharma­ceutical ingredient EMPROVE® api DAB EMPROVE® api Ph Eur, BP, USP

That’s why EMPROVE® keeps 100164 Boric acid cryst., suitable for use as active pharmaceutical
ingredient EMPROVE® api Ph Eur, BP, NF
105040 Potassium iodide, suitable for use as active pharmaceutical
ingredient EMPROVE® api Ph Eur, BP, JP, USP

the paperwork out of your way 102422 Calcium carbonate precipitated (≤ 0.002 % Fe), suitable
for use as active pharmaceutical ingredient
106236 Sodium acetate anhydrous, suitable for use as active
EMPROVE® api Ph Eur, BP, USP pharmaceutical ingredient EMPROVE® api USP, FCC, E 262

102465 Calcium chloride dihydrate, suitable for use as active 106235 Sodium acetate trihydrate, suitable for use
as active pharmaceutical ingredient
pharmaceutical ingredient EMPROVE® api Ph Eur, BP, JP, USP EMPROVE® api Ph Eur, BP, JP, USP, FCC, E 262

Preparing the documentation for your products can With Merck Millipore and EMPROVE® you’re on 500112 Cocarboxylase chloride (thiamine diphosphoric acid ester 106444 Sodium chloride, suitable for use as active pharmaceutical
chloride), suitable for use as active pharmaceutical
be time-consuming and costly, but it is necessary the safe side – now and in the future. Our experts ingredient EMPROVE® api ingredient EMPROVE® api Ph Eur, BP, JP, USP
due to increasing regulatory requirements. So what are actively involved in various international
500111 Cocarboxylase tetrahydrate (thiamine diphosphoric acid 106441 Sodium fluoride, suitable for use as active pharmaceutical
if somebody already did this work for you, providing committees occupied with developing regulations ester tetrahydrate), suitable for use as active
pharma­ceutical ingredient EMPROVE® api ingredient EMPROVE® api Ph Eur, BP, USP
top quality at the same time? With the EMPROVE® for pharmaceutical raw materials. Thus, we can
concept, we have set a worldwide benchmark for quickly recognize regulatory trends, helping you to 102367 Magnesium chloride hexahydrate cryst., suitable for use as 500667 Thiamine phosphoric acid ester chloride dihydrate, suitable
the documentation of pharma­ceutical raw materials. react promptly. active pharmaceutical ingredient
EMPROVE® api Ph Eur, BP, USP for use as active pharmaceutical ingredient EMPROVE® api
We already offer about 300 EMPROVE® products –
and the list is getting longer. What EMPROVE® means for you: 105303 D(-)-Mannitol low in endotoxins, suitable for use as active 108432 Urea cryst., suitable for use as active pharmaceutical
pharmaceutical ingredient EMPROVE® api Ph Eur, BP, USP, JP ingredient EMPROVE® api Ph Eur, BP, USP
All EMPROVE® raw materials are accompanied • Top-quality raw materials
106143 Meglumine low in endotoxins, suitable for use as active 108815 Zinc chloride, suitable for use as active pharmaceutical
by comprehensive dossiers in the internationally • Comprehensive documentation pharmaceutical ingredient EMPROVE® api Ph Eur, JP, USP ingredient EMPROVE® api Ph Eur, BP, USP
accepted CTD format. The usage categories are: • Faster time to market
EMPROVE® exp for excipients, EMPROVE® bio for • Lower costs 100320 Potassium chloride, suitable for use as active pharmaceutical
biopharmaceutical production, and EMPROVE® api • Safer products ingredient EMPROVE® api Ph Eur, USP, FCC, E 262
for active pharmaceutical ingredients. For APIs
we provide access to ASMF, DMF, or CEP. Our web page www.merckmillipore.com is the
central platform for our customers in the pharma­
EMPROVE® 4 Depending on your application, the corresponding ceutical industry. Here you can find information
EMPROVE® dossiers offer information on the on products and services, you can download the
Pharmaceutical Raw Materials by Merck Millipore 5 manufacturing process, test methods used, or EMPROVE® Basic Dossiers, and get information
stability data. That way, you can avoid potential about our other dossiers – simply, quickly, and
Formulations 6 sources of error and gain certainty in the approval conveniently, 24/7.
process, ensuring the safety of your products.
Formulations for Solid Dosage Forms 6
Since EMPROVE® dossiers are ready-to-use, you
Formulations for Semi-solid Dosage Forms 7 are also able to accelerate internal qualification
pro­cesses and bring your products to market faster.
Formulations for Liquid Dosage Forms 7 You don’t have to develop test methods or evaluate
stability data. All details on the raw materials used
Active Pharmaceutical Ingredients (API) 8 are already professionally prepared – reducing your
workload and speeding up your processes.
Drug Delivery Compounds (DDC) 10

Products for Solid Dosage Forms 12

Products for Semi-solid Dosage Forms 19

Products for Liquid Dosage Forms 24

Products for Active Pharmaceutical Ingredients (API) 33

4 For more information, visit www.merckmillipore.com For more information, visit www.merckmillipore.com 33

w303114_me_brosch_application_envelope_RZ_v12.indd 2 10.07.13 13:39


The typical technical data above serve to generally characterize the excipient. These values are not meant as specifications and they do
not have binding character. The product specification is available separately from the website www.merckmillipore.com

We provide information and advice to our customers on application technologies and regulatory matters to the best of our knowledge
and ability, but without obligation or liability. Existing laws and regulations are to be observed in all cases by our customers. This also
applies in respect to any rights of third parties. Our information and advice do not relieve our customers of their own responsibility for
checking the suitability of our products for the envisaged purpose.

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Merck Millipore is a division of

For more information and documentation


please contact:
Phone: +49 6151-72 0
Email: pcs.salessupportEU@merckgroup.com

Merck Millipore
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www.merckmillipore.com
Merck Millipore and the M logo are trademarks of Merck KGaA, Darmstadt, Germany.
w303114 07/13

Parteck and EMPROVE are registered trademarks of Merck KGaA, Darmstadt, Germany.
PS-SBU-11-04579 05/2013
© 2013 Merck KGaA, Darmstadt, Germany. All rights reserved.

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