1.

The end product of Embden-Meyerhof Pathway of Glucose is metabolism in erythrocyte

is?
Answer: Lactate

2. Which od the following leukocytes maturation series characterized with “S” shaped
nucleus?
Answer: Band

3. Portland is embryonic hemoglobin which is composed of 2 zeta & 2 Gamma

Answer: True

4. Which of the following describes normal erythrocyte?

Answer: mean diameter of 7- 8 um

5. Anicytosis is the variation of cell’s _________

Answer: Size

6. What leukocyte granules may not be stained very well during staining process due to
solubility to water? Answer: basophil

7. Thalassemia & sideroblastic anemia are conditions characterized with microcytic red
blood cell with high MCV values?
Answer: False

8. Traditionally, the hallmark of differentiating myeloblast from myelocytes

morphologically has been the visual identification of ______ in the promyelocyte?
Answer: Secondary granules

9. Which one of the RBC indices reflects the concentration of the hemoglobin per
individual red blood cell?
Answer: MCH

10. B cells are responsible for cell mediated immune response of our body?
Answer: False

11. Stem cell factor are mainly produce by?

Answer: bone marrow stromal cells

12. Plasma cells derived from?

Answer: B cells

13. What leukocyte has a nucleus which is maybe round or oval but more frequently deeply
intended or horse shoe shaped?
Answer: Monocyte

14. Which of the following CD markers is more appropriately associated with myelocyte?
Answer: CD 45, CD 33, CD13

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15. Segmented neutrophil?
Answer: Approximately 56% of normal adult leukocytes in the peripheral blood

16. Average life span of segmented neutrophil granulocyte in the circulating blood is
approximately 5-7?
Answer: true

17. Which of the following is characteristics of erythropoietin?

Answer: glycoprotein, secreted by liver, secreted by kidenys

18. In health adult man, the smallest type of leukocytes are?

Answer: Lymphocytes

19. IL 4 is a T-cell growth factor & mast cell-activating erythroid & myeloid proliferation. It
is a 30 to 40 kda glycoprotein encoded on what chromosome?
Answer: Chromosome 5

20. Increase intravascular hemolysis will give result to high reticulocyte count, low
hemoglobin and increased platelets?
Answer: False

21. The marginating pool designates white blood cells located along the vessel
endothelium?
Answer: True

22. Spleen, lymph nodes, Peyer’s Patches and tonsils are primary lymphoid organs?
Answer: False

23. A patient who is admitted into the hospital with suspected anemia. A CBC done and the
following values were 3.00x1012/L; Hgb 9.5 gm/dl; Hct 0.28lL/L. A reticulocyte count
was also done, and found to be 11.5%. Theses indicate
Answer: polychromasia should be evident on the stained blood smear

24. Which of the following cell types is capable in differentiating into osteoclast,
macrophage, and dendritic cells?
Answer: Monocytes

25. A hormone released from the kidney that is unique for erythroid regeneration is?
Answer: erythropoietin

26. Megakaryocytes give rise to?

Answer: thrombocytes

27. All the following characteristics of red blood cell in stages of development except?
Answer: Distinct granulation of cytoplasm

28. The granulocyte cells that are believed to be descend from common multipotential stem
cell in the bone marrow are?
Answer:

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29. Erythropoietin is the hormone that acts to stimulates & regulate the production of RBCs
in the bone marrow. This hormone is produced in the specific parts of kidney?
Answer: Renal medulla

30. Macrocytic is?

Answer: Larger than normal

31. Potassium is an anion which stays inside the cell to maintain homeostasis. Sodium is a
cation mainly seen outside the cell?
Answer: False

32. Which of the following is not correct when RBC mature?

Answer: None of the above

33. When the iron in the hemoglobin molecule is in ferric state, the hemoglobin is termed
as:
Answer: methemoglobin

34. If a defect in the oxidative pathway (hexose monophosphate shunt) occurs, what result?
Answer: Either (insufficient amount of reduces glutathione & denaturation of
hemoglobin)

35. B lymphoid cells that have specific cluster differentiation of?

Answer: CD 10

36. What particular blood cell is not produces in CGU-GEMM?

Answer: lymphocytes

37. Which chemical substances are responsible for the differentiation of replication of
pluripotent stem cells?
Answer: Cytokines

38. The erythrocyte membrane is important in the following except:

Answer: carrier for cell antigen

39. The function of methemoglobin reductase pathway is to?

Answer: Produce methemoglobin

40. Hematocrit is the percentage of packed red blood cells in a given volume and can be
computed using hemoglobin and rbc count?
Answer: True

41. Stimulation of erythropoietin is caused by:

Answer: Tissue hypoxia

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42. What does the bone marrow start produce RBCs?
Answer: 5th month of gestation

43. Lymphocyte?
Answer: Light sky blue

44. In which stage of neutrophilic maturation are specific granules first seen?
Answer: Myelocyte

45. Which of the following is a characteristic of erythropoietin?

Answer: Produced in the liver of unborn

46. Globin is necessary for hemoglobin synthesis. Globin production begins in what stage of
erythrocyte maturation?
Answer:

47. How long do reticulocytes last in the blood stream?

Answer: 2-3 days

48. The following are the characteristics of RBC except?

Answer: none of the above

49. Opsonin is the process of phagocytosis when the phagocytes are moving towards the
stimulus. Chemotaxis are particles that enhances the eating process and speed up the
ingestion?
Answer: False

50. The Embden-Meyerhof glycolytic pathway uses ___% of the total erythrocyte’s total
glucose?
Answer: 90%

51. As a blood cell matures, the overall cell diameter in most cases _____?
Answer: decreases

52. The chromatin pattern, in most cells, as the cell matures?

Answer: clumped

53. What is the largest lymphoid organ in the body?

Answer: Spleen

54. Which of the following is true about normal adult bone marrow?
Answer: M:E ratio 3:1

55. Eosinophil?
Answer: large orange granules

56. Which of the following features distinguishes a monocyte from a lymphocyte?

Answer: abundant gray-blue cytoplasm

57. How does the bone marrow respond to anemic stress?

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 Answer: Production is expanded and red blood cells are released to circulation
prematurely

58. The Embden-Meyerhof pathway net gain ATP provides high energy phosphates to?
Answer: Power cation pump needed for the sodium-potassium concentration

59. What test is the most effective means of assessing red blood cell generation in response
to anemia?
Answer: mean cell volume

60. NADH and reduced glutathione are produced by activity of?

Answer: Rapoport-Lumbering pathway

61. Monocyte?
Answer: Kidney bean-shaped nucleus

62. In the blast stage of development of leukocytes, the cytoplasm of the cell is?
Answer: Light blue and lacks vacuoles

63. Erythrocyte survival depends on an adequate of ATP, for the following reasons?
Answer: to bind with oxygen

64. Which of the following parameters may provide an indication of anemia before the MCV
indicates overt size?
Answer: MCV

65. Orthochromic normoblast is similar to?

Answer: Orthochromic erythroblast

66. What cells are important in maintaining normal hemostasis?

Answer: Platelet

67. Causes of monocytosis include?

Answer: Tuberculosis, Hodgkin’s and non-hematologic malignancies

68. The erythrocyte stage that marks the beginning of hemoglobinization is called?
Answer: Polychromatophilic normoblast

69. Normally, hemoglobin concentration is maintained in steady state by?

Answer: balance in the production and destruction of erythrocytes

70. The body’s most common and efficient method of removal of aged or abnormal
erythrocytes and recovery of essential components such as iron and amino acids?
Answer: extravascular erythrocyte destruction

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