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  • Pathophysiology: Risk Factors

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    1) Arterial wall injury, such as endothelial injury, allows lipids and platelets to accumulate in the area, increasing permeability. 2) Oxidized LDL attracts monocytes and macrophages, which begin to form plaques as lipids are engulfed by foam cells. 3) Smooth muscle cells multiply within the plaques, decreasing coronary tissue perfusion and oxygenation, which can lead to angina or myocardial infarction.

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    1) Arterial wall injury, such as endothelial injury, allows lipids and platelets to accumulate in the area, increasing permeability. 2) Oxidized LDL attracts monocytes and macrophages, which begin to form plaques as lipids are engulfed by foam cells. 3) Smooth muscle cells multiply within the plaques, decreasing coronary tissue perfusion and oxygenation, which can lead to angina or myocardial infarction.

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    13 views1 page

    Pathophysiology: Risk Factors

    Uploaded by

    shaitabligan
    1) Arterial wall injury, such as endothelial injury, allows lipids and platelets to accumulate in the area, increasing permeability. 2) Oxidized LDL attracts monocytes and macrophages, which begin to form plaques as lipids are engulfed by foam cells. 3) Smooth muscle cells multiply within the plaques, decreasing coronary tissue perfusion and oxygenation, which can lead to angina or myocardial infarction.

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    of 1

    PATHOPHYSIOLOGY

    RISK FACTORS A.NON-SPECIFIC


    NON-MODIFIABLE INJURY TO
    AND MODIFIABLE ARTERIAL WALL
    (ENDOTHELIAL
    INJURY)

    DESQUAMATION OF
    ENDOTHELIAL LINING

    B. LIPIDS AND PLATELET INCREASED


    ACCUMULATION IN THE PERMEABILITY
    AREA

    OXIDIZED LDL ATTRACTS PLAQUES BEGIN TO


    MONOCYTES AND FORM
    MACROPHAGES

    CAHD LIPIDS ARE ENGULFED


    BY FOAM CELLS AND
    SMOOTH MUSCLE CELLS
    MULTIPLY

    DECREASED CORONARY CORONARY ISCHEMIA


    TISSUE PERFUSION

    DECREASED MYOCARDIAL OXYGENATION


    ANGINA PECTORIS
    MYOCARDIAL INFARCTION

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