PATHOPHYSIOLOGY

Predisposing Precipitating
Factors: Factors:
-67 years old -Cigarette smoking
-Male -Environmental
exposure
-Family history
Diagnostics Multistep carcinogens -Precursor Lesions
-CBC with (Nicotine)
differential
- renal and
metabolic panels Infiltrates neuroendocrine cells of basal bronchial epithelium
-X-ray of the kidneys, (bronchial submucosa)
ureters, bladder
(KUB)
-Arterial blood gas
test
Small cell
- Urinalysis
lung
- Sputum culture
circanoma

Widespread, Paraneoplastic Growth of tumor Presence of a

rapid syndromes causes distal mass irritates
metastasis, -SIADH obstruction and the cough
responsive to -Ectopic infection receptors in
chemotherapy cushing the airway
syndrome -productive cough
with green sputum
Chemotherapy -Extrinsic or
-shortness of breath
-decreased breath intraluminal
-First line of sounds of the lung airway
treatment for -atelectasis obstruction
SCLC, which -postobstructive
are often pneumonia - Activation of
disseminated -wheezing mechanoreceptor
-hemoptysis s and
upon clinical
-mediastinal chemoreceptors
presentation. involvement in lungs due to
(pericardial
-in limited cachexia or
effusion,
disease, dysphagia, SVC hypoxemia/acido
combination syndrome) sis
chemotherapy
concomitantly -Tumour
with involving pleural
radiotherapy is surface causing
the cornerstone pleuritic chest
oftreatment pain

Patient’s Name / Room No. | 1

Patient’s Name / Room No. | 2