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Bausnue Jepunama s dore 10 ihe ‘ua omnowenue ronenmpayuit IL-10/L-6 ¢ cueopomne poeu seusomnnsx na du, Te w Ide cymau nocte nanecenua 4MT epuwecxo xpos rpaswuposaxmux Kpsic 8 Bune coorHowennR KoHueHTpaunt IL-10/ IL-6: UMT npusoasa x cuwxermo coorHourentin IL-1O/ IL-6 wa 3~7-e cytkn nocne HaneceaHn ‘pasar; wa 1-10-e cyraH sto coornomenne Guict0 ioke emMaa. Tloaysesnnte gantsie nomepxnpaior axyans- HocTb skclepaMeHTansHoro nloHcka cpeacTs, cno- ‘cob HAyHEpoRaTs BoccTaHoBneHNe Sananca wiToKHHo8, Hapyisentioro npx MT. 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MEAMLIMHCKHIA >KYPHAA, HoH HOKasaTe-IRM YpOBEN aKTHBHOCTH QYEK- ust awacysiok eeTeMBt MpH wexaiNeGeCKOH 4e- penko-wosrogoittpaawe H morys Gs:tb ckoppexri- poaarut npenapavom eJleprnar> Tloayveunne aanuste pacxpoisaior neperex ‘uanocT® HenonSgoRaKEN 9Toro HaTypanbiioro ununyHonoayaupyiouero npentapara uyKeoTaA Loit npHponst ax xevermn saGonenanti, o6y- ‘CHOBAEHHBIX He TOMbKO TPaBMoll, HO H APYTHNH nospexnarouinnr nosaeiiersaM Aurepatypa 1, Kenauna 9-H. Batnsope 10.11 epunat —npuporusi psyuonoayasrop aaa aereitaspocausx M.: Hay. 3, 2005 2. Omevccmeennese npenapam wo npuporsoi UK epi: nat, Depposnp. Hays, wuchopmauis aan ceutazitcTon paxrixyionuix spateR/Tlox pen E. A, Kopnenoit M— ‘Teepe: Tpuaza, 2008 & PusBoxuna E T., Bomunera BE, Wanun CH.» 0p ‘Axranocss sauerice Byer opranusua np enpeece ‘eae xoppemts npeneparox flepanas // Mex. wows ‘orn. 2008.7. 10, 4-5.C. 431438, 4, Mepounee B.A. KOuinoe BT, Kaun B 7, ebede0a EB. Vawseyzoguanonoras. Exarepuaéypr: YpO PAH, 2002, 5. Meavenno KB. NemaepmnssxB. A. Kpasyos 10.11 Uw ‘ytomaroaoriccktensuees npn tmaenol epento wosrosoli panne / /Vaarynozorus. 2008, T. 30. Ne 3. 180-188. 6, Kemauncrud C.A., Cuxsupyes A.C. tron CT ‘Pomaate, 2008, 7. Drenth IP. Van Uume SH, Van Dueren M. Endurance run inereases circulation IL-6 and I-1 but downregulates ex vivo TNFalla and IL beta production/ /J. Appl Physiol, 1995, Vol. 79. P. 1497-1508, 8, Bupuecmep FP, Meqummo A. Harsazas snosysono re M.: BHIIOM. Ja6. sat, 2007. 9, Wachre T., Halvorsen B., Damas JK. et al. Inlam matory imbalance between IL-10 and TNF alpha in unstable angina: potential plaque stabilizing ellects of IL10/ /Bsrop. J Clin, lnvest. 2002. Vol. $2, Ne 11 P.s03-s10, Ye. G. Rybakina, S$. N. Shanin, I. A, Kozinets, E. V. Dmitrienko Institute for Experimental Medicine, St. Petersburg Correction of the immune system functional activity alter experimental ‘brain trauma with Derinat medication, ‘The aim ofthe study was investigation of correcting action of Derinat — medication of nucleotide nature -on certain indicators of the immune system functional activity (cytotoxic and proberatve activities of splenocytes, blood intezleukin10/intereukn 6 ra tio) nats exposed to experimental brain uma. was shown tha 4days long intraperitoneal administration of Derinat in airals exposed lo severe mechanical bain trauma led to prevention of trauma induced prolonged stimulation of the immune competent cells and by the 14 day provoked normalization ofboth eytotonie and proliferative splenocyte activites. Interleukin 10/nteriew kin 6 blood rato, tat was decreased in trauma exposed rats, completely restored under Derinat action up tothe same values asin intact animals. The results obtained demonstrate obvious perspectives of Derinat employment for treatment of patients with brain Key words: immune system, experiment, craniocerebral raums, Derinat 34 wnwterramedica spb.