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  • Drugs, VD, Half Life and Loading Dose

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    The document lists 20 drugs along with their volume of distribution (Vd), half-life (t1/2), and typical loading doses. The Vd ranges from 0.1-0.2 L/kg for several drugs like warfarin, atenolol, and prednisolone to as high as 200 L/kg for chloroquine. Half-lives also vary significantly from 1-3 days for digoxin to 11 hours for alprazolam and 18 hours for ivermectin. Loading doses depend on whether administration is oral or intravenous as well as weight-based or fixed dosing.

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    The document lists 20 drugs along with their volume of distribution (Vd), half-life (t1/2), and typical loading doses. The Vd ranges from 0.1-0.2 L/kg for several drugs like warfarin, atenolol, and prednisolone to as high as 200 L/kg for chloroquine. Half-lives also vary significantly from 1-3 days for digoxin to 11 hours for alprazolam and 18 hours for ivermectin. Loading doses depend on whether administration is oral or intravenous as well as weight-based or fixed dosing.

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    17 views1 page

    Drugs, VD, Half Life and Loading Dose

    Uploaded by

    abirami p
    The document lists 20 drugs along with their volume of distribution (Vd), half-life (t1/2), and typical loading doses. The Vd ranges from 0.1-0.2 L/kg for several drugs like warfarin, atenolol, and prednisolone to as high as 200 L/kg for chloroquine. Half-lives also vary significantly from 1-3 days for digoxin to 11 hours for alprazolam and 18 hours for ivermectin. Loading doses depend on whether administration is oral or intravenous as well as weight-based or fixed dosing.

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    © All Rights Reserved
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    of 1

    S.

    No Name of the Vd t1/2 Loading dose


    drug
    1. Warfarin 0.1 – 0.2 L/kg 20-60 hrs 2-5 mg PO
    10 mg – healthy
    people
    2. Atenolol 0.1 – 0.2 L/kg 6-9 hrs 50-100 mg
    3. Aspirin 0.15 L/kg 3-5 hrs. 3 g PO/day
    Higher doses
    - 15-30 hrs
    4. Ibuprofen 0.2 L/kg 2-4 hrs 200-400 mg q 4 to
    6 hrs
    5. Prednisolone 0.2 – 0.7 L/kg 3-4 hrs 200 mg PO
    6. Ketoconazole 0.36 L/kg 2-8 hrs 200-400 mg PO
    7. Theophylline 0.4 – 0.7 L/kg 8 hrs 4.6 mg/kg IV over
    30 mins
    8. Methotrexate 0.4 – 0.8 L/kg 3-10 hrs 3.3 mg/m2/day
    9. Metronidazole 0.5 L/kg 6-8 hrs 15 mg/kg IV
    10. Digoxin 0.6 L/kg 1-3 days IV - 8-12 mcg/kg
    Oral - 10-15 mcg/kg
    11. Azathioprine 0.8 L/kg 3 hrs 3-5 mg/kg/day
    12. Acetaminophen 0.9 L/kg 2-3 hrs 1 g IV q 6 hrs
    13. Indomethacin 0.9 L/kg 4.5 hrs 75-150 mg PO
    14. Lidocaine 1 – 2 L/kg 2-8 hrs 1-1.5 mg/kg IV
    over 2 to 3 mins
    15. Alprazolam 1.6 L/kg 11 hrs 0.25-0.5 mg PO q 6
    to 8 hrs
    16. Chlorpromazine 2 – 5 L/kg 30 hrs 30-75 mg/day q 6-
    12 hrs
    17. Ivermectin 3 – 3.5 L/kg 18 hrs 0.2 mg/kg PO
    18. Ribavirin 16-30 L/kg 24 hrs 400-600 mg
    19. Imipramine 18 L/kg 6-18 hrs 75-150 mg PO
    20. Chloroquine 200 L/kg 3-5 days 16.7 mg/kg

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