PHILIPPINE ASSOCIATION OF COLLEGES OF PHARMACY (PACOP)

COURSE SPECIFICATIONS

COURSE TITLE Physical Pharmacy COURSE CODE

CREDIT UNITS 2 units lecture COURSE PRE-REQUISITE/S Pharmaceutical Dosage Forms and
1 unit laboratory Medical Devices
CONTACT HOURS 2 hours lecture; 3 hours laboratory per week COURSE CO-REQUISITE/S None

COURSE PLACEMENT 2nd year 2nd semester COURSE FACILITATOR

COURSE
DESCRIPTION Rationale: This course deals with the physicochemical principles underlying dosage forms and drug delivery systems

Focus: This course focuses on the correlation of these physicochemical principles to dosage form design, preparation, stabilization, evaluation and delivery to
patients

Outcomes: At the end of the course, the students are expected to:
 acquire basic knowledge and skills pertinent to dosage formulation
 apply the physicochemical properties of drugs as they relate to manufacturing and therapeutic response
 interpret theoretical principles in terms of concrete laboratory situations
 analyze and solve accurately problems encountered in drug design

PROGRAM LEARNING OUTCOMES YEAR LEVEL LEARNING OUTCOMES

At the end of the program, the graduate should be able to
1. practice pharmacy in a professional and ethical manner;
2. provide pharmaceutical care;
3. conduct relevant research and disseminate findings;
4. apply managerial and entrepreneurial skills;
5. communicate and facilitate effectively.
At the end of the second year level, the student should be able to:
1. demonstrate knowledge and skills in identifying different dosage forms, drugs
of biological origin, and ensuring quality of medical and pharmaceutical
products, and services,
2. demonstrate knowledge of the pharmacy and chemistry of pharmaceutical
products,
3. recognize important elements of the patient’s health profile and health promotion,
including pharmacovigilance in the context of the healthcare system,
4. read and interpret prescription correctly,
5. document important information used in patient care and pharmacy operations,
6. relates ethical principles to leadership and management in pharmacy;

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 7. demonstrate appreciation of art;
8. practice good housekeeping in the laboratory and other working areas
9. identify the different elements or components in a pharmacy operation while
practicing good management skills

Essential Learning Constructive Alignment

Teaching/Learning
Program
Content Functional Intended Learning Activities (TLAs) Assessment
Week Declarative Knowledge Learning
Standards Knowledge Outcomes (ILOs) Tasks (ATs)
Outcomes
(PLOs)
Unit I. INTRODUCTION
1,2  Demonstrate  Describing PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
understanding physical using Lecture Board work
on the concept pharmacy and Forum
of physical its placement in Exam/quiz
pharmacy the area of Assigned reading
pharmaceutics Laboratory
1.1 Density & Specific Gravity Problem sets reports
 Demonstrate  Differentiating
understanding density and Laboratory
in specific gravity experiments
determination
of density and  Calculating
specific gravity density and
of solids and specific gravity
liquids of substances
1.2 Expressions of Concentrations
 Demonstrate 1.2.1 Molarity  Describing the
knowledge in 1.2.2 Molality different
expressing 1.2.3 Normality concentration
different 1.2.4 Mole fraction expressions
concentrations 1.2.5 Percentage strength
of solutions 1.2.6 Milliequivalents  Solving
1.2.7 Osmolarity problems
related to
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 concentration
expressions

Laboratory
1. Concentration Expressions
2. Density & Specific Gravity

Unit II. STATES OF MATTER

3,4 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
2.1 Forces of attraction using Lecture Board work
 Demonstrate 2.1.1 Intramolecular and  Differentiating Forum-
understanding Intermolecular attraction the forces of Exam/quiz
on the different 2.1.1 van der Waals attraction that Assigned reading
forces of Forces stabilize Laboratory
attraction 2.1.2 Ion-dipole molecular Problem sets reports
2.1.3 Ion-induced systems
dipole Laboratory
2.1.4 Hydrogen experiments
bonding

2.2 States of matter

 Demonstrate 2.2.1Gaseous State  Comparing the
knowledge of 2.2.2 Liquid State properties of the
the various 2.2.3 Solid State various states of
states of matter matter
and their
properties
2.3 Transition State
 Demonstrate 2.3.1 Processes involved  Describing the
knowledge on 2.3.2 Factors affecting different
the various phase transitions transition states
transition states 2.3.3 Phase Rule, Phase and the factors
Diagrams and Eutectic affecting them
Mixtures  Discussing the
relevance of
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 phase equilibria
Laboratory
3. Eutectic Mixtures

Unit III. HOMOGENOUS SYSTEM

5,7,8 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
3.1. Solubility and Distribution using Lecture Board work
(6- PRELIMINARY  Demonstrate Phenomena  Describing the Forum
GRADING PERIOD) knowledge on 3.1.1. Types of solutes solubility and Exam/quiz
solubility and and its properties distribution of Assigned reading
distribution 3.1.2. General principles substances Laboratory
phenomena of solute-solvent  Interpreting Problem sets reports
interaction solubility ratio
3.1.3. Distribution  Differentiating Laboratory
coefficient the types of experiments
pharmaceutical
solutions
 Discussing the
significance of
solubility and
partition
coefficient
3.2. Colligative Properties of
 Demonstrate Solutions  Performing
knowledge on 3.2.1. Vapor pressure calculations
the different lowering related to the
colligative 3.2.2. Boiling point colligative
properties of elevation properties of
solutions 3.2.3. Freezing point solutions
depression
3.2.4. Osmotic pressure

3.3. Acid-Base Equilibria  Explaining the

 Demonstrate 3.3.1 Theories of acids relationship
understanding and bases between pH and
the concepts on 3.3.2 Ionization of weak pKa
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 acids and bases acids and bases
3.3.3 pH calculations

3.4. Buffer system and Isotonic  Using the

 Demonstrate Solutions Henderson-
understanding 3.4.1 Buffer equation Hasselbalch
of buffer and 3.4.2 Factors influencing Equation in the
isotonicity and the pH of buffer solutions preparation of
their 3.4.3 Buffer capacity buffers
relationship to 3.4.4 Buffer in  Performing
biological pharmaceutical systems isotonicity
systems and biologic system adjustment
3.4.5 Influence of buffer calculations
capacity and pH on tissue,
pH and solubility
3.5.6 Buffered isotonic
solutions
3.5.7 Measurement of
tonicity

Laboratory
1. Solubility Determination
2. Colligative Properties of
Solutions
3. pH Determination
4. Buffer Preparation
5. Partition Coefficient
Unit IV. COMPLEXATION
9 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
4.1 Complexes and Chelates using Lecture Board work
 Demonstrate 4.1.2. Classification of  Explaining the Forum
understanding complexes factors which Exam/quiz
of 4.1.2 Pharmaceutical affects Assigned reading
complexation applications of complexes complexation Laboratory
and chelation and chelates Problem sets reports

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 Laboratory
Laboratory experiments
1. Determination of
pharmaceutical products
containing complexes

Unit V. HETEROGENOUS SYSTEMS

10,11 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
5.1 Colloidal using Lecture Board work
(12 – MIDTERM  Demonstrate 5.1.1 Types of colloidal  Distinguishing Forum
GRADING PERIOD) knowledge on systems colloidal types Exam/quiz
the different 5.1.2 Properties of and their Assigned reading
types of colloids pharmaceutical Laboratory
colloids and 5.1.3 Pharmaceutical relevance Problem sets reports
their applications
applications in Laboratory
pharmacy experiments
5.2 Coarse Dispersions
 Demonstrate 5.2.1 Classification of  Discussing the
knowledge on coarse dispersions classifications,
the 5.2.2 Desirable qualities, properties and
classification properties and formulation the factors
and properties of suspensions and affecting the
of coarse emulsions stability of
dispersions 5.2.3 Stability and suspensions and
bioavailability of emulsions
suspensions and
emulsions
5.3 Interfacial Phenomena
 Demonstrate 5.3.1 Measurement of  Understanding
knowledge on interfacial and surface interfacial
the tension phenomena and
measurement 5.3.2 Application to describing the
and application pharmacy methods of
to pharmacy of measuring
interfacial interfacial and

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 phenomena surface tension
5.4 Rheology
 Demonstrate 5.4.1 Types of flow  Comparing the
knowledge on 5.4.2 Determination of various flow
the concepts rheologic properties properties
and 5.4.3 Techniques for between
applications of rheological measurements Newtonian and
rheology in 5.4.4 Application to non-Newtonian
pharmacy pharmaceutical materials
preparations

Laboratory
1. Coarse Dispersions
2. Interfacial and surface tension
3. Viscosity determination

Unit VI. MICROMERITICS

13,14 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /
6.1 Fundamental Properties of using Lecture Board work
 Demonstrate Particles  Describing the Forum
knowledge of 6.1 Particle Size Analysis different Exam/quiz
the 6.2 Surface Area methods of Assigned reading
fundamental 6.2 Derived Properties of determining Laboratory
and derived Particles particle size, Problem sets reports
properties of 6.2.1Bulk Density surface area,
particles and 6.2.2 Angle of Repose bulk density, Laboratory
their 6.2.3 Compressibility angle of repose, experiments
application to 6.2.4 Porosity compressibility
pharmacy 6.3 Pharmaceutical application and porosity of
particles.
Laboratory
1. Sieve analysis
2. Bulk density of powders
3. Angle of repose
Unit VII. CHEMICAL KINETICS
15,16,17 PLO 3 ILO 1, ILO 2 Interactive Lecturing Recitation /

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 7.1 Linear Equation and Linear using Lecture Board work
(18 – FINAL GRADING  Demonstrate Regression  Applying Forum
PERIOD) understanding calculations on Exam/quiz
of linear linear equation Assigned reading
equation and and linear Laboratory
linear regression to Problem sets reports
regression zero-order, first-
7.2 Orders of Reaction order kinetics, Laboratory
 Demonstrate 7.2.1 Factors affecting and half-life. experiments
knowledge of reaction rates
orders of 7.2.2 Zero-order process
reaction, half- 7.2.3 First-order process
life, shelf-life 7.3 Half-Life
and stability 7.4 Shelf-Life and Expiration
studies Dating  Discussing the
7.4.1 Decomposition and significance of
stabilization of medicinal expiration
agents dating
7.5 Stability Studies  Understanding
7.5.1 Methods of the stability-
evaluating the stability of testing
pharmaceutical regulatory
preparations requirements
and protocols
Laboratory
1. Shelf-life determination

Learning Resources LCD projector, Powerpoint presentations, LED TV, audio-visual materials
Basic Readings Martin’s Physical Pharmacy and Pharmaceutical Sciences
Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems
Aulton’s Pharmaceutics: The Design and Manufacture of Medicines
Extended Readings Pharmacopeias (eg. USP, BP, PP)
ASEAN Guidelines (eg. Stability, Variation)
WHO and ICH Guidelines (eg. Interchangeability, Validation, Pharmaceutical Quality Systems)

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Course Assessment Recitation / Board work
Exam/quiz
Laboratory reports
Course Policies
Committee Members
Consultation Schedule

Course Title AY/Term of Prepared by: Approved by: Page

effectivity

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