Mycolic acid Isoniazid

cell
wall catalase
MOA: INH Drug Kas A Ind: Latent TB
Arabinogalactan (prodrug) KatG Active TB
peptidoglycon
MOR: KatG Kas A SE: Hepatitis
plasma Fast BG + BG - Def - Peripheral neuropathy
membrane Latent TB Acetylation P450 -; (Phenytoin)
slow
INH + BG
Eyethambutol
RNA
Transcribed MOA: inhibit arabinosyl transferase (emb)
MOR: expression of emb visual acuity Visual Screen
M. Tuberculosis = Active SE: retrobulbar neuritis
red/green color blindness every visit
Rifampin RNA-polymerase Red Fluids

BG + Isoniazid mycolic Hepatitis Pyrazinamide

acid synthesis BG-Def PN
MOA: Plasma membrane function
Pyrazinamide Plasma Membrane Uric Acid SE: Uric Acid Stones
Function transport Stones
HAART, Protease -;
Rifampin P450 induction
Ethambutol Arabinosyl Transferase Eyethanbutol Rifamycins
Rifabutin Rifabutin
area/ red blind
visual activity MOA: inhibit RNA Polymerase (DP Rp)
MAC M. Leprae MOR: Alter B - Binding site
IND: Tuberculosis , Leprosy, MAC
Azithromycin PPX CD4 CSO Tuberculoid Dopsure, ritampin PPX N. Meningitis
Azithromycin Lepromatous Dopsure, ritampin, C _____ SEi Body Fluids red - Sweat, tears, urine
Trifampin P450 inducers