University of St.
La Salle
Name of Student: ___________________________________________________________________________ Section and Group: ________________________
Name of CI: _________________________________________________________________________________ Area of Exposure: _________________________
Dosage/Frequency/Ti
Name of Drug Mechanism of Action
ming/Route
Generic Name: Assists all enzymes involved
in phosphate transfer
Magnesium reactions that use
Sulfate adenosine triphosphate
(ATP). Magnesium is
required for normal function
Brand Name: of the ATP-dependent
sodium-potassium pump in
MgSO4 muscle membranes. It may
effectively treat digitalis
glycoside–induced
arrhythmias because
Classification: correction of
hypomagnesemia improves
Antacid, the sodium-potassium
antiarrhythmic, pump’s ability to distribute
anticonvulsant, potassium into intracellular
electrolyte spaces and because
replacement, magnesium decreases
laxative calcium uptake and
potassium outflow through
College of Nursing
DRUG STUDY
Indication
To correct magnesium
deficiency caused by
alcoholism, magnesium-
depleting drugs,
malnutrition, or restricted
diet; to prevent
magnesium deficiency
To prevent and control
seizures in preeclampsia
or eclampsia as well as
seizures caused by
epilepsy,
glomerulonephritsor
hypothyroidism
To relieve indigestion
with hyperacidity
To relieve constipation, to
evacuate colon for rectal
Contraindication Adverse Effect Nursing Responsibilities
Hypersensitivity to CNS: Confusion, •Be aware that magnesium sulfate
magnesium salts or decreased reflexes, is the elemental form of
any component of dizziness, syncope magnesium. Oral preparations
magnesium- CV: Arrhythmias, aren’t all equivalent.
containing hypotension •Be aware that drug isn’t
preparations For GI: Flatulence, metabolized. Drug remaining in
magnesium chloride: vomiting the GI tract produces watery stool
Coma, heart disease, MS: Muscle cramps within 30 minutes to 3 hours.
renal impairment For 710 mannitol •Make sure patient chews
magnesium sulfate: RESP: Dyspnea, chewable tablets thoroughly before
Heart block, MI, respiratory swallowing.
preeclampsia 2 hours depression or •Avoid giving other oral drugs
or less before paralysis within 2 hours of magnesium-
delivery (I.V. form) SKIN: Diaphoresis containing antacid. •Before giving
Other: Allergic drug as laxative, shake oral
For use as laxative: reaction, solution, liquid, or liquid
Acute abdominal hypermagnesemia, concentrate well and give with a
problem (as injection-site pain or large amount of water.
indicated by irritation (I.M. •Frequently assess cardiac status of
abdominal pain, form), laxative patient taking drugs that lower
nausea, or vomiting), dependence, heart rate, such as beta blockers,
myocardial cell membranes.
As a laxative, magnesium
exerts a hyperosmotic effect
in the small intestine. It
causes water retention that
distends the bowel and
causes the duodenum to
secrete cholecystokinin. This
substance stimulates fluid
secretion and intestinal
motility.
or bowel examination diverticulitis, fecal magnesium toxicity because magnesium may aggravate
impaction, intestinal symptoms of heart block
To treat mild magnesium obstruction or
deficiency perforation,
colostomy or
To treat severe ileostomy, severe
hypomagnesemia renal impairment,
ulcerative colitis
To provide supplemental
magnesium in total
parenteral nutrition

As an antacid, magnesium
reacts with water,
converting magnesium
oxide to magnesium
hydroxide. Magnesium
hydroxide rapidly reacts
with gastric acid to
form water and magnesium
chloride, which increases
gastric pH.

As an anticonvulsant,
magnesium depresses the
CNS and blocks peripheral
neuromuscular impulse
transmission by decreasing
available acetylcholine.