Calculation and Visualization of synergy scores for Drug Combinations

Drug combinations:

Drug combination Synergy score Most synergistic area score Method

kopi - Tehh 9.73 18.19 Loewe

Chosen parameters:

Readout: viability ; Baseline correction: Yes ;

 kopi & Tehh

Dose−response matrix (inhibition)

Dose−response curve for drug: Tehh

100
320 17.78 16.25 7.13 23.02 51.67 9.45 39.76
80

60
160 7.17 4.91 12.92 7.62 9.82 15.29 24.96
40
●
20 ●
● ● ● ●
0
80 3.15 10.53 1.3 0.38 8.74 11.17 25.68
inhibition (%)
100
10 20 50 100 200

Tehh (nM)
75
Concentration (nM)
40 7.62 12.04 4.73 9.71 5.97 25.68 23.21
50

Dose−response curve for drug: kopi 25

20 7.72 12.41 5.58 12.3 14.52 19.81 22.48

100

80

60 10 29.08 6.17 2.48 8.4 6.66 4.47 20.53

40

20 ● ●
● ● 0 100 19.32 15.63 2.57 3.54 4.77 9.42
0 ● ●

10 20 50 100 200 0 10 20 40 80 160 320

kopi (nM)
Concentration (nM)
 Loewe synergy score: 9.728
−60 −30 0 30 60

320
Loewe synergy score: 9.728
−60 −40 −20 0 20 40 60

160

60
80
40
Tehh (nM)

20

δ − score
40 0

−20

−40
20
−60
320
160
80
10 320
Te

40 160
hh

20 80
(n

40
M

)
i (nM
20
)

10
0
10 kop
0 10 20 40 80 160 320
kopi (nM)