Calculation and Visualization of synergy scores for Drug Combinations

Drug combinations:

Drug combination Synergy score Most synergistic area score Method

kopi - Tehh 3.08 9.68 Loewe

Chosen parameters:

Readout: viability ; Baseline correction: Yes ;

 kopi & Tehh

320 33.41 22.04 7.13 23.02 51.67 48 47.37

160 19.37 4.91 16.71 28.24 29.8 33.02 24.96

80 17.18 9.02 22.9 27.06 29.96 13.89 27.95

inhibition (%)
100
Tehh (nM)

75
40 15.45 19.92 22.2 23.69 11.6 25.68 28.59
50

25

20 10.51 16.78 7.22 6.21 14.52 26.58 22.48

10 8.55 3.76 2.48 8.4 12 16.72 25.97

0 100 2.57 9.42 15.63 20.28 21.1 23.29

0 10 20 40 80 160 320
kopi (nM)
 kopi (nM) & Tehh (nM)

Loewe synergy score: 3.08

−30 −20 −10 0 10 20 30

30

20

10
δ − score

−10

−20

−30

320

160

80
320
Te

40 160
hh

80
(n

20
M

40
)

10 20
i (nM)
10 kop