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Room Area
Determination of the air velocity in CFM and air changes per hour ACPH in pharmaceutical clean
rooms and also know its requirements in different cleanroom classes like 100, 1000, 10000, 100000.
Now calculate the area of the filter by multiplying the length and width of the filter in feet.
A=lxw
l = length of HEPA filter
w = width of HEPA filter
Calculate the total air volume per minute supplied in the clean room by the following formula:
T=AxV
A = Area of HEPA filter in square feet
V = Average air velocity in feet per minute
Calculate the total air in the room multiplying the length, width and height of the room in feet.
Volume = L x W x H
Now we can calculate the Air Changes per hour using the following formula:
Air Changes per Hour = T X 60
Volume
Related: Cleanroom Validation
The requirement of number of air changes per hour for any room depends on the class of the
room,number of personnel working in the area and frequency of access the room. Cleanliness of any
clean room is maintained by the air changes per hour. More air changes per hour are required for the
better clean room class than the lower one.
More air changes per hour are required to maintain the area where dust is generated as in granulation and
tablet compression areas. In these areas dust is to be removed in a short period, hence more air changes
per hour are required.
Following is the list of the air changes per hour indifferent classes of classified area.
Therefore the air changes per hour show the quality of the air in the cleanroom that helps the maintenance
of the clean area quality.