Drug Study

Generic Name: Valproic Acid

Brand Name: Depakene

Classification: Anticonvulsant

Dosage, frequency, and route of administration: 750 mg tab, OD, Oral route

Mechanism of action: It enhances the brain γ-aminobutyric

acid (GABA) levels via multiple actions
of synthesis and degradation, and
modulation of other neurotransmitters,
voltage sensitive Na+ channels, extra
hypothalamic neuropeptides, secondary
messenger systems, and neuro
protection.

Desired effect: Valproic acid is used to treat or prevent

the manic episodes of bipolar disorder
by increasing the amount of chemical
called gamma-aminobutyric acid in the
brain. GABA blocks transmission across
nerves in the brain and has a calming
effect.

Nursing Responsibilities Rationale

1. Assess appropriateness of the
prescribed therapy, patient's
condition, and dose, route and rate This is to prevent error before
of the solution/medication order administering the medication.
before administering the
medication.
2. Check the patient's medical record If an allergy or contraindications exist,
for an allergy or contraindication to don't administer the medication and
the prescribed medication. notify the practitioner.

3. Monitor patient’s response to the

To evaluate effectiveness of the drug.
drug.

Tremors may indicate need for

4. Watch for tremors
dosage reduction.

5. Instruct the patient to avoid Alcohol may decrease drug

drinking alcohol while taking the effectiveness can increase the
 nervous system side effects such as
medication. dizziness, drowsiness, and difficulty
concentrating.
6. Discuss with patients the side It will help the patient identify
effects of the medication such as undesired side effects that may
dizziness, and drowsiness. require intervention.

7. Tell patient to take with food but Tablet may dissolve before
not carbonated beverages  swallowing, causing irritation and
unpleasant taste.
To protect the patient from fall
8. Institute safety measure such as
experiencing some adverse effects
raising the side rails.
such dizziness and drowsiness
9. Offer the patient support and This helps the patient cope with the
encouragement to drug therapy. disease and drug regimen.

10. Orient the patient and significant To ensure patient safety and improve
other and institute safety measures patient tolerance of the drug and drug
if CNS effects occur. effects.
To help the patient avoid making
11. Educate the patient and significant
medication errors during self-
other about the medication
medication and understand what
including the time when to take it
to do if the patient has questions or
and its importance.
concerns about the medication.