Appendix 1 – Anaphylaxis defining criteria

Reference: Cardona V, Ansotegui IJ, Ebisawa M, et al. World allergy organization anaphylaxis guidance 2020. World Allergy Organ J
2020;13:100472.
Appendix 2 – List of PEG-containing drugs*

Generic name
Molecular weight General description
(brand name)

Methylprednisolone acetate An anti-inflammatory glucocorticoid for intramuscular, intra-

PEG 3350
(Depo-Medrol) articular, soft tissue or intralesional injection

Methoxy polyethylene glycol- 30-kD methoxy

Used to treat anemia in adults with chronic kidney disease
epoetin beta (Micera) PEG butanoic acid

Pegfilgrastim (Neulasta)
Used to help reduce the chance of infection due to a low white blood
20-kD
cell count, in people with certain types of cancer (nonmyeloid), who
monomethoxy
receive anticancer medicines (chemotherapy) that can cause fever
PEG
and low white blood cell count

Medroxyprogesterone acetate Contraceptive and adjunctive therapy and palliative treatment of

PEG 3350
(Depo-Provera) inoperable, recurrent, and metastatic endometrial or renal carcinoma

Brilliant Blue G Ophthalmic Disclosing agent indicated to selectively stain the internal limiting
PEG 3350
Solution (TissueBlue) membrane

Sulfur hexafluoride (Lumason) PEG 4000 Ultrasound contrast agent

Reduction of intraocular pressure in patients with open-angle

Biomatoprost implant (Durysta) PEG, unspecified
glaucoma or ocular hypertension

Trastuzumab (Herceptin,
Herzuma, Kanjinti, Ogivri,
Ontruzant)
Adjuvant treatment of HER2 overexpressing node-positive or node-
PEG 3350
negative breast cancer

IL-1 blocker for treatment of cryopyrin-associated periodic

Rilonacept (Arcalyst) PEG 3350
syndromes

Perflutren lipid microsphere Contrast agent used to brighten and clarify images of the heart
PEG 5000
(Definity) during echocardiograms

* This list will be revised from time to time based on the best available evidence. Please refer to the College website
at http://www.paediatrician.org.hk/ for the most updated version.

Reference: Banerji A, Wickner PG, Saff R, et al. mRNA vaccines to prevent COVID-19 disease and reported allergic reactions: current evidence
and suggested approach. J Allergy Clin Immunol Pract 2021;9:1423-1437.