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    The document presents results from several tests measuring the effects of different drug treatments on mice over 4 days. The tests include a von Frey test measuring mechanical threshold, a paw edema test measuring paw swelling, a weight assessment test, a thermal hyperalgesia test measuring pain response to heat, a muscle strength test, and an inverted screen test measuring motor function. The results show that treatments with the drug Iccarin at doses of 5, 25, and 50 mg/kg had effects comparable to the drug Tramadol on measures of pain response and motor function.

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    PIS Model

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    The document presents results from several tests measuring the effects of different drug treatments on mice over 4 days. The tests include a von Frey test measuring mechanical threshold, a paw edema test measuring paw swelling, a weight assessment test, a thermal hyperalgesia test measuring pain response to heat, a muscle strength test, and an inverted screen test measuring motor function. The results show that treatments with the drug Iccarin at doses of 5, 25, and 50 mg/kg had effects comparable to the drug Tramadol on measures of pain response and motor function.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    5 views3 pages

    Graphs

    Uploaded by

    Sarah
    The document presents results from several tests measuring the effects of different drug treatments on mice over 4 days. The tests include a von Frey test measuring mechanical threshold, a paw edema test measuring paw swelling, a weight assessment test, a thermal hyperalgesia test measuring pain response to heat, a muscle strength test, and an inverted screen test measuring motor function. The results show that treatments with the drug Iccarin at doses of 5, 25, and 50 mg/kg had effects comparable to the drug Tramadol on measures of pain response and motor function.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 3

    Mechanical Threshold in mice Von-Frey Test

    5
    Normal Control
    4 Negative control
    3 Tramadol(50mg/kg)
    2 Iccarin(5mg/kg)
    Iccarin(25mg/kg)
    1
    Iccarin(50mg/kg)
    0
    1 2 3 4
    -1
    Days

    Paw Edema Test


    4
    Normal Control
    3 Negative control
    Paw edema (mm)

    Tramadol(50mg/kg)
    2
    Iccarin(5mg/kg)
    1 Iccarin(25mg/kg)
    Iccarin(50mg/kg)
    0
    1 2 3 4
    -1 Days
    Weight Assesment Test
    40
    Normal Control
    30 Negative control
    Weight(gram)

    Tramadol(50mg/kg)
    20
    Iccarin(5mg/kg)
    10 Iccarin(25mg/kg)
    Iccarin(50mg/kg)
    0
    1 2 3 4
    -10 Days

    Thermal hyperalgesia
    Paw withdrawl Threshold (Sec)

    50
    Normal Control
    40 Negative control
    30 Tramadol(50mg/kg)
    20 Iccarin(5mg/kg)
    Iccarin(25mg/kg)
    10
    Iccarin(50mg/kg)
    0
    1 2 3 4 5
    -10
    days
    Muscle Strength Test
    40
    Normal Control
    30 Negative control
    Muscle Strength

    Tramadol(50mg/kg)
    20
    Iccarin(5mg/kg)
    10 Iccarin(25mg/kg)
    Iccarin(50mg/kg)
    0
    1 2 3 4
    -10 Days

    Inverted Screen Test


    80
    Normal Control
    60 Negative control
    Tramadol(50mg/kg)
    40 Iccarin(5mg/kg)
    (Sec)
    Time

    Iccarin(25mg/kg)
    20
    Iccarin(50mg/kg)
    0
    1 2 3 4
    -20 Days

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