CU

3 Pharmacokinetics

1. The critical concentration of a drug in the body is that concentration of drug that will

a. Produced the desired effect of the drug

b. Cause a fatal reaction in the host
c. Cause adverse effects to the drugs
d. Block further absorption of the drug from the GIT
2. Drugs that are taken orally are

a. Absorbed through the small intestine and directed to the liver by the portal vein
b. Absorbed through the stomach and delivered into the circulation through the lymphatic
fluid
c. Absorbed through the small intestines and delivered into the renal vein
d. Broken down in the GIT and absorbed with certain nutrients
3. Achieving a critical concentration of a drug in the body involves a dynamic equilibrium between
all of the following, except

a. Drug excretion
b. Drug distribution
c. Drug absorption
d. Drug effects
4. A patient’s gender can affect absorption of the drug that is

a. Administered intramuscularly because men have more vascular muscles and absorb
more quickly
b. Administered subcutaneously because women have more fats and drugs are not
absorbed well
c. Administered orally because women do not absorb well from small intestine
d. Administered IV because men have a more muscular endothelium than women
5. Half life refers to
a. Time it take for the drug to reduce to half from the peak level it previously achieved
b. Time it takes for the drug to be excreted after half the hour
c. Time it takes for the drug to be absorbed and metabolized in the body
d. Time is takes for the drug to be used by the body and totally be excreted in the kidneys
6. Critical concentration refers to
a. Therapeutic level
b. Over dose of drugs
c. Under dose of drugs
d. Higher than usual dose
7. Drugs that are excreted in the urine may reach toxic levels in a patient who has

a. Hepatitis
b. High BUN and creatinine
c. Type 2 DM
d. High bilirubin
 e. All of the above
8. If the drug comes with recommended doses for pediatric patients, the dose is taking into
account
a. The difficulty older people have remembering to take their medications
b. The potential for decreased kidney and liver function
c. Immature system’s difficulty in handling certain drugs
d. The particular disease known to affect the elderly
9. The decrease in response to a drug because of its repeated administration

a. Biotransformation
b. Bioavailabilty
c. Cummulation
d. Tolerance
10. Which of the following does not affect the absorption of the drug?
a. Oral suspension
b. Transdermal patch
c. Intravenous drug
d. None of the above