The document describes the endomembrane system and its role in producing antibodies in white blood cells. As antibodies are produced, the white blood cell's cytoplasm fills with endoplasmic reticulum (ER) and Golgi apparatus. Antibodies are made on the rough ER and transported to the smooth ER in vesicles. Vesicles then fuse with the Golgi apparatus, where the antibodies are modified before being transported in secretory vesicles to the cell membrane and released into the bloodstream to combat viruses. Diagrams are included and explained showing the structures of the endomembrane system and key steps in antibody production and transport.
The document describes the endomembrane system and its role in producing antibodies in white blood cells. As antibodies are produced, the white blood cell's cytoplasm fills with endoplasmic reticulum (ER) and Golgi apparatus. Antibodies are made on the rough ER and transported to the smooth ER in vesicles. Vesicles then fuse with the Golgi apparatus, where the antibodies are modified before being transported in secretory vesicles to the cell membrane and released into the bloodstream to combat viruses. Diagrams are included and explained showing the structures of the endomembrane system and key steps in antibody production and transport.
The document describes the endomembrane system and its role in producing antibodies in white blood cells. As antibodies are produced, the white blood cell's cytoplasm fills with endoplasmic reticulum (ER) and Golgi apparatus. Antibodies are made on the rough ER and transported to the smooth ER in vesicles. Vesicles then fuse with the Golgi apparatus, where the antibodies are modified before being transported in secretory vesicles to the cell membrane and released into the bloodstream to combat viruses. Diagrams are included and explained showing the structures of the endomembrane system and key steps in antibody production and transport.
1 The Endomembrane System: The Cell in Action: ER, Golgi, and Lysosomes:
Name: Velasco, Josiah M. Period: Date: 10/08/2021
The Cell in Action: ER, Golgi, and Lysosomes: 1. Scenario : Counterattack!
When you fight off a virus,
your immune system produces antibodies. Antibodies are virus-killing proteins that are made in white blood cells and released into the blood. As white blood cells produce antibodies, their appearance changes. Their cytoplasm becomes filled with endoplasmic reticulum (ER). There’s also a lot of Golgi Apparatus. What’s going on? Figure 1: A White blood cell fills up with endoplasmic reticulum as it produces antibodies
The ER is a vast internal
network of channels separated from the rest of the cytoplasm by membrane . The Golgi is similar, except for that instead of channels, the Golgi forms a series of flattened, elongated sacs, also bound by membranes.
In the diagram to the left,
Figure 2: Nucleus, ER, Golgi, Membrane the nucleus is shown at 1. The endoplasmic reticulum is at 2 and 3. The Golgi is at 5. The left side of the ER is covered by many ribosomes, which are shown as dots in this illustration. Ribosomes are the cell’s protein factories: they’ll make any protein that they’re told to make, based on instructions they receive from the nucleus. ER with ribosomes is called Rough ER. ER without ribosomes is smooth ER, and we’ll discuss it more below. Antibodies, like all proteins that will be exported out of the cell, are made at the rough ER (2). As the antibody is made, it gets put into the channels of the ER. It then moves to the Smooth ER (3). In the same way that bubbles can form from a soap film, the smooth ER will bud off a bubble of membrane, also known as a vesicle (4). A vesicle is the name we give to any small, membrane bound sac that’s transporting substances from one area of the cell to another. This vesicle, containing the antibody, will merge with the Golgi Apparatus (5). The Golgi has enzymes that modify the antibody, getting the antibody into the exact form it will need to be in to bind with and destroy the virus. When the Golgi is done, it buds off another vesicle (6). This vesicle will fuse with the cell membrane (8). As it does, the antibody will be dumped into the cell’s exterior. In this case, that means the bloodstream. The antibody will now float in the blood and, hopefully, bind with the virus, helping to destroy it. 2. Understanding Cell Processes and Structures: Based on the reading on the opposite side, create a key for the diagram below and to the right. Note that we’re deliberately skipping numbers 3 and 7. Numbe Name Based on the reading above, a quick summary of r its function 1 Nucleus Nucleus is the sender of instructions to ribosomes (cell’s protein factories) as the receiver to make any protein. 2 Endoplasmic reticulum A White blood cell fills up with endoplasmic reticulum as it produces antibodies. 4 Vesicle A vesicle is the name we give to any small, membrane bound sac that’s transporting substances from one area of the cell to another. 5 Golgi apparatus The Golgi forms a series of flattened, elongated sacs, also bound by membranes. It has enzymes that modify the antibody, getting the antibody into the exact form it will need to be in to bind with and destroy the virus. 6 Secretory Vesicle This vesicle will fuse with the cell membrane. As it does, the antibody will be dumped into the cell’s exterior. In this case, that means the bloodstream. The antibody will now float in the blood and, hopefully, bind with the virus, helping to destroy it. 8 Cell membrane Cell membranes protect and organize cells. All cells have an outer plasma membrane that regulates not only what enters the cell, but also how much of any given substance comes in.
3. The endomembrane system: Create a key to the diagram below.
Numb Name Function/Role
er 1 Nuclear membrane The nuclear membrane serves as a barrier between the nucleus and the cytoplasm, separating gene regulation and transcription in the nucleus from translation in the cytoplasm 2 Nucleus pore Regulates the transportation of molecules between the nucleus and the cytoplasm. 3 Rough endoplasmic reticulum Endoplasmic reticulum produces proteins for the rest of the cell to function, Rough ER is the one who make those proteins. 4 Smooth endoplasmic reticulum It synthesizes lipids, phospholipids as in plasma membranes, and steroids. 5 Ribosomes on the rough endoplasmic reticulum The rough endoplasmic reticulum has on it ribosomes, which are small, round organelles whose function it is to make those proteins. Sometimes, when those proteins are made improperly, the proteins stay within the endoplasmic reticulum. 6 Proteins (macromolecules) Membrane proteins serve a range of important functions that helps cells to communicate, maintain their shape, carry out changes triggered by chemical messengers, and transport and share material. 7 Transport vesicle Transport vesicles carry proteins from the rough endoplasmic reticulum to the cis face of the Golgi apparatus, where they fuse with the Golgi membrane and empty their contents into the Golgi lumen. 8 Golgi apparatus The Golgi apparatus, or Golgi complex, functions as a factory in which proteins received from the ER are further processed and sorted for transport to their eventual destinations: lysosomes, the plasma membrane, or secretion. In addition, as noted earlier, glycolipids and sphingomyelin are synthesized within the Golgi. 9 Cisternae of the Golgi apparatus The cisternae play a crucial role in the packaging, modification, and transport functions for the cell overall. The proteins and polysaccharides that get processed here within the cisterna will then be sent to their specified locations. 10 Secretory vesicle It mediates the vesicular transport of cargo hormones or neurotransmitters - from an organelle to specific sites at the cell membrane, where it docks and fuses to release its content. 11 Lysosomes (filled with hydrolytic enzymes) They break down excess or worn-out cell parts. They may be used to destroy invading viruses and bacteria. If the cell is damaged beyond repair, lysosomes can help it to self-destruct in a process called programmed cell death, or apoptosis. 12 Cell membrane Cell membranes serve as barriers and gatekeepers. They are semi- permeable, which means that some molecules can diffuse across the lipid bilayer but others cannot.