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Transylvanian Review
Centrul de Studii Transilvane| str. Mihail Kogalniceanu nr. 12-14, et.5, Cluj-Napoca
Email: transylvanianreview@gmail.com
Online Submission System: http://transylvanianreviewjournal.org/
Saryono and Proverawati Transylvanian Review: Vol XXVI, No. 29, June 2018
Abstract
Background: people commonly consume some seeds like steeping as beverage. This is the first study that was to
prove the effects of anti-atherogenic properties of beverage of the date seeds in pre-menopause women.
Materials and methods: The quasi-experimental design was used in the study. Thirty-two of pre-menopause women
with hyperlipidemia history in Gununglurah village, Banyumas, Central Java were recruited. Each participant
signed an informed consent to obtain a 5 cc blood sample through the mediana cubital vein. Lipid profiles test was
done before and after treatment. Beverage of the Date seeds of Deglet Nour cultivar was consumed for 14 days with
the dosage of 2.5 grams each day. The data were analyzed by using the paired t-test with a significance level of p<
0.05.
Results: Prior to treatment, pre-menopause women tend to have unhealthy lipid profile. The mean scores of total
cholesterol, triglyceride, HDL and LDL levels were 251.53 35.23, 232.50 35.17, 35.69 6.55, 167.11 40.31
mg/dL respectively. After consuming beverage of the date seeds, the total cholesterol, triglycerides, LDL, and
atherogenic levels were decreased, while HDL level was significantly increased (p< 0.05).
Conclusion: The study demonstrated that the lipid profiles of the pre-menopause women were improved after date
seed beverage consumption. The implication of the study was that pre-menopause women could consume the date
seed beverage routinely to maintain a good lipid profiles and keep healthy. The professional health care also can
give the education regarding with the benefit of the date seed beverage in decreasing the lipid profiles in pre-
menopause women.
Corresponding author: School of Nursing, Health Sciences of Faculty, University of Jenderal Soedirman,
Purwokerto, Indonesia.
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Saryono and Proverawati Transylvanian Review: Vol XXVI, No. 29, June 2018
powder was packed into 2.5 grams of date seeds for
Introduction each pack and distributed to each participant.
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Saryono and Proverawati Transylvanian Review: Vol XXVI, No. 29, June 2018
Five milliliters of blood sample were taken active compound like flavonoid, tannin, saponin and
through the mediana cubital vein before and after alkaloid. This compound have an important role as
treatment. The blood was collected in EDTA antioxidant to stop free radical chain reaction. The
vacutainer for several tests of total cholesterol (TC), average of age and body weight of the participants
LDL, Triglycerides (TG), and HDL. The lipid profiles were 51 years old and 68 kg (Table 2). The mean of
parameters are measured using Enzymatic the study sample has an ideal body mass index but
Colorimetric Assay method, while atherogenic index has high blood pressure. Pre-menopause or elderly
(AI) is measured using log 10 (TG/HDLc). will generally begin to be increasing the rate of free
radical oxidation product. Fat oxidation in the blood
Statistical Analysis vessels result a stiffness of blood vessels. This will
The paired t-test was used to compare the mean decrease blood vessel elasticity so that blood pressure
score before and after treatment. The significance increases. The mean of TC, TG, LDL, and atherogenic
level was approved if p< 0.05. Ethical permission and index were increased and HDL level was decreased
informed consent were done prior to the study. before consuming the date seeds beverage.
Nevertheless, after consuming the date seeds
Results beverage for 14 days, the average of TC, TG, LDL, and
atherogenic index were decreased and HDL level was
The result of qualitative phytochemical analysis increased (Table 3). The paired t- test result showed
demonstrated that date seed powder contain saponin, that there was a significant difference before and
flavonoid, alkaloid and tannin. Among the test result, after treatment (p< 0.005). The beverage of date seeds
flavonoid and tannin test displayed strong color, can improve lipid profiles through decreasing of TC,
suggesting the highest content of flavonoid and TG, LDL and atherogenic index and increasing of
tannin. However, quantitative test of date seeds HDL levels.
powder contains mainly of flavonoids the amount of
21.68 mg / mL (Table 1). Date seeds contain more
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Saryono and Proverawati Transylvanian Review: Vol XXVI, No. 29, June 2018
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