GENESIS

(Post Graduation Medical orientation Centre)

Exam : Resi_Cell Injury_Genetics_Class_Test_2021
Class/Chapter :
Total Mark : 40 Time : 2100 Min
Date : 2021-02-24

1. Apoptotic cells usually exibit distinctive morphological 2. Cell membrane damage occurs due to:
features is usually seen in pure apoptosis? a). a) Progressive loss of membrane phospholipids
a). a) Cellular swelling b). b) Cytoskeletal injury
b). b) Phagocytosis of apoptotic bodies by neutrophils c). c) Loss of intracellular calcium
c). c) Early disruption of plasma membrane d). d) Inactivation of intracellular proteases
d). d) Nuclear stabilization e). e) Free radical induced injury
e). e) chromatin condensation TTFFT
FFFFT
3. Restoration of blood flow to an area of ischaemia leads to
a). a) Injury is paradoxically exacerbated and proceeds at an
accelerated pace
b). b) Activation of complement pathway – usually by IgG antibody
c). c) Sustain loss of cells are halted
d). d) Increased generation of ROS that blocks mitochondrial
permeability transition
e). e) Production of cytokines and increased expression of adhesion
molecules by parenchymal and endothelial cells
TFFFT

4. Coagulation necrosis 5. Hypertrophy is associated with an

a). a) Is a basic form of necrosis a). a) increase in the number of mitosis
b). b) Is encountered most often in tuberculosis b). b) increase in the bulk of a tissue or organ
c). c) Cell takes acidophilic stain c). c) increase in the number of cells in an organ or tissue
d). d) Preservation cellular outline d). d) absolute decrease in interstitial tissue
e). e) Is characteristic of focal bacterial infection e). e) increase in functional capacity of organs
TFTTF FTFFT

6. Regarding death receptor pathway 7. Regarding pyroptosis

a). a) Is mediated by receptor-ligand interaction
b). b) The prototypic death receptors are the type I TNF receptor
and Fas (CD95)
c). c) Fas Ligand is a cytoplasmic enzyme expressed mainly on
activated T lymphocyte
d). d) Causes activation of caspase 8
e). e) Involves Bcl-family proteins.
TTFTF
a). a) Associated with activation of a cytosolic danger-sensing
protein complex called the inflammasome
b). b) Inflammasome activation doesn’t result in caspase activation
c). c) Induced by production of cytokines but never cause fever
d). d) Doesn’t elicit inflammation
e). e) By this process some infectious microbes cause the death of
infected cell
TFFFT

8. Regarding Autophagy 9. Hydrogen peroxide can be neutralized by in our body-

a). a) May promote cancer growth a). a) Myeloperoxidase
b). b) May act as defence against cancer b). b) Catalase
c). c) In microautophagy there is outward bulging of lysosomal c). c) Superoxide dismutase
membrane for delivery d). d) Glucose-6-phosphate dehydrogenease
d). d) There is occurrence of indirect translocation across the e). e) Glutathione peroxidase
lysosomal membrane by chaperone proteins FTFFT
e). e) Involves the delivery of cytoplasmic materials to the lysosome
for degradation 10. Pathogenesis of fatty change in liver
TTFFT a). a) Increased phospholipids incorporation
b). b) Decreased conversion to cholesterol
c). c) Excess entry of apoprotein
d). d) Coupling and excretion defects.
e). e) Excess esterification of triglyceride
FTFTT

11. The sites of metastaticcalcification 12. Cellular aging-

a). a) Kidney a). a) Results from DNA damage
b). b) Wall of inferior venacava b). b) Is characterized by genetic instability
c). c) Old tuberculous lesion c). c) Is not modified by total calorie intake
d). d) Atheroma d). d) Results from elongation of telomerase
e). e) Cornea e). e) Results from activation of tumor suppressor genes
TFFFT TTFFT

13. Starvation is associated with a reduction in size of the: 14. Regarding irreversible cell injury
a). a) Fat depots a). a) If ischemia persists for 5-10 mins in the myocardium,
b). b) Heart irreversible injury occurs
c). c) Central nervous system b). b) Increased phospholipids reacylation and synthesis
d). d) Liver c). c) Activation of intracellular proteases causes degradation of
e). e) Bones cytoskeletal elements
TTFTF d). d) Pale coloration of nucleus due to fading of basophilia of

https://www.genesisedu.info/admin/exam-print-ans/706 1/3
 chromatin
e). e) Membrane damage is the central factor in the pathogenesis
FFTTT

15. Squamous metaplasia occurs in: 16. The following diseases are due to increased apoptosis
a). a) Colon a). a) Auto immune disorders
b). b) Cervix b). b) Spinal muscular atrophy
c). c) Uterus c). c) AIDS
d). d) Prostate d). d) Myocardial infarction
e). e) Pleura e). e) Viral hepatitis
FFTTF FFTTT

17. Caspase dependent mechanisms are-- 18. Examples of diseases caused by misfolding of proteins--
a). a) Extrinsic pathway of apoptosis a). a) Alpha-1 antitrypsin deficiency
b). b) Intrinsic pathway of apoptosis b). b) Creutzfeldt- Jacob disease
c). c) Necroptosis c). c) Familial hypercholesterolemia
d). d) Necrosis d). d) Retinitis pigmentosa
e). e) Pyroptosis e). e) Tay-Sachs disease
TTFFT TTTTT

19. Causes of cell injury are-- 20. Pro-apoptotic proteins are—

a). a) Autoimmune reactions a). a) BAK
b). b) Extremes of temperature b). b) BAX
c). c) Genetic defects c). c) BCL-2
d). d) Nutritional excess d). d) BCL-XL
e). e) Worm infections e). e) MCL-2
TTTTT TTFFF

21. Followings are genetically transmitted diseases; 22. Characteristics of autosomal dominant
a). a) Huntington’s chorea a). a) Both parents affected
b). b) Wilson’s disease b). b) There is full penetrance & acceptance of gene
c). c) Multiple sclerosis c). c) Homozygous gene show phenotype
d). d) Parkinson’s disease d). d) Vertical transmission
e). e) Myotonia dystrophica e). e) High new mutation rate
TTFFT FFFFT

23. Autosomal recessive diseases
a). a) Are transmitted on 50% of offspring
b). b) Remains as carrier in 50% of offspring
c). c) Complete penetrance is common
d). d) Increase risk of disease among offspring of consunquineous
marriage
e). e) Are more common among female children
FTTTF
24. The following statements are correct regarding X- linked
recessive trait
a). a) The trait manifests only in males.
b). b) The gene responsible for the condition is transmitted from an
affected man to all his daughters.
c). c) The gene is never transmitted directly from father to son.
d). d) A carrier female will transmit the condition to 25% of her
sons.
e). e) Normal offspring may be produced if mating occurs between
an affected male and a carrier female.
FTTFT

25. Which of the following genetic disorders are inherited as 26. Following are true statements regarding chromosome
X linked recessive? disorders--
a). a) Neurofibromatosis a). a) In Fragile X syndrome, the triplet repeat does not change in
b). b) Haemophilia A size significantly when passed from father to daughter.
c). c) Phenyl Ketonuria b). b) Fragile X syndrome is a single well defined condition.
d). d) Duchenne Muscular dystrophy c). c) Girls with bilateral inguinal hernia should have their
e). e) Glucose 6-phosphate dehydrogenese deficiency chromosomes tested.
FTFTT d). d) Normal karyotyping is a good way of diagnosing Fragile X
syndrome in girls.
e). e) Microarray-CGH analysis will detect genetic imbalances in
approximately 50% children with neurodevelopmental disorders.
TFTFF

27. Down’s syndrome: 28. Turner’s syndrome is characterized by

a). a) Has an incidence of 1:700 a). a) 45 XY chromosomal abnormality
b). b) Is associated with the age of the mothers b). b) Secondary amenorrohea
c). c) Mosaicism accounts for 2% of all Down’s syndrome c). c) Coarctation of the aorta
d). d) Is more accurately diagnosed in pregnant woman with d). d) Multicystic ovary
amniocentesis than hormonal tests e). e) Absence of pubic hair
e). e) Is associated with congenital glaucoma FFTFF
TTTTF
29. True statements include:
a). a) RNA can be studied by PCR (Polymerase chain reaction), It has
to be translated into complementary DNA
b). b) Western blotting is used to detect specific protein in a mixture
of protein.
c). c) Northern blotting is used to detect DNA sequence
d). d) Southern blotting is primarily used to detect DNA sequence
e). e) Gel electrophoresis is used in both Southern and Northe rn

https://www.genesisedu.info/admin/exam-print-ans/706 2/3
 blotting
TTFTT

30. Prenatal diagnosis is done in the following cases-- 31. In mitochondrial genetics
a). a) Congenital hypothyroidism a). a) Heteroplasmy refers to the presence of more than one
b). b) Neural tube defect mutation in mitochondria.
c). c) G6PD deficiency b). b) Mitochondrial genes mutate less often than nuclear genes.
d). d) Common variable immunodeficiency c). c) Mitochondrial conditions affect only muscle and nerve tissue.
e). e) Thalassaemia d). d) The risk of passing a mitochondrial condition to the next
FTTFT generation may be as high as 100%
e). e) Mitrochondrial diseases have nothing to do with nuclear genes.
FFFTF

32. Examples of chromosomal deletion- 33. Examples of trinucleotide repeat expansion disease
a). a) Retinoblastoma a). a) Fragile X syndrome
b). b) Squamous cell carcinoma of the lung b). b) Cystic fibrosis
c). c) Colorectal carcinoma c). c) Duchenne’s muscular dystrophy
d). d) Multiple endocrine neoplasia type 2A d). d) Myotonic dystrophy
e). e) Papillary carcinoma of the thyroid e). e) Friedreich’s ataxia
TFTTF TFFTT

34. Defects with structural protein synthesis are associated 35. Point mutations occur in
with: a). a) Cystic fibrosis
a). a) Down syndrome b). b) Alpha 2 antitrypsin deficiency
b). b) Hereditary spherocytosis c). c) Haemochromatosis
c). c) Marfan syndrome d). d) Hereditary motor and sensory neuropathy type- 1
d). d) Klinefelter syndrome e). e) Achondroplasia
e). e) Osteogenesis imperfecta FTTFT
FTTFT
36. Properties of genetic code?
a). a) Specific codes always cedes for different amino acid
b). b) Genetic code is universal without any minor exceptions.
c). c) Redundancy is sometimes called degenerate
d). d) Comma less and overlapping
e). e) It is read from a fixed starting point
FFTFT

37. Indications for Barr body count 38. Autosomatdominat disorders-

a). a) Inguinal mass in male a). a) Hereditary hemorrhagic telangiectasia
b). b) Severe hypospadias b). b) Brigade’s syndrome
c). c) Infertility of male c). c) Gilbert’s syndrome
d). d) Lymphoedema in male newborn d). d) Homocystinuria
e). e) Stigmata of turner’s syndrome e). e) Neurogenic muscular atnephy
FTTFT TTFFF

39. Metabdic disorders of AR disorders-
a). a)Phenylketonuria
b). b)Nephrogenic diabetes incipidus
c). c)Glucone-6-P dehydnoginane deficiency
d). d)Familial Hypercholesterolimia
e). e)Glycogen storage disease
TFFFT
40. When a hemophilic male marries a carrier female-
a). a) All of their son will be affected
b). b) Half of their son will be carriers
c). c) Half of their daughter will be carriers
d). d) There will be no affected daughters
e). e) Half of their non will be healthy
FTFTF

https://www.genesisedu.info/admin/exam-print-ans/706 3/3