GENESIS

(Post Graduation Medical orientation Centre)

Exam : Resi_Neoplasm_Class_Test_2021
Class/Chapter :
Total Mark : 40 Time : 2100 Min
Date : 2021-01-12

1. Best comparison between sarcoma and carcinoma 2. Cancers display following fundamental changes in cell
a). a) Lung is commonest site of metastasis in case of both physiology
carcinoma and sarcoma a). a) Sensitivity to growth-inhibitory signals
b). b) Haemorrhage and necrosis is more in carcinoma, as it contains b). b) Self-sufficiency in growth signals
numerous vessels c). c) Evasion of necrosis
c). c) Blood borne metastasis is not uncommon in carcinoma but d). d) Immortality
more rapid than sarcoma e). e) Ability to evade host immune response
d). d) Sarcoma rare in old age but carcinoma is common FTFTT
e). e) Carcinoma is epithelial in origin while sarcoma mesenchmal
TFFTT 3. Tumors which commonly metastasize to bones are
a). a) Carcinoma of the prostate
b). b) Carcinoma of the breast
c). c) Choriocarcinoma of the placenta
d). d) Carcinoma of the gallbladder
e). e) Renal cell carcinoma
TTFFT

4. Tumors presenting with early metastasis are 5. Locally malignant tumours are
a). a) Pancreatic carcinoma a). a) Ameloblastoma
b). b) Spermatocytic seminoma b). b) Basal cell carcinoma
c). c) Ameloblastoma c). c) Chondrosarcoma
d). d) Embryonal carcinoma d). d) Marjolin’s ulcer
e). e) Bowen's disease e). e) Neuroblastoma
TFFTF TTFTF

6. Parasites involved in the development of malignancy 7. Human oncogenic DNA viruses are
a). a) Schistosoma haematobium a). a) Parvovirus B19
b). b) Cysticercusbovis b). b) Epstein Barr virus
c). c) E granulosus c). c) Hepatitis B virus
d). d) Clonorcis sinensis d). d) Human papilloma virus
e). e) T gondii e). e) Human T –cell leukaemia virus
TFFTF FTTTF

8. Following are direct acting alkylation carcinogens 9. The following tumours of ovary are hormone secreting
a). a) βnapthylamine a). a) Theca cell tumour
b). b) βProprio lactone b). b) Solid teratoma
c). c) Aflatoxin c). c) Dysgerminoma
d). d) 1acetylimidazole d). d) Arrhenoblastoma
e). e) Dimethyl sulfate e). e) Fibroma
FTFFT TFFTF

10. Following malignancy(ies) is (are) hormone dependent 11. Hormone related carcinoma include
a). a) Papillary carcinoma of thyroid a). a) Breast carcinoma
b). b) Renal cell carcinoma b). b) Thyroid carcinoma
c). c) Carcinoma of breast c). c) Prostate carcinoma
d). d) Carcinoma of pancreas d). d) Colorectal carcinoma
e). e) Carcinoma of prostate e). e) Leukemia
TFTFT TTTFF

12. Paraneoplastic syndromes 13. Basal cell carcinoma

a). a) Occur in about 90% of patients with malignant diseases a). a) Slowly growing & very aggressive
b). b) May represent the earliest manifestation of an occult neoplasm b). b) Do not metastasize
c). c) May even be lethal c). c) Female are more affected
d). d) May mimic metastatic disease d). d) Common in lightly pigmented people
e). e) Rarely includes endocrinopathies e). e) Locally invasive
FTTTF TTFTT

14. The embryonic tumours of infancy include 15. Acanthosis rigricans Occur as a paraneoplastic syndrome
a). a) Nephroblastoma for
b). b) Osteogenic sarcoma a). a) Breast CA
c). c) Lymphoma b). b) Adult T cell leukaemia
d). d) Hodgkin disease c). c) Gastric carcinoma
e). e) Thyroid Carcinoma d). d) Cerebellar hemangioma
TFFFF e). e) Uterine caneered
FFTFT

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16. TP 53 gene 17. Alpha –fetoprotein is found in increase amount in
a). a) Is regarded as guardian of the genome a). a) Primary carcinoma of liver
b). b) Is a proto oncogene b). b) Colorectal carcinoma
c). c) Is a tumour suppressor gene c). c) Liver cirrhosis
d). d) Is present in chromosome 10 d). d) Duodenal atresia
e). e) Has no role in DNA repair and apoptosis e). e) Prostate cancer
TFTFF TFFTF

18. Frozen section is done 19. FNAC is the best option for
a). a) To see surgical margins of a malignant tumour a). a) Carcinoma of best
b). b) To see ganglion cells in suspected Hirschsprung disease b). b) Adrenal carcinoma
c). c) Peroperatively c). c) Cervical carcinoma
d). d) To categorize malignant tumour d). d) Follicular carcinoma
e). e) For immunohistochemistry e). e) Carcinoma of cervix uterus
TTTFT TFFFF

20. Exfoliative cytology is useful for the diagnosis of: 21. Preservatives are used after biopsy to:
a). a) Meningioma a). a) Process the tissue for microtome sectioning
b). b) Bronchial cancer b). b) Prevent autolysis of biopsy sample
c). c) Multiple myeloma c). c) Stabilize tissue architecture
d). d) Cervical cancer d). d) Prevent bacterial growth
e). e) Vesical cancer e). e) Keep tissue viable
FTFTT TTTFF

22. Cancer cachexia is associated with 23. Avascular necrosis of bone is caused by
a). a) Equal loss of both fat and lean muscle a). a) Steroid intake
b). b) More loss of fat than muscle b). b) Trauma
c). c) Elevated basal metabolic rate c). c) Radiotherapy
d). d) Reduced basal metabolic rate d). d) Tuberculosis
e). e) Evidence of systemic inflammation e). e) Hemoglobinopathies
TFTFT TTTFT

24. Arsenic poisoning is related to 25. Regarding all tumours following are true
a). a) Bowen’s disease a). a) Have two component parenchyma & stroma
b). b) malignant melanoma b). b) Parenchyma is composed of non-neoplastic components
c). c) basal cell carcinoma c). c) Benign tumours have no parenchymal structure
d). d) keratoacanthoma d). d) Biological character of neoplasm largely depends upon stromal
e). e) squamous cell carcinoma component
TFTFT e). e) Stromal component is crucial to the growth of neoplasm
TFFFT

26. Following are the examples of mixed tumours 27. Following tumours are histologically malignant
a). a) Tumour of salivary gland a). a) Mature teratoma
b). b) Fibroadenoma b). b) Melanoma
c). c) Teratoma c). c) Mesothelioma
d). d) Choriostoma d). d) Seminoma
e). e) Hematolymphoid tumours e). e) Papilloma
TTTFF FTTTF

28. Fundamental features by which most benign and 29. Anaplasia refers to -
malignant neoplasm can be distinguished are a). a) Backward formation
a). a) Nomenclature b). b) Lack of differentiation
b). b) Rapidity of growth c). c) Gaining of cellular polarity
c). c) Differentiation and anaplasia d). d) Light staining of nucleus
d). d) Local invasion e). e) Reliable indicator of benign neoplasm
e). e) Metastasic change TTFFF
FFTTT
30. Chronic inflammatory condition that lead to formation of
cancers
a). a) Chronic cholecystitis
b). b) Sjogren syndrome
c). c) IBD
d). d) Rheumatoid arthritis
e). e) Urethritis
TTTFF

31. Autosomal recessive syndromes that causes defective 32. Regarding `RB gene
DNA repair- a). a) Guardian of the genome
a). a) Retinoblastoma b). b) Directly or indirectly activated in most of the human cancers
b). b) Bloom syndrome c). c) If retinoblasts gains more RB gene activation it produces
c). c) Xeroderma pigmentosa retinoblastoma
d). d) Li-Frauemeni syndrome d). d) Mutated RB gene is only found in retinoblastoma
e). e) MEN 1& 2 e). e) Governer of the cell cycle
FTTFF FFFFT

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33. Regarding differentiation and anaplasia of a tumor 34. Hypoglycemia appers as a paraneoplastic syndromes in
a). a) malignant tumors are never well-differentiated following tumours
b). b) benign tumors may show features of anaplasia a). a) Gastric carcinoma
c). c) staging is dependent on the above factors b). b) Pancreatic carcinoma
d). d) are assessed under microscope c). c) Thymoma
e). e) are subjective assessment d). d) Fibrosarcoma
FFFTF e). e) Ovarian carcinoma
FFFTT

35. Following Agents used for histopathology? 36. What are steps in invasion of extracellular matrix?
a). a) Bouin's Fluid a). a) Loosening of intercellular connection
b). b) 37% Normal saline b). b) Local degradation of basement membrane
c). c) 100% Methanol c). c) Changes in attachment of tumor cells to extracellular protein
d). d) 10%. Formal saline d). d) Locomotion
e). e) Alchohol e). e) Self instefficiency to growth signals
TFFTF TTTTF

37. Broder's classification of tumors attempted to classify 38. Carcinoembryonic antigen is elevated in
tumors according to: a). a) Heart failure
a). a) Their origin b). b) Ulcerative colitis
b). b) Degree of differentiation of a tumor c). c) Primary liver cancer
c). c) Degree of stromal response d). d) Seminoma
d). d) Degree of lymphocytic infiltration of the tumor e). e) Colorectal cancer
e). e) Number of mitosis found in a given area of the tumor FTFFT
FTFFT
39. Alpha fetoprotein is found in increase amount in
a). a) Primary carcinoma of liver
b). b) Colorectal carcinoma
c). c) Liver cirrhosis
d). d) Duodenal atresia
e). e) prostate cancer
TFFTF

40. An increase in the frequency of malignant disease occurs

in the following conditions:
a). a) Following the long-term administration of immunosuppressive
agent
b). b) Large bowel crohns disease
c). c) Coeliac disease
d). d) Ulcerative colitis
e). e) Xeroderma pigmentosum
TFTTT

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