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    Chastine Mae Garaygay
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    1. The substance impedes the binding of NAD+ to electrons. This prevents the formation of NADH needed to produce ATP through cellular respiration. Without sufficient ATP, the body breaks down stored fats, leading to weight loss. 2. Increasing the permeability of the inner mitochondrial membrane to protons allows more protons to pass through the membrane. This increases the proton gradient needed to drive ATP synthesis. The increased ATP production satisfies the body's energy demands without breaking down as many fat stores, so weight gain may result. 3. Adding more protons to the intermembrane space of mitochondria also increases the proton gradient for ATP production. Like the previous substance, this could lead to weight gain by meeting

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    Original Title

    Activity-PLaying-with-Cell-Respiration

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    1. The substance impedes the binding of NAD+ to electrons. This prevents the formation of NADH needed to produce ATP through cellular respiration. Without sufficient ATP, the body breaks down stored fats, leading to weight loss. 2. Increasing the permeability of the inner mitochondrial membrane to protons allows more protons to pass through the membrane. This increases the proton gradient needed to drive ATP synthesis. The increased ATP production satisfies the body's energy demands without breaking down as many fat stores, so weight gain may result. 3. Adding more protons to the intermembrane space of mitochondria also increases the proton gradient for ATP production. Like the previous substance, this could lead to weight gain by meeting

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    26 views2 pages

    Other Than The One Described

    Uploaded by

    Chastine Mae Garaygay
    1. The substance impedes the binding of NAD+ to electrons. This prevents the formation of NADH needed to produce ATP through cellular respiration. Without sufficient ATP, the body breaks down stored fats, leading to weight loss. 2. Increasing the permeability of the inner mitochondrial membrane to protons allows more protons to pass through the membrane. This increases the proton gradient needed to drive ATP synthesis. The increased ATP production satisfies the body's energy demands without breaking down as many fat stores, so weight gain may result. 3. Adding more protons to the intermembrane space of mitochondria also increases the proton gradient for ATP production. Like the previous substance, this could lead to weight gain by meeting

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    of 2

    Performance Task

    Activity-“‘Playing’ with Respiration”

    Consider the impact of each substance on cellular respiration. Each substance has an influence at the
    cellular level, and has no effect on hunger. Assume that the substances have no other impact on the cell
    other than the one described.

    1. Substance’s Effect: Impedes the binding of NAD+ to electrons.

    Facilitator: Chastine Mae T. Garaygay

     Classification: Potentially effective in promoting (circle one):


    Weight Loss Weight Gain

     Explanation for effect:

    2,4-DINITROPHENOL
     Is an organic compound. It is a yellow crystalline solid that has a sweet musty odor.
     Is an uncoupler, or has the ability to separate the flow of electrons and the pumping of H +
    ions for ATP synthesis.

    Does DNP promotes weight loss or weight gain?

    The substance impedes the binding of NAD + to electrons. Now what is NAD+? It stands for
    Nicotinamide Adenine Dinucleotide, it is a carrier molecule that carries electrons and protons that
    can be utilized by the mitochondria to produce ATP. NAD+ is converted to NADH and since there
    is an uncoupler, NADH couldn't be formed to be used by the cell and the cell could not produce
    ATP. When the body is not receiving enough ATP to break down the foods that we eat, it will
    breakdown fats as a form of storage energy which will lead to weight loss.

    2. Substance’s Effect: Makes the lipid bilayer of the inner mitochondrial membrane highly permeable to
    (H+) protons.

    Facilitator: Janna Alo

     Classification: Potentially effective in promoting (circle one):


    Weight Loss Weight Gain

     Explanation for effect:

    3. Substance’s Effect: Increases the number of free hydrogen ions or protons (H+) in the intermembrane
    space of the mitochondria (between the outer and inner membranes).

    Facilitator: Thalia Grace Granada

     Classification: Potentially effective in promoting (circle one):


    Weight Loss Weight Gain

     Explanation for effect:


    Performance Task
    Learning that when glucose or another source of energy such as creatinine which is used by our
    muscle cells, is degraded, it releases protons as well as energy. Then, those protons will be stored in the
    internal membrane space, and when those protons go through the inter-membrane of mitochondria,
    they make the ATPase enzyme work, where said enzyme takes that energy to produce ATP. Further, if
    something ever happens such as preventing the protons to go through the inter-membrane of
    mitochondria, then they can’t make the ATPase enzyme work, so that energy will be released as heat.
    Leading for the body to “feel” that it is in need of more ATP, hence, your body cells will go “oh it
    seems that I haven’t degraded enough glucose, so let’s degrade more glucose”: resulting for you to lose
    weight.

    4. Substance’s Effect: Partially blocks the H+/pyruvate symporter, interfering with the transport of
    pyruvate into the mitochondria.

    Facilitator: Shane M. Sumagaysay

     Classification: Potentially effective in promoting (circle one):


    Weight Loss Weight Gain

     Explanation for effect:

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