Name of Dosage, Indication Contra- Mechanism Adverse Nursing

Drug Route & indication of Action Effects Responsibility

Frequency
Generic Adult: PO Symptomati Narrow- Synthetic GI: Dry mouth, Before:
Name: 5–15 mg/d c treatment angle tertiary nausea, - Give before or
Trihexy- in divided of all forms glaucoma. amine constipation. after meals,
phenidol doses of Safety during anticholinergi depending on
parkinsonis pregnancy c agent Special how patient
m (arterio- (category C), similar to Senses: reacts.
Brand sclerotic, lactation, or atropine. Blurred vision,
Name: idiopathic, in children is Thought to mydriasis, During:
Artane posten- not act by photophobia, - Be aware that
cephalitic). established. blocking angle-closure incidence and
Also to excess of glaucoma. severity of
Therapeu- prevent or acetylcholine adverse effects
tic Class: control at certain Urogenital: are usually
Anticholi- drug- cerebral Urinary dose related
nergic induced synaptic hesitancy or and may be
extrapyrami sites. retention. minimized by
dal Relaxes dosage
Medicatio disorders. smooth CNS: reduction.
n Ticket: muscle by Dizziness, Older adults
direct effect nervousness, appear more
and by insomnia, sensitive to
atropinelike drowsiness, usual adult
blocking confusion, doses.
action on the agitation, - Monitor vital
para- delirium, signs. Pulse is
sympathetic psychotic a particularly
nervous manifestations, sensitive
system. euphoria. indicator of
response to
CV: drug. Report
Tachycardia, tachycardia,
palpitations, palpitations,
hypotension, paradoxical
orthostatic bradycardia, or
hypotension. fall in BP.

Body as a After:
Whole: Hyper- - Assess for
sensitivity and report
reactions. severe CNS
stimulation
(see
ADVERSE
EFFECTS) that
occurs with
high doses,
and in patients
with
arteriosclerosis
, or those with
history of
hypersensitivity
 to other drugs.
- Monitor daily
I&O if patient
develops
urinary
hesitancy or
retention.
Voiding before
taking drug
may relieve
problem.
- Check for
abdominal
distention and
bowel sounds if
constipation is
a problem.
- Monitor
intraocular
pressure at
regular
intervals.
Kamo lay pagAPA hihi if need ang reference
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Name of Dosage, Indication Contra- Mechanism Adverse Nursing

Drug Route & indication of Action Effects Responsibility
Frequenc
y
Generic Adult: PO Manageme Known Potent CNS: Before:
Name: 0.5–10 nt of hypersensitiv phenothiazin Extrapyramida - Give oral
Fluphenaz mg/d in 1– manifestatio ity to e, l symptoms preparations at
ine 4 divided ns of phenothiazin antipsychotic (resembling least 1 h before
doses psychotic es; agent. Blocks Parkinson's or 2 h after the
(max: of disorders. subcortical postsynaptic disease), antacid.
Brand 20 mg/d) brain dopamine tardive Antacids
Name: damage, receptors in dyskinesia, diminish
Sedepres IM/SC HCl comatose or the brain. sedation, absorption.
2.5–10 severely Similar to drowsiness,
mg/d depressed other dizziness, During:
Therapeu- divided states, blood phenothiazin headache, - Be alert for
tic Class: q6–8h dyscrasias, es with the mental red, dry, hot
Antipsych (max: 10 renal or following depression, skin; full,
otic mg/d); hepatic exceptions: catatonic-like bounding pulse,
Decanoat disease. more potent state, impaired dilated pupils,
e 12.5–25 Safety during per weight, thermoregulati dyspnea,
Medication mg q1– pregnancy higher on, grand mal mental
Ticket: 4wk; (category C) incidence of seizures. confusion,
Enanthate or lactation is extrapyramid elevated BP,
25 mg not al CV: temperature
q2wk established. complication Tachycardia, over 40.6° C
Parenteral s, and lower hypertension, (105° F). Inform
form not frequency of hypotension. physician and
recommende sedative, institute
d for children hypotensive, GI: Dry mouth, measures to
<12 y. and nausea, reduce body
antiemetic epigastric temperature
effects. pain, rapidly.
constipation, Extended
fecal exposure to
impaction, high
cholecystic environmental
jaundice. temperature, to
sun's rays, or to
Urogenital: a high fever
Urinary places the
retention, patient taking
polyuria, this drug at risk
inhibition of for heat stroke.
ejaculation. - Report
immediately
onset of mental
depression and
extrapyramidal
symptoms. Both
occur
frequently,
particularly with
long-acting
forms
(decanoate and
enanthate).

After:
- Monitor BP
during early
therapy. If
systolic drop is
more than 20
mm Hg, inform
physician.
- Monitor I&O
ratio and bowel
elimination
pattern. Check
for abdominal
distension and
pain. Monitor
for xerostomia
and
constipation.
- Lab tests:
Monitor kidney
function in
 patients on
long-term
treatment.
Withhold drug
and notify
physician if
BUN is elevated
(normal BUN:
10–20 mg/dL).
Also perform
WBC with
differential, liver
function tests,
periodically.

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Name of Dosage, Indication Contra- Mechanism Adverse Nursing

Drug Route & indication of Action Effects Responsibility
Frequency
Generic Adult: PO Manifestatio Hypersensiti Xanthene CNS: Before:
Name: 2 mg t.i.d., ns of vity to derivative Drowsiness, - Empty capsule
Taractan may psychotic thioxanthene chemically insomnia, and give with
increase disorders. s and and dizziness, water or mix with
up to 15 phenothiazin pharmacologi cerebral food; useful if
Brand mg/d as es; children cally similar edema, patient unable or
Name: needed or <12 y; to convulsions, unwilling to
Navane tolerated comatose chlorprothixe extrapyramidal swallow the
(max: 60 states; CNS ne and the symptoms capsule.
mg/d) depression; piperazine (dose related), - Give IM
Therapeu- circulatory phenothiazin paradoxical injection deep
tic Class: IM 4 mg collapse; es. exaggeration into upper outer
Phenothia b.i.d. to blood Mechanism of psychotic quadrant of
zine q.i.d. dyscrasias. of symptoms; buttock. Aspirate
Antipsych (max: 30 Safety during antipsychotic sudden death, carefully before
otic mg/d) pregnancy effects is neuroleptic injection. Rotate
(category C) unclear; malignant injection sites.
or lactation is thought to be syndrome,
Medicatio not related to tardive During:
n Ticket: established. blockade of dyskinesia, - Report
postsynaptic depressed extrapyramidal
dopamine cough reflex. effects
receptors in (pseudoparkinso
the brain. GI: nism, akathisia,
Xerostomia, dystonia) to
constipation. physician; dose
adjustment or
CV: short-term
Tachycardia, therapy with an
orthostatic antiparkinsonism
hypotension agent may
(especially provide relief.
with IM). - Be alert to first
symptoms of
Urogenital: tardive
Impotence, dyskinesia (see
gynecomastia, Appendix F).
galactorrhea, Discontinue drug
amenorrhea. immediately and
inform physician.
Skin: Rash,
contact After:
dermatitis, - Monitor BP for
photosensitivit excessive
y. hypotensive
response when
Special thiothixene is
Senses: added to drug
Blurred vision, regimen of
pigmentary patient on
retinopathy. hypertensive
treatment until
Metabolic: therapy is
Decreased stabilized.
serum uric - Monitor
acid levels. response when
patient is
changed from IM
to PO forms
(capsules,
concentrate).
Dosage
adjustment may
be necessary.
- Monitor for
therapeutic
response.
Although
therapeutic
response can be
observed 1–6 h
following IM
injection, it may
be days or
several weeks
before there is a
response with
oral drug.
- Keep patient
recumbent for at
least 1 h
following IM
because of
possibility of
orthostatic
hypotension.
 Check BP
periodically.

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