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  • Nuclear Receptors: G-Protein Coupled

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    Jordan Douglas
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    This document outlines several key cellular signaling pathways including: 1) G protein-coupled receptors that can activate adenylyl cyclase and increase cyclic AMP (cAMP) levels leading to protein kinase A (PKA) activation; 2) G protein-coupled receptors that activate phospholipase C and generate inositol triphosphate (IP3) and diacylglycerol (DAG) to mobilize calcium and activate protein kinase C (PKC); and 3) four superfamilies of cell surface receptors including tyrosine kinase receptors, serine/threonine kinase receptors, and cytokine receptors that activate intracellular signaling cascades upon ligand binding.

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    receptors

    Original Title

    FOUR_superfamilies_receptors

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    This document outlines several key cellular signaling pathways including: 1) G protein-coupled receptors that can activate adenylyl cyclase and increase cyclic AMP (cAMP) levels leading to protein kinase A (PKA) activation; 2) G protein-coupled receptors that activate phospholipase C and generate inositol triphosphate (IP3) and diacylglycerol (DAG) to mobilize calcium and activate protein kinase C (PKC); and 3) four superfamilies of cell surface receptors including tyrosine kinase receptors, serine/threonine kinase receptors, and cytokine receptors that activate intracellular signaling cascades upon ligand binding.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    2 views2 pages

    Nuclear Receptors: G-Protein Coupled

    Uploaded by

    Jordan Douglas
    This document outlines several key cellular signaling pathways including: 1) G protein-coupled receptors that can activate adenylyl cyclase and increase cyclic AMP (cAMP) levels leading to protein kinase A (PKA) activation; 2) G protein-coupled receptors that activate phospholipase C and generate inositol triphosphate (IP3) and diacylglycerol (DAG) to mobilize calcium and activate protein kinase C (PKC); and 3) four superfamilies of cell surface receptors including tyrosine kinase receptors, serine/threonine kinase receptors, and cytokine receptors that activate intracellular signaling cascades upon ligand binding.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    Adnyyl cyclase -- cAMP -- PKA

    PLC + PIP2 --> Inositol triphosphate (IP3)


    Intracellular [calcium] + diacylglcyerol
    G-Protein coupled
    (DAG) PKC

    receptors
    GPCR-linked ion channels Calcium channel
    Potassium channel

    Rho kinase

    MAP kinase

    Ligand-gated ion

    channels
    Properties &
    Examples:For fast
    response
    Mechanisms Kinases receptors
    Agonist binding receptor
    dimerization
    authophosphorylation of tyrosine
    residues FOUR superfamilies receptors
    SH2 domain binding to
    phosphorylated receptors SH2
    gets phosphorylated activation of
    various cellular responses

    Three main types: (1) Tyrosine kinase;


    (2) serine/threonine kinase (3) cytokine
    receptors

    Binding to intracellular Ligand-receptor complex binds to HRE in


    receptors gene promoters Up-regulation or down-
    regulation of gene
    expression

    Nuclear receptors

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