Lanthanide‐Doped Near‐Infrared Nanoparticles for Biophotonics - Li - 2... https://onlinelibrary.wiley.com/doi/10.1002/adma.

202000678

Advanced Materials / Volume 33, Issue 6 / 2000678

Progress Report

Lanthanide-Doped Near-Infrared Nanoparticles for Biophotonics

Hui Li, Xin Wang, Tymish Y. Ohulchanskyy, Guanying Chen 

First published: 08 July 2020

https://doi.org/10.1002/adma.202000678
Citations: 31

Abstract
Light in the near-infrared (NIR) spectral region is increasingly utilized in bioapplications,
providing deeper penetration in biological tissues owing to the lower absorption and
scattering in comparison with light in the visible range. Lanthanide-doped luminescent
nanoparticles with excitation and/or emission in the NIR range have recently attracted
tremendous attention as one of the prime candidates for noninvasive biological
applications due to their unique optical properties, such as large Stokes shift, spectrally
sharp luminescence emissions, long luminescence lifetimes, and excellent photostability.
Herein, recent advances of lanthanide-doped nanoparticles with NIR upconversion or
downshifting luminescence and their uses in cutting-edge biophotonic applications are
presented. A set of e�cient strategies for overcoming the fundamental limit of low
luminescence brightness of lanthanide-doped nanoparticles is introduced. An in-depth
literature review of their state-of-art biophotonics applications is also included, showing
their superiority for high-resolution imaging, single-nanoparticle-level detection, and
e�cacy for tissue-penetrating diagnostics and therapeutics.

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