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Suxamethonium
> Indications > Incompatibility > Drug Interactions
> Dosage > Contraindications > Mechanism of Action
> Dosage Details > Special Precaution > Storage
> Reconstitution > Adverse Drug Reactions > MIMS Class  
> Monitoring Parameters
> Overdosage

Indications Muscle relaxant in general anesth.

Dosage Adult : IV As suxamethonium Cl: 0.3-1.1 mg/kg inj as a single dose, then 50-100% of the initial dose may be
given at 5-10 min intervals. For prolonged procedures, 0.1-0.2% soln by infusion at 2.5-4 mg/min. Max: 500
mg/hr. IM As suxamethonium Cl: 3-4 mg/kg. Max: 150 mg.
Dosage Details Intramuscular
Muscle relaxant in general anaesthesia
Adult: As suxamethonium Cl: 3-4 mg/kg. Max: 150 mg.
Child: As suxamethonium Cl: <1 yr Up to 5 mg/kg; ≥1 yr Up to 4 mg/kg. Max: 150 mg.

Intravenous
Muscle relaxant in general anaesthesia
Adult: As suxamethonium Cl: Single dose of 0.3-1.1 mg/kg by inj. Supplementary doses of 50-100% of
the initial dose may be given at 5-10 min intervals. For prolonged procedures, 0.1-0.2% soln by infusion
at 2.5-4 mg/min, adjusted as necessary. Max (repeated inj or continuous infusion): 500 mg/hr.
Child: As suxamethonium Cl: <1 yr 2 mg/kg; 1-12 yr 1 mg/kg.
Reconstitution Intravenous: Most Read Articles
IV infusion: Suxamethonium Cl 1 g powd for inj or 20 mL of a soln containing 50 mg/mL may be added to
1,000 mL or 500 mL of diluent (e.g. dextrose 5%, dextrose 5% and NaCl 0.9%, NaCl 0.9%, or (1/6) M Na
lactate inj) to provide a soln containing 1 mg/mL (0.1%) or 2 mg/mL (0.2%), respectively. Alternatively, 1. Do small practices have a
suxamethonium Cl 500 mg powd for inj or 10 mL of a soln containing 50 mg/mL may be added to 500 mL place in the future of
or 250 mL of diluents to provide a soln containing 1 mg/mL (0.1%) or 2 mg/mL (0.2%), respectively. healthcare?
Incompatibility Intravenous:
Alkaline soln w/ pH exceeding 8.5 (e.g. barbiturates). Y-site: Thiopental, heparin. 2. 6 of the worst hospital
systems around the world
Contraindications Genetically determined disorders of plasma pseudocholinesterase; personal or familial history of
malignant hyperthermia, myopathies associated w/ elevated serum creatine kinase values, angle-closure
glaucoma, penetrating eye injuries, raised intraocular pressure; neurological deficits involving acute major
muscle wasting (upper and/or lower motor neuron lesions); extensive denervation of skeletal muscle 3. 5 common foods that may
because of disease or injury to the CNS, pre-existing hyperkalaemia. Patient recovering from major trauma, interact with medications
extensive or severe burns.
Special Precautions Hypersensitivity to any neuromuscular blocker. Patient w/ reduced plasma cholinesterase activity, bone
fractures, neuromuscular disorders, cardiac or resp disease, electrolyte imbalance, suspected cardiac 4. Healthcare professionals: 5
glycoside toxicity. Childn. Pregnancy and lactation. volunteering opportunities in
Adverse Drug Reactions Prolonged resp depression or apnoea, bradycardia, tachycardia, hypotension, HTN, raised intraocular the Asia-Pacific...
pressure, hyperkalaemia, muscle fasciculation, excessive salivation, jaw rigidity, rash.
Potentially Fatal: Anaphylactic and anaphylactoid reactions, acute rhabdomyolysis w/ hyperkalaemia
5. Philippines to host
followed by ventricular dysrhythmias and cardiac arrest, malignant hyperthermia. International Medical Tourism
Monitoring Parameters Monitor cardiac function and oxygenation during admin; temp, serum K and Ca, assisted ventilator status; Summit 2017
neuromuscular function w/ peripheral nerve stimulator.
Overdosage Symptoms: Apnoea, prolonged muscle paralysis, decreased resp reserve, low tidal vol. Management:
Symptomatic and supportive treatment. Maintain airway and adequate ventilation until recovery of normal
Infections due to β-
respiration is assured. Use of neostigmine to reverse a non-depolarising suxamethonium-induced block lactamase-producing
should be accompanied by appropriate doses of an anticholinergic agent (e.g. atropine). Haemophilus influenzae
including resp tr..
Drug Interactions Prolonged neuromuscular blocking effects w/ specific anticholinesterase agents (e.g. neostigmine),
cytotoxic compd (e.g. cyclophosphamide), antiarrhythmics (e.g. quinidine), aminoglycosides, psychiatric
drugs (e.g. chlorpromazine), Mg salts, anaesth agents (e.g. morphine), SSRIs, organophosphate NasoClear (sodium chloride)
insecticides. Increased susceptibility to the effects of suxamethonium-exacerbated hyperkalaemia w/
digitalis-like drugs.
Mechanism of Action Description: Suxamethonium Cl is an ultrashort-acting depolarising type skeletal muscle relaxant. It blocks Nexonav (esomeprazole
magnesium trihydrate)
the neuromuscular junction by binding to the cholinergic receptors and depolarising it.
Onset: 0.5-1 min (IV); approx 2-3 min (IM).
Duration: 4-6 min (IV); 10-30 min (IM). Pulmodual (ipratropium
Pharmacokinetics: bromide, salbutamol sulfate)
Distribution: Crosses the placenta (small amounts).
Metabolism: Rapidly hydrolysed by plasma cholinesterase.
Excretion: Via urine, approx 10% as unchanged drug.
Teli 40/Teli 80 (telmisartan)
Storage Store between 2-8°C.
MIMS Class Neuromuscular Blocking Agents Treatment of CAD:
Symptomatic treatment of
  chronic stable angina
  pectoris in CAD adul..
Disclaimer: This information is independently developed by MIMS based on Suxamethonium from various references and is provided for your reference only. Therapeutic
uses and prescribing information may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Wosulin-30/70 (insulin,
Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse insulin, isophane, ...)
of the information contained herein, its contents or omissions, or otherwise. Copyright © 2016 MIMS. All rights reserved. Powered by MIMS.com

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