PCOG

For numbers 1-5, refer to the structure of a beta-lactam

antibiotic.

1. The functional group attached to the acyl amino 6. Preservatives like parabens increase their
group is called a/an: preservative property by

A.) Phenoxyethyl A.) Reducing the parent compound

B.) Isoxazoyl B.) Decreasing molecular weight
C.) Imidazole C.) Attaching a halogen to the parent compound
D.) Benzyl D.) Substituting the parent compound with a
E.) Methoxypheny lipophilic group
E.) Increasing the molecular weight
2. Halogen substituents are best placed in what
position? 7. Sodium pump is an example of
A.)enzyme-linked tyrosine kinase receptor
A.) 1,2-substitution B.) G-protein coupled receptor
C.) Ion- channel
B.) 1,3-substitution
D.)Gene transcription-linked receptor
C.) 1,4-substitution E.) None of the above
D.) Both A and B
E.) Both A and C 8. This is an approach in drug discovery wherein
there is already an existing drug that can be
3. This antibiotic is primarily indicated for what type used to identify a new lead compound?
of infection?
A.) Random Screening
A.) Klebsiella B.) Molecular Docking
B.) Enterobacter C.) Parent compound modification
C.) Psudomonas D.) Biotechnology techniques
D.) Staphylococci E.) Rational Drug Design
E.) Streptococi
9. Azeotropic distillation of benzene is done in what
4. Adding more than 1 chloride atoms in the concentration of ethanol?
structure confers what modification on the
A.) 95%
pharmacokinetic profile of the drug?
B.) 70%
C.) 50%
A.) Liberation
D.) 99%
B.) Absorption
E.) 10%
C.) Distribution
D.) Metabolism
10. Radical reactions may also proceed using this
E.) Excretion
reagent

5. What is the role of chloride atoms in the A.) Bromine water

structure? B.) Hydrogen peroxide
C.) Nitric acid
A.) Increase the susceptibility to penicillinase D.) Sodium oxalate
B.) Increasing the plasma concentration E.) Potassium bitartrate
C.) Acid resistance property
D.) Increase in parenteral absorption
E.) Increase in oral absorption
 16. The addition of hydrogen molecule to an alkene
is catalyzed by what metal?
For numbers 11-14, refer to the series of the reaction
A.) Silver
11. What is the reagent needed for the first
B.) Palladium
reaction?
C.) Berrylium
D.) Gallium
A.) NaOH/ Oxidizing agent
E.) Osmium
B.) CH3 Cl/AlCl3
C.) HNO3/H2SO4
17. Methoxybenzene is also known as _____
D.) NaOH/ Reducing agent
E.) CH3Br/NaNH2
A.) Anisole
B.) Toluene
12. The product formed with the reaction is
C.) Aniline
A.) Benzyl alcohol D.) Xylene
B.) Phenol E.) Anethole
C.) Benzoic acid
18. Which of the following compounds can be use to
D.) Xylene
synthesize primary alcohol?
E.) Anisole
A.) Propane
13. The reagent needed for the reaction to proceed
B.) Formaldehyde
is
C.) 3-chloropentane
A.) CH3Br/NaNH2 D.) Acetone
B.) NaOH/Reducing agent E.) Ethanamine
C.) CH3COCl/AlCl3
19. Which of the following cephalosporin is excreted
D.) HNO3/H2SO4
in bile?
E.) NaOH/ Oxidizing agent
A.) Cefixime
14. The reagent needed for the reaction to proceed B.) Cefotaxime
is C.) Ceftriaxone
D.) Moxalactam
A) NaOH/Oxidizing agent E.) Loracarbef
B) CH3Br/NaNH2/NO2
C) H2O/H2SO4 20. What is the product of aromatic hydroxylation of
D) NaOH/Reducing agent this drug?
E) NBS

15. When a carbonyl group reacts with a secondary

21. Preservatives use for molds
amine, what will be the resulting product?
A.) Ethylparaben
A.) Imine
B.) Methylparaben
B.) Amide
C.) Butylparaben
C.) Tertiary amine
D.) Propylparaben
D.) Enamine
E.) Isopropylparaben
E.) Secondary amine
 22. Which is true about drug absorption? A.) Aryl amide
I. For weakly acidic drug, it must e in its B.) Acyl amide
unionized form C.) Polyamide
II. For weakly acidic drug, it must be in its D.) Carboxyamide
ionized form E.) Phenylamide
III. For weakly basic drug, it must be in its
unionized form 27. Which of the following is true on ideal antiseptic?
IV. For weakly basic drug, it must be in its I. Low toxicity
ionized form II. Sustained and rapid lethal action against
microorganisms
A.) I, II, III III. High surface tension
B.) I and III IV. Non-irritating and non-allergenic
C.) II and IV
D.) III and IV A.) I, II, IV
E.) I and III B.) III only
C.) I, II, III, IV
23. This anti-convulsant compound is susceptible to D.) II and III
what metabolic pathway? E.) III and IV

A.) Aromatic hydroxylation 28. Aztreonam can elevate this enzyme

B.) Methylation
C.) Sulfate conjugation A.) Creatinine kinase
D.) Oxidative deamination B.) Pyruvate kinase
E.) GSH conjugation C.) Alanine aminotransferase
D.) Creatinine phosphokinase
For numbers 24-26, refer to the general structure of E.) Thrombin
penicillin
For numbers 29-33, Refer to the structure of this
24. Which of the following will confer resistance antibacterial agent
against beta lactamases when synthesizing
analogs of penicillin? 29. The functional group in the box is an additional
chemical entity of this drug that makes it a
A.) Halogens prodrug, what is the probable reason of adding
B.) Ring deactivators that moiety to the parent compound?
C.) Electron withdrawing group
D.) Bulky group A.) Increase in absorption
E.) Ring activators B.) Increase in palatability
C.) Decrease in Protein binding
25. What functional group is being modified if D.) Increase in solubility
formulation into a salt is needed? E.) Decrease in absorption

A.) Amide
B.) Carboxylic acid 30. The main functional group of this prodrug is a/an
C.) Carbonyl
D.) Alkyl A.) Amide
E.) 225g B.) Nitro
C.) Alcohol
D.) Ester
E.) Acyl halide

31. When the drug will undergo metabolism, which

of the following enzymes will act on it?

26. What is the functional group attached to the beta A.) Ligases
lactam ring? B.) Hydrolases
C.) Transferases
 D.) Isomerases
E.) Lyases 38. The type of bond that exists in the structure

32. When the drug is acted upon by different A.) Amide bond
enzymes during its metabolism, what is/are the B.) Ether bond
products? C.) Tert-amine bond
D.) Ester bond
A.) Alcohol E.) Glycosidic bond
B.) Amide
C.) Carboxylic acid 39. This compound may produce the following
D.) A and B effects, except
E.) B and C
A.) Vasoconstriction
33. This drug is an example of B.) Bradycardia
C.) Metallic taste
A.) Cell wall synthesis inhibitor D.) CNS depression
B.) Cell membrane disruptor E.) Sodium channel blockage
C.) Protein synthesis inhibitor
D.) Nucleic acid synthesis inhibitor 40. The compound is an example of what class of
E.) Alkylating agent drugs?

34. The compound use to identify the partition A.) Anesthetic

coefficient in-vitro B.) Barbiturate
C.) Sedatives
A.) Tert-butyl alcohol D.) Analgesic
B.) Phenol E.) Anxiolytics
C.) Isopentyl alcohol
D.) N-octanol 41. The absorption of this compound is governed by
E.) Benzyl alcohol what equation?

35. yyu is metabolized by humans principally by A.) Noyes-Whitney equation

B.) Fick’s Law of Diffusion
A.) Aceylationiouub C.) Beer’’s Law
B.) Deamination D.) Henderson-Hasselbalch equation
C.) Methylation E.) None of the above
D.) Conjugation
E.) Oxidation 42. This compound is derived from the destructive
distillation of castor oil and it is use as a
36. The total affinity of the ligand to its receptor keratolytic agent

A.) Intrinsic activity A.) Salicylic acid

B.) Agonistic activity B.) Undecylanic acid
C.) Avidity C.) Benzoic acid
D.) Antagonistic activity D.) Chrysarobin
E.) Agonistic affinity E.) Propionic acid
43. The following are example of G protein coupled
receptors, except
37. Dimethylbenzene is also known as
A.) GABA receptors
A.) Anisole B.) Beta-2 receptors
B.) Aniline C.) Muscarinic receptors
C.) Xylene D.) Alpha -1 receptors
D.) Phenol E.) Beta -1 receptors
E.) Ethylene
44. DNA Alkylating agent binds to its target by
For numbers 38-41, refer to the structure below means of what bond?
 C.) Ethacrinic acid
A.) Hydrogen bonding D.) Acetazolamide
B.) Electrostatic bonding E.) Spironolactone
C.) Hydrophobic bonding
D.) Ionic bonding 51. What is 1,4- dihydroxybenzene?
E.) Covalent bonding
A.) Catechol
45. In the presence of a full agonist, a partial agonist B.) Phenol
becomes C.) Xylene
D.) Hydroquinone
A.) Agonist E.) Resorcinol
B.) Antagonist
C.) Partial agonist 52. Halogenation of alkanes is possible in what type
D.) Inverse agonist of reaction?
E.) No effect
A.) Substitution
46. A long-acting HMG-CoA reductase inhibitor B.) Elimination
C.) Radical reactions
A.) Rosuvastatin D.) Addition
B.) Lovastatin E.) Combustion
C.) Fluvastatin
D.) Simvastatin 53. Alkylation of aminobenzene will likely proceed to
E.) Pravastatin what position?

47. This is the most important CYP 450 isozyme A.) Ortho position
that is responsible for the metabolism of almost B.) Meta position
50% of the drugs available in the market C.) Para position
D.) Both A and B
A.) CYP 2D6 E.) Both A and C
B.) CYP 3A4
C.) CYP 2A9 54. This is a derivative of two carboxylic acids, in
D.) CYP 1A2 which the compound is formed by the removal of
E.) CYP 2D10 one molecule of water in two RCOOH

48. A theory that advances the idea that maximum A.) Ether
pharmacologic effect can be obtained if all the B.) Acid anhydride
receptors are occupied C.) Amide
D.) Acyl halide
A.) Hypothesis of Paton E.) Ester
B.) Lock and Key Theory
C.) Hypothesis of Clark
D.) Induced fit theory For numbers 55-58, Refer to the structure of Bricanyl®
E.) Hypothesis of Ariens & Stephenson
49. The anti-angina effect of nitrates is primarily due
55. The drug is a derivative of
to the release of what gas?
A.) Catechol
A.) Nitrous oxide
B.) Phenol
B.) Dinitrogen oxide
C.) Xylene
C.) Nitrogen dioxide
D.) Hydroquinone
D.) Nitric oxide
E.) Resorcinol
E.) Dinitrogen dioxide
56. The compound is not affected by which enzyme
50. Diuretic that acts on the distal convulated tubule
during its metabolism?

A.) Indapamide A.) COMT

B.) Furosemide
B.) MAO E.) Tautomerization
C.) Carboxylases
D.) Both A and B For numbers 63-66, refer to the structure of an anxiolytic
E.) Both A and C drug

63. The affinity of the drug to the

57. The compound is a selective agonist of what
receptor exerts an anxiolytic and hypnotic
receptor?
effects
A.) Alpha 1
A.) Glutamate
B.) M1
B.) Histamine
C.) Beta 1
C.) Gamma-aminobutyric acid
D.) Beta 2
D.) Glycine
E.) N1
E.) Dopamine
58. The compound is used to manage
64. The binding affinity of the compound to its
A.) Hypertension receptor is highly influenced by_______ in its
B.) Asthma structure
C.) Glaucoma
D.) Arrhythmia A.)Benzene ring
E.) Hypotension B.) Chloro substituted benzene ring
C.) Carbonyl moiety
D.) Imidazole ring
59. Benzene undergoes what type of reaction? E.) Seven membered heterocyclic nitrogen ring
A.) Nucleophilic substitution 65. Increase the concentration of _______ ions in
B.) Electrophilic addition the cell makes this drug a sedative - hypnotic.
C.) Electrophilic substitution
D.) Radical reactions A.) Calcium
E.) Nucleophilic addition B.)Chloride
C.) Phosphate
60. Which of the following carbocation intermediate D.) Potassium
is the most stable? E.) Sodium

A.) Primary
B.) Secondary
C.) Tertiary 66. An essential moiety for this compound to exert
D.) Quarternary its sedative hypnotic effect
E.) None of the above
A.) Benzene ring
61. Regioselectivity of an organic reaction in which B.) Chloro substituted benzene ring
the orientation of the substituents stabilizes the C.) Carbonyl moiety
product is governed by D.) Imidazole ring
E.) Seven membered heterocyclic nitrogen ring
A.) Le Chatelier’s Principle
B.) Markovnikov’s Rule 67. The acetylation of morphine yields
C.) Heck Reaction
D.) Hund’s Rule A.) Codeine
E.) Pauli’s Principle B.) Papaverine
C.) Noscapine
D.) Heroin
62. An enol is not a stable compound because it
E.) Thebaine
undergoes
68. Primidone is a prodrug that is converted into
A.) Electrophilic attack
B.) Hydrophobic attack A.) Entacapone
C.) Hydrophilic attack B.) Diazepam
D.) Hydrogen shift C) Phenobarbital
D.) Carbamazepine B.) Rate of metabolism is in constant concentration
E.) Aminophylline C.) Rate of metabolism is not over time due to the
presence of enzymes
For numbers 69-72, Refer to the structure of Zovirax D.) Dose dependent
E.) Constant fraction of the drug is metabolize
69. The structure of Zovirax is an analog of
76. Carbamazepine undergoes what Phase I
A.)Thymine metabolism reaction?
B.) Adenine
C.) Guanosine A.) Aromatic hydroxylation
D.) Uracil B.) Olefinic carbon oxidation
E.) Cytosine C.) Oxidative deamination
D.) Allylic carbon oxidation
70. What is the difference of the structure of Zovirax E.) Reduction of the - OH group
to the conventional Nucleic acid base?
77. Thiopental is being converted into pentobarbital
A.) It contains a ribose moiety upon metabolism by what pathway?
B.) It contains a deoxyribose moiety
C.) It contains an open sugar moiety A.) Oxidation
D.) There is a substituted amino group B.) Desulfuration
E.) The hydroxyl group is not attached in the oxygen C.) Dealkylation
atom D.) Reduction
E.) Direct amine conjugation
71. The structure of Zovirax® competitively inhibits
what enzyme?

A.) DNA polymerase 78. Which of the following is true about penciclovir?
B.) Reverse transcriptase
C.) Ligase A.) The structure is similar to acyclovir, except with
D.) RNA polymerase the side of oxygen which is replaced by a carbon
E.) Protease and a hydroxyl group
B.) Short half life in tissues compared to acyclovir
72. Zovirax® is effective against the strain of C.) Competes for the viral RNA Polymerase and
inhibits its synthesis
A.) Varicella D.) It acts as a chain terminator
B.) HSV E.) All of the above
C.) Vesicular Slomatitis Virus
D.) All of the above 79. The first type of drugs for HIV to be available
E.) None of the above
A.) NNRTI
73. In phenols, substitution at _______ position B.) NRTI
increases bactericidal activity C.) Entry inhibitors
D.) Protease inhibitors
E.) Integrase inhibitors
A.) Ortho
B.) Meta
80. Which of the following HIV drugs is also used for
C.) Para
D.) All of the above Hepatitis B infection?
E.) None of the above
A.) Azidothymidine
74. C3H6O can be a/an B.) Saquinavir
C.) Didanosine
A.) Ketone D.) Lamivudine
B.) Ether E.) Efavirenz
C.) Aldehyde
D.) Both A and B 81. Metabolic disorder is commonly seen in what
E.) Both A and C type of HIV drugs?

75. Zero order drug metabolism A.) Integrase inhibitors

B.) Protease inhibitors
A.) Saturated Kinetics C.) NNRTI
D.) NRTI
E.) Entry inhibitors A.) Lewis acid
B.) Bronsted acid
82. Acylation of the Ring II of aminoglycosides C.) Lewis base
produces ______ D.) Arrhenius base
E.) Bronsted base
A.) Amikacin
B.) Streptomycin 89. Sulfonamides are synthetic analogs of:
C.) Tobramycin
D.) Gentamicin A.) Gamma aminobutyric acid
E.) Kanamycin B.) Para amino benzoic acid
C.) Tricarboxylic acid
83. Coordination of what metal in tetracycline D.) Sulfonic acid
structure increases its activity? E.) Carbolic acid
90. Compounds with two or more chiral centers are
A.) Iron termed as
B.) Manganese
C.) Cobalt A.) Epimers
D.) Palladium B.) Enantiomers
E.) Nickel C.) Stereoisomers
84. Glycopeptides exert their mechanism of action D.) Diastereomers
via E.) Constitutiona Isomers

A.) Inhibition of 30s ribosomal subunit For numbers 91-95, Refer to the structure below
B.) Inhibition of cell wall synthesis
C.) Inhibition of 50s ribosomal subunit 91. This drug may likely bind to what protein?
D.) Inhibition of DNA gyrase
E.) Inhibition of cell membrane synthesis A.) Albumin
B.) Alpha glycoprotein
85. Which if the following cephalosporins can cross C.) Ubuquitin
the blood brain barrier? D.) Globulin
E. Bilirubin
A.) Cefprozil
B.) Cefuroxime 92. What is the IUPAC name of the drug?
C.) Cefalexin
D.) Cefmetazole A.) Octanoic acid
E.) Cefazolin B.) 2-propylpentanoic acid
C.) 4-propylpentanoic acid
86. This agent is used to chelate copper in which an D.) 1-butylbutanoic acid
excess amount causes Wilson's disease E.) 2-methylheptanoic acid

A.) EDTA 93. This drug may likely affects what

B.) Dimercaprol neurotransmitter?
C. Penicillamine
D.) BAL A.) GABA
E.) Deferoxamine B.) Dopamine
C.) Glutamate
87. This class of penicillin contains a benzyl moiety D.) Norepinephrine
that is responsible for its acid labile property E.) Serotonin

94. This drug affects what type of ion gated

A.) Penicillin V
B.) Oxacillin channel?
C.) Piperacillin
D.) Methicillin A.) Sodium
E.) Penicillin G B.) Potassium
C.) Calcium
88. In the Freidles Craft Alkylation of Aromatic rings, D.) Both A and B
what catalyst is needed for the reaction to E.) Both A and C
proceed?
95. This drug is a powerful _____
 102. Drugs with superior lipid solubility usually
A.) Antibiotic possess what moiety?
B.) Skeletal muscle relaxant
C.) Antidepressant A.) Oxygen
D.) Anticonvulsant B.) Nitrogen
E.) Antipsychotic C.) Chlorine
D.) Sulfur
E.) Fluorine
96. Insulin Receptors are classified as _______
For numbers 103-107, Refer to the synthesis of
Aspirin below
A.) Ion gated channel receptors
B.) Tyrosine kinase receptors
103. The compound that reacts to salicylic acid to
C.) G- protein coupled receptors
make aspirin is an example of a/an______
D.) Gene transcription linked receptor
E.) Nuclear receptor
A.) Alcohol
B.) Ketone
97. The efficacy of salicylic acid as well as its
C. Ether
solubility in water as compared to p-
D.) Acid anhydride
hydroxybenzoic acid is greatly affected by what
E.) Ester
phenomenon?
104. The major product (Aspirin) ia prone to
A.) Dipole movement
hydrolysis, which of the following is/are the product/s
B.) Common ion effect
of its hydrolysis
C.) Hydrophobic interactions
D.) Hydrogen bonding
A.) Carboxylic acid
E.) Electrostatic forces
B.) Alcohol
C.) Ester
98. The inhibition of the CYP 450 dependent
D. Both A and B
lanosterol 14-alpha demethylase is the main
E. Both A and C
mechanism of action of?
105. When aspirin has been hydrolyzed, one of its
A.) Ketoconazole products produces a keratolytic property, what is that
B.) Amphotericin B product?
C.) Azelaic acid
D.) Griseofulvin A.) Salicylic acid
E.) Nystatin B.) Undecylenic acid
C.) Ester
99.Alkylation of aminobenzene will likely proceed to D. Methyl salicylate
what position? E.)Alcohol
A.) Ortho only 106. What is the functional group of the major
B.) Ortho and Meta product has been formed?
C.) Meta and Para
D.) Para only A.) Ether
E.) Ortho and Para B.) Alcohol
C.) Phenolic
100. An aliphatic phenothiazine derivative D.) Carboxylic acid
E.) Ester
A.) Chlorpromazine
B.) Thiorizadine
C.) Fluphenazine
D.) Perphenazine
E.) Clozapine
107. What is the color of the product when aspirin is
101. Decarboxylation of L- Dihydroxyphenylalanine treated with Ferric Chloride?
produces
A.) Blue
A.) Tyrosine B.) Violet
B.) Epinephrine C.) Yellow
C.) Ephedrine D.) Red
D) Dopamine E.) Colorless
E.) Norepinephrine
108. Which of the following compounds can be used 115. A non-prodrug ACE inhibitor
to synthesize secondary alcohols?
A.) Quinapril
A.) Formaldehyde B.) Captopril
B.) Ethanoic acid C.) Fosinopril
C.) Propanone D.) Enalapril
D.) Ethyl ethanoate E.) Imidapril
E.) Tert-butylbromide
For numbers 116-119, Refer to the structure of
109. The following drugs undergo acetylation Azithromycin
reaction upon metabolism except
116. Compound such as Azithromycin possess the
A.) Hydralazine following characteristics, except
B.) Ethanol
C.) Isoniazid A.) Large lactone ring
D.) Procainamide B.) Ketone Group
E.) Sulfanilamide C.) Ether group
D.) Alkyl group
110. Mercury exhibits is antimicrobial action by E.) Glycosidically linked sugar

A.) Hydrolysis and protein denaturation 117. This class of antibiotic exerts its action by
B.) Oxidation of sulfhydryl group ________
C.) Disruption of cytoplasmic membrane
D.) Inhibitio of protein synthesis A.) Binding to the 50s ribosomal subunit of bacteria
E.) Protein denaturation inactivation of the bacterial B.) Inhibition of cell wall cross linking
enzyme C.) Inhibition of bacterial transpeptidation
D.) Binding to the 30s ribosomal subunit of bacteria
111. Which of the following antibiotics is derived E.) Inhibition of Nucleic acid synthesis
from Streptomyces orientalis?
A.) Nystatin
B.) Bacitracin
C.) Vancomycin
D.) Amphotericin B
E.) Amikacin

112. Diuretic that acts on the thick ascending limb

(TAL) 118.The preparation of Azithromycin is done by
______ of its analog.
A.) Indapamide
B.) Furosemide A.) Acetylation
C.) Acetazolamide B.) Oxidation
D.) Amiloride C.) N-methylation
E.) Mannitol D.) Reduction
E.) Cross linking
113. This is a butyrophenone derived antipsychotic
agent that is frequently used for Tourette's syndrome 119. The presence of a tertiary amine group in the
compounds provides the following characteristics of
A.) Clozaril
B.) Haldol A.) Superior lipid solubility
C.) Thorazine B.) Increasing in plasma concentration
D.) Daxolin C.) Acid - labile property
E.) Zoloft D.) Stability to acid - catalyzed degradation
E.) Decreasing in plasma concentration
114.This compound is the basis of the synthesis of
thiazide diuretics by treating with acylating agents 120. Theophylline is also known as ____

A.) Acetazolamide A.) 5,7- Dimethylxanthine

B.) Dichlorphenamide B.) 1,7- Dimethylxanthine
C.) Chloraminophenamide C.) 3,7- Dimethylxanthine
D.) Methazolamide D.) 1,3- Dimethylxanthine
E.) Indapamide E.) 2,7- Dimethylxanthine
 128. These are functional macromolecules that
For numbers 121-123, Refer to the structure below undergo structural conformation when a substrate
binds to it.
121. What functional group is attached to the
primary amine moiety? A.) Receptors
B.) Enzymes
A.) Carboxyl C.) Ion channel
B.) Acetyl D.) Ligands
C.) Benzyl E.) Apienzymes
D.) Carbonyl
E.) Methyl 129. A drug with a pKa of 4.76 is likely to be
excreted in what medium?
122. The main group of this compound
A.) Acidic
A.) Phenolic B.) Basic
B.) Benzoic C.) Neutral
C.) Amino D.) All of the above
D.) Amide E.) None of the above
E.) Hydroxyl

123. The compound possess only minimal ________ 130. The bond that connects the moieties of
property. prilocaine is/ an

A.) Analgesic A.) Ester

B.) Anti-inflammatory B.) Amide
C.) Anti-asthma C.) Carbonyl
D.)Antipyretic D.) Ether
E.) Anti-platelet E.) Amine

124. The prototype narcotic analgesic For numbers 131-135, Refer to the structure of
Adrenalin
A.) Fentanyl
B.) Morphine
C.) Meperidine 131. The drug is derivative of ________
D.) Codeine
E.) Naloxone A.) Phenol
B.) Resorcinol
125. Cyclophosphamide belongs to what class of C.) Benzene
chemotherapeutic agents? D.) Catechol
E.) Hydroquinone
A.) Antimetabolites
B.) Antibiotics 132. The parent compound is highly susceptible to
C.) Alkylating agents what type of metabolic reaction?
D.) Microtubule synthesis inhibitors
E.) None of the above A.) Reduction
B.) Methylation
126. The amino acid precursor of catecholamines C.) Hydrolysis
D.) Oxidation
A.) Tryptophan E.) Glycine conjugation
B.) Threonine
C.) Histidine 133. The compound is an endogenous substance in
D.) Tyrosine the body that functions as
E.) Arginine
A.) Neurotransmitters
127. A nucleophile is a species that is rich in B.) Enzyme
C.) Substrate
A.) Protons D.) Ligand
B.) Neutrons E.) Hormone
C.) Radical
D.) Double bonds 134. The compound is used to manage _______
E.) Electrons
A.) Tachycardia
B.) Shock D.) Salicylic acid
C.) Pain E.) Tartaric acid
D.) Stroke
E.) Coagulation For numbers 141-145, Refer to the structure of
Indocin

141. What is the most common adverse effect of this

drug?

A.) Optic neuritis

B.) Gastrointestinal irritation
C.) Tachycardia
135. What configuration of this compound possess a D.) Adrenal insufficiency
biological activity? E.) Hypoglycemia

A.) S-isomer 142. In what enzyme does this drug acts?

B.) R-isomer
C.) Levo isomer A.) COX
D.) Z- isomer B.) COMT
E.) E-isomer C.) LOX
D.) PLA
136. This product of arachidonic acid pathway is a E.) MAO
potent platelet aggregator
143. This drug can be used to treat patients with
A.) PGE
B.) LTC4 A.) Acromegaly
C.) HETE B.) Patent ductus arteriosus
D.) TXA2 C.) Coagulation disorder
E.) PGF D.) Renal failure
E.) Asthma
137. A compound with a molecular formula of
C2H6O is most like to be a/a ______ 144. This drug may likely bind to what protein?

A.) Alcohol A.) Albumin

B.) Ether B.) Globulin
C.) Ketone C.) Alpha glycoprotein
D.) Both B and C D.) All of the above
E.) Both A and B E.) None of the above

138. Sulbactam is usually combined with what 145. The drug is a derivative of what compound?
antibiotic?
A.) Imidazole
A.) Amoxicillin B.) Xanthine
B.) Methoxypenicillin C.) Furan
C.) Piperacillin D.) Piperidine
D.) Benzylpenicillin E.) Indole
E.) Ampicillin
146. Name of this compound
139. Addition of alcohol to an alkene yields what
product? A.) Pyran
B.) Indole
A.) Carboxylic acid C.) Pyrrole
B.) Ether D.) Imidazole
C.) Alkane E.) Furan
D.) Ester
E.) Ketone

140. Orthohydroxybenzoic acid is _____

147. This is the common name of p- hydroxy phenol
A.) Carboxylic acid
B.)Oxalic acid A.) Catechol
C.) Citric acid B.) Resorcinol
C.) Quinone C.) Rhombic
D.) Hydroquinone D.) Tetrahedral
E.) Benzoic acid E.) Cubic

148. Polyene anti-infectives exert their mechanism 155. A uricosuric agent used to prevent the rapid
of action by excretion of penicillin

A.) Sulindac
A.) Cell wall synthesis inhibition B.) Probenecid
B.) Inhibition of the 30s ribosomal subunit C.) Colchicine
C.) Cell membrane synthesis inhibition D.) Felbamate
D.) Inhibition of the 50s ribosomal subunit E.) Lamotrigine
E.) DNA synthesis Inhibition
156. Friedle - Crafts alkylation of benzene requires
149. Which of the drugs below exhibit auto- this catalyst
oxidation?
A.) Bronsted base
A.) Carbamazepine B.) Lewis acid
B.) Sotalol C.) Bronsted acid
C.) Isoniazid D.) Arrhenius acid
D.) Epinephrine E.) Lewis base
E.) Metformin
157. This is the property of carbon atom where it
150. A rare spiro chemical structure is observed in form bonds with other carbon atoms
what antifungal drug?
A.) Covalent bonding
A.) Amphothericin B B.) Catenation
B.) Griseofulvin C.) Non- polar bonding
C.) Tolnaftate D.) Electronegativity
D.) Miconazole E.) Ionic bonding
E.) Azelaic acid
158. Geometry of an sp3 hybridized orbital
151. Typical reaction of alkanes
A.) Rhombic
A.) Nucleophilic addition B.) Planar
B.) Radical halogenation C.) Tetrahedral
C.) Elimination D.) Cubic
D.) Electrophilic substitution E.) Octagonal
E.) Cyclization
159. It is the strain occured when electrons in a C-H
152. Secondary alcohols are oxidized into bond will repel the electrons in another C-H bond if
the bonds get too close to each other
A.) Aldehyde
B.) Esters A.) Angular strain
C.) Ketone B.) Torsional strain
D.) Carboxylic acids C.) Equatorial strain
E.) Ethers D.) Steric strain
E.) Axial strain

153. Which of the following diuretic inhibits an 160. Lindlar's catalyst is employed to produce a/an
enzyme? ______ from the reaction of H2 to an alkyne

A.) Furosemide A.) Ketone

B.) Thiazides B.) Alkene
C.) Mannitol C.) Amine
D.) Indapamide D.) Amide
E.) Acetazolamide E.) Alcohol

154. Acetylene has a geometrical configuration of 161. Predict the product of the reaction

A.) Planar A.) Ar-OCl

B.) Octagonal B.) Ar-OR
C.) Ar-Cl A.) Hepatotoxicity
D.) Ar-CO B.) Cardiotoxicity
E.) Ar- COR C.) Neurotoxicity
D.) Nephrotoxicity
162. Corticosteroids are protent Anti-inflammatory
drugs because they inhibit which enzyme? E.) Dermal toxicity

A.) Lipoxygenase 169. A theory that states that the effectiveness of the
B.) Phospholipase drug last as long as the receptors are occupied
C.) Transferase
D.) Thromboxane A.) Hypothesis of Paton
E.) Cyclooxygenase B.) Lock and Key theory
C.) Hypothesis of Clark
163. G- protein coupled receptors are activated via D.) Induced fit theory
these secondary messengers, except E.) Hypothesis of Ariens & Stephenson
A.) cAMP
170. Bacitracin is not usually given parenterally
B.) IP3
because of its
C.) DAG
D.) cGMP
A.) Insolubility
E.) NO
B.) Nephrotoxicity
C.) Pain on the administration site
164. An enol is not a stable compound because it
D.) Lack of stability
undergoes
E.) Lack of potency
171. Which of the following medications would
A.) Nucleophilic attack represents arthritis therapy that is least likely to
B.) Hydrophobic interactions cause gastric ulceration?
C.) Hydrogen shift
D.) Tautomerization A.) Sulindac
E.) Hydrophilic attack
B.) Rofecoxib
165. Which is the most stable conformation of C.) Tolmetin
cyclohexane D.) Piroxicam
E.) Phenylbutazone
A.) Chair
B.) Boat 172. Methylbenzene is also known as
C.) Staggered
D.) Eclipsed A.) Anisole
E.) Planar B.) Toluene
C.) Aniline
166. It is the strain put on a molecule when atoms
D.) Xylene
Or groups are too close to one another.
E.) Anethole
A.) Angular Strain
B.) Torsional Srain 173. Alkyl substituent that are bounded to the ____
carbons of an alkene have a stabilizing effect on the
C.) Equatorial Strain
alkene.
D.) Steric Strain
E.) Axial Strain A.) sp
B.) Tetrahedral
167. An aliphatic phenothiazine derivative C.) sp2
D.) Octagonal
A.) Chlorpromazine
E.) sp3
B.) Fluphenazine
C.) Perphenazine 174. Reactions of terminal alkynes follow the ____
D.) Thioridazine when it is treated with excess HCL/HBr
E.) Thiothixene
A.) Le Chatelier’s Principle
168. What is the prominent adverse effect of B.) Markovnikov’s rule
aminogycosides? C.) Heck Reaction
D.) Hund’s Rule
 E.) Pauli’s Principle D.) Sterilant
E.) Fungicidal
175. Addition of water to an alkyne leads to the
formation of 182. In the structure of cephalosporins, the beta
lactam ring should have the ____ configuration that is
A.) Alcohol essential for its activity
B.) Carboxylic acid
C.) Ketone A.) Trans
D.) Aldehyde B.) E
E.) Ester C.) Levo
D.) Dextro
176. Primary reaction of alkyl halides E.) Cis
183. Which of the following characteristics of the bicyclic
A.) Nucleophilic addition ring system of penicillins is true?
B.) Radical halogenations
C.) Elimination A.) Strain is essential for greater activity
D.) Electrophilic substitution B.) Substitution of an alkyl group to the
E.) Nucleophilic substitution Hydrogen moiety in the beta lactam ring confers
Greater efficacy
177. SN2 reaction is primarily observed in C.) The trans streochemistry in the beta lactam
Ring ring confers greater efficacy
A.) Secondary amines D.) Activity increases when the carboxylic acid
B.) Tertiary alkyl Group is modified into an ester
C.) Primary alkyl halides E.) Sulfur is an essential atom in the bicycling
D.) Primary alcohols Ring system
E.) All of the above 184. Which of the following is true for hydrogen peroxide

A.) Active against aerobic microorganism

178. Which of the following is not a characteristic of B.) Good only as topical agent
an ideal antiseptic agent? C.) Inactive for anaerobic microorganism
D.) Superior tissue penetrability
A.) Low toxicity E.) Use as a preservative for heat sensitive
B.) High surface tension chemicals
C.) Non-allergenic
D.) Low surface tension 185. Which of the following exerts their action by
E.)Sustained and rapid lethal action against distortion of cells and eventually causing lysis?
microorganisms
A.) Benzalkonium chloride
179. Which organism is the standard for determining B.) Phenol
the efficacy of alcohols as antiseptic? C.) Iodine
D.) Cresol
A.) Streptococcus agalactiae E.) Alcohol
B.) Staphylococcus aureus
C.) Salmonella Typhi 186. Organism used as standard for the efficacy of
D.) Hemophilus influenza phenol and its derivatives
E.) Klebsiella pneumonia
A.) Streptococcus agalactiae
180. This agent is prepared by sulfuric acid catalyzed B.) Staphylococcus aureus
hydration of propene C.) Salmonella typhi
D.) Hemophilus influenzae
A.) Methoxypropane E.) Klebsiella pneumonia
B.) N-Propanol
C.) Isopropyl alcohol 187. Used to treat diaper rash in infants caused by
Candida albbicans
D.) Propylene
E.) Propanoic acid A.) Methylbenzethonium chloride
B.) Thimerosal
181. Chlorocresol is primarily used as C.) Ethylene oxide
D.) Chlorhexedine
A.) Preservative E.) Methylene blue
B.) Alkylating agent
C.) Astringent
 D.) Akene
E.) Alkyl halide

188. Which of the following is used as a keratolytic 195. Thimerosal is a preservative that contains
agent? A.) Hg
A.) Thymol B.) Fe
B.) Resorcinol C.) Co
C.) Eugenol D.) Ni
D.) Chlorocresol E.) Cu
E.)Hexachlorphene
196. Imidazole nucleus is primarily found in what type of
189.) Which of the following is the salt of Penicillin G? anti-infective agents?

A.) Potassium A.) Antiseptics

B.) Calcium B.) Antiviral
C.) Sodium C.) Disinfectants
D.) All of these D.) Antimycobacterials
E.) None of these E.) Antifungal

190. Saponification is the alkali hydrolysis of 197. The receptor of steroidal hormones are primarily
found in the____.
A.) R-O-R
B.)R-COOR A.) Cell membrane
C.) R-COOH B.) Nucleus
D.) R-OH C.) Ribosomes
E.) Ar-OH D.) Cytoplasm
E.) Cell wall
191. Aminobenzene is also known as
198. DNA alkylating agents binds to its target by means
A.) Anisole of what bond?
B.) Toluene
C.) Aniline A.) Hydrophobic
D.) Xylene B.) Ionic
E.) Anethole C.) Covalent
D.) Electrostatic
192. This is a derivative of two carboxylic acids, in which E.) Hydrogen
the compound is formed by the removal of one molecule
of water in two RCOOH 199. Theobromine is also known as

A.) Acyl halide A.) 5, 7 –Dimethylxanthine

B.) Esters B.) 1, 7 - Dimethylxanthine
C.) Alkyl halide C.) 3, 7- Dimethylxanthine
D.) Acid anhydride D.) 1, 3 – Dimethylxanthine
E.) Ethers E.) 2, 7- Dimethylxanthine

193. Saquinavir belongs to what group of HIV drugs?

A.) Nucleosides Reverse Transcriptase Inhibitor

B.) Protease Inhibitor 200. The following are the effects of protein binding,
C.) RNA synthesis inhibitor except
D.)Fusion inhibitor
E.) Non-Nucleoside Reverse Transcriptase A.) Prevent rapid excretion of the drug
Inhibitor B.) Limits the amount available for the
metabolism
C.) Decreases free drug molecules
D.) Decreases half-life of drugs
E.) None of the above
194. Dehydration of secondary alcohols yield
201. This agent is used to chelate copper in which an
A.) Alkyne excess amount causes Wilsson’s disease
B.) Alkane
C.) Ketone A.) Deferoxamine
 B.) EDTA D.) Tryptophan
C.) Penicillamine E.) Histidine
D.)BAL
E.)Dimercaprol 209. Dynacin® binds to the _____ ribsomal subunit

202. A paraben used to preserve the drug from molds A.) 20s
A.) Mehylparaben B.) 30s
B.) Ethylparaben C.) 60s
C.) Propylparaben D.) 40s
D.) Butylparaben E.) 50s
E.) N-butylparaben

203. Reduction of Aldehydes yield For numbers 210-212, Refer to the structure of
Tagamet®
A.) Carboxylic acid
B.) Primary alcohols 210. The heterocyclic ring in its structure is
C.) Ethers
D.) Ketones A.) Indole
E.) Secondary alcohols B.) Furan
C.) Pyran
204. Alkenes have a general formula of D.)Pyridine
E.) Imidazole
A.) CnH2n+1
B.) CnH2n+2 211. This drug has a weak antiandrogenic effect,
C.) CnH2n therefore, one of its adverse effects is :
D.) CnHn
E.) CnH2n-2 A.) Gynecomastia
B.) Hirsutism
205. In the presence of a full agonists, a partial agonist C.) Adrenaline crisis
becomes _____ D.) Flushing
E.) Cushing syndrome
A.) Remained as partial agonist
B.) Antagonist 212. This drug antagonize what receptor?
C.) Both agonist and antagonist
D.) Inverse agonist A.) Alpha 1
E.) Full agonist B.) Dopamine
C.) Muscarinic 3
D.) Histamine 1
E.) Beta 1

206. These are substances that donate an electron pair 213. The following molecules readily penetrate a variety
of cells and tissues, Except
A.) Lewis acid
B.) Bronsted base A.) Hydrophobic
C.) Lewis base B.) Non - ionized
D.) Arrhenius base C.) Hydrophilic
E.) Bronsted acid D.) Lipid soluble
E.) Non polar
207. The following agents are used to treat hyperacidity
and GI ulceration, except 214. Active site directed irreversible inhibition is
exhibited in what type of bond
A.) Cytotek
B.) Ranitidine A.) Electrostatic
C.) Omeprazole B.) Van der Waals
D.) Aripiprazole C.) Hydrogen bonding
E.) Maalox D.) Ionic
E.) Covalent
208. The amino acid precursor of serotonin
For numbers 215-217, Refer to the structure of
A.) Threonine Aldomet®
B.) Arginine
C.) Tyrosine 215. This drug is an analog of what neurotransmitter?
 A.) Benzodiazepine
A.) Norepinephrine B.) Imidazole
B.) Serotonin C.) Barbiturates
C.) Glutamate D.) Indole
D.) GABA E.) Pyrrole
E.) Histamine
223. Gq receptors stimulates________ that leads to
216. This drug exerts effect as a _______ increase in the intracellular calcium level

A.) Hydroxylase inhibitor A.) Phospholipase

B.) Decarboxylase inhibitor B.) Lipoxygenase
C.) Transferase inhibitor C.) DOPA Decarboxylase
D.) Carboxylase inhibitor D.) Carboxylase
E.) Protease inhibitor E.) Cyclooxygenase

217. This is primarily indicated for ______

224. Cholestyramine confers what type of antagonism?
A.) Cardiac failure
B.) Hypertension A.) Pharmacodynamic
C.) Muscle pain B.) Chemical
D.) Aldosteronism C.) Physical
E.) Cushing syndrome D.) Pharmacokinetic
E.) Physiological

218. A lipoxygenase enzyme inhibitor 225. Dehydrated alcohol is prepared by the azeotropic
distillation using what solvent?
A.) Montelukast
B.) Zileuton A.) Toluene
C.) Cromolyn B.) Pyridine
D.) Zafirlukast C.) Chloroform
E.) Nedocromyl D.) Benzene
E.) Hexane
For numbers 219-222, Refer to the structure of Luminal®
226. Which of the following is the most effective?

219. The compound may likely increase the A.) Tert-butyl alcohol
concentration of ______ in the cell B.) N-decanol
C.) 3-hexanol
A.) Sodium D.) Ethanol
B.) Calcium E.) 4-pentanol
C.) Magnesium
D.) Potassium 227. Used in combination with camphor in liquid
E.) Chloride petrolatum

220. The compound has an affinity to what receptor? A.) P-Chlorophenol

B.) Eugenol
A.) Glutamate C.) Chlorhexidine
B.) Serotonin D.) Cresol
C.) GABA E.) Thymol
D.) Glycine
E.) Histamine 228. Which of the following substituents increase the
activity of phenol?
221. The compound is used to treat what condition?
A.) Chlorine
A.) Asthma B.) Sulfur
B.) Fungal infection C.) Phosphorus
C.) Depression D.) Oxygen
D.) Convulsion E.) Nitrogen
E.) Hypertension
229. It induces cell proliferation (epithelial) leading to
222. This compound resembles a/an sloughing and repair
A.) Carbamide peroxide
B.) Hexylresorcinol A.) Renal failure
C.) Cetylpyridium chloride B.) Rash
D.)Chlorhexidine C.) Mouth sore
E.) Benzoyl peroxide D.) Vertigo
E.) Cardiomegaly

230. Which of the following dyes is used as vaginal 237. Insulin preparation that is made of 70% crystalline
suppository? and 30% amorphous form

A.) Methylene blue A.) Humalin

B.) Malachite green B.) Insulin NPH
C.) Gentian violet C.) Short acting insulin
D.) Carbolfuchsin D.) Insulin glargine
E.) Bromocresol E.) Insulin Lispro

231. Which of the following penicillin is prone to renal 238. Type of antagonism that forms a chelate/ complex
tubular secretion?
A.) Physical
A.) Methicillin B.) Pharmacokinetic
B.) Pen G C.) Physiological
C.) Carbenicillin D.) Chemical
D.) Cloxacillin E.) Pharmacodynamic
E.) Ampicillin
239. Secondary messenger produced when adenyl
232. The structure contains the salt of what amino acid? cyclase is activated

A.) Alanine A.) IP3

B.) Valine B.) DAG
C.) Lysine C.) cAMP
D.) Isoleucine D.) Both A and B
E.) Arginine E.) Both B and C

233. The first type of drug released to treat HIV infection For numbers 240-241, Refer to the reaction :

A.) Nucleoside Reverse Transcriptase Inhibitor 240. The metabolic pathway is an example of
B.) Protease Inhibitor
C.) RNA synthesis inhibitor A.) Reductive elimination
D.) Fusion Inhibitor B.) Oxidative deamination
E.) Non-Nucleoside Reverse Transcriptase Inhibitor C.) Reductive deamination
D.) Hydrolysis
234. The ability of a substance to exist in different E.) Oxidative dealkylation
crystalline form
241. This pathway is true for what kind of compounds?
A.) Isomerism
B.) Lattice A.) Endogenous radicals
C.) Crystallization B.) Endogenous amides
D.) Polymorphism C.) Endogenous amino acids
E.) Ampotherism D.) Endogenous amines
E.) None of these
235. The first step that determines the onset of action,
rate of absorption and bioavailability 242. Which of the following is/are true regarding the
phase I drug metabolism?
A.) Liberation
B.) Metabolism I. Also known as conjugation reaction
C.) Elimination II. Includes oxidation, reduction and hydrolysis
D.) Absorption III. Generally tends to provide a functional group or
E.) Distribution "handle" to the molecule

A.) I only
236. Nevirapine is known to cause _______ for HIV B.) I, II, III
patients with low CD4 count C.) II only
D.) II and III
E.) I and III A.) Tertiary carbocation
B.) Primary carbanion
243. Biogenic amines are inactivated primarily by C.) Primary carbocation
D.) Methyl radical
A.) Oxidation E.) Secondary carbocation
B.) Methylation
C.) GSH conjugation 249. Which of the following reagents can be used to
D.) Sulfate conjugation solubilize phenol in water?
E.) Reduction
A.) HCl
244. Which of fhe following is /are true regarding phase B.) NaOH
II drug metabolism? C.) CH2Cl2
D.) HBr
I. Allows the attachment of small, polar and ionizable E.) NH2CONH2
endogenous compounds
II. Allows the termination or attenuated of a biologic 250. Ethanol is identified by this reagent in its
activity confirmatory test
III. Serves to protect the body against chemically
reactive compounds or metabolites A.) Ammonium cyanide
B.) Phosphomolybdic acid
A.) II and III C.) Aluminum chloride
B.) I, II, III D.) Potassium perchlorate
C.) I only E.) Sodium nitroprusside
D.) I and II
E.) III only 251. Violet color result with ferric chloride is commonly
observed in
245. Which of the following can be used to synthesize
methyl orange? A.) Aspirin
B.) Phenol
A.) Methyl alcohol C.) Propylamide
B.) Toluene D.) Benzene
C.) Benzyl chloride E.) Acetic acid
D.) Sulfanilic acid
E.) Ammonium nitrite 252. Benzoic acid can be obtained from toluene by
means of what process?

A.) Reduction
B.) Substitution
C.) Oxidation
D.) Elimination
E.) Conjugation

246. Which of the following compounds is considered as 253. Which of the following compounds inhibits squalene
a chromophore? oxidase?

A.) Nitro A.) Tolnaftate

B.) Butyl B.) Undecylanic acid
C.) R-O-R C.) Natamycin
D.) R-OH D.) Ketoconazole
E.) Cyclohexane E.) Benzoic acid

247. Which of the following catalyst is required for the 254. Inhibition of the production of folic acid is the
synthesis of an ester mechanism of action of

A.) HBr A.) Griseofulvin

B.) CH3Cl B.) Sulfamethoxazole
C.) NH4NO3 C.) Norfloxacin
D.) H2SO4 D.) Nystatin
E.) CCl4 E.) Nalidixic acid

248. Which of the following form is the stable?

255. Polyene antifungals bind to ______ to promote ion E.) None of the above
leakage resulting to fungal death
262. Adding more than 1 chloride atom in the structure
A.) Microtubules confers what modification on the pharmacokinetic profile
B.) DNA of the drug?
C.) Cell wall
D.) Ribosomes A.) Liberation
E.) Ergosterol B.) Absorption
C.) Excretion
256. The second synthetic analog of Benzylpenicillin D.) Distribution
E.) Metabolism
A.) Phenoxymethylpenicillin
B.) Methicillin
C.) Oxacillin
D.) Ampicillin
E.) Cloxacillin

257. The subtype of the CYP 450 enzyme system

responsible for genetic polymorphism 263. This antibiotic is primarily indicated for what type of
infection?
A.) CYP 1A2
B) CYP 2A9 A.) Enterobacter
C.)CYP 2D6 B.) Streptococci
D.) CYP 1A9 C.) Pseudomonas
E.)CYP 3A4 D.) Klebaiella
E.) Staphylococci
258. The spectrum of activity of penicillin is governed by
what functional group? 264. Functional group of the beta - lactam ring

A.) Beta lactam ring A.) Ether

B.) Carbonyl group B.) Ketone
C.) Acyl amine group C.) Amide
D.) Carboxylic acid group D.) Amine
E.) Thiazolidine ring E.) Carbonyl

For numbers 259-263, Refer to the structure of this beta For numbers 265-269, Refer to the structure of a phenol
lactam antibiotic : derivative compound

259. The functional group attached to the acyl amino 265. This compound is insoluble in what medium?
group is called a/an
A.) Water
A.) Benzyl B.) Alcohol
B.) Isoxazoyl C.) Ether
C.) Phenoxymethyl D.) Carbon tetrachloride
D.) Phenyl E.) Benzene
E.) Methoxyphenyl
266. This compound is active against _______ organism
260. What is the role of chloride atoms in the structure?
A.) Gram positive
A.) Increase the susceptibility to penicillinase B.) Acid fast
B.) Increase the plasma concentration C.) Aerobic
C.) Increase in parenteral absorption D.) Facultative anaerobe
D.) Acid resistance property E.) Gram negative
E.) Increase spectrum of activity
267. This compound has a greater potency of action due
261. Halogen substituents are best placed in what to the presence of what group?
position?
A.) Alkyl
A.) Ortho B.) Halogen
B.) Meta C.) Phenolic
C.) Para D.) Biphenyl
D.) All of the above E.) Hydroxyl
268. This preparation is to be delivered in what route?
275. Preservative in BCG Vaccine
A.) Intramuscular
B.) Intradermal A.) Nitromersol
C.) Topical B.) Thimerosal
D.) Subcutaneous C.) Benzalkonium chloride
E.) Intravenous D.) Methylparaben
E.) Sodium benzoate

269. The compound is commonly known as 276. Metabolism of alcohol is a series of

A.) Hexetidine A.) Reduction

B.) Hexachlorophene B.) Methyl transfer
C.) Chlorocresol C.) Glycine conjugation
D.) Chlorhexidine D.) GSH conjugation
E.) Chlorophenol E.) Oxidation

270. Second generation cephalosporin that can cross 277. Dye used to treat the inflammation of the bladder
the blood brain barrier
A.) Methylene blue
A.) Cefamandole B.) Malachite green
B.) Cefprozil C.) Gentian violet
C.) Cefuroxime D.) Carbolfuchsin
D.) Cefaclor E.) Bromocresol
E.) Loracarbef
For numbers 278-281,Refer to the general structure of
271. Compounds that will kill or inhibit the growth of, in a cephalosporin
living tissue
278. Which moiety in the structure binds to the PBP?
A.) Disinfectant
B.) Antibiotic A.) Amide group
C.) Antiseptic B.) Carboxy group
D.) Preservativs C.) Dihydrothiazine group
E.) Sterilant D.) Carbonyl group
E.) Acyl amino
272. It is the characteristics of a substance that gives its
ability to spread into wounds. 279. The R3 substituent confers the following properties,
except
A.) High viscosity
B.) Low zeta potential A.) Salt form
C.) High partition coefficient B.) Drug interaction
D.) Low surface tension C.) Protein binding
E.) High pH D.) Chemical stability
E.) Pharmacological property
273. Tigemonam is primarily administered in what route?
280. The R7 substituent is importantin _______
A.) IV
B.) Subq A.) Spectrum of activity
C.) Topical B.) Classification of generation
D.) IM C.) Synthesis of a newer version
E.) PO D.) All of these
E.) None of these
274. Redman syndrome is seen in

A.) Telavancin 281. Substitution of a bulky group in the X substituent

B.) Chloramphenicol confers
C.) Imipenem
D.) Teicoplanin A.) Acid labile property
E.) Vancomycin B.) Increase in metabolism
C.) Decrease in GFR
D.) Increase in gram negative activity
E.) Decrease in protein binding A.) Norfloxacin
B.) Levofloxacin
282. Aztreonam can elevate this enzyme C.) Ofloxacin
D.) Ciprofloxacin
A.) Creatinine kinase E.) Gatifloxacin
B.) Alanine aminotransferase
C.) Beta amylase 289. Inhibits the enzyme which is responsible for the
D.) Angiotensin I assembly of matured viral particles
E.) Pyruvate kinase
A.) Didanosine
283. This group attached to the naphthalene group of B.) Zidovudine
nafcillin confers beta lactamase resistance C.) Indinavir
D.) Abacavir
A.) Dichlorobenzene E.) Lamivudine
B.) Ethoxy
C.) Benzyl 290. This antifungal drug is derived from Ricinus
D.) Isoxazoyl communis
E.) Phenyl
A.) Undecylenic acid
284. Acylation of the amino group in the second ring of B.) Ricinoleic acid
aminoglycosides produces ______ C.) Salicylic acid
D.) Ricin
A.) Kanamycin E.) Propionic acid
B.) Streptomycin
C.) Neomycin 291. Which of the following is unstable in acidic
D.) Gentamicin condition?
E.) Amikacin
A.) Ampicillin
285. This is the target site of HIV B.) Methicillin
C.) Phenoxymethylpenicillin
A.) CD8 D.) Nafcillin
B.) CCR5 E.) Carbenicillin
C.) CD4
D.) CD32
E.) CD28

286. Antitubercular drug that is in combination with

pyridoxine
292. Carbamazepine undergoes what metabolic
A.) Isoniazid pathway?
B.) Ethambutol
C.) Rifampicin A.) Aromatic hydroxylation
D.) Pyrazinamide B.) Olefinic oxidation
E.) Streptomycin C.) Reductive elimination
D.) Oxidative N-dealkylation
E.) Desulfuration
287. The chances of methemoglobinemia and
haemolytic anemia are higher when administering : 293. To Prepare beta-lactamase resistant penicillin, one
should use
I. Acetaminophen
II. Phenacetin A.) The aromatic ring that is directly attached to the side-
III. Acetanilide chain carbonyl and both ortho positions should be
substituted by methoxy groups.
A.) I only B.) The aromatic ring that is directly attached to the side
B.) I and II only - chain carbonyl and ortho and para positions should be
C.) II and III only substituted by methoxy groups.
D.) I, II and III C.) The aromatic ring that is directly attached to the side
E.) III only - chain carbonyl and meta and para positions should be
substituted by methoxy groups.
288. This agent is the least active among all D.) A methylene between the aromatic ring and carbonyl
fluoroquinolones group of side chain
E.) None of the above
 E.) Nucleophilic addition
294. Triethylenephosphoramide is an active metabolite
of

A.) Procarbazine
B.) Camustine
C.) Thiotepa
D.) Ifosfamide
E.) None of the above

295. Which of the following preparations contains 2%

iodine in sodium iodide?

A.) Iodine solution

B.) Lugol's solution
C.) Povidone-iodine
D.) Iodine tincture
E.) None of the above

296. Which of the following belongs to the class of

echinocandins?

A.) Caspofungin
B.) Griseofulvin
C.) Naftiline
D.) Ampothericin B
E.) Nystatin

297. Concentration of dehydrated alcohol

A.) 95%
B.) 49%
C.) 99%
D.) 70%
E.) 10%

298. An acy ureidopenicillin

A.) Piperacillin
B.) Carbenicillin
C.) Methicillin
D.) Ticarcillin
E.) Cloxacillin

299. Chemically known as 5-methyl-3-phenyl-4-

isoxazoyl penicillin

A.) Nafcillin
B.) Ticarcillin
C.) Oxacillin
D.) Methicillin
E.) Mezlocillin

300. Synthesis of Orange II Dihydrate is possible via

A.) Freidel-Crafts Acylation

B.) Diazotization
C.) Elimination
D.) Electrophilic aromatic substitution