Subject: QUALITY CONTROL I and II

General Instructions: Choose the letter of the best answer

_______1. The synonym of 0.1N Bromine solution.

A.) Koettsdorfer solution D.) All of these

B.) Kjeldahl solution E.) None of these
C.) Koppeschaar’s solution

_______2. An oxidizing agent ______electrons.

A.) Gains D.) Receives

B.) Loses E.) Shares
C.) Donates

_______3. It pertains to a reaction with acid and a base resulting to the formation of

salt and water.

A) Neutralization D.) Oxidation

B.) Complexation E.) Reduction
C.) Precipitation

_______4. Indicator used in ceric sulfate titrations

A.)Ferrous phenanthroline D.) Potassium permanganate

B.) Ferric alum E.)Phenolphthalein
C.)Eosin Y

_______5. The theoretical point at which the added titrant is chemically equivalent to the
analyte in the sample.

A.) Stoichiometric point D.) Both A and B

B.) End point E. Both A and C
C.) Equivalence point

_______6. A method of analysis which involves the determination of a solution of known

concentration required to react with a given amount of substance to be analyzed:

A.) Gravimetric analysis D.) Both A and B

B.) Titrimetric analysis E.) Both B and C
C.) Volumetric analysis

_______7. The following are the reasons of using the disodium form of EDTA in preparing
standard solutions of EDTA except:

A.)Less Soluble in water D.) All of these

B.) Non hygroscopic E.)None of these
C.) Very stable

_______8. The weight of a substance that is chemically equivalent to one milliliter of a

standard solution.

A.) Gram-equivalent weight D.) Gram-milliequivalent weight

B.) Milliequivalent weight E.) Millimole
C.)Titer value
______9. It refers to the direct or residual analysisof acids using standard basics solutions:

A.)Kjeldahl method D.) Compleximetry

B.Acidimetry E.) Precipitimetry
C.) Alkalimetry

_______10. Inaccurate measurements resulting from not reading at proper eye level:

A.) Color blind D.) Parallax

B.) Double vision E.) None of these
C.) Thermal after-effect

_______11. A permanent change in volume with volumetric apparatus caused by heat

or hot solutions.

A.) Parallax D.) All of these

B.) Color Blind E.) None of these
C.) Thermal after-effect

_______12. What is the method of analysis involved in the essay of sodium hydroxide?

A.) Direct Acidimetry D.) Direct compleximetry

B.) Direct alkalimetry E.) Direct permanganometry
C.)Direct precipitimetry

_______13. It is the point at which titration process is stopped.

A.) Equivalence point D.) Both A and C

B.) End point E.) Both B and C
C.) Stoichiometric point

_______14. What is the method of analysis involved in the essay of aspirin capsules?

A.) Residual acidimetry D.) Residual precipitimetry

B.) Residual alkalimetry E.) Residual permanganometry

_______15. Which of the following is/are the way/s of faciliating the digestion of nitrogen
to ammonium sulfate?

A.) Addition of potassium sulfate D.) Use of copper sulfate

B.) Use of selenium E.) All of these
C.) Addition of anhydrous sodium sulfate

_______16. The indicator used when titrating weak acid with a strong base:

A.) Ferric alum D.) Ferroin

B.) Methyl red E.) Dichloroflouroscein
C.) Phenolphthalein

_______17. What is the allowable quantity of moisture in nonaqueous titration?

A.) Less than 5.0 % D.) Less than 0.005 %

B.) Less than 0.5 % E.) Less than 0.0005 %
C.) Less than 0.05 %

_______18. What is the commonly employed titrant in nonaqueous acidimetry?

A.) Hydrochloric acid D.) Sulfuric acid

B.) Bromic acid E.) Nitric acid
C.) Perchloric acid
________ 19. The indicator used when titrating weak base with a strong acid:

A.) Methyl orange D.) Methyl red

B.) Methyl yellow E.) Methylene red
C.) Methylene blue

________ 20. It refers to the analysis of metal ions:

A.) Precipitation D.) Complexation

B.) Neutralization E.) Oxidation
C.) Reduction

________ 21. Ferric ammonium sulfate , an indicator used in precipitimetry, is

commonly known as _____

A.) DCF D.) Ferroin

B.) Eosin Y E.) TEE
C.) Ferric alum

_______ 22. Which of the following indicator/s is/are used when titrating a strong
with a strong alkali?

A.) Methyl red D.) All of these

B.) Phenolphtalein E.) None of these
C.) Methyl orange

_______ 23. A water-soluble vitamin used as a masking agent:

A.) Vitamin A D.) Vitamin D

B.) Vitamin B E.) Vitamin E
C.) Vitamin C

_______ 24 The following are examples of adsorption indicators in precipitimetry

except:

A.) Tetrabromophenolphthalein ethyl ester D.) Dichloroflourescein

B.) Hydroxynaphthol blue E.) None of these
C.) Eosin Y.

______ 25.What type of analysis involves a change in the valence of the reacting
substances?

A.) Complexation D.) Precipitation

B.) Oxidation-reduction E.) Recombination
C.) Neutralization

_______ 26. What is the purpose of using mixed indicators in some titrations?

A.) Shapen up the color change D.) All of these

B.) Speed up the reaction E.) None of these
C.) Enhance the solubility of the analyte

______ 27. A solid substance of known purity used in preparing standard solutions:

A.) Primary standard D.) Titrand

B.) Analyte E.) Titrant
C.) Secondary standard
______ 28 . What is the indicator used in iodimetry and iodometry?

A.) Phenolphthalein D.) Starch

B.) Ferric alum E.) Potassium permanganate
C.) Hydroxynapthol blue

______ 29. What is the analyte being assayed in iodometry?

A.) Oxidizing agents D.) Basic agents

B.) Acidic agents E.) Reducing agents
C.) Metallic agents

______ 30. Which of the following theory explains the actions of indicators?

A.) Physicchemical theory D.) All of these

B.) Organic theory E.) None of these
C.) Colloidal theory

_______ 31. It refers to the analysis of a metal in the presence of another metal:

A.) Chelation D.) Cerimetry

B.) Masking E.) Digestion
C.) Complexation

_______ 32. The following are ways of forming the equivalent precipitate in
gravimetric analysis except:

A.) Precipitation D.) All of these

B.) Ignition E.) None of these

_______ 33.What is the precipitate form of sulfate following gravimetric ?

A.) Sodium sulfate D.) Magnesium sulfate

B.) Potassium sulfate E.) Calcium sulfate
C.) Barium sulfate

_______ 34. What is the precipitating form of sulfate following gravimetry?

A.) Sliver nitrate D.) Hydrogen sulfide

B.) Magnesia mixture E.) Sodium phosphate

_______ 35. Which of the following is the chemical reaction involved in titrmetric
analysis?

A.) Neutralization D.) Oxidation-reduction

B.) Precipitation E.) All of the above
C.) Complexation

_______ 36. What is the most suitable solvent for the extraction of resins and
resinous materials

A.) Absolute alcohol D.) 80 % Ethanol

B.) Ether E.) N-hexamene
C.) Distilled water
 ______ 37. It refers to the number of mg of KOH required tp neutralize the free
acids present in a sample:

A.) Acid number D.) Ester number

B.) Iodine number E.) Koettsdorfer number
C.) Saponification number

________ 38. Which is the chemical formula of Potassium biphthalate?

A.) KCI D.) KHCO 3

B.) KHC 8H4O4 E.) KHO
C.) K 2CO3

_______ 39. The components of titrimetric analysis are following except:

A.) Analyte D.) Solvent

B.) Titrant E.) None of these
C.) Indicator

_______ 40. What is the composition of crude fiber?

A.) Saponins D.) Phyosterol

B.) Cellulose E.) Proteins
C.) Starch

________ 41. What is the term of referring to Koettsdorfer number?

A.) Acid value D.) Hydroxyl value

B.) Iodine value E.) Ester value
C.) Saponification value

_________ 42. It refers to the method of analyzing the nitrogen content present in
a sample:

A.) Masking D.) Gravimetry

B.) Iodemetry E.) Acidimetry
C.) Kjeldahl method

_________ 43. It refers to the direct or residual analysis of bases using standard
acid solutions:

A.) Alkalimetry D.) Permanganometry

B.) Iodimetry E.) Acidimetry
C.) Cerimetry

_________ 44.) This value serves as a quantitative measure of the proportion of

unsaturated fatty acids present in a sample:

A.) Acid value D.) Hydroxyl value

B.) Ester value E.) Iodine value
C.) Saponification value

_________ 45. Type of oils whose iodine number is more than 120:

A.) Drying oils D.) All of these

B.) Semidrying oils E.) None of these
C.) Nondrying oils

_________ 46. It refers to the method of assaying alcohol content:

 A.) Bisulfite method D.) Hydroxylamine method
B.) Kjeldahl method E.) Masking method
C.) Acetylization method

________ 47. What is the main element present in alkaloids?

A.) Carbon D.) Nitrogen

B.) Hydrogen E.) Sulfur
C.) Oxygen

________ 48. What is the method of titration involved in ultimate assay?

A.) Direct titration D.) All of these

B.) Indirect titration E.) None of these
C.) Residual titration

________ 49. It refers to the nearness of a value to a target value:

A.) Accuracy D.) Error

B.) Defect E.) Any of these
C.) Precision

________ 50.) A buret with a glass stopcock can be used for:

A.) Acids D.) Salts

B.) Bases E.) Oxidizing agents
C.) Alcohols

________ 51. Two substances reacting upon reaching the end-point must have
same :

A.) Volume D.) Weight

B.) Normality E.) % Purity
C.) Number of equivalent

_________ 52. In titrimetric analysis, the substance being analyzed is the:

A.) Indicator D.) Titrand

B.) Normality E.) Both C and D
C.) Analyte

_________ 53. The following are expressions of concentration in volumetric

solutions except:

A.) Molarity D.) Formality

B.) Normality E.) Titer
C.) Molality

_________ 54. An organic compound that changes from one color to another
at a certain pH is called:

A.) Titrand D.) Indicator

B.) Active consitituent E.) Titrant
C.) Analyte

_________ 55. A substance that has a high degree of purity and is used in
direct standardization purposes:

A.) Analyte D.) Secondary standard

B.) Primary standard E.) CP grade
 ________ 56. The experimental way of determining when equivalent amounts
of reactants have reacted together is:

A.) Titration D.) All of these

B.) Masking E.) None of these
C.) Standardization

________ 57. A concentration expression referring to the number of

milliequivalents of sclute per milliliter of solution

A.) Molality D.) Molality

B.) Normality E.) % purity
C.) Formality

________ 58.A solution of known concentration used to standardize another

solution is

A.) Dilute solution D.)Concentrated solution

B.) Standard solution E.) Secondary standard
C.) Primary standard

_________ 59. What is the significance of controlling the temperature in

nonaqueous titrations:

A.) To avoid competition of the titrant with weak nitrogen base

B.) To prevent the volatilization of the titrant
C.) To meet the requirements of the USP in conducting non-
aqueous titrations.
D.) All of these
E.) None of these

________ 60. Based on Arrhenius concept of non-aqueous neutralization

______ are weakly protophylic substances.

A.) Acids D.) Reducing agents

B.) Oxidizing agents E.) Bases
C.) Metals

________ 61. Which titrant in nonaqueous alkalimetry produces a

gelatinous reaction product?

A.) Sodium methoxide D.) Sodium aminometheoxide

B.) Lithium methoxide E.) Sodium triphenylmethane
C.) Potassium methoxide

________ 62. The process by which the exact concentration of a solution is

determined is.

A.) Titration D.) Direct titration

B.) Standardization E.) Residual titration
C.) Masking

_________ 63. Class of systematic error that are invariably caused by faulty and
uncalibrated instruments:
 A.) Personal errors D.) Constant errors
B.) Instrumentals errors E.) Proportional errors
C.) Regeant errors

__________ 64. Silica from the soil that is left after treatment with diluted acid is the

A.) Total ash D.) Loss on drying

B.) Moisture E.) Extractive
C.) Acid-insoluble ash

__________ 65. A type of titration where the first is added in excess with the sample
and the second titrant reacts with the added excess

A.) Direct titration D.) Back titration

B.) Residual titration E.) B and D
C.) Indirect titration

___________ 66. Residual titration method under EDTA titrations is applied to which
metal ion

A.) Potassium D.) Calcium

B.) Magnesium E.) Sodium
C.)Aluminum

__________ 67. The measurement of a weak base in a non-aqueous medium of a given

sample with standard perchloric acid:

A.) Non-aqueous alkalimetry D.) Alkalimetry

B.) Acidimetry E.) Non-aqueous acidimetry
C.) Compleximetry

__________ 68. Ferric alum TS is used as indicator in volumetric precipitation analysis

if the titrant used is:

A.) Sodium Hydroxide solution D.) Hydrochloric acid solution

B.) Ammonium thiocyanate solution E.) Zinc sulfate solution
C.) EDTA solution

__________69. The masking agent used in the assay of Magnesium with EDTA in the
presence of Aluminum.

A.) Triethanolamine D.) Citrates

B.) Thioglycol E.) Ascorbic acid
C.) Potassium Cyanide

__________ 70. Assay of sodium is an example of assay under

A.) Cerimetry D.) Iodimetry

B.) Iodometry E.) Brominimetry
C.) Permanganometry

_________ 71. The apparatus used in assay of volatile oils in spirits:

A.) Cassia flask D.) Distillation flask

B.) Babcock bottle E.) Erlenmeyer flask
C.) Iodine flask

__________ 72. What is the color of phenolphthalein in vinegar?

 A.) Purple D.) Colorless
B.) Blue E.) Pink
C.) Yellow

_________ 73. The primary standard used in the standardization of potassium

permanganate:

A.) Potassium permanganate D.) Sodium hydroxide

B.) Sodium oxalate E.) Potassium dichromate
C.) Potassium biphthalate

__________ 74. The components of blank titration are the following except:

A.) Analyte D.) Indicator

B.) Titrant E.) None of these
C.) Solvent

___________ 75.The following are the cleansing agents for volumetric analysis
except:

A.) Sodium dichromate in sulfuric acid

B.) Synthetic detergent solution
C.) Nitric acid and hydrochloric acid
D.) Solution of trisodium phosphate
E.) None of these

_________ 76. The method of assay for sulfonamides is:

A.) Kjeldahl method D.) Trimetric analysis

B.) Diazotization method E.) Volumetric analysis
C.) Gravimetric method

__________ 77. A water content determination method that uses a xylene tube is:

A.) Karl fischer titration D.) Gravimetric method

B.) Azeotropic method E.) Electrolytic hygrometric method
C.) Dew point method

__________ 78. Adsorption indicators are used in which method of analysis

A.) Acidimetry D.) Precipitimetry

B.) Alkalimetry E.) Oxidation-reduction
C.) Compleximetry

_________ 79. The indicator used in which method of analysis

A.) Phenolphthalein D.) Starch TS

B.) Hydroxynaphthol blue E.) Potassium permanganate
C.) Eosin Y

_________ 80. Specific gravity refers to the ratio of the volume of oil to thst of an
equal volume of pure water when both are determined at 25C. The
official method for determining specific gravity is:

A.) Pycnometer D.) Both A and B

B.) Westphal balance E.) All of these
C.) Hydrometer

___________ 81. It refers to a molecule that provides a group for attachment to metals
 A.) Chelate D.) All of these
B.) Complex E.) None of these
C.) Ligand

___________ 82. A process wherein the sample is made to liberate iodine, which is then
titrated with a standard solution of sodium thiosulfate:

A.) Cerimetry D.) All of these

B.) Iodimetry E.) Iodometry
C.) Diazotization method

____________ 83. Malic Acid present in cherry juice may be determined by:

A.) Direct permanganometry D.) Iodimetry

B.) Indirect permanganometry E.) Iodometry
C.) Residual permanganometry

____________ 84. The Kjeldahl method of analysis used to determine which analyte?

A.) Moisture content D.) Cellulose

B.) Nitrogen content E.) Fat content
C.) Sulfonamides

___________ 85. The iodine value of oils is a quantitative measure of

A.) Cellulose D.) Nitrogen content

B.) Unsaturated fatty acids E.) Water content
C.) Free fatty acids

___________ 86. The number of mg of KOH needed to neutralize the free acids and
saponify the esters in 1 g fat or oil

A.) Acid Value D.) Hydroxyl value

B.) Ester value E.) Iodine value
C.) Saponification.

_____________ 87. Analysis where the constituents of a sample are separated and then
the product are weighed:

A.) Gasometry D.) Volumetric analysis

B.) Titrimetry E.) Diazotization method
C.) Gravimetry

_____________ 88. It refers to the number of milligrams of potassium hydroxide required

to neutralize the acetic , acid obtained by the saponification of 1 gram
of acetylated fatty acid.

A.) Acid value D.) Acetyl value

B.) Saponification value E.) Ester value
C.) Hydroxyl value

_____________ 89. A type of analysis that identifies the amount of a single chemical specie
in a given sample:

A.) Classical method of analysis D.) Volumetric analysis

B.) Ultimate assay E.) Proximate assay
C.) Instrumental assay

___________ 90. EDTA is considered as a/an _____ ligand

 A.) Unidentate D.) Octadentate
B.) Tridentate E.) Pentadentate
C.) Hexadentate

___________ 91. It is present in Koppeschaar’s solution:

A.) Bromine D.) Flourine

B.) Chlorine E.) None of these
C.) Iodine

___________ 92. A means of facilitating the digestion of nitrogen to ammonium sulfate

by interaction with anhydrous sodium sulfate or potassium sulfate:

A.) Use of catalysts D.) All of these

B.) Digestion with sulfuric acid E.) None of these
C.) Gunning method

___________ 93. The temperature for ignition described as dull red heat is

A.) 500-550 oC D.) 1000-1200 oC

B.) 550-700oC E.) 1200-1600oC
C.) 800-1000 oC

___________ 94.Acetylization method of analysis in volatile oils is used to determine

A.) Aldehydes D.) Ketones

B.) Phenols E.) Alcohols
C.) Acids

___________ 95. The valence number of Mn in KMnO 4 is:

A.) +1 D.) +7
B.) +3 E.) +9
C.) +5

___________ 96. The alkaloidal test solution “mercuric potassium iodine TS” is also
known as :

A.) Valser’s reagent B.) Dragendorff’s reagent

B.) Mayer’s reagent C.) None of these
C.) Wagner’s reagent

____________ 97. Determine the iodine value of a sample of olive oil weighing 0.2100 g
if 24.15 mL and 12.00 mL of 0.1100 N sodium thiosulfate solution which
are required for the blank and residual titrations respectively.

A.) 80.5 D.) 80.8

B.) 80.6 E.) 80.9
C.) 80.7

___________ 98. Which of the following physical properties is possessed by alkaloids?

I. Alkaloids combine directly with acids to form salts that are usually
soluble in water?
II. Alkaloids are liberated from aqueous solutions of their salts by alkalies
III. Alkaloids form highly insoluble precipitates with a considerable number
of reagents especially with the salts of some heavy metals
 A.) I only D.) II and III
B.) I and II E.) I,II and III
C.) I and III

____________ 99. Which of the following factors does NOT affect the yield of alkaloids
in plants?

A.) Age of the plant when it was collected

B.) Season of the year when the drug was harvested
C.) Menstrum used in the extraction of the alkaloid
D.) Soil and climate in which the drug was grown
E.) Conditions when the drug was collected;dried and stored

___________ 100. The glassware that is required in the determination of iodine value of
volatile oils

A.) Cassia flask D.) Iodine flask

B.) Erlenmeyer flask E.) Distillation flask
C.) Babcock bottle

___________ 101. What is the unsaponfiable matter present in animal oils and fats?

A.) Ergosterol D.) All of these

B.) Phytosterol E.) None of these
C.) Cholesterol

_________ 102. Acid-insoluble ash is mainly composed of _______

A,) Organic compounds D.) Inorganic matter

B.) Silica E.) Adulterants
C.) Inorganic salts

_________ 103. Find the acid number of rosin sample weighing 1.100 g which required
28.00 mL 0.1100 N NaOH to bring about the end point.

A.) 157.0 D.) 157.3

B.) 157.1 E.) 157.4
C.) 157.2

_________ 104. The temperature equivalent 800 oC is described as:

A.) White heat D.) Dull red heat

B.) Yellow red heat E.) Very dull red heat
C.) Bright red heat

________ 105. A precipitate of AgCl weighing 0.2432 g was obtained from a 25-mL
sample of a hydrochloric acid solution. What is the % w/w HCL content
of the solution ? (Atomic weights : Ag=108,Cl=35,H=1)

A.) 0.2449% D.) 3.0707%

B.) 3.8642% E.) 2.4499%
C.) 25.8787%

________ 106. What is the component of starch that reacts with iodine to form the
intensely blue-colored solution?
 A.) Alpha-Amylose D.) Both A and B
B.) Beta-Amylose E.) Both B and C
C.) Amylopectin

_______ 107.) What weight of arsenic trioxide ( 98.73% ) would be used as a sample
so that 35.00 mL of 0.1 N iodine would be needed to titrate it? (Atomic
weighs : As=175, O=16,I=126.9)

A.) 0.1753 g D.) 0.1756 g

B.) 0.1754 g E.) 0.1757 g
C.) 0.1755 g

_________ 108. A 1.1000 g sample of sodium nitrate was dissolved in sufficient

water to make 100 mL . A 10-mL sample of the solution was added
to 50.00 mL of 0.1 N KMnO 4 in the presence of sulfuric acid . The
mixture was treated with 25.00 mL of 0.0975 N oxalic acid and titrated
with 4.58 mL with 0.1 N KMnO 4. Calculate the % sodium nitrate in the

sample . (Atomic weighs Na=23, N=14, O=16)

A.) 80.36% D.) 80.37%

B.) 90.73% E.) 90.74%
C.) 9.47%

__________ 109. Which of the following is NOT an advantage of permanganate

titrations?

A.) Easily standardized D.) It reacts rapidly

B.) Retains its concentration over E.) Does not need an indicator
long periods of time
C.) It is stable even on boiling

_________ 110. What is the best standard to be used in the standardization of

potassium permanganate?

A.) Sodium hydroxide D.) Sodium biphthalate

B.) Sodium oxalate E.) Sodium carbonate
C.) Sodium chloride

_________ 111. The solvent for fats and fixed oils.

A.) Distilled water D.) 95% ethyl alcohol

B.) n-hexane E.) Chloroform
C.) 80% ethanol

_________ 112. A 2.00mL sample of hydrogen peroxide solution required 8.5mL of

a permanganate solution in titration. If each milliliter of the
permanganate solution is equivalent to 0.007294 g of Fe, what % w/v
of hydrogen peroxide was in the sample ? ( Atomic weights:H=1,O=16
Fe=56)

A.) 0.90% D.) 1.88%

B.) 0.94% E.) 2.00%
C.) 1.80%

_________ 113. Masking is accomplished by adjusting the pH of the titration

medium to favor the analysis of a single metal even in the
 presence of other metals. Bismuth could be solely analyze of the
presence of other metals by adjusting the pH level at_____.

A.) pH 2 D.) pH 11
B.) pH 5 E.) pH 13
C.) pH 7

_________ 114. A 0.2182 g sample of solution chloride was assayed by the Volhard
method using 50.00 mL of 0.0985 N silver nitrate and 11.75 mL of
0.1340 N ammonium thiocyanate . Calculate the % sodium chloride
in the sample ( Atomic weights: Na=23, Cl=35)

A.) 89.00% D.) 89.06%

B.) 89.02% E.) 89.08%
C.) 89.04%

_________ 115. Which acidic solution is being added in precipitation titrations in

order to prevent the precipitation of silver as well as to prevent the
hydrolysis of ferric alum?

A.) Boric acid D.) Perchloric acid

B.) Hydrochloric acid E.) Sulfuric acid
C.) Nitric acid

_________ 116. A chemical reagent that is added in Volhard titrations to form a

film over the precipitated silver chloride particles and prevent its
reaction with ammonium thiocyanate.

A.) Triethanolamine D.) Nitric acid

B.) Nitrobenzene E.) Ferric ammonium sulfate
C.) Thioglycol

________ 117. The end-point determination of a reaction in precipitimetry may be

determined in which of the following way/s:
I. Cessation of precipitation or appearance of turbidity
II. Use of internal indicators
III. Instrumentals methods like potentiometry

A.) I only D.) I and II

B.) II only E.) I, II, and III
C.) III only

_______ 118. A 4.0520 g sample of hydrolic acid .with specific gravity of 1.18,
required 26.25 mL of 0.0952 N sodium hydroxide in titration .What
is the % hydrochloric acid ? (Atomic weights: H=1, Cl=35, Na=23,
C=12, O=16)

A.) 2.20% D.) 2.23%

B.) 2.21% E.) 2.24%
C.) 2.22%

_______ 119. In relation to Question #118 , What is the what is the normality
of hydrochloric acid ?
 A.) 32.81 N D.) 32.84 N
B.) 32.82 N E.) 32.85 N
C.) 32.85 N

________ 120. In relation to Question #118 What is the sodium carbonate

titer of the sample ?

A.) 1.7391 g D.) 1.7394 g

B.) 1.7392 g E.) 1.7395 g
C.) 1.7393 g

_________ 121. Calculate the magnesium oxide content of milk of magnesia 12.32
g of which was dissolved in 50.00 mL of 0.0340 N sulfuric acid ,
producing amixture that required 24.60 mL of 1.1255 N sodium hydroxide
(Atomic weights: Mg=24,O=16)

A.) 3.88% D.) 7.79%

B.) 3.89% E.) 7.80%
C.) 3.90%

________ 122. It refers to the nearness or closeness of the measured values with
one another

A. Accuracy D.) Defect

B.) Error E.) None of these
C.) Precission

_________ 123. If a 0.2800 g sample of sodium bicarbonate ( 96.5%) is titrated

with 0.9165 N sulfuric . What volume of the acid should be required
to produce an end point? ( Atomic weights: Na=23, H=1, C=12, O=16)

A.) 3.49 mL D.) 3.52 mL

B.) 3.50 mL E.) 3.53 mL
C.) 3.51 mL

_________ 124.If the amount of indicator to be used is not specified in the assay
monograph. How much indicator should be added in the analysis?

A.) One drop D.) Four drops

B.) Two drops E.) Five drops
C.) Three drops

________ 125. A theory explaining the reactions of indicators, which is based in

certain groupings of elements in a given compound

A.)Physicochemical theory D.) All of these

B.) Organic theory E.) None of these
C.) Colloidal theory

________ 126. What is the color reaction of methyl red indicator in bases?

A.) Red D.) Blue

B.) Green E.) Purple
C.) Yellow
 ________ 127. Which is the following is NOT a function of indicators?

A.) Determine end-points in neutralization reaction

B.) Determine the pH
C.) Indicate that a desired pH has been achieved
D.) For direct titrations, the reaction must be rapid so a sharp end point
is observed
E.) None of these

_________ 128. The following requirements must be met by any of the reactions in
titrimetric analysis,EXCEPT:

A.) The reaction must proceed to completion by having an equilibrium

constant that is equal to or less than 10 8
B.) The reaction must proceed in a stoichiometric manner
C.) There must be a suitable end-point detecting device
D.) All of these
E.) None of these

_________ 129. Which of the following statements is NOT true regarding transfer
or delivery pipets?

A.) Pipets should be filled to above 1 cm above the mark

B.) Wipe off any liquid adhering to the outer surface of the pipet
C.) Filling pipets by mouth is sometimes recommended
D.) All of these
C.) None of these

_________ 130. A sample of potassium dichromate weighing 1.5650 g was assayed

iodometrically using 26.60 mL of 0.1120 N sodium thiosulfate. Each mL of

0.1 N sodium thiosulfate is equivalent to 49.03 mg of potassium dichromate

What is the % purity or the sample? (Atomic weights:K=39,Cr=52,O=16)

A.) 9.34% D.) 93.50%

B.) 93.40% E.) 94.30%
C.) 0.93%

_________ 131. Calculate the amount of caffeine extracted from coffee beans using
0.0215 g of the sample. The volume of 0.0252 N sulfuric acid added to the
extract was 25.40 mL, the excess was titrated by 21.75 mL of 0.0215 N
sodium hydroxide. Each mL of 0.02 N sulfuric acid is equivalent to 3.8658
mg of caffeine.

A.) 3.26% D.) 3.29%

B.) 3.27% E.) 3.30%
C.) 3.28%

_________ 132. Type of errors that can be determined and corrected

A.) Defective D.) Both A and B

B.) Determinate error E.) Both A and C
C.) Indeterminate error

_________ 133. If a sample of beeswax is found to have an acid number of 15.50 and

and saponification value of 71.20,the ester value of the sample is:

 A.) 86.70 D.) 50.00
B.) 55.70 E.) None of these
C.) 89.00

______134.Given the following data for tragacanth powder. Weight of empty

crucible – 52.452 g; Weight of crucible and sample - 61.648g; Weight
of crucible with sample after drying – 60.502g; Weight of crucible and residue
left after incineration – 53.006g; What is the moisture content in grams?

A.) 1.146 g D.) 1.166 g

B.) 1.144 g E.) 1.441 g
C.) 1.164 g

_______ 135. In relation to Question # 134 ,What is the % moisture content of

the sample ?

A.) 12.64% D.) 12.54%

B.) 12.46% E.) 12.47%
C.) 12.45%

________ 136. In relation to Question #134,what is the total ash content I grams?

A.) 0.545 g D.) 0.556 g

B.) 0.555 g E.) 0.445 g
C.) 0.554 g

________ 137. In relation to Question #134 , what is the % total ash?

A.) 6.20% D.) 6.22%

B.) 6.02% E.) 6.92%
C.) 6.00%

_________ 138. Calculate the calcium carbonate content of a sample of chalk

weighing 0.2545 g and consuming 16.67 mL of 0.1150M of EDTA
solution ( Ca=40 ,C=12 , O=16) The percentage of Calcium carbonate

A.) 75.33% D.) 37.66%

B.) 75.34% E.) 37.65%
C.) 75.30%

________ 139. This is used for the quantitative preparation of astandard

solution

A.) Erlenmeyer flask D.) Volumetric flask

B.) Pipet E.) Beaker
C.) Graduated cylinder

________ 140. It refers to the process of removing an appropriate number of items

A.) Inspection D.) Inspection analysis
B.) Analysis E.) Sampling inspection
C.) Sampling

________ 141. A method that deals with the transitions between energy levels that
are generated by radiant energy after subjecting the molecules in a
magnetic field
 A.) Chromatography D.) Spectrometry
B.) Polarimetry E.) Refractometry
C.) Nuclear Magnetic Resonance

________ 142. The ____ of a nuclei is based on the nuclei’s change and mass

A.) Spin D.) Affinity

B.) Mass E.) None of these
C.) Charge

_________ 143. A branch of electrochemistry which deals with the study and measurement
of electrode potential
A.) Polarography D.) Chromatography
B.) Potentiometry E.) Colorimetry
C.) Refractometry

_______ 144. A method of analysis based of measurement of current resulting from the
electrolysis of an electroactive species at a given electrode at a given electrode

potential under controlled conditions

A.) Chromatography D.) Potentiometry

B.) Colorimetry E.) Refractometry
C.) Polarography

_______ 145. It deals with the study of the rotatory powder of substances

A.) Spectrometry D.) Refractometry

B.) NMR E.) Polarimetry
C.) Potentiometry

________ 146. A radiationless process when the downward transitions occur at a

greater than the upward transitions resulting to the appearance of useful
NMR signals

A.) Saturation D.) Relaxation

B.) Resonance E.) Angular velocity
C.) Magnetic moment

_________ 147 It deals with the study and measurement of index of refraction of
substances in order to assess their composition purity

A.) Polarimetry D.) Refractometry

B.) Potentiometry E.) Spectrometry
C.) Polarography

_________ 148. An instrument that measures the durability of tablets to withsland shock
and abrasion during transport

A.) Spectrophotometer D.) Friabilator

B.) Refractometer E.) Coulter counter
C.) Hardness Tester

__________ 149. It is used as a reference in proton NMR and assigned a chemical shift of
zero
 A.) Tetramethylsilane D.) Trimethoxsilane
B.) Tetramethoxsilane E.) None of these
C.) Trimethylsilane

_________ 150. The type of chromatography where the cellulose of paper is used as the
adsorbent

A.) Column chromatography D.) Gas chromatography

B.) Paper chromatography E.) Liquid chromatography
C.) Thin layer chromatography

__________ 151. It is defined as the ratio of velocity of light in air to the velocity of light
in the medium or the ration of the sine of angle of refraction

A.) Angle of rotation D.) Optical activity

B.) Specific rotation E.) Rotatory activity
C.) Index of refraction

_________ 152. In paper chromatography,the data needed to compute the Rf value is

A.) Distance travel by solute D.) Both A and B

B.) Distance travel by the solvent E.) Both A and C
C.) Distance travel by the blank

_________ 153. In TLC, the separation takes place on a planer surface by:

A.) Differential migration D.) Relative solubility

B.) Electrostatic forces E.) Capillary action
C.) Molecular size

_________ 154. Gypsum in silica gel G is used as:

A.) Disintegrant D.) Diluent

B.) Dessicant E.) Antiadherent
C.) Binder

_________ 155. Wavelength used in all polarimetric measurements

A.) 598 nm D.) 958 nm

B.) 589 um E.) 589 nm
C.) 859 um

_________ 156. For a liquid, it is defined as the angular rotation in degrees through
which the plans of polarization of polarized monochromatic light is rotated
by passage through 1 dm or 100 mm of the liquid calculated on a basis of
specific gravity of 1.0

A.) Index of refraction D.) Specific rotation

B.) Optical activity E.) Angle of refraction
C.) Angle of rotation

_________ 157. It is used in the analysis of volatile substances

A.) Column chromatography D.) Paper chromatography

B.) Liquid chromatography E.) Gas chromatography
C.) Thin layer chromatography

________ 158. Used to measure the optial activity of liquid substances

 A.) pH meter D.) Polarizing microscope
B.) Polariscope E.) Potentiometer
C.) Refractometer

________ 159. A law stating that the power of a transmitted radiant beam decreases
exponentially as the concentration of the solution containing the
absorbing chemical species increases arithmetically

A.) Beer’s law D.) Beer-Lambert’s law

B.) Lambert’s law E.) Beer-Bouguer’s law
C.) Bouguer’s law

_________ 160. Most commonly used,highly abundant,and the most sensitive isotope
in NMR analysis
A.) C12 D.) O16
B.) H1 E.) P31
C.) N14

__________ 161. The calcium and sodium content of the blood can be determined by:

A.)Flame spectroscopy D.) Nephelometry

B.) Turbidimetry E.) Colorimetry
C.) Chromatography

_________ 162. In microbial assay, the instrumental method used to prepare the inocolumn
is:

A.) Nephelometry D.)Turbidimetry

B.) Flame photometry C.) Spectrometry
C.) IR spectroscopy

___________ 163. Acetylene and aldehyde groups present in a compound that absorbs
radiant energy are called:

A.) Active components D.) All of these

B.) Chromophore E.) None of these
C.) Inactive components

__________ 164. It is the number of complete cycles that pass a given point per second

A.) Frequency D.) Radiant energy

B.) Wavenumber E.) Spectrum
C.) Wavelength

__________ 165. A spectrophotometer differs from a colorimeter because it consist of:

A.) Prism D.) Optical scale

B.) Cell compartment E.) None of these
C.) Lamp house

___________ 166. The law related to spectrometry wherin the power of transmitted light
decreases exponentially as the thickness of the solution increases arithmetically

A.) Charles’ law D.) Boyle’s law

B.) Beer’s law E.) Henry’s law
C.) Lambert’s law

____________ 167. The instrument used to measure Na and K ions quantitatively

 A.) Colorimeter D.) Flame photometer
B.) Spectrometer E.) Refractometer
C.) Spectrophotometer

__________ 168. Thiamine is assayed by:

A.) Flame spectroscopy D.) Flame photometer

B.) Spectrometer E.) Refractometer
C.) Flourometry

__________ 169. The following are optical methods of analysis except:

A.) Flame spectroscopy D.) Chromatography

B.) Colorimetry E.) Nephelometry
C.) Turbidimetry

__________ 170. A plot of absorbance against a concentration of a standard drawn

in straight line is:

A.) Charles’ D.) Bougouer’s

B.) Lambert’s E.) Henry’s
C.) Beer’s

_________ 171. The method of assay for Vitamin B12 and calcium pantothenate is by:

A.) Flourometry D.) Nephelometry

B.) Colorimetry E.) Spectrophotometry
C.) Turbidimetry

__________ 172. In IR spectrometry water is not used as a solvent for the sample because
the water will:

A.) Absorb IR radiation D.) Both A and B

B.) Dissolve the NaCl cell holder E.) Both B and C
C.) Not dissolve the sample

_________ 173. A type of biological assay performed with microorganisms, like bacteria,
yeast and molds

A.) Bioassay D.) Fungal assay

B.) Microbial assay E.) Viral assay
C.) Bacterial assay

__________ 174. It refers to the complete wave or cycle from the peak of the next wave :

A.) Wavelength D.) All of these

B.) Frequency E.) None of these
C.) Wavenumber

_________ 175.The most commonly used matrix in pellet making

A.) Cal D.) Nal

B.) KCl E.) Csl
C.) KBr

_________ 176. USP limit for content uniformity

A.) 90-110% D.) 80-120%

B.) 95-105% E.) 97.50-102.50%
C.) 85-115%
 _________ 177. A test which is determined by selecting NLT 30 tablets from each
production batch and assaying 10 tablets individually as directed in the assay
of the official compendial monograph:

A.) Content uniformity test D.) Disintegration test

B) Weight variation test E.) Friability test
C.) Dissolution test

___________ 178. Potentiometry finds application in:

A.) Biologic assay D.) Pharmacological screening

B.) pH determination E.) Toxicity testing
C.) Qualitative assay

___________ 179. Karl Fischer electrometric titration is a method used to assay samples
for it
A.) Carbon content D.) Water content
B.) Nitrogen content E.) Volatile of content

C.) Ash content

_________ 180. Colorimetric methods of analysis are absorptimetric methods that

utilize the____ region of the spectrum

A.) Ultraviolet D.) All of these

B.) Visible E.) None of these
C.) Infrared

________ 181. Which of the following regions of the electromagnetic spectrum is useful
in Spectrometric analysis?

I. X-rays
II. Ultraviolet
III. Visible
IV. Infrared
V. Radio waves

A.) I only D.) I and V

B.) II,III and IV E.) II,III,IV and V
C.) III and IV

________ 182. Which of the following is true about spectrometry?

I. A method of analysis dealing with the measurement of spectra
II. Measures the wavelength in the electromagnetic spectrum where the radiant
energy has interacted with a chemical specie
III. Measures the power of transmitted,fluorescent,reflected or emitted energy

A.) I only D.) I and III

B.) II only E.) I,II and III
C.) III only

_________ 183. It deals with the measurement of the monochromatic radiation absorbed by
chemical species

A.)Spectrophotometry D.) Nephelometry

B.) Flame photometry E.) Turbidimetry
C.) Flourometry
 ________ 184. The wavelength ranging from 3 to 15 micrometers falls under which region
of the spectrum?

A.) Ultraviolet D.) Mid infrared

B.) Visible E.) Far infrared
C.) Near infrared

__________ 185.One micrometer is equivalent to:

A.) 10 -2 cm D.) 10 -8cm

B.) 10-4 cm E.) 10 -9cm
C.) 10 -7cm

________ 186. In the formula E = hv,”h” is the____

A.) Energy D.) Planck’s constant
B.) Frequency E.) Wavenumber
C.) Wavelength

_________ 187. A fundamental vibration of atoms in which the distance increases or

decreases along the bond axis:

A.) Scissoring D.) Wagging

B.) Deformation E.) Twisting
C.) Stretching

________ 188. What microorganism is used in the microbial assay test for Vitamin B12?

A.) Lactobacillus shirota D.) Lactobacillus bifidus

B.) Lactobacillus plantarum E.) All of these
C.) Lactobacillus leichmanii

________ 189. Which of the following is NOT true about the fingerprint region?

I. Wavelength range of 8 to 15 um
II. Gives the spectrum of a molecule as a whole
III. Energy absorption is because of the functional groups

A.) I only D.) I and II

B.) II only E.) II and III
C.) III only

________ 190. A microbial assay for antibiotics that measures the diameter of the zones
of microbial growth inhibition in a solid nutrient medium.

A.) Cylinder plate method D.) All of these

B.) Broth dilution method E.) None of these
C.) Turbidimetric method

________ 191.

________ 192. The turbidimetric assay of antibiotic potency is based on the inhibitation
of microbial growth by measuring the turbidity of the bacterial suspension.
The degree of turbidity is measured in terms of:
 A.) Absorbance D.) All of these
B.) Transmittance E.) None of these
C.) Concentration

_________ 193. Mull technique in IR spectroscopy is:

A.) Dissolving the solid in a suitable organic solvent D.) All of these
B.) Incorporating the solid in a pellet E.) None of these
C.) Dispersing the finely ground solid in liquid
petrolatum

__________ 194.In cylinder plate method of the microbial assay for antibiotics,the
measurements are based on the of the zone of microbial growth inhibition

A.)Radius D.) All of these

B.)Diameter E.)None of these
C.)Circumference

___________195.Fluorometry is the official method use in the analysis of which vitamins?

A.)Nicotinamide D.)Folic acid

B.) Riboflavin E.) Cyanocobalamin

C.) Pyridoxine

_________196. The microbial assay for this compound is based on the inability of the
microorganism to synthesize the factor being assayed

A.) Antibiotics D.) Hypotensive drugs

B.) Insulin E.) Sulfonamides
C.) Vitamins

__________ 197. Turbidimetric and nephelometric methods of assay analyze what

type/s of samples?

A.) Suspension D.) Both A and B

B.) Solution E.) Both A and C

_________ 198. Vitamin B12 is also known as:

A.)Thiamine D.) Pyridoxine

B.) Riboflavin E.) Folic acid
C.) Cyanocobalamin

_______ 199. These are substances or bacterial components that cause fever or
febrile reaction

A.) Toxins D.) Exotoxins

B.) Pyrogens E.) Antigens
C.) Enzymes

________ 200. Turbidimetry is the method use for the assay of which vitamins

A.) Tocopherol D.) Folic acid

B.) Thiamine E.) Cyanocobalamin
C.) Ascorbic Acid

_________ 201. What is the minimum number of rabbits used in Pyrogrn test?
 A.) One D.) Four
B.) Two E.) Five
C.) Three

________ 202. What biological animal is used when conducting in Pyrogen test?

A.) Dogs D.) Frogs

B.) Horses E.) Rats
C.) Rabbits

________203. A spectrometric method of analysis which is used in the standardization

of bacterial incolumns in microbial assays.

A.) Spectrophotometry D.) Flame photometry

B.) Flourometry E.) Nephelometry
C.) Turbidimetry

_________ 204. A decisions to accept is made in the pyrogen test if the temperature
rise in one rabbit is:

A.) Less than 0.5oC D.) Equal or less than 0.5oC

B.) Equal to 0.5 oC E.) Equal to or more than 0.5 oC
C.) More than 0.5 oC

_________ 205. It is the process by which a solid enters into solution.

A.) Disintegration D.) All of these

B.) Deaggregation E.) None of these
C.) Dissolution

_________ 206. A spectrometric method of analysis that measures the reflected light
passing through a turbid solution or a suspension

A.) Flourometry D.) Polarimetry

B.) Refractometry E.) Spectrophotometry
C.) Nephelometry

________ 207. If the requirement for the pyrogen test was not met,a repeat test
is a required using additional rabbits

A.) One D.) Seven

B.) Three E.) Nine
C.) Five

_________ 208.Which is true for dissolution test?

A.) A simple and inexpensive indicator of a product’s physical activity

B.) It is a useful tool in the early stages of drug development and molecular
manipulation
C.) It serves as an approximation of the drug’s biological activity
D.) All of these
E.)None of these

_________ 209. The following are the basic components of the instrument used in
NMR studies,EXCEPT
A.) Radiofrequency transmitter D.) Prism or diffraction grating
B.) Magnet E.) Detector and recorder
C.) Method of sweeping through the spectrum
 _________ 210. In the repeat test for pyrogens using a total of eight rabbits,the
requirement is met if the total rise in temperature is:

A.) Less than 3.3 Celsius D.) Equal to or less than 3.3 Celsius
B.) Equal to 3.3 Celsius E.) Equal to or more than 3.3 Celsius
C.) More than 3.3 Celsius

________ 211. The solvent used in NMR assay must be free from

A.) Neutrons D.) Positrons

B.) Electrons E.) Negatrons
C.) Protons

________ 212. Which of the following physicochemical properties does NOT affect
dissolution of drugs?

A.) Solubility D.) Polmorphism

B.) Particle size E.) Solid phase characteristics of the drug
C.) Method of granulation

_________ 213. Which of the following is/are used as dissolution media when conducting
the dissolution test?

A.) Distilled water D.) All of these

B.) Simulated gastric fluid E.) None of these
C.) Simulated intestinal

_________ 214. Which among the following solvents in NMR assay?

A.) Chloroform D.) Absolute alcohol

B.) Carbon tetrachloride E.) All of these
C.) Ether

________ 215. This is also known ain s “in-vitro” pyrogen test

A.) Rabbit test D.) Both A and CE

B.) Bacterial endotoxin test E.) Both B and
C.)LAL test

_________216. What is the most popular indicator electrode used in pH determination?

A.) Quinhydrone electrode D.) Calomel electrode

B.) Glass electrode E.) Standard hydrogen electrode
C.) Ag/AgCI electrode

__________217. Apparatus 1 in a dissolution apparatus:

A.) Basket D.) Flow-through cell

B.) Paddle E.) Paddle over disk
C.) Receprocating cylinder

__________218. The following are the principal objectives of chromatography, EXCEPT:

A.) Resulotion of mixtures into constituent part

B.) Compsrison of substance suspected of being identical
C.) Dilution of substance from concentraded solutions
 D.) Purification of samples
E.) Quantitative separation from complex mixtures

__________219. What is the reference electrode used in polarography?

A.) Saturated hydrogen electrode D.) Glass electrode

B.) Quinhydrone electrode E.) Saturated calomel electrode
C.) Dropping mercury electrode

__________220.LAL in bacterial test is also known as

A.) Limulus amebocyte lysate D.) Limnulus amebocyte lysate

B.) Limulus amebocide lysate E.) None of these
C.) Linnaeus amebocyte lysate

__________221.Which of the following is NOT a principle of separation in chromatography?

A.) Absorption D.) lon-exchange

B.) Adsorption E.) Molecular exclusion
C.) Partition

_________222. Apparatus 2 in a dissolution tester is:

A.) Basket D.) Flow-through cell

B.) Paddle E.) Paddle over disk
C.) Partition

__________223.It is the current resulting from the oxidation or reduction of electroactive

substances at the microelectrode

A.) Electric current D.) All of these

B.) Charging Current E.) None of these
C.) Faradaic current

________ 224 What instrument is used to determine the position of the separated radioactive
components following chromatography?

A.) Painting the column D.) Spraying with colored solution

B.) Charring E.) Geiger-Muller counter
C.) Use of iodine vapors

_________ 225. LAL is an aqueous extract of the circulating amebocytes obtained from

A.) Horses D.) Mice

B.) Crab E.) Dogs
C.) Horseshoe crab

__________ 226. What is the required temperature of the dissolution media?

A.) 35oC D.) 35-39 oC

B.) 37oC E.) 36-38 oC
C.) 36.5-37.6oC

__________ 227. A law stating that when two immiscible solvents are in contact with each
other and a substance which is soluble in each is added ,the substance distributes
itself in a way that at equilibrium and a given temperature ,the ratio of the
concentrations of the two solutions is constant.
 A.) Beer’s law D.) Stokes’s law
B.) Lambert’s law E.) Bougouer’s law
C.) Nernst’s law

_________ 228.) It is considered as the most rapid way of determining water content of
samples

A.)Gravimetric method D.) Dew point

B.) Karl fischer titration
C.) Xylene method

_________ 229. The observed result in bacterial endotoxin test is the formation of:

A.) Zone inhibition D.) Color change

B.) Transmittance E.) Acid production
C.) Gel Clot

_________ 230. A type of paper chromatography which is accomplished by allowing the

mobile phase to rise upward following capillary attraction

A.) Ascending chromatography D.) All of these

B.) Descending chromatography E.) None of these
C.) Radial chromatography

________ 231. Which of the following is NOT a component of Karl Fischer reagent?

A.)Pyridine D.) Sulfuric acid

B.) Iodine E.) None of these
C. Methanol

___________ 232. It refers to the ability of tablets resist chipping ,abrasion or breakage
under conditions of storage transportation and handling before usage.

A.) Thickness D.) Content uniformity

B.Disintegration E.) Weight variation
C.) Methanol

__________ 233. Which chromatographic technique is used in the separation of water-

insoluble substance like steroids?

A.) Adsorption chromatography D.) Ion-exchange chromatography

B.) Parition Chromatography
C.) Reversed-phase chromatography

__________ 234. The bacterial source of the USP References Standard for Endotoxin is:

A.) Staphylococcus aureus D.) Haemophilus influenza

B.) Strephylococcus pyogenes E.) Vibrio cholera
C.) Escherichia coli

__________ 235. A substance that rotates plane polarized light to the right is designated as

A.) Dextrorotatory D.) All of these

B.) Levorotatory E.) None of these
C.) optically active

___________236. Which among the chromatograpihic technique separates constituents of

the sample based on the molecular size?
 A.) lon-exchange D.) Reversed-phase
B.) Partition E.) Gel-filtration
C.) Adsorption

____________237. A tablet hardness tester that uses a coil spring mechanism to break the tablet.

A.) Srtong- Cobb HT D.) Reversed-phase

B.) Pfizer HT E.) Schleuniger HT
C.) Erweka HT

____________238. Calculate the percent moisture in aminosalicylic acid if 9.00 mL of KFR ,having
a water equivalence factor of 4.10,was consumed by a 5.100g sample.

A.) 723.52% D.) 531.38%

B.) 723.53% E.) 531.39%
C.) 531.37%

___________239. A type of chromatography that involves the spotting of a sample of a mixture of

components at one end of an adsorbent –coated glass plate followed by passage
of a solvent through the adsorbent for the purpose of separating the
components of the sample.

A.) Paper chromatography D.) Gas chromatography

B.) Column chomatography E.) Liquid chromatography
C.) Thin layer chromatography

___________240. This is the in-vivo way of determining the presence of pyrogens.

A.) Bacterial endotoxin test D.) Turbidimetric

B.) Cylinder plate method E.) None of these
C.) Rabbit test

___________241. The prism that is used in examining the polarized light is called the:

A.) Polarizer D.) Nicol prism

B.) Diffraction grating E.) None of these
C.) Analyzer

__________242. What is the best solvent system to be used in separating components of an

unknown sample?

A.) Benzene with 10% ethanol D.) Chloroform with benzene

B.) Benzene with 10%methanol E.) Choroform with 10% ether
C.) Ether with 10% ethanol

________243.What is the minimum satisfactory hardness value for a compressed tablet?

A.) 2 kg D.) 4-10kg

B.) 2-3kg E.) 10kg
C.) 4 kg
_______ 244. Mikhail Tswett discovered chromatography through an experiment regarding:

A.) Proteins D.) Pigments

B.)Alkaloids E.)Carbohydrates
C.) Glycosides

________ 245. Which of the following methods can be used in visualizing separated
components that are colorless?

A.) Charring using sulfuric acid D.) All of these

B.) Use of iodine crystals E.) None of these
C.) Examination using UV radiation

__________ 246. A tablet hardness tester that uses an air pump

A.) Schleuniger HT D.) Stokes-Monsanto HT

B.) Pfizer HT E.) Strong-Cobb HT
C.) Erweka HT

________ 247. USP defines this method as a technique of separating molecular mixtures

A.) Filtration D.) Refractometry

B.)Chromatography E.) Potentiometry
C.) Spectrophotometry

_______ 248. The inert gas used as mobile phase in gas chromatography is referred to
as:

A.) Vehicle gas D.) All of these

B.) Carrier gas E.) None of these
C.)Gas substrate

________ 249. A hardness tester that operates on the same mechanical principle as
ordinary pliers

A.) Stokes-Monsanto HT D.) Schleuniger

B.) Pfizer HT E.) Erweka HT

________ 250. A hardness tester that eliminates the operator variability in measuring
tablet hardness

A.) Erweka HT D.) Strong-Cobb HT

B.) Schleuniger HT E.)Stokes-Monsanto HT
C.) Pfizer HT
________ 251. It refers to the time required by an average molecule of component
to pass from the injection point through the column to the detector

A.)Retention factor D.) Any of these

B.) Retention volume E.) None of these
C.) Retention time

________ 252.This is also known as “crushing strength”

A.) Hardness D.) Content uniformly

B.)Thickness E.) Weight variation
C.) Friability

________ 253. An instrument that is used to determine tablet friability

A.) Dissolution apparatus D.) Disintegration apparatus

B.) Friabilator E.) Moisture analyzer
C.) Hardness tester

________ 254. Which is the following is NOT an advantage of HPLC?

A.) Precise D.) Ease of operation

B.) Slow separation E.) None of these

C.) Accurate

_________ 255. It refers to the ability of a tablet to withstand abrasion in packaging,

handling,and shipping

A.) Content uniformly D.) Hardness

B.)Friability E.)Thickness
C.) Crushing strength

_________ 256. A test that exposes tablets to rolling and repeated shocks to determine
the weight loss on tables.

A.) Disintegration test D.) Friability test

B.) Hardness test E.) Dissolution test
C.) Thickness test

_______ 257. What is the prerequisite for solvents used in high pressure liquid
Chromatography?

A.) Free from protons D.) All of these

B.) HPLC grade E.) None of these
C.) Degassed

_______ 258. Which of the following can be used in measuring tablet thickness?
 A.)Hardness tester D.) Dissolution apparatus
B.) Vernier caliper E.) Ruler
C.) Friabilator

________ 259. What is the tolerable limit/allowance in thickness test for tablets?

A.) 85 to 115% D.) 92.5 to 107.5%

B.) 87.50 to 112.50% E.) 95 to 105%
C.) 90 to 110%

________ 260. What is the number of tablets required in weight variation test?

A.) 10 tablets D.)25 tablets

B.) 15 tablets E.) 30 tablets
C.) 20 tablets

_______ 261.What are the variation limits if the computed average weight
for a bath of tablets is 100mg?

A.) 95 mg to 105 mg D.) 90 mg to 110 mg

B.) 80 mg to 120 mg E.) 85 mg to 115 mg
C.) 92.50 mg to 107.50 mg

_________262. Using a spectrophotometer to measure the concentration of the

sample,the following data werw obtained:

Absorbance of standard solution = 0.225

Absorbance of sample solution = 0.214
Concentration of standard solution = 17.7 mcg

A.) 18.6 mcg D.) 16.9 mcg

B.) 19.0 mcg E.) 17.7 mcg
C.) 16.8 mcg

_____________263. LAL test applicable in the determination of:

A.) Microorganisms D.) All of these

B.) Pyrogens E.) None of these
C.) Chemical impurities

_____________264.

_____________265.The amount of dissolved drug can be determined by:

A.) Friabilator D.) Moisture anayzer

B.) Dissolution tester E.) Spectrophotometer
C.) Hardness tester

__________266. Content uniformity is to be performer for ali tables whose active ingredients is

A.) Less than 50 mg D.) More than 50mg

B.) Less than 100 mg E.) More than 100mg
C.) 50mg to 100mg
 _________267.Stationary phase:
I. The fixed phase in chromatography
II. A porous or ficaly divided solid or a liquid that has been coated in a thin layer
on an inert supporting material.
III. The particles should be small and homogenous so as to provide a large
surface area so that sorption of the solutes will occur frequently
and efficiently

A). I only D.) II and III

B.) II only E.) I, II and III
C.) III only

_________268. The initial content uniformity test is conducted using:

A.) 10 tablets D.) 25 tablets

B.) 15 tablets E.) 30 tablets
C.) 20 tablets

________269. The following pharmaceutical excipients affect the disintegration of tablets ,EXCEPT:

A.) Binders D.) Disintegrants

B.) Colorants E.) Diluents
C.) Granulating agents

________270. It is the universal detector used in gas chromatography since it responds to all
type of solutes.

A.) Flame ionization detector D.) Thermoionic specific detector

B.) Thermal conductivity detector E.) Flame photometric detector
C.) Electron capture detector

___________271. A passing tablet friability result is a maximum weigth of NMT what % of the weight
of the tablets being tested:

A.)0.50% D.) 2.00%

B.) 1.00% E.) 2.50%
C.1.50%
__________272. What tablet attribute is correlated with the biological activity of the active
ingredients?

A.) Hardness D.) Disintegration

B.) Dissolution E.) Thickness
C.) Friability

__________273. A dector in gas chromatography which is most frequently used because it is highly
sensitive is able to detect microgram quantities of solutes and is an almost
universal detector.

A.) FID D.) TSD

B.) TCD E.) ECD
C.) NPD
_________274. Given a tablet thickness of 0.47 cm,what should be the acceptance range?

A.) 0.4465 to 0.4935 cm D.) 0.3525 to 0.5875 cm

B.) 0.4348 to 0. 5050 cm E.) 0.3760 to 0. 5640 cm
C.) 0.4230 to 0.5170 cm

_______275. A spectrometric method that measure the amount of light that that scattered by
a suspension

A.) Colorimetry D.) Flame photometry

B.)Turbidimetry E.)AAS
C.) Nephelometry

_______ 276. A modified form of the flame ionization detector that shows increased response
to compounds containing nitrogen phosphorus

A.) Thermal conductivity detector D.) Flame ionization detector

B.) Thermoionic specific detector E.) Electron capture detector
C.) Flame photometric detector

________ 277. Microbiological assays are recommended for which of the following?

A.) Anesthetics D. Antipsychotics

B.) Sedatives E.)Tranquilizer

C.) Antibiotics

________ 278. A QC test that measure the time required for tablet to undergo disintegration
under specified set of conditions

A.) Dissolution test D.) Disintegration test

B.) Hardness test E.) Content uniformity test
C.) Friability test

________ 279. What is the strongest adsorbent used in column chromatography

A.) Starch D.) Alumina

B.) Calcium carbonate E.) Charcoal
C.) Silica gel

________ 280. In disintegration test the particles must pass through sieve#____

A.)10 D.) 60
B.)20 E.) 80
C.) 40

_______ 281. The basket rack assembly is a component of which of the following instrument

A.) Hardness tester D.) Friabilator

B.) Vernier caliper E.) FTIR
C.) Disintegration apparatus
________282. It refers to a chromatographic method in which the separation takes place
within a packed column.

A.) Paper chromatography D.) gas chromatography

B.) Vernier caliper E.) Thin layer chromatography
C.) Liquid chromatography

________283. The temperature of the testing fluid used in disintegration must be maintained at

A.) 30 to 40 celsius D.) 36 to 38 celsius

B.) 32 to 38 celsius E.) 35 to 40 celsius
C.) 35 to 39 celsius

________284. For the result of the disintegration test to be accepted using 18 samples ,the
allowed tablets that fail to disintegrateis:

A.) Zero D.) Six

B.) Two E.) Eight
C.) Four

________285. Which of the following methods can be performed to removed unwanted gases of the
mobile phase used in I IPLC?

A.) Used of a vacuum D.) All of these

B.) Sonication E.) None of these
C.) Sparging with helium

________286. What is the disintegration time for sublingual tablets like isoproterenol HCl CT?

A.) 3 minutes D.) 2hours

B.) 30 minutes E.) 3 hours
C.) 1 hour

________ 287. A test that measures the amount of time required for a given percentage
of the drug,substance in a tablet to go into a solution under a specified
set of condition

A.)Friability test D.) Thickness test

B.) Dissolution test E.) Disintegration test
C.) Hardness test

________ 288. What part of the HPLC instrument is used to contain the mobile phase?

A.) Reservoir D.) Analytical column

B.) Pump E.) Detector
C.)Injector port

________ 289.It is the one responsible for the test and measure of materials and products

A.) Total Quality Management D.) All of these

B.) Quality Control E.) None of these
C.) Quality Assurance

________ 290. It is the one responsible for establishing the system to ensure product quality

A.) Total Quality Management D.) All of these

B.) Quality Control E.) None of these
C.) Quality Assurance
________ 291.It refers to the sum of all factors which contribute directly or indirectly to the safety
effectiveness and reliability of a product

A.) Safety D.) Efficancy

B.) Purity E.) All of these
C.) Quality

_________ 292. Organic volatile chemical from the process or generated during processing is an
example of what class of impurity?

A.) Organic D.) All of these

B.) Inorganic E.) None of these
C.)Solvents

_________293. Phase of Pharmaceutical Product Development categorized as definitive clinical

efficancy studies

A.) Phase 0 D.) Phase III

B.) Phase I E.) Phase IV
C.) Phase II

_________ 294. It is an optional component/part of the HPLC instrument which functions to saturate
the mobile phase in order to retard dissolution and to trap particulate matter thereby
protecting the main column

A.) Guard column D.) Both A and B

B.) Analytical column E.) Both A and C
C.) Precolumn

________ 295. Which of the following is/are the application/s of quantitative

A.) Analysis and determination of the purity and quality

drugs and chemicals used in pharmacy
B.) Analysis of the chemical constituents found in the human body
whose altered concentrations during disease states serve as diagnostic
aids in the practice of medicine.
C.) Analysis of medicinal agents and their metabolites found in the biological
systems
D.) All of these
E.) None of these