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CLINICAL

Early detection of eating disorders in


general practice
Elizabeth Rowe

E
Background ating disorders are complex, these modifications broaden the criteria
potentially life-threatening conditions for specific eating disorders such as
General practitioners (GPs) are often characterised by significant anorexia nervosa and bulimia nervosa,
the first health professional consulted
disturbances in eating behaviour that but also more precisely categorise the
in regard to eating disorders and
result in serious medical, psychiatric previous diagnostic category of EDNOS.
their varied presentations. Given the
and psychosocial consequences. Eating Patients who lose significant amounts
prognostic significance of early detection
disorders are formally classified on the of weight and meet the other diagnostic
of, and intervention for, such conditions,
basis of the Diagnostic and statistical criteria for anorexia nervosa, but who are
it is important that GPs feel confident to
do so. manual of mental disorders, 5th edition not underweight, will now be diagnosed
(DSM-5) criteria (Table 1).1 with atypical anorexia nervosa.4
Objective
DSM-5 classification and Magnitude of the problem
The aim of this article was to criteria The prevalence of eating disorders in
heighten awareness of the role of early The diagnostic criteria for anorexia nervosa Australia is conservatively estimated to
identification and diagnosis of eating and bulimia nervosa were updated in the be 9% of the adult population, and this
disorders, especially anorexia nervosa DSM-5. Other eating disorders, including figure continues to increase.5 In fact,
and bulimia nervosa, in the primary
binge-eating disorder (BED), pica, a 2015 study of older adolescents and
care setting. The focus will be on their
rumination and avoidant/restrictive food adults found a point prevalence as high as
presentations and diagnosis, including
intake disorder (ARFID), have also been 16.3%, where BED accounted for 6.3%
changes to the Diagnostic and statistical
added in the DSM-5. In addition, atypical and subthreshold BED 7%. By contrast,
manual of mental disorders, 5th edition
presentations are now included under the anorexia nervosa and bulimia nervosa
(DSM-5), with a brief overview of
management recommendations and newly named categories of other specified each occurred in less than 1% of the
admission criteria. feeding or eating disorder (OSFED), and population.6
unspecified feeding or eating disorder In spite of the seemingly low prevalence
Discussion (UFED); these replace eating disorder not rate in the general population, anorexia
otherwise specified (EDNOS). nervosa and bulimia nervosa are of great
Eating disorders are complex, potentially Some of the significant revisions significance because of their incidence
life-threatening illnesses with significant are the removal of amenorrhoea as a in adolescent female patients and their
medical and psychosocial consequences.
diagnostic criterion for anorexia nervosa mortality rate.7 These conditions represent
Early detection and intervention can
in female patients, and reduction of binge the third most common chronic illness
significantly contribute to better outcomes,
frequency to an average of once per week (after asthma and obesity) in adolescent
and GPs are ideally placed to effect this.
for bulimia nervosa.2 The modifications female patients.7 In addition, anorexia
were anticipated to better represent the nervosa has the highest mortality rate of
symptoms and behaviours of patients all psychiatric disorders;8 long-term studies
dealing with these conditions, and enable report mortality rates of approximately
more specific eating disorder diagnoses, 20%.9 It has been noted that ‘compared
thereby facilitating initiation of appropriate with their peers without the illness, the
and timely management.2–4 In theory, risk of premature death is approximately

© The Royal Australian College of General Practitioners 2017 REPRINTED FROM AFP VOL.46, NO.11, NOVEMBER 2017 833
CLINICAL EARLY DETECTION OF EATING DISORDERS

Table 1. Summary of DSM-5 diagnostic criteria for eating disorders

Anorexia nervosa Bulimia nervosa

a. Restriction of energy intake resulting in a significantly low body a. Recurrent episodes of binge eating (this involves eating an excessive
weight; or a less than minimally expected weight (based on age, sex amount of food in a discrete period of time AND a sense of lack of
or developed trajectory) control)
b. Intense fear of gaining weight; or persistent behaviour that interferes b. Recurrent inappropriate compensatory behaviours to prevent weight
with weight gain, despite low weight gain, such as vomiting, laxatives, diuretics, fasting or excessive
c. Disturbance in body image; or persistent lack of recognition of the exercise
seriousness of the current low body weight c. Frequency of at least once per week for three months
Subtypes: Restricting type, binge-eating/purging type d. Self-evaluation unduly influenced by body shape and weight
e. Absence of anorexia nervosa

Binge eating disorder Other specified feeding or eating disorder (OSFED)

a. Recurrent episodes of binge eating Eating disorders causing significant distress but not meeting criteria for
b. Associated with symptoms such as eating more rapidly, feeling other diagnostic categories
uncomfortably full, not feeling hungry, eating alone due to Examples:
embarrassment and/or feelings of self-disgust • Atypical anorexia nervosa – ‘normal weight anorexia nervosa’
c. Marked distress regarding binge eating • Bulimia nervosa (of low frequency and/or limited duration)
d. Frequency of at least once per week for three months • Subthreshold binge-eating disorder
e. Absence of compensatory behaviours, anorexia nervosa and bulimia • Purging disorder
nervosa • Night eating syndrome

Avoidant/restrictive food intake disorder (ARFID) Unspecified feeding or eating disorder (UFED)

a. Eating or feeding disturbance with persistent failure to meet nutritional Presentations in which clinically significant symptoms occur but do not
needs associated with either significant weight loss (or growth failure), meet full criteria for other eating disorders. Includes situations where the
significant nutritional deficiency, dependence on enteral/supplemental clinician chooses not to specify the reason criteria are not met or where
feeding or marked interference with psychosocial functioning this may be unknown (eg emergency room setting)
b. Not explained by lack of available food or culturally sanctioned
practice
c. Absence of anorexia nervosa, bulimia nervosa or body image
disturbance
d. No intercurrent medical illness

tenfold higher in a person with anorexia of most presentations. Given that early the adolescent brought in by a parent
nervosa’.10 intervention may limit the progression and who is concerned about their child’s
In addition, these illnesses represent improve outcomes of eating disorders, nutritional intake, behaviours surrounding
a significant socioeconomic cost to the early recognition is imperative.12–15 Hence, food and/or weight, should alert the GP
community. In 2012, Deloitte Access it is appropriate to commence medical to the possibility of an eating disorder
Economics estimated the figure to be management before a patient fulfils all with a more directed history and
$69.7 billion. Of this amount, the direct of the diagnostic criteria of a particular examination protocol.
healthcare cost is $99.9 million and the eating disorder,14 thereby limiting or However, far more challenging from
remainder is due to productivity loss reversing symptom progression and a detection and therefore diagnostic
and loss of healthy years of life.11 optimising prognosis. standpoint is a patient who presents with
seemingly ‘unrelated complaints’.15 These
Importance of early General practice complaints include psychological issues
identification consultation such as stress, depression or anxiety;
To limit the impact of these disorders GPs face a number of challenges in the physical complaints such as fatigue,
in terms of physical, psychiatric and early identification of patients with an dizziness, gastrointestinal problems
economic outcomes, it is essential that eating disorder;15,16 this is particularly (especially constipation and bloating)
general practitioners (GPs) are able to the case when the presentation does and, for female patients, menstrual
identify and initiate management in such not relate to dietary intake or weight. irregularities; chronic health problems
patients, as primary care is the context Conversely, the classic presentation of such as osteoporosis; and socioeconomic

834 REPRINTED FROM AFP VOL.46, NO.11, NOVEMBER 2017 © The Royal Australian College of General Practitioners 2017
EARLY DETECTION OF EATING DISORDERS CLINICAL

consequences such as financial behaviours.14,19 However, other signs can empathic and non-judgemental manner,
insecurity due to inability to sustain be readily observed in the consultation it provides an ideal opportunity for
employment.17–19 or described by family members. The engagement with patients and a greater
Of course, the other impediment warning signs include psychological likelihood that they will accept the
to early identification is delayed manifestations, commonly anxiety; medical care they require.14,18 There are
presentation. Patient factors contributing behaviours such as avoiding meals; and only a few other medical conditions
to this include:15,20 physical issues that include menstrual where the therapeutic alliance between
• ambivalence about recovery irregularity or cessation in female patients. doctor and patient is so critical.19
• stigma and shame A detailed list of these features is shown A thorough history will also eliminate
• denial of, and failure to, perceive the in Table 2. many of the other potential differential
severity of the illness Hence, a detailed history is paramount diagnoses of weight loss or symptoms
• low motivation to change in the assessment process. When a (eg amenorrhoea in female patients). GPs’
• negative attitudes towards seeking help detailed history is performed in an failure to identify that certain symptoms
• lack of knowledge about available
resources
• practical issues (eg distance, cost). Table 2. Eating disorder warning signs1,2,7,14,18,24
There are a number of screening tools that Behavioural
can be used in the primary care setting
• Avoiding eating in public • Excessive use of the toilet
to assist in the detection and diagnosis
• Fussy eater/banned foods • Body checking
of eating disorders. The best known of
• Cooking for others yet not eating • Constant focus on food, diet and exercise
these is the SCOFF questionnaire, which
• Frequent weighing • Has different meals to rest of family
consists of five questions:21
• Excessive exercise • Social isolation
1. Do you make yourself Sick • Stressed when unable to exercise • Calorie counting
because you feel uncomfortably • Trains through injury • Use of diet pills, laxatives, supplements
full? • Restricted/rigid diet • Throws away food
2. Do you worry you have lost • Wears baggy clothing • Denies problem
Control over how much you eat? • Avoiding meals • Slow eating/picking at food
• Raiding the refrigerator • Developing ‘allergies’ to food
3. Have you recently lost more than
• Eating low-calorie foods • Eating in secret
One stone (6.35 kg) in a 3 month
period? Psychological
4. Do you believe yourself to be Fat • A
nxiety, especially in regards to food/ • Poor concentration
when others say you are too thin? eating • Perfectionism
5. Would you say that Food • Depression • Low self-esteem
dominates your life? • Social phobia/withdrawal • Guilt, especially around food
• Distorted body image • Obsessiveness
Each ‘yes’ answer scores one point and
• Negative body image • Subtle cognitive changes
a score of ≥2 indicates a likely diagnosis
• Feelings of lack of control • Hopelessness
of anorexia nervosa or bulimia nervosa.21
• Suicidality
However, the most poignant comment
on diagnosis is conveyed in this quote Physical
from the National Institute for Health and • Sensitivity to the cold • Dry hair or skin
Clinical Excellence (NICE) guidelines: • Brittle nails • Lanugo
‘The most effective screening device • Dorsal finger callouses • Feeling faint, cold or tired
probably remains the general practitioner • Stress fractures • Bone pain
thinking about the possibility of an eating • Muscle cramps • Injuries due to over-exercising
disorder’.19 • Dental caries • Gingivitis
In addition to screening tools, there are • Parotid enlargement • Self harm
a number of ‘warning signs’ that can aid • Irregular or cessation of menstruation • Abdominal pain/distension
in the detection of eating disorders. Some • G
astrointestinal symptoms – bloating, • Early satiety
nausea • Hypercarotenaemia
of these warning signs can be difficult to
• Anaemia • Halitosis
detect because of the patient’s secrecy,
• Insomnia
deception or shame surrounding their

© The Royal Australian College of General Practitioners 2017 REPRINTED FROM AFP VOL.46, NO.11, NOVEMBER 2017 835
CLINICAL EARLY DETECTION OF EATING DISORDERS

and signs may represent an eating A multidisciplinary team approach is


Table 3. Assessment of the
disorder may preclude early detection. often required to manage the physical patient with a suspected eating
NICE guidelines note that ‘diagnosis is and psychosocial consequences of the disorder 7,14,18,19,22–25
often delayed when doctors inadvertently condition. The team could include a
collude by over-investigating and referring psychiatrist, psychologist, paediatrician, The initial physical assessment should
to other specialties rather than confronting dietitian, social worker, psychiatric include:

the possibility of an eating disorder’.19 nurse, community support organisations • H


eight, weight, body mass index (BMI;
adults), BMI percentile for age (children)
Physical examination and investigation and other medical specialists (eg
are the next steps in assessment, but endocrinologist, gastroenterologist).18 The • P
ulse and blood pressure, with postural
measurements
there may not be any abnormal physical role of the GP includes:14,18,22,23
findings and, often, laboratory results are • assessment and initial diagnosis • Temperature

normal.7 Table 3 summarises a relevant (including urgent referral to the • A


ssessment of breathing and breath (eg
assessment for a patient with a suspected emergency department, if indicated) ketosis)

eating disorder. • treatment of medical complications (eg • E


xamination of periphery for circulation
and oedema
iron deficiency)
Management • nutritional/weight assessment • A
ssessment of skin colour (eg anaemia,
hypercarotenaemia, cyanosis)
The first priority in the management of a • referral to appropriate health
patient with an eating disorder is securing professionals • H
ydration state (eg moisture of mucosal
membranes, tissue turgor)
medical and psychiatric safety.2,18 It is • involvement of community or hospital-
• E
xamination of head and neck (eg
prudent to remember that a patient’s based mental health services
parotid swelling, dental enamel erosion,
visible habitus is not a reliable indicator • education for the patient and their gingivitis, conjunctival injection)
of their medical risk. For example, a family
• E
xamination of skin, hair and nails (eg
patient can have a normal body mass • provision of regular ongoing medical dry skin, brittle nails, lanugo, dorsal
index (BMI) but also have a potassium monitoring. finger callouses [Russell’s sign])
level of 2.5 mmol/L due to their purging The more detailed aspects of • S
it-up or squat test (ie a test of muscle
behaviours. In addition, BMI may be management are beyond the scope power)
normal, but the patient might be at of this article, but are provided in the
risk because of rapid weight loss or, in list of resources supplied. Certainly, in Useful laboratory investigations include:
children, there may be failure to gain the scenario of early presentation and • Full blood count
weight.7,18,22 The criteria for admission to diagnosis (or prior to the patient fulfilling • Urea and electrolytes, creatinine
hospital are listed in Table 4.22 diagnostic criteria), education and regular • Liver function tests
For most patients who will not need monitoring in the primary care setting • Blood glucose
immediate hospitalisation, treatment may be all that is required to prevent
• Urinalysis
should be individualised and take place symptom progression.
• Electrocardiography
initially in an outpatient community
setting, if possible.14 Decisions Conclusion • Iron studies

surrounding management options are Eating disorders are serious, • B12, folate
dependent on:2 life‑threatening conditions with significant • Calcium, magnesium, phosphate
• age of the patient physical, psychiatric, psychosocial • H
ormonal testing – thyroid function
• symptom severity and financial outcomes. The impact of tests, follicle stimulating hormone,
• course of illness these consequences can be minimised luteinising hormone, oestradiol, prolactin

• medical stability or avoided by early identification and • P


lain X-rays – useful for identification of
bone age in cases of delayed growth
• patient motivation management in the general practice
• psychosocial or family support setting. This article outlines an approach • B
one densitometry – relevant after
9–12 months of the disease or of
• regional availability of specialised to assessment in the primary care
amenorrhoea and as a baseline in
inpatient/outpatient programs setting with an emphasis on early adolescents. The recommendation is
• associated psychiatric comorbidity. detection. Ideally, this is achieved by a for two-yearly scans thereafter while the
Other significant factors that influence thorough history, a trusting therapeutic DEXA scans are abnormal.
the necessary treatment interventions relationship between doctor and patient,
Other investigations may be indicated in certain
are whether identification or presentation and intervention before a patient fulfils
clinical presentations to exclude other differential
occurs early, and the competence of the all of the diagnostic criteria of a particular diagnoses (eg coeliac autoantibodies).
GP in the field of eating disorders.16 eating disorder.

836 REPRINTED FROM AFP VOL.46, NO.11, NOVEMBER 2017 © The Royal Australian College of General Practitioners 2017
EARLY DETECTION OF EATING DISORDERS CLINICAL

Table 4. RANZCP clinical practice guidelines for the treatment of eating disorders 2014

Psychiatric admission indicated* Medical admission indicated†

Weight Body mass index (BMI) <14 kg/m2 BMI <12 kg/m2

Rapid weight loss 1 kg per week over several weeks or grossly inadequate
nutritional intake (<100 kcal daily) or continued weight
loss despite community treatment

Systolic blood pressure <90 mmHg <80 mmHg

Postural blood pressure >10 mmHg drop with standing >20 mmHg drop with standing

Heart rate ≤40 bpm or >120 bpm or postural tachycardia >20 bpm

Temperature <35.5°C or cold/blue extremities <35°C or cold/blue extremities

12-lead Any arrhythmia including QTc prolongation, non-specific ST


electrocardiogram or T-wave changes including inversion or biphasic waves

Blood sugar Below normal range‡ <2.5 mmol/L

Sodium <130 mmol/L‡ <125 mmol/L

Potassium Below normal range‡ <3.0 mmol/L

Magnesium Below normal range‡

Phosphate Below normal range‡

Estimated glomerular <60 ml/min/1.73m2 or rapidly dropping (25% drop within


filtration rate a week)

Albumin Below normal range <30 g/L

Liver enzymes Mildly elevated Markedly elevated (AST and ALT >500)‡

Neutrophils <1.5 × 109/L <1.0 × 109/L

Risk assessment Suicidal ideation


Active self-harm
Moderate to high agitation and distress

*Patients who are not as unwell as indicated above may still require admission to a psychiatric or other inpatient facility. †Medical admission refers to admission to a
medical ward, short-stay medical assessment unit or similar. ‡Please note, any biochemical abnormality that has not responded to adequate replacement within the first
24 hours of admission should be reviewed by a medical registrar urgently.
ALT, alanine aminotransferase; AST, aspartate aminotransferase

Admission criteria for children

Indicators for admission* and specialist consultation

Medical status Heart rate: <50 bpm QTc: >450 msec


Cardiac arrhythmia Temperature: <35.5oC
Postural tachycardia: >20/min Hypokalaemia
Blood pressure: <80/50 mm Neutropaenia
Postural hypotension: >20 mm

Weight Children <75% of expected body weight or rapid weight loss

Note: These are a guide only and do not replace the need for individual clinical judgement
*For children, admission would generally be to a medical ward. †People may also require admission for:
• uncontrolled eating disorder behaviour
• failure to respond to outpatient treatment
• severe psychiatric comorbidity
Reproduced with permission from the Royal Australian and New Zealand College of Psychiatrists. Clinical practice guidelines for the treatment of eating disorders.
Melbourne: RANZCP, 2014.

© The Royal Australian College of General Practitioners 2017 REPRINTED FROM AFP VOL.46, NO.11, NOVEMBER 2017 837
CLINICAL EARLY DETECTION OF EATING DISORDERS

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