VASCULAR

DEVELOPMENT
ARTERIAL SYSTEM

Dr.B.B.Gosai
Professor in Anatomy
Ojvensha e-learning resources
 Learning Objectives:
• Development of aortic arches.
• Fate of the aortic arches.
• Development of Vitelline and umbilical
arteries and their fate.
• Arterial system defects like ductus
arteriosus, coarctation of aorta,abnormal
origin of right subclavian artery and aortic
arch defects.
 References:
• Langman’s Medical Embryology by
T.W.Sadler

• Other reference text book:

• Keith Moore’s Developing Human
 Main arteries of the embryo
• Aortic sac and aortic arches
• Dorsal aortae
• Vitelline arteries
• Umbilical arteries
 Aortic Arches
• Arteries arising from aortic sac for
pharyngeal arches of head & neck.
• Six aortic arches.
• Fifth aortic arch never forms or is
incompletely formed and disappear.
• Rest of the aortic arches forms the various
arteries by changes in their pattern.
 Division of truncus arteriosus
• Aorticopulmonary septum divide truncus
arteriosus into Ventral Aorta and
Pulmonary Artery.
• Aortic sac –dilated part of truncus
arteriosus: right horn form Brachiocephalic
artery and left horn form proximal part of
aortic arch.
 Fate of the Aortic arches
• First aortic arch: Most of it disappear. Small
part persist to form Maxillary artery.
• Second aortic arch: Most of it disappear. Small
part persist to form Hyoid and Stapedial
arteries.
• Third aortic arch: forms Common Carotid
artery and first part of Internal carotid artery.
Remaining part of Internal carotid artery is
formed by dorsal aorta. External carotid artery
is formed by sprouting of third aortic arch.
 Fate of the Aortic arches
• Fourth aortic arch: Persists on both sides.
– On left side it forms part of Arch of Aorta.
– On right side it forms proximal segment of right subclavian
artery.
– Rest of the right subclavian artery is formed by right dorsal
aorta and right 7th intersegmental artery.
• Fifth aortic arch: Never forms or incompletely formed and
disappear.
• Sixth aortic arch: also known as Pulmonary arch.
– On left side: Proximal part forms left pulmonary artery and
Distal part forms ductus arteriosus (during intrauterine life).
– On right side: Proximal part forms right pulmonary artery
and Distal disappear.
 Relation of Recurrent Laryngeal nerves

• Recurrent laryngeal nerves

wind around sixth aortic
arches.
• On right side distal part of sixth
arch disappear and right
recurrent laryngeal nerve now
winds around right subclavian
artery.
• On left side distal part of sixth
arch persists as ligamentum
arteriosum and left recurrent
laryngeal nerve winds around
arch of aorta near ligamentum
arteriosum.
 Vitelline and Umbilical arteries
• Vitelline arteries fuse and form:
– celiac artery for foregut
– Superior mesenteric artery for midgut
– Inferior mesenteric artery for hindgut
• Umbilical arteries paired and form:
– Proximal portion: internal iliac and superior
vesicle arteries
– Distal portion: obliterated to form medial
umbilical ligaments
 Arterial System Defects
• Coarctation of the Aorta: Narrowing of the aorta
• Double Aortic Arch: right dorsal aorta persists and form vascular ring
around trachea and oesophagus and may compress these
structures
• Right Arch of Aorta: left fourth arch and left dorsal aorta disappear.
Ligamentum arteriosum passing behind oesophagus compress it
and leads to difficulty in swallowing
• Anomalous Right Subclavian Artery: when artery is formed by right
dorsal aorta.
• Patent Ductus Arteriosus :Usually ductus arteriosus obliterate after
birth and form ligamentum arteriosum. Persistence of ductus
arteriosus leads to admixture of oxygenated and deoxygenated
blood.
COARCTACTION OF AORTA
DOUBLE AORTIC ARCH
Patent Ductus arteriosus
….Thanks….