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Functions:
• Gas exchange
• Regulation of blood pH
• Voice production
• Olfaction
• Protection against some microorganisms
NOSE
- External nose and the nasal cavity
o External nose
- Mainly composed of hyaline cartilage plates
- The bridge of the nose consists of the nasal bones
o Nasal cavity
- A passageway for air
- Cleans the air
- Humidifies and warms the air
- Contains the sensory organ for smell
- With the paranasal sinuses, it is a resonating chamber for
speech
Openings:
▪ Nares or nostrils: external openings
▪ Choanae: openings into the pharynx
❖ Vestibule
- Anterior part
❖ Hard palate
- Bony plate that forms the floor of the nasal cavity
- Separates the nasal cavity from the oral cavity
❖ Nasal septum
- Divides the nasal cavity into right and left parts
❖ Olfactory epithelium
- Most superior part of the nasal cavity
- Sensory organ for smell
❖ Conchae
- Bony ridges at the lateral walls of the nasal cavity
❖ Meatus
LARYNX
- Located in the anterior part of the throat and extends from
the base of the tongue to the trachea
- Prevents the entry of swallowed materials into the lower
respiratory tract
- Regulates the passage of air into and out of the lower
PLEURA
- Surround the lungs and provide protection against friction
MUSCLES OF RESPIRATION
o Muscles of Inspiration
PULMONARY VOLUMES
o Tidal volume – the volume of air inspired or expired with
each breath (500 mL)
o Inspiratory reserve volume – the amount of air that can be
inspired forcefully after inspiration of the tidal volume
(3000 mL)
o Expiratory reserve volume – the amount of air that can be
forcefully expired after expiration of the tidal volume (1100
mL)
o Residual volume – the volume of air still remaining in the
respiratory passages and lungs after the most forceful
expiration (1200 mL)
PULMONARY CAPACITIES
o Inspiratory capacity – the amount of air that a person can
inspire maximally after a normal expiration
(TV + IRV = 3500 mL)
o Functional residual capacity – the amount of air
remaining in the lungs at the end of a normal expiration
(ERV + RV = 2300 mL)
o Vital capacity – the maximum level of air that a person can
expel from the respiratory tract after a maximum
inspiration
(IRV + ERV + TV = 4600 mL)
o Total lung capacity – the sum of the inspiratory and
expiratory reserve volumes plus the tidal volume and the
URINARY SYSTEM
Consists of:
• Two kidneys
• Two ureters
• Urinary bladder
• Urethra
Functions:
• Excretion
• Regulation of blood volume and pressure
• Regulation of concentration of solutes in the blood
• Regulation of the pH of the extracellular fluid
• Regulation of red blood cell synthesis
• Vitamin D synthesis
KIDNEYS
- Bean-shaped
- Each is about the size of a tightly clenched fist
- Extend from the level of the last thoracic (T12) to the third
lumbar (L3) vertebrae
- Liver is superior to the right kidney, causing the right kidney
to be slightly lower than the left
- Each kidney measures about 11 cm long, 5 cm wide, and 3
cm thick and weighs about 130 g
o Renal capsule – fibrous connective tissue surrounding
each kidney
o Perirenal fat – adipose tissue covering the capsule; acts as
a shock absorber, cushioning the kidneys are against
mechanical shock
o Renal fascia – anchors the kidneys and surrounding
adipose tissue to the abdominal wall
o Hilum – found on the medial side of each kidney, where
blood vessels and nerve enter and exit the kidney
o Cortical nephrons
- Their loops of Henle do not extend deep into the medulla
o Juxtaglomerular apparatus
URINE PRODUCTION
o Filtration – the movement of water and small solute across
the filtration membrane as a result of a pressure difference
*Filtrate: fluid entering the nephron
o Glomerular filtration rate (GFR) – the amount of filtrate
produced each minute; ~125 mL/minute or 180 L/day
o Tubular reabsorption – the movement of water and solutes
from the filtrate back into the blood
o Tubular secretion – the active transport of solutes across
the walls of the nephron into the filtrate
URETERS & URINARY BLADDER
o Ureters – tubes through which urine flows from the
kidneys to the urinary bladder
o Urinary bladder – a hollow, muscular container that lies in
the pelvic cavity
o Urethra – transports urine to the outside of the body
*WALLS (I-O)
- Transitional epithelium, lamina propria, muscular coat, and
fibrous adventitia
ENDOCRINE SYSTEM
- Composed of glands that typically secrete chemical signals
into the circulatory system
• Hormones
- Produced in minute amounts by a collection of cells
- Secreted into the interstitial spaces
PITUITARY GLAND
- Hypophysis
- Secretes nine (9) major hormones that regulate numerous
body functions and the secretory activity of several other
endocrine glands
- Hypothalamus and pituitary gland are major sites where
the nervous and endocrine systems interact
- Hypothalamus regulates the secretory activity of the
pituitary gland
*The posterior pituitary is an extension of the
hypothalamus
- Roughly 1 cm in diameter, weighs 0.5-1.0 g, and rests in the
sella turcica of the sphenoid bone
- Connected to the hypothalamus by a
stalk of tissue
called the infundibulum
*Divided functionally into two parts:
➢ Posterior pituitary (neurohypophysis)
➢ Anterior pituitary (adenohypophysis)
o Posterior pituitary
- Neurohypophysis
- Extension of the hypothalamus
o Anterior pituitary
- Three areas:
➢ Pars tuberalis
➢ Pars intermedia
➢ Pars distalis
HYPOTHALAMIC FUNCTIONS
HORMONES
Growth hormone- Increased growth
releasing hormone hormone secretion
(GHRH)
Growth hormone- Decreased growth
inhibiting hormone hormone secretion
(GHIH) or
somatostatin
Thyrotropin-releasing Increased thyroid-
hormone (TRH) stimulating hormone
secretion
Corticotropin- Increased
releasing hormone adrenocorticotropic
(CRH) hormone secretion
Gonadotropin- Increased secretion
releasing hormone LH and FSH
(GnRH)
Prolactin-releasing Increased or
hormone (PRH) and decreased prolactin
prolactin-inhibiting secretion
hormone (PIH)
HORMONES FUNCTIONS
Thyroid hormones Increased metabolic
- Triiodothyronine T3 rate, essential for
- Tetraiodothyronine T4 normal process of
growth and
maturation
Calcitonin Decreased rate of
breakdown of bone
by osteoclasts;
prevention of a
large increase in
blood Ca levels
PARATHYROID GLAND
- Embedded in the posterior part of each lobe of thyroid gland
- Two cell types:
➢ Chief cells – secrete parathyroid hormone
➢ Oxyphils – unknown function
HORMONES FUNCTIONS
Parathyroid hormone Increased rate of
breakdown of bone
by osteoclasts;
increased
reabsorption of Ca in
kidneys; Increased
absorption of Ca from
the small intestine,
increased vitamin D
synthesis; increased
blood Ca levels
PANCREAS
- Lies behind the peritoneum between the greater curvature of
the stomach and the duodenum
- Elongated structure approximately 15 cm long; weighing
approximately 85 – 100 g
- Both an exocrine gland and an endocrine gland
*Exocrine portion consists of acini which produce pancreatic
juice
*Endocrine part consists of pancreatic islets (islets of
Langerhans) which secrete hormones
➢ Alpha cells (20%) – secrete glucagon
➢ Beta cells (75%) – secrete insulin
➢ Delta cells (5%) – secrete somatostatin
PINEAL BODY
- In the epithalamus
o Melatonin
- Inhibition of gonadotropin-releasing hormone-secretion,
thereby inhibiting reproduction; significance is not clear in
humans; may help regulate sleep-wake cycles
o Arginine
- Possible inhibition of gonadotropin-releasing hormone
secretion
THYMUS
REPRODUCTIVE SYSTEM
MALE REPRODUCTIVE SYSTEM
• Testes
• Series of ducts: epididymides, ductus deferentia, and
urethra
• Accessory glands: seminal vesicles, prostate gland, and
bulbourethral glands
• Supporting structure: scrotum and penis
Functions of MS:
• Production of sperm cells
• Sustaining and transfer of the sperm cells to the female
• Production of male sex hormones
SCROTUM
- Contains the testes and is divided into two internal
compartments by an incomplete connective tissue septum
- Raphe – an irregular ridge at the midline of the scrotum
- Dartos and cremaster muscles – help regulate testicular
temperature
PERINEUM
- The area between the thighs
- Boundaries:
➢ Anterior: symphysis pubis
➢ Posterior: coccyx
➢ Lateral: ischial tuberosities
- Two triangles
- Divided by the superficial transverse & deep transverse
TESTES
- Small, ovoid organs, each about 4-5 cm long, within the
scrotum
- Both an exocrine & endocrine gland
➢ Exocrine: sperm (seminiferous tubules)
➢ Endocrine: testosterone (interstitial or Leydig cells)
o Tunica albuginea – the outer connective tissue capsule of
the testes
- The seminiferous tubules empty into a set of short, straight
tubules, the tubuli recti, which in turn empty into a tubular
network called the rete testis
- The rete testis empties into 15-20 tubules called efferent
ductules
DUCTS
o Efferent ductules – extend from the testes to the head of
the epididymis
o Epididymis – a comma-shaped structure on the posterior
side of the testis that is the site of final sperm cell
maturation
- Head, body, and tail
- 12-16 days to travel through the epididymis and appear
in the ejaculate
o Ductus or Vas deferens – passes from the epididymis into
the abdominal cavity
➢ Spermatic cord: ductus deferens, testicular artery and
venous plexus, lymphatic vessels, and nerves
➢ Coverings of the spermatic cord (O-I): external
spermatic fascia, cremaster muscle, and internal
spermatic fascia
• Uterine tubes
• Vagina
• External genital organs
• Mammary glands
BROAD LIGAMENT
- An extension of the peritoneum that spreads out on
both sides of the uterus and to which the ovaries and
uterine tubes are attached
- Holds the internal reproductive organs in place
PARTS:
- Mesosalpinx
- Mesovarium
- Mesometrium
OVARIES
- Small organs about 2-3.5 cm long and 1-1.5 cm wide
o Mesovarium – peritoneal fold that attaches each ovary to
the posterior surface of the broad ligament
o Suspensory ligament – extends from the mesovarium to
the body wall
o Ovarian ligament – attaches the ovary to the superior
margin of the uterus
OVULATION
- Release of a secondary oocyte from an ovary
FERTILIZATION
- Begins when a sperm cell binds to the plasma membrane
and penetrates into the cytoplasm of a secondary oocyte
- Forms a zygote
*23 pairs (46) of chromosomes
VAGINA
- A tube about 10 cm long that extends from the uterus to the
outside of the body
- The female organ of copulation, functioning to receive the
penis during intercourse
- It allows menstrual flow and childbirth
- Hymen – thin mucous membrane that covers the vaginal
opening, or orifice
- Wall consists of an outer muscular layer and inner mucous
membrane
➢ Muscular layer – smooth muscle that allows the
vagina to increase in size to accommodate the penis
during intercourse and to stretch greatly during
childbirth
➢ Mucous membrane – moist stratified squamous
epithelium that forms a protective surface layer;
releases most of the lubricating secretions produced by
the female during intercourse
EXTERNAL GENITALIA
- Vulva or pudendum
- Consists of the vestibule and its surrounding structures
o Vestibule – the space into which the vagina opens
posteriorly and the urethra opens anteriorly
o Labia minora – a pair of thin, longitudinal skin folds
which forms the border on each side of the vestibule
o Clitoris – a small erectile structure located in the anterior
MENSTRUAL CYCLE
- Females experience their first episode of menstrual bleeding
or menarche between the ages of 11 and 16
- Elevated rates of estrogen and progesterone secretion
- Refers to the cyclic changes that occur in sex
- Refers to the cyclic changes that occur in sexually mature,
o Menstruation
- The discharge of the blood and elements of the uterine tube
mucous membrane
o First day of menses
- Day 1 of the menstrual cycle, and menses typically lasts 4-5
days
o Follicular or proliferative phase
- Time between the ending of menses and ovulation
- Rapid development of ovarian follicles
- Rapid proliferation of the uterine mucosa
o Ovulation
- Occurs on about 14 of a 28-day menstrual cycle
*Variable
- The time between ovulation, on day 14, and the next menses
is typically 14 days
o Luteal or secretory phase
- Period after ovulation and before the next menses
- Existence of the corpus luteum
- Maturation of and secretion by uterine glands
MENOPAUSE
- Cessation of menstrual cycles
- 40-50 years old
o Female climacteric or perimenopause
- the time from the onset of irregular cycles to their complete
cessation, which is often 3 to 5 years
- “hot flashes”, irritability, fatigue, anxiety, and occasionally
severe emotional disturbances