Drug Classification Mechanism of Action Indication Contraindication Adverse Effects Nursing

Responsibilities
Generic Name: Chemical class: Mainly stimulates beta1- To treat low cardiac Hypersensitivity to CNS: Fever, headache, Before:
Dobutamine Synthetic adrenergic receptors, and output and heart failure dobutamine or its nervousness,  Educate patient
Hydrochloride catecholamine mildly stimulates beta2- and components, idiopathic restlessness about the
alpha1- adrenergic hypertrophic subaortic CV: Angina, bradycardia, dangers of
Brand Name: Therapeutic receptors. Beta1-receptor stenosis hypertension, overdose;
Dobutrex class: Cardiac stimulation produces a hypotension, palpitations, encourage
stimulant positive inotropic effect on PVCs, tachycardia patient to adhere
Dosage: the myocardium, increasing GI: Nausea, vomiting to proper dosing
cardiac output by boosting RESP: Dyspnea schedule.
Route: IVTT myocardial contractility and SKIN: Extravasation with  Advise patient to
stroke volume. Increased tissue necrosis increase fluid
Frequency: myocardial contractility and sloughing, rash intake.
raises coronary blood flow Other: Hypokalemia  Keep in mind
Timing: and myocardial oxygen that patient
consumption. Systolic blood should be
pressure typically rises as a adequately
result of increased stroke digitalized before
volume. Other hemo administration.
dynamic effects include
decreased systemic During:
vascular resistance, which  Inspect
reduces afterload, and parenteral
decreased ventricular fil solution for
particles and
discoloration
before
administering it.
 Give I.V. drug
using an infusion
pump.
 Monitor blood
pressure often
 during therapy

After:
 Explain the need
for frequent
hemo dynamic
monitoring.
 Monitor
hemodynamic
parameters, such
as central venous
pressure,
pulmonary artery
wedge pressure,
and cardiac
output, as
indicated, to
assess drug’s
effectiveness.
 Monitor heart
rate and rhythm
con tinuously
for PVCs, which
may result from
drug’s
stimulatory
effect on heart’s
conduction
system, and
sinus
tachycardia,
which results
from positive
 chronotropic
effect of beta
stimulation and
may increase
heart rate by 5 to
15 beats/minute.

Reference:

2015 Nurses Drug Handbook (Jones and Bartlett Learning)

Drug Classification Mechanism of Action Indication Contraindication Adverse Effects Nursing

Generic Name: Bronchodilator It relaxes the smooth
Salbutamol , Adrenergics muscles of the bronchioles
allowing maximum passage
Brand Name: of air. It decreases
intracellular calcium which
Dosage: will relax the smooth
muscles of the lungs by
Route: ORAL mobilizing kinase through
activation of cyclic-3’5’-
Frequency: adenosine monophosphate
(cAMP).
Timing:
Salbutamol is indicated for
(i) the symptomatic relief
and prevention of
bronchospasm due to
bronchial asthma, chronic
bronchitis, reversible
obstructive airway disease,
and other chronic
bronchopulmonary
disorders in which
bronchospasm is a
complicating factor, and/or
(ii) the acute prophylaxis
against exercise-induced
bronchospasm and other
stimuli known to induce
bronchospasm.
Responsibilities
IV (in the treatment of Significant: Hypersensitivity Before:
premature labour): Pre- reactions (e.g. urticaria,  Assess lung
existing or risk factors for angioedema, rash, sounds, PR and
ischaemic heart disease, bronchospasm, BP before drug
gestational age <22 weeks, oropharyngeal oedema), administration
conditions in which hypokalaemia (high doses). and during peak
prolongation of pregnancy of medication.
is hazardous, intrauterine CD: Tachycardia,
foetal death, known lethal palpitations, chest pain. During:
congenital or lethal Rarely, cardiac arrythmias  Observe fore
chromosomal (e.g. atrial fibrillation, paradoxical
malformation, pulmonary supraventricular spasm and
hypertension. Non-IV tachycardia, extrasystoles), withhold
formulation is not myocardial ischaemia. medication and
indicated for use in notify physician
uncomplicated premature GI: Nausea, vomiting, if condition
labour or threatened mouth and throat irritation occurs.
abortion. (inhalation).  Administer PO
 General disorders and medications
administration site with meals to
conditions: Weakness. minimize gastric
irritation.
Metabolism and nutrition  If administering
disorders: Hyperglycaemia. medication
Rarely, lactic acidosis (high through
doses). inhalation, allow
at least 1
Musculoskeletal and minute between
connective tissue inhalation of
disorders: Muscle cramps. aerosol
medication.
CN: Tremor, headache,
dizziness, drowsiness, After :
restlessness.  Advise the
Psychiatric disorders: patient to rinse
Nervousness, irritability, mouth with
insomnia. water after each
Respiratory, thoracic and inhalation to
mediastinal disorders: minimize dry
Pharyngitis, rhinitis, mouth.
pulmonary oedema  Inform the
(parenteral). patient that
Vascular disorders: Albuterol may
Peripheral vasodilation, cause an unusual
flushing. or bad taste.

Reference:

https://rnspeak.com/salbutamol-drug-study/

https://www.mims.com/philippines/drug/info/salbutamol?mtype=generic